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P38997 (LYS1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Short name=SDH
EC=1.5.1.7
Alternative name(s):
Lysine--2-oxoglutarate reductase
Gene names
Name:LYS5
Ordered Locus Names:YALI0B15444g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.

Sequence similarities

Belongs to the AlaDH/PNT family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Lysine biosynthesis
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlysine biosynthetic process via aminoadipic acid

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionsaccharopine dehydrogenase (NAD+, L-lysine-forming) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
PRO_0000199015

Sites

Active site2051 By similarity

Sequences

Sequence LengthMass (Da)Tools
P38997 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B1B749FA008B8A36

FASTA36940,612
        10         20         30         40         50         60 
MTAPVKLHLR AETKPLEHRS ALTPTTTRKL LDAGFEVFVE KSPLRIFDDQ EFVDVGATLV 

        70         80         90        100        110        120 
EEGSWVSAPE DRMIIGLKEL PEESFPLSHE HIQFAHCYKD QGGWKDVLSR FPAGNGTLYD 

       130        140        150        160        170        180 
LEFLEDDNGR RVAAFGFHAG FAGAAIGVET WAFQQTHPDS ENLPGVSAYP NETELVDKIK 

       190        200        210        220        230        240 
KDLAAAVEKG SKLPTVLVIG ALGRCGSGAI DLARKVGIPE ENIIRWDMNE TKKGGPFQEI 

       250        260        270        280        290        300 
ADADIFINCI YLSQPIPPFI NYDLLNKETR KLSVIVDVSA DTTNPHNPVP VYTIATTFDH 

       310        320        330        340        350        360 
PTVPVETTAG PKLSVCSIDH LPSLLPREAS EAFSEALLPS LLQLPQRDTA PVWTRAKALF 


DKHVLRIGE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34929 Genomic DNA. Translation: AAA35248.1.
CR382128 Genomic DNA. Translation: CAG83182.1.
PIRA36467.
RefSeqXP_500931.1. XM_500931.1.

3D structure databases

ProteinModelPortalP38997.
SMRP38997. Positions 3-367.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.P38997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG83182; CAG83182; YALI0_B15444g.
GeneID2907616.
KEGGyli:YALI0B15444g.

Phylogenomic databases

eggNOGNOG79735.
HOGENOMHOG000143704.
KOK00290.
OMAPIYSINT.
OrthoDBEOG74R21N.

Enzyme and pathway databases

UniPathwayUPA00033; UER00034.

Family and domain databases

InterProIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR027281. Lys1.
[Graphical view]
PANTHERPTHR11133:SF4. PTHR11133:SF4. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF018250. Saccharopine_DH_Lys. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS1_YARLI
AccessionPrimary (citable) accession number: P38997
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways