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Protein

Probable phosphatidylinositol 4-phosphate 5-kinase MSS4

Gene

MSS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  • 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • phosphatidylinositol-3-phosphate binding Source: SGD
  • phosphatidylinositol-4-phosphate binding Source: SGD

GO - Biological processi

  • ascospore-type prospore assembly Source: SGD
  • cortical actin cytoskeleton organization Source: CACAO
  • phosphatidylinositol phosphorylation Source: SGD

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YDR208W-MONOMER
ReactomeiR-SCE-1660499 Synthesis of PIPs at the plasma membrane
R-SCE-6811555 PI5P Regulates TP53 Acetylation
R-SCE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SCE-8847453 Synthesis of PIPs in the nucleus
R-SCE-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 4-phosphate 5-kinase MSS4 (EC:2.7.1.68)
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase
Diphosphoinositide kinase
PIP5K
Gene namesi
Name:MSS4
Ordered Locus Names:YDR208W
ORF Names:YD8142A.05
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR208W
SGDiS000002616 MSS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854551 – 779Probable phosphatidylinositol 4-phosphate 5-kinase MSS4Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207PhosphoserineCombined sources1
Modified residuei222PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei659PhosphothreonineCombined sources1
Modified residuei661PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38994
PaxDbiP38994
PRIDEiP38994

PTM databases

iPTMnetiP38994

Interactioni

Protein-protein interaction databases

BioGridi32258, 314 interactors
IntActiP38994, 3 interactors
MINTiP38994
STRINGi4932.YDR208W

Structurei

3D structure databases

ProteinModelPortaliP38994
SMRiP38994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini376 – 756PIPKPROSITE-ProRule annotationAdd BLAST381

Phylogenomic databases

GeneTreeiENSGT00760000119184
HOGENOMiHOG000193875
InParanoidiP38994
KOiK00889
OMAiFYEFIED
OrthoDBiEOG092C4AR2

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 1 hit
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

P38994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLRSQPPS VVPLHLTTST SRKTEQEPSL LHSAIIERHQ DRSVPNSNSN
60 70 80 90 100
PDSNHRIKKD RNNHTSYHSS SNSESNMESP RLSDGESSTP TSIEELNPTI
110 120 130 140 150
NNSRLVKRNY SISIDPLHDN SNNNTDDDHP NTITSPRPNS TSNKEMQKYS
160 170 180 190 200
FPEGKESKKI TTPSLNSNNC LDLDNSSLVH TDSYIQDLND DHILLNKRVS
210 220 230 240 250
RRSSRISAVT ATSTTIKQRR NTQDSNLPNI PFHASKHSQI LPMDDSDVIK
260 270 280 290 300
LANGDTSMKP NSATKISHSM TSLPLHPLPQ PSQKSKQYHM ISKSTTSLPP
310 320 330 340 350
ENDHYYQHSR GTNHNHAANA AAVNNNTTTT TAATGLKRSE SATAEIKKMR
360 370 380 390 400
QSLLHKREMK RKRKTFLVDD DRVLIGNKVS EGHVNFIIAY NMLTGIRVAV
410 420 430 440 450
SRCSGIMKPL TPADFRFTKK LAFDYHGNEL TPSSQYAFKF KDYCPEVFRE
460 470 480 490 500
LRALFGLDPA DYLVSLTSKY ILSELNSPGK SGSFFYYSRD YKYIIKTIHH
510 520 530 540 550
SEHIHLRKHI QEYYNHVRDN PNTLICQFYG LHRVKMPISF QNKIKHRKIY
560 570 580 590 600
FLVMNNLFPP HLDIHITYDL KGSTWGRFTN LDKERLAKDR SYRPVMKDLN
610 620 630 640 650
WLEEGQKIKF GPLKKKTFLT QLKKDVELLA KLNTMDYSLL IGIHDINKAK
660 670 680 690 700
EDDLQLADTA SIEEQPQTQG PIRTGTGTVV RHFFREFEGG IRASDQFNND
710 720 730 740 750
VDLIYYVGII DFLTNYSVMK KLETFWRSLR HDTKLVSAIP PRDYANRFYE
760 770
FIEDSVDPLP QKKTQSSYRD DPNQKNYKD
Length:779
Mass (Da):89,320
Last modified:October 1, 1996 - v2
Checksum:iF66B796229CFB8F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti610F → L in BAA02869 (PubMed:8152413).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13716 Genomic DNA Translation: BAA02869.1
Z68194 Genomic DNA Translation: CAA92347.1
BK006938 Genomic DNA Translation: DAA12049.1
PIRiS61571
RefSeqiNP_010494.1, NM_001180516.1

Genome annotation databases

EnsemblFungiiYDR208W; YDR208W; YDR208W
GeneIDi851789
KEGGisce:YDR208W

Similar proteinsi

Entry informationi

Entry nameiMSS4_YEAST
AccessioniPrimary (citable) accession number: P38994
Secondary accession number(s): D6VSI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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