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Protein

High-affinity hexose transporter HXT6

Gene

HXT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • pentose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29897-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity hexose transporter HXT6
Gene namesi
Name:HXT7
Ordered Locus Names:YDR342C
ORF Names:D9651.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR342C.
SGDiS000002750. HXT7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
Transmembranei61 – 81Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini82 – 116ExtracellularSequence analysisAdd BLAST35
Transmembranei117 – 137Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini138 – 143CytoplasmicSequence analysis6
Transmembranei144 – 164Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini165 – 174ExtracellularSequence analysis10
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 201CytoplasmicSequence analysis6
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 236ExtracellularSequence analysisAdd BLAST14
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 340CytoplasmicSequence analysisAdd BLAST83
Transmembranei341 – 357Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini358 – 363ExtracellularSequence analysis6
Transmembranei364 – 381Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini382 – 388CytoplasmicSequence analysis7
Transmembranei389 – 409Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini410 – 431ExtracellularSequence analysisAdd BLAST22
Transmembranei432 – 452Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini453 – 469CytoplasmicSequence analysisAdd BLAST17
Transmembranei470 – 490Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini491ExtracellularSequence analysis1
Transmembranei492 – 512Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini513 – 570CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503971 – 570High-affinity hexose transporter HXT6Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Modified residuei556PhosphothreonineCombined sources1
Cross-linki560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP39004.
PRIDEiP39004.

PTM databases

iPTMnetiP39004.

Interactioni

Protein-protein interaction databases

BioGridi32399. 50 interactors.
DIPiDIP-5182N.
IntActiP39004. 18 interactors.
MINTiMINT-553106.

Structurei

3D structure databases

ProteinModelPortaliP39004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP39004.
KOiK08139.
OMAiYVAISIF.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP
60 70 80 90 100
VVEIPKRPAS AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG
110 120 130 140 150
MKHKDGTNYL SKVRTGLIVS IFNIGCAIGG IILSKLGDMY GRKVGLIVVV
160 170 180 190 200
VIYIIGIIIQ IASINKWYQY FIGRIISGLG VGGIAVLSPM LISEVSPKHL
210 220 230 240 250
RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG LCFAWALFMI
260 270 280 290 300
GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV
310 320 330 340 350
EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI
360 370 380 390 400
FKAVGLSDSF ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC
410 420 430 440 450
MVVYASVGVT RLWPNGQDQP SSKGAGNCMI VFACFYIFCF ATTWAPIPYV
460 470 480 490 500
VVSETFPLRV KSKAMSIATA ANWLWGFLIG FFTPFITGAI NFYYGYVFMG
510 520 530 540 550
CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW VPPSRRGANY
560 570
DAEEMTHDDK PLYKRMFSTK
Length:570
Mass (Da):62,735
Last modified:February 1, 1995 - v1
Checksum:i251A2CF0F0FEB75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31692 Genomic DNA. Translation: CAA83497.1.
U51032 Genomic DNA. Translation: AAB64778.1.
BK006938 Genomic DNA. Translation: DAA12183.1.
PIRiS43186.
RefSeqiNP_010629.3. NM_001180650.3.

Genome annotation databases

EnsemblFungiiYDR342C; YDR342C; YDR342C.
GeneIDi851943.
KEGGisce:YDR342C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31692 Genomic DNA. Translation: CAA83497.1.
U51032 Genomic DNA. Translation: AAB64778.1.
BK006938 Genomic DNA. Translation: DAA12183.1.
PIRiS43186.
RefSeqiNP_010629.3. NM_001180650.3.

3D structure databases

ProteinModelPortaliP39004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32399. 50 interactors.
DIPiDIP-5182N.
IntActiP39004. 18 interactors.
MINTiMINT-553106.

Protein family/group databases

TCDBi2.A.1.1.31. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP39004.

Proteomic databases

MaxQBiP39004.
PRIDEiP39004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR342C; YDR342C; YDR342C.
GeneIDi851943.
KEGGisce:YDR342C.

Organism-specific databases

EuPathDBiFungiDB:YDR342C.
SGDiS000002750. HXT7.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP39004.
KOiK08139.
OMAiYVAISIF.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-29897-MONOMER.

Miscellaneous databases

PROiP39004.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXT7_YEAST
AccessioniPrimary (citable) accession number: P39004
Secondary accession number(s): D6VSX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.