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Protein

40S ribosomal protein S19a

Gene

RpS19a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19a
Gene namesi
Name:RpS19a
Synonyms:RpS19
ORF Names:CG4464
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0010412. RpS19a.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: GO_Central
  • ribosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 15615540S ribosomal protein S19aPRO_0000153824Add
BLAST

Proteomic databases

PaxDbiP39018.
PRIDEiP39018.

Expressioni

Gene expression databases

BgeeiFBgn0010412.
GenevisibleiP39018. DM.

Interactioni

Protein-protein interaction databases

BioGridi58971. 4 interactions.
IntActiP39018. 20 interactions.
MINTiMINT-778839.
STRINGi7227.FBpp0074086.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AT1-156[»]
ProteinModelPortaliP39018.
SMRiP39018. Positions 2-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19e family.Curated

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
InParanoidiP39018.
KOiK02966.
OMAiMIKIYGG.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39018.

Family and domain databases

InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDID QHAVTKAVAV FLKKTGKLKV PDQMDIVKTA KFKELAPYDP
60 70 80 90 100
DWFYVRCASI LRHLYHRSPA GVGSITKIYG GRKRNGVHPS HFCRAADGAA
110 120 130 140 150
RKALQALEHA RLVEKHPDGG RKLSSIGQRD LDRIANQIVF KQRDAAKQTG

PIVISK
Length:156
Mass (Da):17,291
Last modified:January 23, 2007 - v3
Checksum:iE70529088E255DEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → I in CAA51677 (PubMed:8367309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73153 mRNA. Translation: CAA51677.1.
AF216206 Genomic DNA. Translation: AAF65682.1.
AE014298 Genomic DNA. Translation: AAN09412.1.
AY118868 mRNA. Translation: AAM50728.1.
RefSeqiNP_001285338.1. NM_001298409.1.
NP_001285339.1. NM_001298410.1.
NP_523376.1. NM_078652.4.
NP_727992.1. NM_167526.3.
NP_727993.1. NM_167527.3.
UniGeneiDm.20646.

Genome annotation databases

EnsemblMetazoaiFBtr0074311; FBpp0074086; FBgn0010412.
FBtr0074312; FBpp0074087; FBgn0010412.
FBtr0074313; FBpp0074088; FBgn0010412.
FBtr0340149; FBpp0309135; FBgn0010412.
FBtr0345129; FBpp0311350; FBgn0010412.
GeneIDi32635.
KEGGidme:Dmel_CG4464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73153 mRNA. Translation: CAA51677.1.
AF216206 Genomic DNA. Translation: AAF65682.1.
AE014298 Genomic DNA. Translation: AAN09412.1.
AY118868 mRNA. Translation: AAM50728.1.
RefSeqiNP_001285338.1. NM_001298409.1.
NP_001285339.1. NM_001298410.1.
NP_523376.1. NM_078652.4.
NP_727992.1. NM_167526.3.
NP_727993.1. NM_167527.3.
UniGeneiDm.20646.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AT1-156[»]
ProteinModelPortaliP39018.
SMRiP39018. Positions 2-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58971. 4 interactions.
IntActiP39018. 20 interactions.
MINTiMINT-778839.
STRINGi7227.FBpp0074086.

Proteomic databases

PaxDbiP39018.
PRIDEiP39018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074311; FBpp0074086; FBgn0010412.
FBtr0074312; FBpp0074087; FBgn0010412.
FBtr0074313; FBpp0074088; FBgn0010412.
FBtr0340149; FBpp0309135; FBgn0010412.
FBtr0345129; FBpp0311350; FBgn0010412.
GeneIDi32635.
KEGGidme:Dmel_CG4464.

Organism-specific databases

CTDi32635.
FlyBaseiFBgn0010412. RpS19a.

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
InParanoidiP39018.
KOiK02966.
OMAiMIKIYGG.
OrthoDBiEOG091G0QM7.
PhylomeDBiP39018.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GenomeRNAii32635.
PROiP39018.

Gene expression databases

BgeeiFBgn0010412.
GenevisibleiP39018. DM.

Family and domain databases

InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS19A_DROME
AccessioniPrimary (citable) accession number: P39018
Secondary accession number(s): A4V4N1, B7Z0Y8, Q9VXE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.