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Protein

Copper-transporting ATPase

Gene

CCC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles.

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Copper
Metal bindingi16 – 161Copper
Metal bindingi91 – 911CopperPROSITE-ProRule annotation
Metal bindingi94 – 941CopperPROSITE-ProRule annotation
Active sitei627 – 62714-aspartylphosphate intermediateBy similarity
Metal bindingi838 – 8381MagnesiumPROSITE-ProRule annotation
Metal bindingi842 – 8421MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: SGD
  • copper ion binding Source: SGD
  • copper-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • copper ion export Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29839-MONOMER.
BRENDAi3.6.3.4. 984.
ReactomeiR-SCE-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.5.17. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.54)
Alternative name(s):
Cu(2+)-ATPase
Gene namesi
Name:CCC2
Ordered Locus Names:YDR270W
ORF Names:D9954.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR270W.
SGDiS000002678. CCC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 262262CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Topological domaini284 – 30320Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 33511CytoplasmicSequence analysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence analysisAdd
BLAST
Topological domaini357 – 37014Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence analysisAdd
BLAST
Topological domaini392 – 528137CytoplasmicSequence analysisAdd
BLAST
Transmembranei529 – 54921HelicalSequence analysisAdd
BLAST
Topological domaini550 – 57728Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei578 – 59821HelicalSequence analysisAdd
BLAST
Topological domaini599 – 901303CytoplasmicSequence analysisAdd
BLAST
Transmembranei902 – 92423HelicalSequence analysisAdd
BLAST
Topological domaini925 – 9273Lumenal, vesicleSequence analysis
Transmembranei928 – 95023HelicalSequence analysisAdd
BLAST
Topological domaini951 – 100454CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Copper-transporting ATPasePRO_0000046318Add
BLAST

Proteomic databases

MaxQBiP38995.

PTM databases

iPTMnetiP38995.

Interactioni

Protein-protein interaction databases

BioGridi32325. 29 interactions.
IntActiP38995. 2 interactions.
MINTiMINT-367619.

Structurei

Secondary structure

1
1004
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Helixi14 – 2512Combined sources
Beta strandi27 – 337Combined sources
Turni37 – 404Combined sources
Beta strandi41 – 466Combined sources
Beta strandi48 – 503Combined sources
Helixi52 – 6211Combined sources
Beta strandi66 – 705Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FVQNMR-A2-72[»]
1FVSNMR-A2-72[»]
1UV1model-B2-72[»]
1UV2model-B2-72[»]
2GGPNMR-B2-72[»]
ProteinModelPortaliP38995.
SMRiP38995. Positions 2-238, 299-956.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38995.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6866HMA 1PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 14767HMA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
InParanoidiP38995.
KOiK17686.
OMAiIVWITIG.
OrthoDBiEOG092C0DN9.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV
60 70 80 90 100
TADSIKEIIE DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK
110 120 130 140 150
QVEGIEGVES VVVSLVTEEC HVIYEPSKTT LETAREMIED CGFDSNIIMD
160 170 180 190 200
GNGNADMTEK TVILKVTKAF EDESPLILSS VSERFQFLLD LGVKSIEISD
210 220 230 240 250
DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT QLRLLSKEDE
260 270 280 290 300
IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF
310 320 330 340 350
YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF
360 370 380 390 400
SVFSLVHNMF HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA
410 420 430 440 450
LSKLIQLTPS VCSIISDVER NETKEIPIEL LQVNDIVEIK PGMKIPADGI
460 470 480 490 500
ITRGESEIDE SLMTGESILV PKKTGFPVIA GSVNGPGHFY FRTTTVGEET
510 520 530 540 550
KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL TFFIWCFILN
560 570 580 590 600
ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG
610 620 630 640 650
VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG
660 670 680 690 700
NVDEDEVLAC IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL
710 720 730 740 750
GKGIVSKCQV NGNTYDICIG NEALILEDAL KKSGFINSNV DQGNTVSYVS
760 770 780 790 800
VNGHVFGLFE INDEVKHDSY ATVQYLQRNG YETYMITGDN NSAAKRVARE
810 820 830 840 850
VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI NDAPALALSD
860 870 880 890 900
LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL
910 920 930 940 950
NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML
960 970 980 990 1000
KKWTPPDIES HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN

EEVL
Length:1,004
Mass (Da):109,829
Last modified:February 1, 1995 - v1
Checksum:i571E9F73EA1F599F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36317 Genomic DNA. Translation: AAC37425.1.
U51030 Genomic DNA. Translation: AAB64451.1.
BK006938 Genomic DNA. Translation: DAA12113.1.
PIRiS55353.
RefSeqiNP_010556.1. NM_001180578.1.

Genome annotation databases

EnsemblFungiiYDR270W; YDR270W; YDR270W.
GeneIDi851862.
KEGGisce:YDR270W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36317 Genomic DNA. Translation: AAC37425.1.
U51030 Genomic DNA. Translation: AAB64451.1.
BK006938 Genomic DNA. Translation: DAA12113.1.
PIRiS55353.
RefSeqiNP_010556.1. NM_001180578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FVQNMR-A2-72[»]
1FVSNMR-A2-72[»]
1UV1model-B2-72[»]
1UV2model-B2-72[»]
2GGPNMR-B2-72[»]
ProteinModelPortaliP38995.
SMRiP38995. Positions 2-238, 299-956.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32325. 29 interactions.
IntActiP38995. 2 interactions.
MINTiMINT-367619.

Protein family/group databases

TCDBi3.A.3.5.17. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP38995.

Proteomic databases

MaxQBiP38995.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR270W; YDR270W; YDR270W.
GeneIDi851862.
KEGGisce:YDR270W.

Organism-specific databases

EuPathDBiFungiDB:YDR270W.
SGDiS000002678. CCC2.

Phylogenomic databases

GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
InParanoidiP38995.
KOiK17686.
OMAiIVWITIG.
OrthoDBiEOG092C0DN9.

Enzyme and pathway databases

BioCyciYEAST:G3O-29839-MONOMER.
BRENDAi3.6.3.4. 984.
ReactomeiR-SCE-936837. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTraceiP38995.
PROiP38995.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATU2_YEAST
AccessioniPrimary (citable) accession number: P38995
Secondary accession number(s): D6VSQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.