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Protein

40S ribosomal protein S19a

Gene

RpS19a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal small subunit assembly Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19a
Gene namesi
Name:RpS19a
Synonyms:RpS19
ORF Names:CG4464
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0010412 RpS19a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001538242 – 15640S ribosomal protein S19aAdd BLAST155

Proteomic databases

PaxDbiP39018
PRIDEiP39018

Expressioni

Gene expression databases

BgeeiFBgn0010412
GenevisibleiP39018 DM

Interactioni

Protein-protein interaction databases

BioGridi58971, 6 interactors
IntActiP39018, 29 interactors
MINTiP39018
STRINGi7227.FBpp0074086

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AT1-156[»]
ProteinModelPortaliP39018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3411 Eukaryota
COG2238 LUCA
GeneTreeiENSGT00390000013102
InParanoidiP39018
KOiK02966
OMAiYIDGPVG
OrthoDBiEOG091G0QM7
PhylomeDBiP39018

Family and domain databases

Gene3Di1.10.10.2700, 1 hit
InterProiView protein in InterPro
IPR001266 Ribosomal_S19e
IPR018277 Ribosomal_S19e_CS
IPR038111 Ribosomal_S19e_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11710 PTHR11710, 1 hit
PfamiView protein in Pfam
PF01090 Ribosomal_S19e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003854 Ribosomal_S19e, 1 hit
SMARTiView protein in SMART
SM01413 Ribosomal_S19e, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00628 RIBOSOMAL_S19E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDID QHAVTKAVAV FLKKTGKLKV PDQMDIVKTA KFKELAPYDP
60 70 80 90 100
DWFYVRCASI LRHLYHRSPA GVGSITKIYG GRKRNGVHPS HFCRAADGAA
110 120 130 140 150
RKALQALEHA RLVEKHPDGG RKLSSIGQRD LDRIANQIVF KQRDAAKQTG

PIVISK
Length:156
Mass (Da):17,291
Last modified:January 23, 2007 - v3
Checksum:iE70529088E255DEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37V → I in CAA51677 (PubMed:8367309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73153 mRNA Translation: CAA51677.1
AF216206 Genomic DNA Translation: AAF65682.1
AE014298 Genomic DNA Translation: AAN09412.1
AY118868 mRNA Translation: AAM50728.1
RefSeqiNP_001285338.1, NM_001298409.1
NP_001285339.1, NM_001298410.1
NP_523376.1, NM_078652.4
NP_727992.1, NM_167526.3
NP_727993.1, NM_167527.3
UniGeneiDm.20646

Genome annotation databases

EnsemblMetazoaiFBtr0074311; FBpp0074086; FBgn0010412
FBtr0074312; FBpp0074087; FBgn0010412
FBtr0074313; FBpp0074088; FBgn0010412
FBtr0340149; FBpp0309135; FBgn0010412
FBtr0345129; FBpp0311350; FBgn0010412
GeneIDi32635
KEGGidme:Dmel_CG4464

Similar proteinsi

Entry informationi

Entry nameiRS19A_DROME
AccessioniPrimary (citable) accession number: P39018
Secondary accession number(s): A4V4N1, B7Z0Y8, Q9VXE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health