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P38997

- LYS1_YARLI

UniProt

P38997 - LYS1_YARLI

Protein

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Gene

LYS5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei205 – 2051By similarity

    GO - Molecular functioni

    1. saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00033; UER00034.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (EC:1.5.1.7)
    Short name:
    SDH
    Alternative name(s):
    Lysine--2-oxoglutarate reductase
    Gene namesi
    Name:LYS5
    Ordered Locus Names:YALI0B15444g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome B

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Saccharopine dehydrogenase [NAD(+), L-lysine-forming]PRO_0000199015Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.P38997.

    Structurei

    3D structure databases

    ProteinModelPortaliP38997.
    SMRiP38997. Positions 3-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AlaDH/PNT family.Curated

    Phylogenomic databases

    eggNOGiNOG79735.
    HOGENOMiHOG000143704.
    KOiK00290.
    OMAiPIYSINT.
    OrthoDBiEOG74R21N.

    Family and domain databases

    InterProiIPR007886. AlaDH/PNT_N.
    IPR007698. AlaDH/PNT_NAD(H)-bd.
    IPR027281. Lys1.
    [Graphical view]
    PfamiPF01262. AlaDh_PNT_C. 1 hit.
    PF05222. AlaDh_PNT_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018250. Saccharopine_DH_Lys. 1 hit.
    SMARTiSM01002. AlaDh_PNT_C. 1 hit.
    SM01003. AlaDh_PNT_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38997-1 [UniParc]FASTAAdd to Basket

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    MTAPVKLHLR AETKPLEHRS ALTPTTTRKL LDAGFEVFVE KSPLRIFDDQ    50
    EFVDVGATLV EEGSWVSAPE DRMIIGLKEL PEESFPLSHE HIQFAHCYKD 100
    QGGWKDVLSR FPAGNGTLYD LEFLEDDNGR RVAAFGFHAG FAGAAIGVET 150
    WAFQQTHPDS ENLPGVSAYP NETELVDKIK KDLAAAVEKG SKLPTVLVIG 200
    ALGRCGSGAI DLARKVGIPE ENIIRWDMNE TKKGGPFQEI ADADIFINCI 250
    YLSQPIPPFI NYDLLNKETR KLSVIVDVSA DTTNPHNPVP VYTIATTFDH 300
    PTVPVETTAG PKLSVCSIDH LPSLLPREAS EAFSEALLPS LLQLPQRDTA 350
    PVWTRAKALF DKHVLRIGE 369
    Length:369
    Mass (Da):40,612
    Last modified:February 1, 1995 - v1
    Checksum:iB1B749FA008B8A36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34929 Genomic DNA. Translation: AAA35248.1.
    CR382128 Genomic DNA. Translation: CAG83182.1.
    PIRiA36467.
    RefSeqiXP_500931.1. XM_500931.1.

    Genome annotation databases

    EnsemblFungiiCAG83182; CAG83182; YALI0_B15444g.
    GeneIDi2907616.
    KEGGiyli:YALI0B15444g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34929 Genomic DNA. Translation: AAA35248.1 .
    CR382128 Genomic DNA. Translation: CAG83182.1 .
    PIRi A36467.
    RefSeqi XP_500931.1. XM_500931.1.

    3D structure databases

    ProteinModelPortali P38997.
    SMRi P38997. Positions 3-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.P38997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG83182 ; CAG83182 ; YALI0_B15444g .
    GeneIDi 2907616.
    KEGGi yli:YALI0B15444g.

    Phylogenomic databases

    eggNOGi NOG79735.
    HOGENOMi HOG000143704.
    KOi K00290.
    OMAi PIYSINT.
    OrthoDBi EOG74R21N.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00034 .

    Family and domain databases

    InterProi IPR007886. AlaDH/PNT_N.
    IPR007698. AlaDH/PNT_NAD(H)-bd.
    IPR027281. Lys1.
    [Graphical view ]
    Pfami PF01262. AlaDh_PNT_C. 1 hit.
    PF05222. AlaDh_PNT_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018250. Saccharopine_DH_Lys. 1 hit.
    SMARTi SM01002. AlaDh_PNT_C. 1 hit.
    SM01003. AlaDh_PNT_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica."
      Xuan J.-W., Fournier P., Declerck N., Chasles M., Gaillardin C.
      Mol. Cell. Biol. 10:4795-4806(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.

    Entry informationi

    Entry nameiLYS1_YARLI
    AccessioniPrimary (citable) accession number: P38997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3