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Protein

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Gene

LYS5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei205 – 2051By similarity

GO - Molecular functioni

  1. saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00033; UER00034.

Names & Taxonomyi

Protein namesi
Recommended name:
Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (EC:1.5.1.7)
Short name:
SDH
Alternative name(s):
Lysine--2-oxoglutarate reductase
Gene namesi
Name:LYS5
Ordered Locus Names:YALI0B15444g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Saccharopine dehydrogenase [NAD(+), L-lysine-forming]PRO_0000199015Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.P38997.

Structurei

3D structure databases

ProteinModelPortaliP38997.
SMRiP38997. Positions 3-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.Curated

Phylogenomic databases

eggNOGiNOG79735.
HOGENOMiHOG000143704.
InParanoidiP38997.
KOiK00290.
OMAiPIYSINT.
OrthoDBiEOG74R21N.

Family and domain databases

InterProiIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR027281. Lys1.
[Graphical view]
PfamiPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFiPIRSF018250. Saccharopine_DH_Lys. 1 hit.
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPVKLHLR AETKPLEHRS ALTPTTTRKL LDAGFEVFVE KSPLRIFDDQ
60 70 80 90 100
EFVDVGATLV EEGSWVSAPE DRMIIGLKEL PEESFPLSHE HIQFAHCYKD
110 120 130 140 150
QGGWKDVLSR FPAGNGTLYD LEFLEDDNGR RVAAFGFHAG FAGAAIGVET
160 170 180 190 200
WAFQQTHPDS ENLPGVSAYP NETELVDKIK KDLAAAVEKG SKLPTVLVIG
210 220 230 240 250
ALGRCGSGAI DLARKVGIPE ENIIRWDMNE TKKGGPFQEI ADADIFINCI
260 270 280 290 300
YLSQPIPPFI NYDLLNKETR KLSVIVDVSA DTTNPHNPVP VYTIATTFDH
310 320 330 340 350
PTVPVETTAG PKLSVCSIDH LPSLLPREAS EAFSEALLPS LLQLPQRDTA
360
PVWTRAKALF DKHVLRIGE
Length:369
Mass (Da):40,612
Last modified:February 1, 1995 - v1
Checksum:iB1B749FA008B8A36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34929 Genomic DNA. Translation: AAA35248.1.
CR382128 Genomic DNA. Translation: CAG83182.1.
PIRiA36467.
RefSeqiXP_500931.1. XM_500931.1.

Genome annotation databases

EnsemblFungiiCAG83182; CAG83182; YALI0_B15444g.
GeneIDi2907616.
KEGGiyli:YALI0B15444g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34929 Genomic DNA. Translation: AAA35248.1.
CR382128 Genomic DNA. Translation: CAG83182.1.
PIRiA36467.
RefSeqiXP_500931.1. XM_500931.1.

3D structure databases

ProteinModelPortaliP38997.
SMRiP38997. Positions 3-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.P38997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG83182; CAG83182; YALI0_B15444g.
GeneIDi2907616.
KEGGiyli:YALI0B15444g.

Phylogenomic databases

eggNOGiNOG79735.
HOGENOMiHOG000143704.
InParanoidiP38997.
KOiK00290.
OMAiPIYSINT.
OrthoDBiEOG74R21N.

Enzyme and pathway databases

UniPathwayiUPA00033; UER00034.

Family and domain databases

InterProiIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR027281. Lys1.
[Graphical view]
PfamiPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFiPIRSF018250. Saccharopine_DH_Lys. 1 hit.
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica."
    Xuan J.-W., Fournier P., Declerck N., Chasles M., Gaillardin C.
    Mol. Cell. Biol. 10:4795-4806(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiLYS1_YARLI
AccessioniPrimary (citable) accession number: P38997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.