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Protein

Homeobox protein MOX-2

Gene

Meox2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 245HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2
Gene namesi
Name:Meox2
Synonyms:Gax, Mox-2, Mox2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3079 Meox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491991 – 303Homeobox protein MOX-2Add BLAST303

Proteomic databases

PaxDbiP39020
PRIDEiP39020

PTM databases

iPTMnetiP39020
PhosphoSitePlusiP39020

Expressioni

Tissue specificityi

Aorta and heart. Also detected in lung and kidney.1 Publication

Inductioni

Rapidly and transiently down-regulated during the transition from G0 to G1 induced by mitogen stimulation.1 Publication

Interactioni

Subunit structurei

Interacts with RNF10.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008803

Structurei

3D structure databases

ProteinModelPortaliP39020
SMRiP39020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 47Poly-Ser6
Compositional biasi64 – 85Gln/His-rich (OPA repeat)Add BLAST22
Compositional biasi68 – 79Poly-HisAdd BLAST12
Compositional biasi80 – 85Poly-Gln6

Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles.By similarity

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
HOGENOMiHOG000230987
HOVERGENiHBG052456
InParanoidiP39020
KOiK09322
PhylomeDBiP39020

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP
110 120 130 140 150
SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPRDYGR
160 170 180 190 200
QALSPAEVEK RSGSKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE
210 220 230 240 250
LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG
260 270 280 290 300
AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANDD SRDSDHSSEH

AHL
Length:303
Mass (Da):33,605
Last modified:February 1, 1995 - v1
Checksum:i7776642AEFA3A2E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17223 mRNA Translation: CAA78931.1
PIRiA48130
RefSeqiNP_058845.1, NM_017149.1
UniGeneiRn.34890

Genome annotation databases

GeneIDi29279
KEGGirno:29279
UCSCiRGD:3079 rat

Similar proteinsi

Entry informationi

Entry nameiMEOX2_RAT
AccessioniPrimary (citable) accession number: P39020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health