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Protein

Copper-transporting ATPase

Gene

CCC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles.

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Copper1
Metal bindingi16Copper1
Metal bindingi91CopperPROSITE-ProRule annotation1
Metal bindingi94CopperPROSITE-ProRule annotation1
Active sitei6274-aspartylphosphate intermediateBy similarity1
Metal bindingi838MagnesiumPROSITE-ProRule annotation1
Metal bindingi842MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: SGD
  • copper ion binding Source: SGD
  • copper-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • copper ion export Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29839-MONOMER.
BRENDAi3.6.3.4. 984.
ReactomeiR-SCE-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.5.17. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.54)
Alternative name(s):
Cu(2+)-ATPase
Gene namesi
Name:CCC2
Ordered Locus Names:YDR270W
ORF Names:D9954.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR270W.
SGDiS000002678. CCC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 262CytoplasmicSequence analysisAdd BLAST262
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 303Lumenal, vesicleSequence analysisAdd BLAST20
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 335CytoplasmicSequence analysisAdd BLAST11
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 370Lumenal, vesicleSequence analysisAdd BLAST14
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 528CytoplasmicSequence analysisAdd BLAST137
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 577Lumenal, vesicleSequence analysisAdd BLAST28
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 901CytoplasmicSequence analysisAdd BLAST303
Transmembranei902 – 924HelicalSequence analysisAdd BLAST23
Topological domaini925 – 927Lumenal, vesicleSequence analysis3
Transmembranei928 – 950HelicalSequence analysisAdd BLAST23
Topological domaini951 – 1004CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463181 – 1004Copper-transporting ATPaseAdd BLAST1004

Proteomic databases

MaxQBiP38995.
PRIDEiP38995.

PTM databases

iPTMnetiP38995.

Interactioni

Protein-protein interaction databases

BioGridi32325. 29 interactors.
DIPiDIP-906N.
IntActiP38995. 2 interactors.
MINTiMINT-367619.

Structurei

Secondary structure

11004
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi14 – 25Combined sources12
Beta strandi27 – 33Combined sources7
Turni37 – 40Combined sources4
Beta strandi41 – 46Combined sources6
Beta strandi48 – 50Combined sources3
Helixi52 – 62Combined sources11
Beta strandi66 – 70Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FVQNMR-A2-72[»]
1FVSNMR-A2-72[»]
1UV1model-B2-72[»]
1UV2model-B2-72[»]
2GGPNMR-B2-72[»]
ProteinModelPortaliP38995.
SMRiP38995.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38995.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 68HMA 1PROSITE-ProRule annotationAdd BLAST66
Domaini81 – 147HMA 2PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Contains 2 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
InParanoidiP38995.
KOiK17686.
OMAiIVWITIG.
OrthoDBiEOG092C0DN9.

Family and domain databases

CDDicd00371. HMA. 2 hits.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV
60 70 80 90 100
TADSIKEIIE DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK
110 120 130 140 150
QVEGIEGVES VVVSLVTEEC HVIYEPSKTT LETAREMIED CGFDSNIIMD
160 170 180 190 200
GNGNADMTEK TVILKVTKAF EDESPLILSS VSERFQFLLD LGVKSIEISD
210 220 230 240 250
DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT QLRLLSKEDE
260 270 280 290 300
IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF
310 320 330 340 350
YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF
360 370 380 390 400
SVFSLVHNMF HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA
410 420 430 440 450
LSKLIQLTPS VCSIISDVER NETKEIPIEL LQVNDIVEIK PGMKIPADGI
460 470 480 490 500
ITRGESEIDE SLMTGESILV PKKTGFPVIA GSVNGPGHFY FRTTTVGEET
510 520 530 540 550
KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL TFFIWCFILN
560 570 580 590 600
ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG
610 620 630 640 650
VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG
660 670 680 690 700
NVDEDEVLAC IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL
710 720 730 740 750
GKGIVSKCQV NGNTYDICIG NEALILEDAL KKSGFINSNV DQGNTVSYVS
760 770 780 790 800
VNGHVFGLFE INDEVKHDSY ATVQYLQRNG YETYMITGDN NSAAKRVARE
810 820 830 840 850
VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI NDAPALALSD
860 870 880 890 900
LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL
910 920 930 940 950
NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML
960 970 980 990 1000
KKWTPPDIES HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN

EEVL
Length:1,004
Mass (Da):109,829
Last modified:February 1, 1995 - v1
Checksum:i571E9F73EA1F599F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36317 Genomic DNA. Translation: AAC37425.1.
U51030 Genomic DNA. Translation: AAB64451.1.
BK006938 Genomic DNA. Translation: DAA12113.1.
PIRiS55353.
RefSeqiNP_010556.1. NM_001180578.1.

Genome annotation databases

EnsemblFungiiYDR270W; YDR270W; YDR270W.
GeneIDi851862.
KEGGisce:YDR270W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36317 Genomic DNA. Translation: AAC37425.1.
U51030 Genomic DNA. Translation: AAB64451.1.
BK006938 Genomic DNA. Translation: DAA12113.1.
PIRiS55353.
RefSeqiNP_010556.1. NM_001180578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FVQNMR-A2-72[»]
1FVSNMR-A2-72[»]
1UV1model-B2-72[»]
1UV2model-B2-72[»]
2GGPNMR-B2-72[»]
ProteinModelPortaliP38995.
SMRiP38995.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32325. 29 interactors.
DIPiDIP-906N.
IntActiP38995. 2 interactors.
MINTiMINT-367619.

Protein family/group databases

TCDBi3.A.3.5.17. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP38995.

Proteomic databases

MaxQBiP38995.
PRIDEiP38995.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR270W; YDR270W; YDR270W.
GeneIDi851862.
KEGGisce:YDR270W.

Organism-specific databases

EuPathDBiFungiDB:YDR270W.
SGDiS000002678. CCC2.

Phylogenomic databases

GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
InParanoidiP38995.
KOiK17686.
OMAiIVWITIG.
OrthoDBiEOG092C0DN9.

Enzyme and pathway databases

BioCyciYEAST:G3O-29839-MONOMER.
BRENDAi3.6.3.4. 984.
ReactomeiR-SCE-936837. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTraceiP38995.
PROiP38995.

Family and domain databases

CDDicd00371. HMA. 2 hits.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATU2_YEAST
AccessioniPrimary (citable) accession number: P38995
Secondary accession number(s): D6VSQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.