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P38989

- SMC2_YEAST

UniProt

P38989 - SMC2_YEAST

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Protein

Structural maintenance of chromosomes protein 2

Gene
SMC2, YFR031C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATP Reviewed prediction

GO - Molecular functioni

  1. AT DNA binding Source: SGD
  2. ATP binding Source: SGD
  3. chromatin binding Source: SGD
  4. DNA secondary structure binding Source: SGD
  5. double-stranded DNA binding Source: SGD
  6. protein binding Source: IntAct

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. meiotic chromosome condensation Source: SGD
  3. meiotic chromosome separation Source: SGD
  4. mitotic chromosome condensation Source: SGD
  5. mitotic sister chromatid segregation Source: SGD
  6. rDNA condensation Source: SGD
  7. synaptonemal complex assembly Source: SGD
  8. tRNA gene clustering Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30479-MONOMER.
ReactomeiREACT_188908. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 2
Alternative name(s):
DA-box protein SMC2
Gene namesi
Name:SMC2
Ordered Locus Names:YFR031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR031c.
SGDiS000001927. SMC2.

Subcellular locationi

Nucleus. Cytoplasm. Chromosome
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear condensin complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11701170Structural maintenance of chromosomes protein 2PRO_0000119013Add
BLAST

Proteomic databases

MaxQBiP38989.
PaxDbiP38989.

Expressioni

Gene expression databases

GenevestigatoriP38989.

Interactioni

Subunit structurei

Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BRN1P381702EBI-17412,EBI-4792
SMC1P329083EBI-17412,EBI-17402
YCG1Q066803EBI-17412,EBI-4799

Protein-protein interaction databases

BioGridi31186. 54 interactions.
DIPiDIP-2983N.
IntActiP38989. 12 interactions.
MINTiMINT-435495.
STRINGi4932.YFR031C.

Structurei

3D structure databases

ProteinModelPortaliP38989.
SMRiP38989. Positions 1-221, 507-691, 950-1169.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni470 – 677208Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili172 – 469298 Reviewed predictionAdd
BLAST
Coiled coili678 – 1027350 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1084 – 111936Ala/Asp-rich (DA-box)Add
BLAST

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer By similarity.

Sequence similaritiesi

Belongs to the SMC family. SMC2 subfamily.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1196.
GeneTreeiENSGT00550000074857.
HOGENOMiHOG000163792.
KOiK06674.
OMAiCQNGKIP.
OrthoDBiEOG7M0P0T.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

P38989-1 [UniParc]FASTAAdd to Basket

« Hide

MKVEELIIDG FKSYATRTVI TDWDPQFNAI TGLNGSGKSN ILDAICFVLG     50
IASMSTVRAS SLQDLIYKRG QAGVTKASVT IVFDNTDKSN SPIGFTNSPQ 100
ISVTRQVVLG GTSKYLINGH RAPQQSVLQL FQSVQLNINN PNFLIMQGKI 150
TKVLNMKPSE ILSLIEEAAG TKMFEDRREK AERTMSKKET KLQENRTLLT 200
EEIEPKLEKL RNEKRMFLEF QSTQTDLEKT ERIVVSYEYY NIKHKHTSIR 250
ETLENGETRM KMLNEFVKKT SEEIDSLNED VEEIKLQKEK ELHKEGTISK 300
LENKENGLLN EISRLKTSLS IKVENLNDTT EKSKALESEI ASSSAKLIEK 350
KSAYANTEKD YKMVQEQLSK QRDLYKRKEE LVSTLTTGIS STGAADGGYN 400
AQLAKAKTEL NEVSLAIKKS SMKMELLKKE LLTIEPKLKE ATKDNELNVK 450
HVKQCQETCD KLRARLVEYG FDPSRIKDLK QREDKLKSHY YQTCKNSEYL 500
KRRVTNLEFN YTKPYPNFEA SFVHGVVGQL FQIDNDNIRY ATALQTCAGG 550
RLFNVVVQDS QTATQLLERG RLRKRVTIIP LDKIYTRPIS SQVLDLAKKI 600
APGKVELAIN LIRFDESITK AMEFIFGNSL ICEDPETAKK ITFHPKIRAR 650
SITLQGDVYD PEGTLSGGSR NTSESLLVDI QKYNQIQKQI ETIQADLNHV 700
TEELQTQYAT SQKTKTIQSD LNLSLHKLDL AKRNLDANPS SQIIARNEEI 750
LRDIGECENE IKTKQMSLKK CQEEVSTIEK DMKEYDSDKG SKLNELKKEL 800
KLLAKELEEQ ESESERKYDL FQNLELETEQ LSSELDSNKT LLHNHLKSIE 850
SLKLENSDLE GKIRGVEDDL VTVQTELNEE KKRLMDIDDE LNELETLIKK 900
KQDEKKSSEL ELQKLVHDLN KYKSNTNNME KIIEDLRQKH EFLEDFDLVR 950
NIVKQNEGID LDTYRERSKQ LNEKFQELRK KVNPNIMNMI ENVEKKEAAL 1000
KTMIKTIEKD KMKIQETISK LNEYKRETLV KTWEKVTLDF GNIFADLLPN 1050
SFAKLVPCEG KDVTQGLEVK VKLGNIWKES LIELSGGQRS LIALSLIMAL 1100
LQFRPAPMYI LDEVDAALDL SHTQNIGHLI KTRFKGSQFI VVSLKEGMFA 1150
NANRVFRTRF QDGTSVVSIM 1170
Length:1,170
Mass (Da):133,928
Last modified:February 1, 1995 - v1
Checksum:i142B41AAE109621F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05820 Genomic DNA. Translation: AAA17416.1.
D50617 Genomic DNA. Translation: BAA09270.1.
BK006940 Genomic DNA. Translation: DAA12471.1.
PIRiA56157.
RefSeqiNP_116687.1. NM_001179996.2.

Genome annotation databases

EnsemblFungiiYFR031C; YFR031C; YFR031C.
GeneIDi850589.
KEGGisce:YFR031C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05820 Genomic DNA. Translation: AAA17416.1 .
D50617 Genomic DNA. Translation: BAA09270.1 .
BK006940 Genomic DNA. Translation: DAA12471.1 .
PIRi A56157.
RefSeqi NP_116687.1. NM_001179996.2.

3D structure databases

ProteinModelPortali P38989.
SMRi P38989. Positions 1-221, 507-691, 950-1169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31186. 54 interactions.
DIPi DIP-2983N.
IntActi P38989. 12 interactions.
MINTi MINT-435495.
STRINGi 4932.YFR031C.

Proteomic databases

MaxQBi P38989.
PaxDbi P38989.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR031C ; YFR031C ; YFR031C .
GeneIDi 850589.
KEGGi sce:YFR031C.

Organism-specific databases

CYGDi YFR031c.
SGDi S000001927. SMC2.

Phylogenomic databases

eggNOGi COG1196.
GeneTreei ENSGT00550000074857.
HOGENOMi HOG000163792.
KOi K06674.
OMAi CQNGKIP.
OrthoDBi EOG7M0P0T.

Enzyme and pathway databases

BioCyci YEAST:G3O-30479-MONOMER.
Reactomei REACT_188908. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

NextBioi 966434.
PROi P38989.

Gene expression databases

Genevestigatori P38989.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view ]
PANTHERi PTHR18937:SF9. PTHR18937:SF9. 1 hit.
Pfami PF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF005719. SMC. 1 hit.
SMARTi SM00968. SMC_hinge. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family."
    Strunnikov A.V., Hogan E., Koshland D.
    Genes Dev. 9:587-599(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H., Hanaoka F., Murakami Y.
    Yeast 12:177-190(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  5. "The condensin complex governs chromosome condensation and mitotic transmission of rDNA."
    Freeman L., Aragon-Alcaide L., Strunnikov A.V.
    J. Cell Biol. 149:811-824(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A CONDENSIN COMPLEX WITH SMC4; BRN1; YCS4 AND YCG1.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMC2_YEAST
AccessioniPrimary (citable) accession number: P38989
Secondary accession number(s): D6VTR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3290 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi