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Protein

Long-chain-fatty-acid--CoA ligase 3

Gene

FAA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10.

Miscellaneous

Present with 6440 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity

Temperature dependencei

Optimum temperature is 25 degrees Celsius.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • decanoate--CoA ligase activity Source: UniProtKB-EC
  • long-chain fatty acid-CoA ligase activity Source: SGD
  • very long-chain fatty acid-CoA ligase activity Source: SGD

GO - Biological processi

  • long-chain fatty acid metabolic process Source: SGD

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YIL009W-MONOMER.
ReactomeiR-SCE-75876. Synthesis of very long-chain fatty acyl-CoAs.

Chemistry databases

SwissLipidsiSLP:000001033.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 3 (EC:6.2.1.3)
Alternative name(s):
Fatty acid activator 3
Long-chain acyl-CoA synthetase 3
Gene namesi
Name:FAA3
Ordered Locus Names:YIL009W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL009W.
SGDiS000001271. FAA3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001931212 – 694Long-chain-fatty-acid--CoA ligase 3Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP39002.
PRIDEiP39002.

PTM databases

iPTMnetiP39002.

Interactioni

Subunit structurei

Interacts with FRK1.1 Publication

Protein-protein interaction databases

BioGridi34983. 44 interactors.
DIPiDIP-4210N.
IntActiP39002. 13 interactors.
MINTiMINT-562678.
STRINGi4932.YIL009W.

Structurei

3D structure databases

ProteinModelPortaliP39002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00870000136474.
HOGENOMiHOG000159459.
InParanoidiP39002.
KOiK01897.
OMAiSIYGTNE.
OrthoDBiEOG092C0RYI.

Family and domain databases

InterProiView protein in InterPro
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQHSVAVG KAANEHETAP RRNVRVKKRP LIRPLNSSAS TLYEFALECF
60 70 80 90 100
NKGGKRDGMA WRDVIEIHET KKTIVRKVDG KDKSIEKTWL YYEMSPYKMM
110 120 130 140 150
TYQELIWVMH DMGRGLAKIG IKPNGEHKFH IFASTSHKWM KIFLGCISQG
160 170 180 190 200
IPVVTAYDTL GESGLIHSMV ETESAAIFTD NQLLAKMIVP LQSAKDIKFL
210 220 230 240 250
IHNEPIDPND RRQNGKLYKA AKDAINKIRE VRPDIKIYSF EEVVKIGKKS
260 270 280 290 300
KDEVKLHPPE PKDLACIMYT SGSISAPKGV VLTHYNIVSG IAGVGHNVFG
310 320 330 340 350
WIGSTDRVLS FLPLAHIFEL VFEFEAFYWN GILGYGSVKT LTNTSTRNCK
360 370 380 390 400
GDLVEFKPTI MIGVAAVWET VRKAILEKIS DLTPVLQKIF WSAYSMKEKS
410 420 430 440 450
VPCTGFLSRM VFKKVRQATG GHLKYIMNGG SAISIDAQKF FSIVLCPMII
460 470 480 490 500
GYGLTETVAN ACVLEPDHFE YGIVGDLVGS VTAKLVDVKD LGYYAKNNQG
510 520 530 540 550
ELLLKGAPVC SEYYKNPIET AVSFTYDGWF RTGDIVEWTP KGQLKIIDRR
560 570 580 590 600
KNLVKTLNGE YIALEKLESV YRSNSYVKNI CVYADESRVK PVGIVVPNPG
610 620 630 640 650
PLSKFAVKLR IMKKGEDIEN YIHDKALRNA VFKEMIATAK SQGLVGIELL
660 670 680 690
CGIVFFDEEW TPENGFVTSA QKLKRREILA AVKSEVERVY KENS
Length:694
Mass (Da):77,947
Last modified:February 1, 1995 - v1
Checksum:i7AB33044335A5295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29647 Genomic DNA. Translation: CAA82755.1.
Z38113 Genomic DNA. Translation: CAA86241.1.
AY558110 Genomic DNA. Translation: AAS56436.1.
BK006942 Genomic DNA. Translation: DAA08537.1.
PIRiB54901.
RefSeqiNP_012257.1. NM_001179359.1.

Genome annotation databases

EnsemblFungiiYIL009W; YIL009W; YIL009W.
GeneIDi854808.
KEGGisce:YIL009W.

Similar proteinsi

Entry informationi

Entry nameiLCF3_YEAST
AccessioniPrimary (citable) accession number: P39002
Secondary accession number(s): D6VVS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names