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P39001 (UME6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulatory protein UME6
Alternative name(s):
Negative transcriptional regulator of IME2
Regulator of inducer of meiosis protein 16
Unscheduled meiotic gene expression protein 6
Gene names
Name:UME6
Synonyms:CAR80, CARGR1, NIM2, RIM16
Ordered Locus Names:YDR207C
ORF Names:YD8142.04C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length836 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. Has both a positive and negative role in regulating phospholipid biosynthesis. Ref.2 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.27 Ref.29

Subunit structure

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Interacts with RIM11, MCK1 and IME1. Ref.12 Ref.14 Ref.16 Ref.20 Ref.22 Ref.28

Subcellular location

Nucleus Ref.25.

Post-translational modification

Phosphorylated by RIM11 and MCK1. Ref.16 Ref.20

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Chromatin regulator
Repressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin remodeling

Inferred from mutant phenotype PubMed 23478442. Source: SGD

lipid particle organization

Inferred from mutant phenotype PubMed 18156287. Source: SGD

negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.13. Source: SGD

negative regulation of transcription from RNA polymerase II promoter during meiosis

Inferred from mutant phenotype PubMed 21123654Ref.10. Source: SGD

negative regulation of transcription from RNA polymerase II promoter during mitosis

Inferred from mutant phenotype Ref.2Ref.10. Source: SGD

nitrogen catabolite repression of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.8. Source: SGD

positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.10. Source: SGD

positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.10. Source: SGD

positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.13. Source: SGD

positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.13. Source: SGD

positive regulation of transcription from RNA polymerase II promoter during meiosis

Inferred from mutant phenotype PubMed 21123654Ref.10. Source: SGD

pseudohyphal growth

Inferred from mutant phenotype PubMed 20876298. Source: SGD

spore germination

Inferred from mutant phenotype PubMed 21059190. Source: SGD

   Cellular_componentRpd3L complex

Inferred from direct assay PubMed 16286007Ref.28. Source: SGD

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding

Inferred from direct assay Ref.2Ref.11. Source: SGD

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

Inferred from direct assay Ref.19Ref.2. Source: SGD

repressing transcription factor binding

Inferred from direct assay Ref.19. Source: SGD

transcription factor binding transcription factor activity

Inferred from genetic interaction Ref.19. Source: SGD

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 836836Transcriptional regulatory protein UME6
PRO_0000114987

Regions

DNA binding771 – 79828Zn(2)-C6 fungal-type Ref.11 Ref.15 Ref.19 Ref.29
Region508 – 59487SIN3-binding

Amino acid modifications

Modified residue1141Phosphoserine Ref.32
Modified residue1411Phosphoserine Ref.31 Ref.32
Modified residue1501Phosphoserine Ref.31 Ref.32
Modified residue2281Phosphoserine Ref.32
Modified residue3161Phosphoserine Ref.32
Modified residue3181Phosphoserine Ref.32
Modified residue6451Phosphoserine Ref.32

Experimental info

Mutagenesis99 – 10911TPVHTPSGSPS → APVHAPAGAPA: Impairs meiotic genes expression, sporulation and interactions with IME1 and RIM11, and abolishes phosphorylation. Ref.16 Ref.20
Mutagenesis99 – 1079TPVHTPSGS → APVHAPSGA: Impairs meiotic genes expression and sporulation, reduces the interaction with IME1, and abolishes phosphorylation. Ref.16 Ref.20
Mutagenesis991T → N or A: Impairs meiotic genes expression and sporulation, reduces interactions with IME1 and RIM11, and reduces phosphorylation. Ref.16 Ref.20
Mutagenesis1031T → A: Impairs meiotic genes expression and sporulation, reduces interaction with IME, and reduces phosphorylation. Ref.20
Mutagenesis1071S → A: Impairs meiotic genes expression and sporulation, reduces interaction with IME, and reduces phosphorylation. Ref.20
Mutagenesis5231A → S: Impairs SIN3-binding and gene repression activity. Ref.22
Mutagenesis5241A → T: Impairs gene repression activity. Ref.22
Mutagenesis5251Missing: Impairs gene repression activity. Ref.22
Mutagenesis5261V → Q: Impairs gene repression activity. Ref.22
Mutagenesis5271L → P: Impairs SIN3-binding and gene repression activity. Ref.22
Mutagenesis5281S → P: Impairs SIN3-binding and gene repression activity. Ref.22
Mutagenesis5301M → T or V: Impairs SIN3-binding and gene repression activity. Ref.22
Mutagenesis6351K → E: Impairs gene repression activity. Ref.22
Sequence conflict1011V → G in BAA04890. Ref.3
Sequence conflict3631I → V in AAA34471. Ref.1
Sequence conflict4431N → T in AAA34471. Ref.1
Sequence conflict4651G → D in AAA34471. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P39001 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 0DDA0A6B4A157182

FASTA83691,124
        10         20         30         40         50         60 
MLDKARSQSK HMDESNAAAS LLSMETTANN HHYLHNKTSR ATLMNSSQDG KKHAEDEVSD 

        70         80         90        100        110        120 
GANSRHPTIS SASIESLKTT YDENPLLSIM KSTCAPNNTP VHTPSGSPSL KVQSGGDIKD 

       130        140        150        160        170        180 
DPKENDTTTT TNTTLQDRRD SDNAVHAAAS PLAPSNTPSD PKSLCNGHVA QATDPQISGA 

       190        200        210        220        230        240 
IQPQYTATNE DVFPYSSTST NSNTATTTIV AGAKKKIHLP PPQAPAVSSP GTTAAGSGAG 

       250        260        270        280        290        300 
TGSGIRSRTG SDLPLIITSA NKNNGKTTNS PMSILSRNNS TNNNDNNSIQ SSDSRESSNN 

       310        320        330        340        350        360 
NEIGGYLRGG TKRGGSPSND SQVQHNVHDD QCAVGVAPRN FYFNKDREIT DPNVKLDENE 

       370        380        390        400        410        420 
SKINISFWLN SKYRDEAYSL NESSSNNASS NTDTPTNSRH ANTSSSITSR NNFQHFRFNQ 

       430        440        450        460        470        480 
IPSQPPTSAS SFTSTNNNNP QRNNINRGED PFATSSRPST GFFYGDLPNR NNRNSPFHTN 

       490        500        510        520        530        540 
EQYIPPPPPK YINSKLDGLR SRLLLGPNSA SSSTKLDDDL GTAAAVLSNM RSSPYRTHDK 

       550        560        570        580        590        600 
PISNVNDMNN TNALGVPASR PHSSSFPSKG VLRPILLRIH NSEQQPIFES NNSTAVFDED 

       610        620        630        640        650        660 
QDQNQDLSPY HLNLNSKKVL DPTFESRTRQ VTWNKNGKRI DRRLSAPEQQ QQLEVPPLKK 

       670        680        690        700        710        720 
SRRSVGNARV ASQTNSDYNS LGESSTSSAP SSPSLKASSG LAYTADYPNA TSPDFAKSKG 

       730        740        750        760        770        780 
KNVKPKAKSK AKQSSKKRPN NTTSKSKANN SQESNNATSS TSQGTRSRTG CWICRLRKKK 

       790        800        810        820        830 
CTEERPHCFN CERLKLDCHY DAFKPDFVSD PKKKQMKLEE IKKKTKEAKR RAMKKK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of the UME6/CAR80 gene from Saccharomyces cerevisiae."
Smart W.C., Park H.-D., Cooper T.G.
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sigma 1278B.
[2]"UME6 is a key regulator of nitrogen repression and meiotic development."
Strich R., Surosky R.T., Steber C.M., Messenguy F., Dubois E., Easton Esposito R.
Genes Dev. 8:796-810(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]Kumeno A.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / GRF88.
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast."
Strich R., Slater M.R., Easton Esposito R.
Proc. Natl. Acad. Sci. U.S.A. 86:10018-10022(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Selection for early meiotic mutants in yeast."
Mitchell A.P., Bowdish K.S.
Genetics 131:65-72(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site."
Park H.-D., Luche R.M., Cooper T.G.
Nucleic Acids Res. 20:1909-1915(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Positive control of yeast meiotic genes by the negative regulator UME6."
Bowdish K.S., Yuan H.E., Mitchell A.P.
Mol. Cell. Biol. 15:2955-2961(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene expression."
Steber C.M., Easton Esposito R.
Proc. Natl. Acad. Sci. U.S.A. 92:12490-12494(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"UME6, a negative regulator of meiosis in Saccharomyces cerevisiae, contains a C-terminal Zn2Cys6 binuclear cluster that binds the URS1 DNA sequence in a zinc-dependent manner."
Anderson S.F., Steber C.M., Easton Esposito R., Coleman J.E.
Protein Sci. 4:1832-1843(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN, DNA-BINDING.
[12]"Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional represssor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1."
Rubin-Bejerano I., Mandel S., Robzyk K., Kassir Y.
Mol. Cell. Biol. 16:2518-2526(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH IME1.
[13]"The yeast UME6 gene is required for both negative and positive transcriptional regulation of phospholipid biosynthetic gene expression."
Jackson J.C., Lopes J.M.
Nucleic Acids Res. 24:1322-1329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters."
Kadosh D., Struhl K.
Cell 89:365-371(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DOMAIN, INTERACTION WITH SIN3.
[15]"Role of UME6 in transcriptional regulation of a DNA repair gene in Saccharomyces cerevisiae."
Sweet D.H., Jang Y.K., Sancar G.B.
Mol. Cell. Biol. 17:6223-6235(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
[16]"Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p."
Malathi K., Xiao Y., Mitchell A.P.
Mol. Cell. Biol. 17:7230-7236(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RIM11 AND IME1, PHOSPHORYLATION, MUTAGENESIS OF THR-99 AND 99-THR--SER-109.
[17]"Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo."
Kadosh D., Struhl K.
Mol. Cell. Biol. 18:5121-5127(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[18]"Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3."
Rundlett S.E., Carmen A.A., Suka N., Turner B.M., Grunstein M.
Nature 392:831-835(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[19]"The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p."
Goldmark J.P., Fazzio T.G., Estep P.W., Church G.M., Tsukiyama T.
Cell 103:423-433(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
[20]"Shared roles of yeast glycogen synthase kinase 3 family members in nitrogen-responsive phosphorylation of meiotic regulator Ume6p."
Xiao Y., Mitchell A.P.
Mol. Cell. Biol. 20:5447-5453(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION, MUTAGENESIS OF THR-99; THR-103 AND SER-107, INTERACTION WITH MCK1.
[21]"Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes."
Elkhaimi M., Kaadige M.R., Kamath D., Jackson J.C., Biliran H. Jr., Lopes J.M.
Nucleic Acids Res. 28:3160-3167(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[22]"Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast."
Washburn B.K., Easton Esposito R.
Mol. Cell. Biol. 21:2057-2069(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SIN3 AND TEA1, MUTAGENESIS OF ALA-523; ALA-524; ALA-525; VAL-526; LEU-527; SER-528; MET-530 AND LYS-635.
[23]"The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast."
Williams R.M., Primig M., Washburn B.K., Winzeler E.A., Bellis M., Sarrauste de Menthiere C., Davis R.W., Easton Esposito R.
Proc. Natl. Acad. Sci. U.S.A. 99:13431-13436(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[24]"Discovery of novel transcription control relationships with gene regulatory networks generated from multiple-disruption full genome expression libraries."
Aburatani S., Tashiro K., Savoie C.J., Nishizawa M., Hayashi K., Ito Y., Muta S., Yamamoto K., Ogawa M., Enomoto A., Masaki M., Watanabe S., Maki Y., Takahashi Y., Eguchi Y., Sakaki Y., Kuhara S.
DNA Res. 10:1-8(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[25]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[26]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[27]"Yeast Ume6p repressor permits activator binding but restricts TBP binding at the HOP1 promoter."
Shimizu M., Takahashi K., Lamb T.M., Shindo H., Mitchell A.P.
Nucleic Acids Res. 31:3033-3037(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[28]"Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex."
Carrozza M.J., Florens L., Swanson S.K., Shia W.-J., Anderson S., Yates J., Washburn M.P., Workman J.L.
Biochim. Biophys. Acta 1731:77-87(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RPD3C(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[29]"Identification of functional transcription factor binding sites using closely related Saccharomyces species."
Doniger S.W., Huh J., Fay J.C.
Genome Res. 15:701-709(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
[30]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[31]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-150, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[32]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-141; SER-150; SER-228; SER-316; SER-318 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L32186 Genomic DNA. Translation: AAA34471.1.
L24539 Unassigned DNA. Translation: AAC14472.1.
D23663 Genomic DNA. Translation: BAA04890.1.
Z68194 Genomic DNA. Translation: CAA92346.1.
BK006938 Genomic DNA. Translation: DAA12048.1.
PIRS61570.
RefSeqNP_010493.1. NM_001180515.1.

3D structure databases

ProteinModelPortalP39001.
SMRP39001. Positions 769-802.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32257. 363 interactions.
DIPDIP-959N.
IntActP39001. 9 interactions.
MINTMINT-387730.
STRING4932.YDR207C.

Proteomic databases

MaxQBP39001.
PaxDbP39001.
PeptideAtlasP39001.
PRIDEP39001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR207C; YDR207C; YDR207C.
GeneID851788.
KEGGsce:YDR207C.

Organism-specific databases

CYGDYDR207c.
SGDS000002615. UME6.

Phylogenomic databases

eggNOGNOG41915.
KOK09243.
OMAQHELPIS.
OrthoDBEOG7DZ8TR.

Enzyme and pathway databases

BioCycYEAST:G3O-29791-MONOMER.

Gene expression databases

GenevestigatorP39001.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio969606.
PROP39001.

Entry information

Entry nameUME6_YEAST
AccessionPrimary (citable) accession number: P39001
Secondary accession number(s): D6VSI8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families