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P38997

- LYS1_YARLI

UniProt

P38997 - LYS1_YARLI

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Protein
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
Gene
LYS5, YALI0B15444g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei205 – 2051 By similarity

GO - Molecular functioni

  1. saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00033; UER00034.

Names & Taxonomyi

Protein namesi
Recommended name:
Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (EC:1.5.1.7)
Short name:
SDH
Alternative name(s):
Lysine--2-oxoglutarate reductase
Gene namesi
Name:LYS5
Ordered Locus Names:YALI0B15444g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
PRO_0000199015Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.P38997.

Structurei

3D structure databases

ProteinModelPortaliP38997.
SMRiP38997. Positions 3-367.

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.

Phylogenomic databases

eggNOGiNOG79735.
HOGENOMiHOG000143704.
KOiK00290.
OMAiPIYSINT.
OrthoDBiEOG74R21N.

Family and domain databases

InterProiIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR027281. Lys1.
[Graphical view]
PfamiPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFiPIRSF018250. Saccharopine_DH_Lys. 1 hit.
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38997-1 [UniParc]FASTAAdd to Basket

« Hide

MTAPVKLHLR AETKPLEHRS ALTPTTTRKL LDAGFEVFVE KSPLRIFDDQ    50
EFVDVGATLV EEGSWVSAPE DRMIIGLKEL PEESFPLSHE HIQFAHCYKD 100
QGGWKDVLSR FPAGNGTLYD LEFLEDDNGR RVAAFGFHAG FAGAAIGVET 150
WAFQQTHPDS ENLPGVSAYP NETELVDKIK KDLAAAVEKG SKLPTVLVIG 200
ALGRCGSGAI DLARKVGIPE ENIIRWDMNE TKKGGPFQEI ADADIFINCI 250
YLSQPIPPFI NYDLLNKETR KLSVIVDVSA DTTNPHNPVP VYTIATTFDH 300
PTVPVETTAG PKLSVCSIDH LPSLLPREAS EAFSEALLPS LLQLPQRDTA 350
PVWTRAKALF DKHVLRIGE 369
Length:369
Mass (Da):40,612
Last modified:February 1, 1995 - v1
Checksum:iB1B749FA008B8A36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34929 Genomic DNA. Translation: AAA35248.1.
CR382128 Genomic DNA. Translation: CAG83182.1.
PIRiA36467.
RefSeqiXP_500931.1. XM_500931.1.

Genome annotation databases

EnsemblFungiiCAG83182; CAG83182; YALI0_B15444g.
GeneIDi2907616.
KEGGiyli:YALI0B15444g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34929 Genomic DNA. Translation: AAA35248.1 .
CR382128 Genomic DNA. Translation: CAG83182.1 .
PIRi A36467.
RefSeqi XP_500931.1. XM_500931.1.

3D structure databases

ProteinModelPortali P38997.
SMRi P38997. Positions 3-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.P38997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83182 ; CAG83182 ; YALI0_B15444g .
GeneIDi 2907616.
KEGGi yli:YALI0B15444g.

Phylogenomic databases

eggNOGi NOG79735.
HOGENOMi HOG000143704.
KOi K00290.
OMAi PIYSINT.
OrthoDBi EOG74R21N.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00034 .

Family and domain databases

InterProi IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR027281. Lys1.
[Graphical view ]
Pfami PF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF018250. Saccharopine_DH_Lys. 1 hit.
SMARTi SM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica."
    Xuan J.-W., Fournier P., Declerck N., Chasles M., Gaillardin C.
    Mol. Cell. Biol. 10:4795-4806(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiLYS1_YARLI
AccessioniPrimary (citable) accession number: P38997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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