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P39006 (PSD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase 1 beta chain
  2. Phosphatidylserine decarboxylase 1 alpha chain
Gene names
Name:PSD1
Ordered Locus Names:YNL169C
ORF Names:N1692
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the regulation of phospholipid biosynthesis and interorganelle trafficking of phosphatidylserine.

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

Cofactor

Pyruvoyl group.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.

Subcellular location

Mitochondrion inner membrane Ref.6 Ref.8.

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium. Ref.7

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransit peptide
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylcholine biosynthetic process

Inferred from direct assay. Source: SGD

   Cellular componentmitochondrial inner membrane

Traceable author statement. Source: SGD

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from mutant phenotype Ref.2. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5757Mitochondrion Potential
Chain58 – 500443Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
PRO_0000029843
Chain58 – 462405Phosphatidylserine decarboxylase 1 beta chain Potential
PRO_0000029844
Chain463 – 50038Phosphatidylserine decarboxylase 1 alpha chain Potential
PRO_0000029845

Sites

Site462 – 4632Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue4631Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
P39006 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D57047C5AD11777A

FASTA50056,595
        10         20         30         40         50         60 
MSIMPVKNAL AQGRTLLMGR MPAVKFSTRM QLRNRTAVLW NRKFSTRLFV QQRRSSGEIV 

        70         80         90        100        110        120 
DRAKAAAANS GRKQVSMKWV VLTSFTIVLG TILLVSRNDS TEEDATEGKK GRRTRKIKIF 

       130        140        150        160        170        180 
NNNWLFFCYS TLPLNAMSRL WGQVNSLTLP IWVRPWGYRL YSFLFGVNLD EMEDPDLTHY 

       190        200        210        220        230        240 
ANLSEFFYRN IKPGTRPVAQ GEDVIASPSD GKILQVGIIN SETGEIEQVK GMTYSIKEFL 

       250        260        270        280        290        300 
GTHSHPLMSK SASSLDLTSD EEKHREFARV NRIQLAGSED TEQPLLNFKN EGDQSVREFK 

       310        320        330        340        350        360 
PSVSKNIHLL SQLSLNYFSN GFSCSEPHDT ELFFAVIYLA PGDYHHFHSP VDWVCKVRRH 

       370        380        390        400        410        420 
FPGDLFSVAP YFQRNFPNLF VLNERVALLG SWKYGFFSMT PVGATNVGSI KLNFDQEFVT 

       430        440        450        460        470        480 
NSKSDKHLEP HTCYQAVYEN ASKILGGMPL VKGEEMGGFE LGSTVVLCFE APTEFKFDVR 

       490        500 
VGDKVKMGQK LGIIGKNDLK

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant."
Clancey C.J., Chang S.-C., Dowhan W.
J. Biol. Chem. 268:24580-24590(1993) [PubMed: 8227017] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204510 / AB320.
[2]"Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele."
Trotter P.J., Pedretti J., Voelker D.R.
J. Biol. Chem. 268:21416-21424(1993) [PubMed: 8407984] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed: 9169873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase."
Nasr F., Becam A.-M., Herbert C.J.
Yeast 12:169-175(1996) [PubMed: 8686380] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-174.
Strain: ATCC 96604 / S288c / FY1679.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
Strain: ATCC 76625 / YPH499.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L20973 Genomic DNA. Translation: AAA34918.1.
Z71444 Genomic DNA. Translation: CAA96056.1.
Z71448 Genomic DNA. Translation: CAA96063.1.
X92517 Genomic DNA. Translation: CAA63270.1.
BK006947 Genomic DNA. Translation: DAA10379.1.
PIRA48053.
RefSeqNP_014230.1. NM_001183007.1.

3D structure databases

ProteinModelPortalP39006.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4599N.
IntActP39006. 5 interactions.
MINTMINT-543949.
STRINGP39006.

Proteomic databases

PeptideAtlasP39006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL169C; YNL169C; YNL169C.
GeneID855552.
KEGGsce:YNL169C.
NMPDRfig|4932.3.peg.5295.

Organism-specific databases

CYGDYNL169c.
SGDS000005113. PSD1.

Phylogenomic databases

eggNOGfuNOG04800.
GeneTreeEFGT00070000008748.
HOGENOMHBG395511.
OMAKGEEMGG.
OrthoDBEOG4H49C2.

Gene expression databases

ArrayExpressP39006.
GenevestigatorP39006.
GermOnlineYNL169C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Other

NextBio979628.

Entry information

Entry namePSD1_YEAST
AccessionPrimary (citable) accession number: P39006
Secondary accession number(s): D6W113
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 14, 2011
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents