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Protein

40S ribosomal protein S19

Gene

RPS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • erythrocyte differentiation Source: HGNC
  • maturation of SSU-rRNA Source: UniProtKB
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
  • monocyte chemotaxis Source: UniProtKB
  • negative regulation of respiratory burst involved in inflammatory response Source: UniProtKB
  • Notch signaling pathway Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • nucleolus organization Source: UniProtKB
  • positive regulation of cellular component movement Source: HGNC
  • positive regulation of respiratory burst involved in inflammatory response Source: UniProtKB
  • protein tetramerization Source: UniProtKB
  • response to extracellular stimulus Source: HGNC
  • ribosomal small subunit assembly Source: UniProtKB
  • ribosomal small subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105372-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SIGNORiP39019.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19
Gene namesi
Name:RPS19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10402. RPS19.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 1 (DBA1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:105650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0554369 – 14Missing in DBA1. 6
Natural variantiVAR_01843815V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 PublicationsCorresponds to variant rs104894717dbSNPEnsembl.1
Natural variantiVAR_04614517A → P in DBA1. 1 Publication1
Natural variantiVAR_05543718 – 19LA → E in DBA1. 2
Natural variantiVAR_01843918L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_04614618L → R in DBA1. 1 Publication1
Natural variantiVAR_05543821F → S in DBA1. 1
Natural variantiVAR_01844047P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_05543952W → C in DBA1. 1
Natural variantiVAR_01844152W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844255T → M in DBA1. 1 PublicationCorresponds to variant rs147508369dbSNPEnsembl.1
Natural variantiVAR_01843756R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_05544057A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication1
Natural variantiVAR_04614758 – 60Missing in DBA1. 1 Publication3
Natural variantiVAR_04614859S → F in DBA1. 1 Publication1
Natural variantiVAR_01844361A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844462R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_00692462R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 PublicationsCorresponds to variant rs104894711dbSNPEnsembl.1
Natural variantiVAR_05544164L → P in DBA1. 1
Natural variantiVAR_05544276T → P in DBA1. 1
Natural variantiVAR_05544378 – 83IYGGRQ → R in DBA1. 6
Natural variantiVAR_018445101R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_018446120G → R in DBA1. 2 Publications1
Natural variantiVAR_055444127G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. Corresponds to variant rs786200936dbSNPEnsembl.1
Natural variantiVAR_018447131L → P in DBA1. 1 Publication1
Natural variantiVAR_046149131L → R in DBA1. 1 Publication1
Natural variantiVAR_055445135A → T in DBA1. 1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNETi6223.
MalaCardsiRPS19.
MIMi105650. phenotype.
OpenTargetsiENSG00000105372.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34803.

Polymorphism and mutation databases

BioMutaiRPS19.
DMDMi730640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001538102 – 14540S ribosomal protein S19Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei67Omega-N-methylarginineCombined sources1
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei143N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP39019.
MaxQBiP39019.
PaxDbiP39019.
PeptideAtlasiP39019.
PRIDEiP39019.
TopDownProteomicsiP39019.

PTM databases

iPTMnetiP39019.
PhosphoSitePlusiP39019.
SwissPalmiP39019.

Expressioni

Tissue specificityi

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

Gene expression databases

BgeeiENSG00000105372.
CleanExiHS_RPS19.
ExpressionAtlasiP39019. baseline and differential.
GenevisibleiP39019. HS.

Organism-specific databases

HPAiHPA063217.

Interactioni

Subunit structurei

Interacts with RPS19BP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PIM1P113097EBI-354451,EBI-696621

GO - Molecular functioni

  • fibroblast growth factor binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112137. 171 interactors.
IntActiP39019. 28 interactors.
MINTiMINT-189322.
STRINGi9606.ENSP00000470004.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-ST1-145[»]
4V6Xelectron microscopy5.00AT1-145[»]
5A2Qelectron microscopy3.90T1-145[»]
5AJ0electron microscopy3.50BT1-145[»]
5FLXelectron microscopy3.90T1-145[»]
ProteinModelPortaliP39019.
SMRiP39019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19e family.Curated

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
HOVERGENiHBG000240.
InParanoidiP39019.
KOiK02966.
OMAiKTGRHKE.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39019.
TreeFamiTF315008.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE
60 70 80 90 100
NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA
110 120 130 140
RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
Length:145
Mass (Da):16,060
Last modified:January 23, 2007 - v2
Checksum:i181F2DB898E56E41
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0554369 – 14Missing in DBA1. 6
Natural variantiVAR_01843815V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 PublicationsCorresponds to variant rs104894717dbSNPEnsembl.1
Natural variantiVAR_04614517A → P in DBA1. 1 Publication1
Natural variantiVAR_05543718 – 19LA → E in DBA1. 2
Natural variantiVAR_01843918L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_04614618L → R in DBA1. 1 Publication1
Natural variantiVAR_05543821F → S in DBA1. 1
Natural variantiVAR_01844047P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_05543952W → C in DBA1. 1
Natural variantiVAR_01844152W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844255T → M in DBA1. 1 PublicationCorresponds to variant rs147508369dbSNPEnsembl.1
Natural variantiVAR_01843756R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_05544057A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication1
Natural variantiVAR_04614758 – 60Missing in DBA1. 1 Publication3
Natural variantiVAR_04614859S → F in DBA1. 1 Publication1
Natural variantiVAR_01844361A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications1
Natural variantiVAR_01844462R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_00692462R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 PublicationsCorresponds to variant rs104894711dbSNPEnsembl.1
Natural variantiVAR_05544164L → P in DBA1. 1
Natural variantiVAR_05544276T → P in DBA1. 1
Natural variantiVAR_05544378 – 83IYGGRQ → R in DBA1. 6
Natural variantiVAR_018445101R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications1
Natural variantiVAR_018446120G → R in DBA1. 2 Publications1
Natural variantiVAR_055444127G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. Corresponds to variant rs786200936dbSNPEnsembl.1
Natural variantiVAR_018447131L → P in DBA1. 1 Publication1
Natural variantiVAR_046149131L → R in DBA1. 1 Publication1
Natural variantiVAR_055445135A → T in DBA1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81757 mRNA. Translation: AAA89070.1.
AF092907, AF092906 Genomic DNA. Translation: AAD13668.1.
BC000023 mRNA. Translation: AAH00023.1.
BC007615 mRNA. Translation: AAH07615.1.
BC018616 mRNA. Translation: AAH18616.1.
AB007155 Genomic DNA. Translation: BAA28593.1.
CCDSiCCDS12588.1.
PIRiI52692.
RefSeqiNP_001013.1. NM_001022.3.
NP_001308412.1. NM_001321483.1.
NP_001308413.1. NM_001321484.1.
UniGeneiHs.438429.

Genome annotation databases

EnsembliENST00000593863; ENSP00000470004; ENSG00000105372.
ENST00000598742; ENSP00000470972; ENSG00000105372.
GeneIDi6223.
KEGGihsa:6223.
UCSCiuc002ort.4. human.

Cross-referencesi

Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81757 mRNA. Translation: AAA89070.1.
AF092907, AF092906 Genomic DNA. Translation: AAD13668.1.
BC000023 mRNA. Translation: AAH00023.1.
BC007615 mRNA. Translation: AAH07615.1.
BC018616 mRNA. Translation: AAH18616.1.
AB007155 Genomic DNA. Translation: BAA28593.1.
CCDSiCCDS12588.1.
PIRiI52692.
RefSeqiNP_001013.1. NM_001022.3.
NP_001308412.1. NM_001321483.1.
NP_001308413.1. NM_001321484.1.
UniGeneiHs.438429.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-ST1-145[»]
4V6Xelectron microscopy5.00AT1-145[»]
5A2Qelectron microscopy3.90T1-145[»]
5AJ0electron microscopy3.50BT1-145[»]
5FLXelectron microscopy3.90T1-145[»]
ProteinModelPortaliP39019.
SMRiP39019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112137. 171 interactors.
IntActiP39019. 28 interactors.
MINTiMINT-189322.
STRINGi9606.ENSP00000470004.

PTM databases

iPTMnetiP39019.
PhosphoSitePlusiP39019.
SwissPalmiP39019.

Polymorphism and mutation databases

BioMutaiRPS19.
DMDMi730640.

Proteomic databases

EPDiP39019.
MaxQBiP39019.
PaxDbiP39019.
PeptideAtlasiP39019.
PRIDEiP39019.
TopDownProteomicsiP39019.

Protocols and materials databases

DNASUi6223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593863; ENSP00000470004; ENSG00000105372.
ENST00000598742; ENSP00000470972; ENSG00000105372.
GeneIDi6223.
KEGGihsa:6223.
UCSCiuc002ort.4. human.

Organism-specific databases

CTDi6223.
DisGeNETi6223.
GeneCardsiRPS19.
GeneReviewsiRPS19.
HGNCiHGNC:10402. RPS19.
HPAiHPA063217.
MalaCardsiRPS19.
MIMi105650. phenotype.
603474. gene.
neXtProtiNX_P39019.
OpenTargetsiENSG00000105372.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
HOVERGENiHBG000240.
InParanoidiP39019.
KOiK02966.
OMAiKTGRHKE.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39019.
TreeFamiTF315008.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105372-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SIGNORiP39019.

Miscellaneous databases

ChiTaRSiRPS19. human.
GeneWikiiRibosomal_protein_S19.
GenomeRNAii6223.
PROiP39019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105372.
CleanExiHS_RPS19.
ExpressionAtlasiP39019. baseline and differential.
GenevisibleiP39019. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS19_HUMAN
AccessioniPrimary (citable) accession number: P39019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.