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Protein

Sphingolipid C4-hydroxylase SUR2

Gene

SUR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin.2 Publications

Miscellaneous

Present with 54300 molecules/cell in log phase SD medium.1 Publication

Pathwayi: sphingolipid biosynthesis

This protein is involved in the pathway sphingolipid biosynthesis, which is part of Membrane lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid biosynthesis and in Membrane lipid metabolism.

GO - Molecular functioni

  • iron ion binding Source: InterPro
  • sphingolipid delta-4 desaturase activity Source: GO_Central
  • sphingosine hydroxylase activity Source: SGD

GO - Biological processi

  • sphingolipid biosynthetic process Source: GO_Central
  • sphingolipid metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YDR297W-MONOMER
YEAST:YDR297W-MONOMER
UniPathwayiUPA00786

Chemistry databases

SwissLipidsiSLP:000000370

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingolipid C4-hydroxylase SUR2 (EC:1.-.-.-)
Alternative name(s):
Syringomycin response protein 2
Gene namesi
Name:SUR2
Synonyms:SYR2
Ordered Locus Names:YDR297W
ORF Names:D9740.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR297W
SGDiS000002705 SUR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723161 – 349Sphingolipid C4-hydroxylase SUR2Add BLAST349

Proteomic databases

MaxQBiP38992
PaxDbiP38992
PRIDEiP38992

Interactioni

Protein-protein interaction databases

BioGridi32349, 221 interactors
DIPiDIP-7741N
IntActiP38992, 34 interactors
MINTiP38992
STRINGi4932.YDR297W

Structurei

3D structure databases

ProteinModelPortaliP38992
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sterol desaturase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000203350
InParanoidiP38992
KOiK04713
OMAiDDHCGYS
OrthoDBiEOG092C2WZW

Family and domain databases

InterProiView protein in InterPro
IPR006694 Fatty_acid_hydroxylase
PfamiView protein in Pfam
PF04116 FA_hydroxylase, 1 hit

Sequencei

Sequence statusi: Complete.

P38992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTSNATAA GSFPLAFGLK TSFGFMHYAK APAINLRPKE SLLPEMSDGV
60 70 80 90 100
LALVAPVVAY WALSGIFHVI DTFHLAEKYR IHPSEEVAKR NKASRMHVFL
110 120 130 140 150
EVILQHIIQT IVGLIFMHFE PIYMTGFEEN AMWKLRADLP RIIPDAAIYY
160 170 180 190 200
GYMYGMSALK IFAGFLFVDT WQYFLHRLMH MNKTLYKWFH SVHHELYVPY
210 220 230 240 250
AYGALFNNPV EGFLLDTLGT GIAMTLTHLT HREQIILFTF ATMKTVDDHC
260 270 280 290 300
GYALPLDPFQ WLFPNNAVYH DIHHQQFGIK TNFAQPFFTF WDNLFQTNFK
310 320 330 340
GFEEYQKKQR RVTIDKYKEF LQERELEKKE KLKNFKAMNA AENEVKKEK
Length:349
Mass (Da):40,734
Last modified:February 1, 1995 - v1
Checksum:i406D778092CA75C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07171 Unassigned DNA Translation: AAA16608.1
U10427 Genomic DNA Translation: AAB41115.1
U28374 Genomic DNA Translation: AAB64733.1
BK006938 Genomic DNA Translation: DAA12136.1
PIRiS48533
RefSeqiNP_010583.1, NM_001180605.1

Genome annotation databases

EnsemblFungiiYDR297W; YDR297W; YDR297W
GeneIDi851891
KEGGisce:YDR297W

Similar proteinsi

Entry informationi

Entry nameiSUR2_YEAST
AccessioniPrimary (citable) accession number: P38992
Secondary accession number(s): D6VSS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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