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Reviewed, UniProtKB/Swiss-Prot P38997 (LYS1_YARLI)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Saccharopine dehydrogenase [NAD+, L-lysine-forming]
      Short name=SDH
    EC=1.5.1.7
Alternative name(s):
    Lysine--2-oxoglutarate reductase
Gene names
Name: LYS5
Ordered Locus Names: YALI0B15444g
OrganismYarrowia lipolytica (Candida lipolytica) [Complete proteome]
Taxonomic identifier4952 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungi route): step 3/3.

Sequence similarities

Belongs to the AlaDH/PNT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Saccharopine dehydrogenase [NAD+, L-lysine-forming]
PRO_0000199015

Sites

Active site2051 By similarity

Sequences

Sequence LengthMass (Da)Tools
P38997-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: B1B749FA008B8A36

FASTA36940,612
        10         20         30         40         50         60 
MTAPVKLHLR AETKPLEHRS ALTPTTTRKL LDAGFEVFVE KSPLRIFDDQ EFVDVGATLV 

        70         80         90        100        110        120 
EEGSWVSAPE DRMIIGLKEL PEESFPLSHE HIQFAHCYKD QGGWKDVLSR FPAGNGTLYD 

       130        140        150        160        170        180 
LEFLEDDNGR RVAAFGFHAG FAGAAIGVET WAFQQTHPDS ENLPGVSAYP NETELVDKIK 

       190        200        210        220        230        240 
KDLAAAVEKG SKLPTVLVIG ALGRCGSGAI DLARKVGIPE ENIIRWDMNE TKKGGPFQEI 

       250        260        270        280        290        300 
ADADIFINCI YLSQPIPPFI NYDLLNKETR KLSVIVDVSA DTTNPHNPVP VYTIATTFDH 

       310        320        330        340        350        360 
PTVPVETTAG PKLSVCSIDH LPSLLPREAS EAFSEALLPS LLQLPQRDTA PVWTRAKALF 


DKHVLRIGE 

« Hide

Cross-references

Sequence databases

M34929 Genomic DNA. Translation: AAA35248.1.
CR382128 Genomic DNA. Translation: CAG83182.1.
PIRA36467.
RefSeqXP_500931.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2907616.
KEGGyli:YALI0B15444g.

Phylogenomic databases

HOGENOMP38997.
OMAP38997. IGALGRC.

Enzyme and pathway databases

BRENDA1.5.1.7. 3602.

Family and domain databases

InterProIPR007698. Ala_DH/PNT_C.
IPR007886. Ala_DH/PNT_N.
[Graphical view]
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS1_YARLI
AccessionPrimary (citable) accession number: P38997
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents