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Protein

40S ribosomal protein S19a

Gene

RpS19a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal small subunit assembly Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19a
Gene namesi
Name:RpS19a
Synonyms:RpS19
ORF Names:CG4464
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0010412. RpS19a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001538242 – 15640S ribosomal protein S19aAdd BLAST155

Proteomic databases

PaxDbiP39018.
PRIDEiP39018.

Expressioni

Gene expression databases

BgeeiFBgn0010412.
GenevisibleiP39018. DM.

Interactioni

Protein-protein interaction databases

BioGridi58971. 6 interactors.
IntActiP39018. 29 interactors.
MINTiMINT-778839.
STRINGi7227.FBpp0074086.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AT1-156[»]
ProteinModelPortaliP39018.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
InParanoidiP39018.
KOiK02966.
OMAiYIDGPVG.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39018.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiView protein in Pfam
PF01090. Ribosomal_S19e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003854. Ribosomal_S19e. 1 hit.
SMARTiView protein in SMART
SM01413. Ribosomal_S19e. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00628. RIBOSOMAL_S19E. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDID QHAVTKAVAV FLKKTGKLKV PDQMDIVKTA KFKELAPYDP
60 70 80 90 100
DWFYVRCASI LRHLYHRSPA GVGSITKIYG GRKRNGVHPS HFCRAADGAA
110 120 130 140 150
RKALQALEHA RLVEKHPDGG RKLSSIGQRD LDRIANQIVF KQRDAAKQTG

PIVISK
Length:156
Mass (Da):17,291
Last modified:January 23, 2007 - v3
Checksum:iE70529088E255DEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37V → I in CAA51677 (PubMed:8367309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73153 mRNA. Translation: CAA51677.1.
AF216206 Genomic DNA. Translation: AAF65682.1.
AE014298 Genomic DNA. Translation: AAN09412.1.
AY118868 mRNA. Translation: AAM50728.1.
RefSeqiNP_001285338.1. NM_001298409.1.
NP_001285339.1. NM_001298410.1.
NP_523376.1. NM_078652.4.
NP_727992.1. NM_167526.3.
NP_727993.1. NM_167527.3.
UniGeneiDm.20646.

Genome annotation databases

EnsemblMetazoaiFBtr0074311; FBpp0074086; FBgn0010412.
FBtr0074312; FBpp0074087; FBgn0010412.
FBtr0074313; FBpp0074088; FBgn0010412.
FBtr0340149; FBpp0309135; FBgn0010412.
FBtr0345129; FBpp0311350; FBgn0010412.
GeneIDi32635.
KEGGidme:Dmel_CG4464.

Similar proteinsi

Entry informationi

Entry nameiRS19A_DROME
AccessioniPrimary (citable) accession number: P39018
Secondary accession number(s): A4V4N1, B7Z0Y8, Q9VXE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families