Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High-affinity hexose transporter HXT6

Gene

HXT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • pentose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29897-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity hexose transporter HXT6
Gene namesi
Name:HXT7
Ordered Locus Names:YDR342C
ORF Names:D9651.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR342C.
SGDiS000002750. HXT7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060CytoplasmicSequence analysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini82 – 11635ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini138 – 1436CytoplasmicSequence analysis
Transmembranei144 – 16421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini165 – 17410ExtracellularSequence analysis
Transmembranei175 – 19521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini196 – 2016CytoplasmicSequence analysis
Transmembranei202 – 22221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 23614ExtracellularSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 34083CytoplasmicSequence analysisAdd
BLAST
Transmembranei341 – 35717Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini358 – 3636ExtracellularSequence analysis
Transmembranei364 – 38118Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini382 – 3887CytoplasmicSequence analysis
Transmembranei389 – 40921Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini410 – 43122ExtracellularSequence analysisAdd
BLAST
Transmembranei432 – 45221Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini453 – 46917CytoplasmicSequence analysisAdd
BLAST
Transmembranei470 – 49021Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini491 – 4911ExtracellularSequence analysis
Transmembranei492 – 51221Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini513 – 57058CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570High-affinity hexose transporter HXT6PRO_0000050397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki40 – 40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence analysis
Cross-linki318 – 318Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei556 – 5561PhosphothreonineCombined sources
Cross-linki560 – 560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP39004.

PTM databases

iPTMnetiP39004.

Interactioni

Protein-protein interaction databases

BioGridi32399. 50 interactions.
DIPiDIP-5182N.
IntActiP39004. 18 interactions.
MINTiMINT-553106.

Structurei

3D structure databases

ProteinModelPortaliP39004.
SMRiP39004. Positions 83-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP39004.
KOiK08139.
OMAiYVAISIF.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP
60 70 80 90 100
VVEIPKRPAS AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG
110 120 130 140 150
MKHKDGTNYL SKVRTGLIVS IFNIGCAIGG IILSKLGDMY GRKVGLIVVV
160 170 180 190 200
VIYIIGIIIQ IASINKWYQY FIGRIISGLG VGGIAVLSPM LISEVSPKHL
210 220 230 240 250
RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG LCFAWALFMI
260 270 280 290 300
GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV
310 320 330 340 350
EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI
360 370 380 390 400
FKAVGLSDSF ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC
410 420 430 440 450
MVVYASVGVT RLWPNGQDQP SSKGAGNCMI VFACFYIFCF ATTWAPIPYV
460 470 480 490 500
VVSETFPLRV KSKAMSIATA ANWLWGFLIG FFTPFITGAI NFYYGYVFMG
510 520 530 540 550
CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW VPPSRRGANY
560 570
DAEEMTHDDK PLYKRMFSTK
Length:570
Mass (Da):62,735
Last modified:February 1, 1995 - v1
Checksum:i251A2CF0F0FEB75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31692 Genomic DNA. Translation: CAA83497.1.
U51032 Genomic DNA. Translation: AAB64778.1.
BK006938 Genomic DNA. Translation: DAA12183.1.
PIRiS43186.
RefSeqiNP_010629.3. NM_001180650.3.

Genome annotation databases

EnsemblFungiiYDR342C; YDR342C; YDR342C.
GeneIDi851943.
KEGGisce:YDR342C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31692 Genomic DNA. Translation: CAA83497.1.
U51032 Genomic DNA. Translation: AAB64778.1.
BK006938 Genomic DNA. Translation: DAA12183.1.
PIRiS43186.
RefSeqiNP_010629.3. NM_001180650.3.

3D structure databases

ProteinModelPortaliP39004.
SMRiP39004. Positions 83-528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32399. 50 interactions.
DIPiDIP-5182N.
IntActiP39004. 18 interactions.
MINTiMINT-553106.

Protein family/group databases

TCDBi2.A.1.1.31. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP39004.

Proteomic databases

MaxQBiP39004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR342C; YDR342C; YDR342C.
GeneIDi851943.
KEGGisce:YDR342C.

Organism-specific databases

EuPathDBiFungiDB:YDR342C.
SGDiS000002750. HXT7.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP39004.
KOiK08139.
OMAiYVAISIF.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-29897-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

PROiP39004.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux."
    Reifenberger E., Ciriacy M.
    Mol. Microbiol. 16:157-167(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MC996.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-40; LYS-318 AND LYS-560.
    Strain: SUB592.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHXT7_YEAST
AccessioniPrimary (citable) accession number: P39004
Secondary accession number(s): D6VSX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.