Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Gene

LYS5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

Pathwayi: L-lysine biosynthesis via AAA pathway

This protein is involved in step 3 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (fungal route).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (LYS5)
This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (fungal route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei205By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Lysine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00033; UER00034

Names & Taxonomyi

Protein namesi
Recommended name:
Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (EC:1.5.1.7)
Short name:
SDH
Alternative name(s):
Lysine--2-oxoglutarate reductase
Gene namesi
Name:LYS5
Ordered Locus Names:YALI0B15444g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990151 – 369Saccharopine dehydrogenase [NAD(+), L-lysine-forming]Add BLAST369

Proteomic databases

PRIDEiP38997

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_500931.1

Structurei

3D structure databases

ProteinModelPortaliP38997
SMRiP38997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.Curated

Phylogenomic databases

HOGENOMiHOG000143704
InParanoidiP38997
KOiK00290
OMAiYFFFSHT
OrthoDBiEOG092C2ZET

Family and domain databases

CDDicd12188 SDH, 1 hit
InterProiView protein in InterPro
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR027281 Lys1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11133:SF15 PTHR11133:SF15, 1 hit
PfamiView protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PIRSFiPIRSF018250 Saccharopine_DH_Lys, 1 hit
SMARTiView protein in SMART
SM01002 AlaDh_PNT_C, 1 hit
SM01003 AlaDh_PNT_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

P38997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPVKLHLR AETKPLEHRS ALTPTTTRKL LDAGFEVFVE KSPLRIFDDQ
60 70 80 90 100
EFVDVGATLV EEGSWVSAPE DRMIIGLKEL PEESFPLSHE HIQFAHCYKD
110 120 130 140 150
QGGWKDVLSR FPAGNGTLYD LEFLEDDNGR RVAAFGFHAG FAGAAIGVET
160 170 180 190 200
WAFQQTHPDS ENLPGVSAYP NETELVDKIK KDLAAAVEKG SKLPTVLVIG
210 220 230 240 250
ALGRCGSGAI DLARKVGIPE ENIIRWDMNE TKKGGPFQEI ADADIFINCI
260 270 280 290 300
YLSQPIPPFI NYDLLNKETR KLSVIVDVSA DTTNPHNPVP VYTIATTFDH
310 320 330 340 350
PTVPVETTAG PKLSVCSIDH LPSLLPREAS EAFSEALLPS LLQLPQRDTA
360
PVWTRAKALF DKHVLRIGE
Length:369
Mass (Da):40,612
Last modified:February 1, 1995 - v1
Checksum:iB1B749FA008B8A36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34929 Genomic DNA Translation: AAA35248.1
CR382128 Genomic DNA Translation: CAG83182.1
PIRiA36467
RefSeqiXP_500931.1, XM_500931.1

Genome annotation databases

EnsemblFungiiCAG83182; CAG83182; YALI0_B15444g
GeneIDi2907616
KEGGiyli:YALI0B15444g

Entry informationi

Entry nameiLYS1_YARLI
AccessioniPrimary (citable) accession number: P38997
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health