Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S19

Gene

RPS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • erythrocyte differentiation Source: HGNC
  • maturation of SSU-rRNA Source: UniProtKB
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
  • monocyte chemotaxis Source: UniProtKB
  • negative regulation of respiratory burst involved in inflammatory response Source: UniProtKB
  • Notch signaling pathway Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • nucleolus organization Source: UniProtKB
  • positive regulation of cellular component movement Source: HGNC
  • positive regulation of respiratory burst involved in inflammatory response Source: UniProtKB
  • protein tetramerization Source: UniProtKB
  • response to extracellular stimulus Source: HGNC
  • ribosomal small subunit assembly Source: UniProtKB
  • ribosomal small subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SIGNORiP39019.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19
Gene namesi
Name:RPS19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10402. RPS19.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 1 (DBA1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:105650
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 146Missing in DBA1.
VAR_055436
Natural varianti15 – 151V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 Publications
Corresponds to variant rs104894717 [ dbSNP | Ensembl ].
VAR_018438
Natural varianti17 – 171A → P in DBA1. 1 Publication
VAR_046145
Natural varianti18 – 192LA → E in DBA1.
VAR_055437
Natural varianti18 – 181L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018439
Natural varianti18 – 181L → R in DBA1. 1 Publication
VAR_046146
Natural varianti21 – 211F → S in DBA1.
VAR_055438
Natural varianti47 – 471P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018440
Natural varianti52 – 521W → C in DBA1.
VAR_055439
Natural varianti52 – 521W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018441
Natural varianti55 – 551T → M in DBA1. 1 Publication
Corresponds to variant rs147508369 [ dbSNP | Ensembl ].
VAR_018442
Natural varianti56 – 561R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications
VAR_018437
Natural varianti57 – 571A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication
VAR_055440
Natural varianti58 – 603Missing in DBA1. 1 Publication
VAR_046147
Natural varianti59 – 591S → F in DBA1. 1 Publication
VAR_046148
Natural varianti61 – 611A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018443
Natural varianti62 – 621R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications
VAR_018444
Natural varianti62 – 621R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 Publications
Corresponds to variant rs104894711 [ dbSNP | Ensembl ].
VAR_006924
Natural varianti64 – 641L → P in DBA1.
VAR_055441
Natural varianti76 – 761T → P in DBA1.
VAR_055442
Natural varianti78 – 836IYGGRQ → R in DBA1.
VAR_055443
Natural varianti101 – 1011R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications
VAR_018445
Natural varianti120 – 1201G → R in DBA1. 2 Publications
VAR_018446
Natural varianti127 – 1271G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit.
Corresponds to variant rs786200936 [ dbSNP | Ensembl ].
VAR_055444
Natural varianti131 – 1311L → P in DBA1. 1 Publication
VAR_018447
Natural varianti131 – 1311L → R in DBA1. 1 Publication
VAR_046149
Natural varianti135 – 1351A → T in DBA1.
VAR_055445

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

MalaCardsiRPS19.
MIMi105650. phenotype.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34803.

Polymorphism and mutation databases

BioMutaiRPS19.
DMDMi730640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 14514440S ribosomal protein S19PRO_0000153810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineCombined sources
Modified residuei111 – 1111N6-acetyllysineCombined sources
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei143 – 1431N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP39019.
MaxQBiP39019.
PaxDbiP39019.
PeptideAtlasiP39019.
PRIDEiP39019.
TopDownProteomicsiP39019.

PTM databases

iPTMnetiP39019.
PhosphoSiteiP39019.
SwissPalmiP39019.

Expressioni

Tissue specificityi

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

Gene expression databases

BgeeiENSG00000105372.
CleanExiHS_RPS19.
ExpressionAtlasiP39019. baseline and differential.
GenevisibleiP39019. HS.

Organism-specific databases

HPAiHPA063217.

Interactioni

Subunit structurei

Interacts with RPS19BP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PIM1P113097EBI-354451,EBI-696621

GO - Molecular functioni

  • fibroblast growth factor binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112137. 171 interactions.
IntActiP39019. 27 interactions.
MINTiMINT-189322.
STRINGi9606.ENSP00000470004.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-ST1-145[»]
4V6Xelectron microscopy5.00AT1-145[»]
5A2Qelectron microscopy3.90T1-145[»]
5AJ0electron microscopy3.50BT1-145[»]
5FLXelectron microscopy3.90T1-145[»]
ProteinModelPortaliP39019.
SMRiP39019. Positions 2-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19e family.Curated

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
HOVERGENiHBG000240.
InParanoidiP39019.
KOiK02966.
OMAiKTGRHKE.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39019.
TreeFamiTF315008.

Family and domain databases

InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE
60 70 80 90 100
NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA
110 120 130 140
RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
Length:145
Mass (Da):16,060
Last modified:January 23, 2007 - v2
Checksum:i181F2DB898E56E41
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 146Missing in DBA1.
VAR_055436
Natural varianti15 – 151V → F in DBA1; affects protein stability; does not localize to the nucleolus. 3 Publications
Corresponds to variant rs104894717 [ dbSNP | Ensembl ].
VAR_018438
Natural varianti17 – 171A → P in DBA1. 1 Publication
VAR_046145
Natural varianti18 – 192LA → E in DBA1.
VAR_055437
Natural varianti18 – 181L → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018439
Natural varianti18 – 181L → R in DBA1. 1 Publication
VAR_046146
Natural varianti21 – 211F → S in DBA1.
VAR_055438
Natural varianti47 – 471P → L in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018440
Natural varianti52 – 521W → C in DBA1.
VAR_055439
Natural varianti52 – 521W → R in DBA1; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018441
Natural varianti55 – 551T → M in DBA1. 1 Publication
Corresponds to variant rs147508369 [ dbSNP | Ensembl ].
VAR_018442
Natural varianti56 – 561R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications
VAR_018437
Natural varianti57 – 571A → P in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 1 Publication
VAR_055440
Natural varianti58 – 603Missing in DBA1. 1 Publication
VAR_046147
Natural varianti59 – 591S → F in DBA1. 1 Publication
VAR_046148
Natural varianti61 – 611A → E in DBA1; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit. 2 Publications
VAR_018443
Natural varianti62 – 621R → Q in DBA1; affects assembly into a functional ribosomal subunit. 3 Publications
VAR_018444
Natural varianti62 – 621R → W in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 4 Publications
Corresponds to variant rs104894711 [ dbSNP | Ensembl ].
VAR_006924
Natural varianti64 – 641L → P in DBA1.
VAR_055441
Natural varianti76 – 761T → P in DBA1.
VAR_055442
Natural varianti78 – 836IYGGRQ → R in DBA1.
VAR_055443
Natural varianti101 – 1011R → H in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit. 3 Publications
VAR_018445
Natural varianti120 – 1201G → R in DBA1. 2 Publications
VAR_018446
Natural varianti127 – 1271G → E in DBA1; affects protein stability; does not localize to the nucleolus; affects assembly into a functional ribosomal subunit.
Corresponds to variant rs786200936 [ dbSNP | Ensembl ].
VAR_055444
Natural varianti131 – 1311L → P in DBA1. 1 Publication
VAR_018447
Natural varianti131 – 1311L → R in DBA1. 1 Publication
VAR_046149
Natural varianti135 – 1351A → T in DBA1.
VAR_055445

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81757 mRNA. Translation: AAA89070.1.
AF092907, AF092906 Genomic DNA. Translation: AAD13668.1.
BC000023 mRNA. Translation: AAH00023.1.
BC007615 mRNA. Translation: AAH07615.1.
BC018616 mRNA. Translation: AAH18616.1.
AB007155 Genomic DNA. Translation: BAA28593.1.
CCDSiCCDS12588.1.
PIRiI52692.
RefSeqiNP_001013.1. NM_001022.3.
NP_001308412.1. NM_001321483.1.
NP_001308413.1. NM_001321484.1.
UniGeneiHs.438429.

Genome annotation databases

EnsembliENST00000593863; ENSP00000470004; ENSG00000105372.
ENST00000598742; ENSP00000470972; ENSG00000105372.
GeneIDi6223.
KEGGihsa:6223.
UCSCiuc002ort.4. human.

Cross-referencesi

Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81757 mRNA. Translation: AAA89070.1.
AF092907, AF092906 Genomic DNA. Translation: AAD13668.1.
BC000023 mRNA. Translation: AAH00023.1.
BC007615 mRNA. Translation: AAH07615.1.
BC018616 mRNA. Translation: AAH18616.1.
AB007155 Genomic DNA. Translation: BAA28593.1.
CCDSiCCDS12588.1.
PIRiI52692.
RefSeqiNP_001013.1. NM_001022.3.
NP_001308412.1. NM_001321483.1.
NP_001308413.1. NM_001321484.1.
UniGeneiHs.438429.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-ST1-145[»]
4V6Xelectron microscopy5.00AT1-145[»]
5A2Qelectron microscopy3.90T1-145[»]
5AJ0electron microscopy3.50BT1-145[»]
5FLXelectron microscopy3.90T1-145[»]
ProteinModelPortaliP39019.
SMRiP39019. Positions 2-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112137. 171 interactions.
IntActiP39019. 27 interactions.
MINTiMINT-189322.
STRINGi9606.ENSP00000470004.

PTM databases

iPTMnetiP39019.
PhosphoSiteiP39019.
SwissPalmiP39019.

Polymorphism and mutation databases

BioMutaiRPS19.
DMDMi730640.

Proteomic databases

EPDiP39019.
MaxQBiP39019.
PaxDbiP39019.
PeptideAtlasiP39019.
PRIDEiP39019.
TopDownProteomicsiP39019.

Protocols and materials databases

DNASUi6223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593863; ENSP00000470004; ENSG00000105372.
ENST00000598742; ENSP00000470972; ENSG00000105372.
GeneIDi6223.
KEGGihsa:6223.
UCSCiuc002ort.4. human.

Organism-specific databases

CTDi6223.
GeneCardsiRPS19.
GeneReviewsiRPS19.
HGNCiHGNC:10402. RPS19.
HPAiHPA063217.
MalaCardsiRPS19.
MIMi105650. phenotype.
603474. gene.
neXtProtiNX_P39019.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
HOVERGENiHBG000240.
InParanoidiP39019.
KOiK02966.
OMAiKTGRHKE.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39019.
TreeFamiTF315008.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SIGNORiP39019.

Miscellaneous databases

ChiTaRSiRPS19. human.
GeneWikiiRibosomal_protein_S19.
GenomeRNAii6223.
PROiP39019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105372.
CleanExiHS_RPS19.
ExpressionAtlasiP39019. baseline and differential.
GenevisibleiP39019. HS.

Family and domain databases

InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS19_HUMAN
AccessioniPrimary (citable) accession number: P39019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.