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P39003 (HXT6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High-affinity hexose transporter HXT6
Gene names
Name:HXT6
Ordered Locus Names:YDR343C
ORF Names:D9651.12
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570High-affinity hexose transporter HXT6
PRO_0000050396

Regions

Topological domain1 – 6060Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=1; Potential
Topological domain82 – 11635Extracellular Potential
Transmembrane117 – 13721Helical; Name=2; Potential
Topological domain138 – 1436Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=3; Potential
Topological domain165 – 17410Extracellular Potential
Transmembrane175 – 19521Helical; Name=4; Potential
Topological domain196 – 2016Cytoplasmic Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Topological domain223 – 23614Extracellular Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 34083Cytoplasmic Potential
Transmembrane341 – 35717Helical; Name=7; Potential
Topological domain358 – 3636Extracellular Potential
Transmembrane364 – 38118Helical; Name=8; Potential
Topological domain382 – 3887Cytoplasmic Potential
Transmembrane389 – 40921Helical; Name=9; Potential
Topological domain410 – 43122Extracellular Potential
Transmembrane432 – 45221Helical; Name=10; Potential
Topological domain453 – 46917Cytoplasmic Potential
Transmembrane470 – 49021Helical; Name=11; Potential
Topological domain4911Extracellular Potential
Transmembrane492 – 51221Helical; Name=12; Potential
Topological domain513 – 57058Cytoplasmic Potential

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Cross-link560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4

Experimental info

Sequence conflict2931V → I in CAA83496. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P39003 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 251A2CF0F0FEA75D

FASTA57062,705
        10         20         30         40         50         60 
MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP VVEIPKRPAS 

        70         80         90        100        110        120 
AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG MKHKDGTNYL SKVRTGLIVS 

       130        140        150        160        170        180 
IFNIGCAIGG IILSKLGDMY GRKVGLIVVV VIYIIGIIIQ IASINKWYQY FIGRIISGLG 

       190        200        210        220        230        240 
VGGIAVLSPM LISEVSPKHL RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG 

       250        260        270        280        290        300 
LCFAWALFMI GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV 

       310        320        330        340        350        360 
EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI FKAVGLSDSF 

       370        380        390        400        410        420 
ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC MVVYASVGVT RLWPNGQDQP 

       430        440        450        460        470        480 
SSKGAGNCMI VFACFYIFCF ATTWAPIPYV VVSETFPLRV KSKAMSIATA ANWLWGFLIG 

       490        500        510        520        530        540 
FFTPFITGAI NFYYGYVFMG CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW 

       550        560        570 
VPPSRRGANY DAEEMAHDDK PLYKRMFSTK

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux."
Reifenberger E., Ciriacy M.
Mol. Microbiol. 16:157-167(1995) [PubMed: 7651133] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MC996.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A proteomics approach to understanding protein ubiquitination."
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P.
Nat. Biotechnol. 21:921-926(2003) [PubMed: 12872131] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-560, MASS SPECTROMETRY.
Strain: SUB592.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z31691 Genomic DNA. Translation: CAA83496.1.
U51032 Genomic DNA. Translation: AAB64779.1.
BK006938 Genomic DNA. Translation: DAA12184.1.
PIRS43185.
RefSeqNP_010630.1. NM_001180651.1.

3D structure databases

ProteinModelPortalP39003.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5372N.
IntActP39003. 10 interactions.
MINTMINT-563331.
STRINGP39003.

Protein family/group databases

TCDB2.A.1.1.31. major facilitator superfamily (MFS).

Proteomic databases

PeptideAtlasP39003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR343C; YDR343C; YDR343C.
GeneID851944.
KEGGsce:YDR343C.

Organism-specific databases

CYGDYDR343c.
SGDS000002751. HXT6.

Phylogenomic databases

eggNOGfuNOG06406.
GeneTreeEFGT00070000008710.
HOGENOMHBG744444.
OrthoDBEOG4SR153.

Gene expression databases

GenevestigatorP39003.
GermOnlineYDR343C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
KOK08139.
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio970027.

Entry information

Entry nameHXT6_YEAST
AccessionPrimary (citable) accession number: P39003
Secondary accession number(s): D6VSX4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents