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Protein

Sphingolipid C4-hydroxylase SUR2

Gene

SUR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin.2 Publications

Pathwayi: sphingolipid biosynthesis

This protein is involved in the pathway sphingolipid biosynthesis, which is part of Membrane lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid biosynthesis and in Membrane lipid metabolism.

GO - Molecular functioni

  • iron ion binding Source: InterPro
  • sphingosine hydroxylase activity Source: SGD

GO - Biological processi

  • fatty acid biosynthetic process Source: InterPro
  • sphingolipid biosynthetic process Source: UniProtKB-UniPathway
  • sphingolipid metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YDR297W-MONOMER.
YEAST:YDR297W-MONOMER.
UniPathwayiUPA00786.

Chemistry

SwissLipidsiSLP:000000370.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingolipid C4-hydroxylase SUR2 (EC:1.-.-.-)
Alternative name(s):
Syringomycin response protein 2
Gene namesi
Name:SUR2
Synonyms:SYR2
Ordered Locus Names:YDR297W
ORF Names:D9740.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR297W.
SGDiS000002705. SUR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Sphingolipid C4-hydroxylase SUR2PRO_0000072316Add
BLAST

Proteomic databases

MaxQBiP38992.

Interactioni

Protein-protein interaction databases

BioGridi32349. 148 interactions.
DIPiDIP-7741N.
IntActiP38992. 34 interactions.
MINTiMINT-1354051.

Structurei

3D structure databases

ProteinModelPortaliP38992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sterol desaturase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000203350.
InParanoidiP38992.
KOiK04713.
OMAiAFTNWEL.
OrthoDBiEOG092C2WZW.

Family and domain databases

InterProiIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamiPF04116. FA_hydroxylase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTSNATAA GSFPLAFGLK TSFGFMHYAK APAINLRPKE SLLPEMSDGV
60 70 80 90 100
LALVAPVVAY WALSGIFHVI DTFHLAEKYR IHPSEEVAKR NKASRMHVFL
110 120 130 140 150
EVILQHIIQT IVGLIFMHFE PIYMTGFEEN AMWKLRADLP RIIPDAAIYY
160 170 180 190 200
GYMYGMSALK IFAGFLFVDT WQYFLHRLMH MNKTLYKWFH SVHHELYVPY
210 220 230 240 250
AYGALFNNPV EGFLLDTLGT GIAMTLTHLT HREQIILFTF ATMKTVDDHC
260 270 280 290 300
GYALPLDPFQ WLFPNNAVYH DIHHQQFGIK TNFAQPFFTF WDNLFQTNFK
310 320 330 340
GFEEYQKKQR RVTIDKYKEF LQERELEKKE KLKNFKAMNA AENEVKKEK
Length:349
Mass (Da):40,734
Last modified:February 1, 1995 - v1
Checksum:i406D778092CA75C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07171 Unassigned DNA. Translation: AAA16608.1.
U10427 Genomic DNA. Translation: AAB41115.1.
U28374 Genomic DNA. Translation: AAB64733.1.
BK006938 Genomic DNA. Translation: DAA12136.1.
PIRiS48533.
RefSeqiNP_010583.1. NM_001180605.1.

Genome annotation databases

EnsemblFungiiYDR297W; YDR297W; YDR297W.
GeneIDi851891.
KEGGisce:YDR297W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07171 Unassigned DNA. Translation: AAA16608.1.
U10427 Genomic DNA. Translation: AAB41115.1.
U28374 Genomic DNA. Translation: AAB64733.1.
BK006938 Genomic DNA. Translation: DAA12136.1.
PIRiS48533.
RefSeqiNP_010583.1. NM_001180605.1.

3D structure databases

ProteinModelPortaliP38992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32349. 148 interactions.
DIPiDIP-7741N.
IntActiP38992. 34 interactions.
MINTiMINT-1354051.

Chemistry

SwissLipidsiSLP:000000370.

Proteomic databases

MaxQBiP38992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR297W; YDR297W; YDR297W.
GeneIDi851891.
KEGGisce:YDR297W.

Organism-specific databases

EuPathDBiFungiDB:YDR297W.
SGDiS000002705. SUR2.

Phylogenomic databases

HOGENOMiHOG000203350.
InParanoidiP38992.
KOiK04713.
OMAiAFTNWEL.
OrthoDBiEOG092C2WZW.

Enzyme and pathway databases

UniPathwayiUPA00786.
BioCyciMetaCyc:YDR297W-MONOMER.
YEAST:YDR297W-MONOMER.

Miscellaneous databases

PROiP38992.

Family and domain databases

InterProiIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamiPF04116. FA_hydroxylase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUR2_YEAST
AccessioniPrimary (citable) accession number: P38992
Secondary accession number(s): D6VSS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 54300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.