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Protein

Structural maintenance of chromosomes protein 2

Gene

SMC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Miscellaneous

Present with 3290 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPSequence analysis8

GO - Molecular functioni

  • AT DNA binding Source: SGD
  • ATP binding Source: SGD
  • chromatin binding Source: SGD
  • DNA secondary structure binding Source: SGD
  • double-stranded DNA binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic chromosome condensation Source: SGD
  • meiotic chromosome separation Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid segregation Source: SGD
  • negative regulation of meiotic DNA double-strand break formation Source: SGD
  • rDNA condensation Source: SGD
  • synaptonemal complex assembly Source: SGD
  • tRNA gene clustering Source: SGD

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30479-MONOMER
ReactomeiR-SCE-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 2
Alternative name(s):
DA-box protein SMC2
Gene namesi
Name:SMC2
Ordered Locus Names:YFR031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR031C
SGDiS000001927 SMC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190131 – 1170Structural maintenance of chromosomes protein 2Add BLAST1170

Proteomic databases

MaxQBiP38989
PaxDbiP38989
PRIDEiP38989

PTM databases

iPTMnetiP38989

Interactioni

Subunit structurei

Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31186, 102 interactors
ComplexPortaliCPX-1869 Nuclear condensin complex
DIPiDIP-2983N
IntActiP38989, 15 interactors
MINTiP38989
STRINGi4932.YFR031C

Structurei

Secondary structure

11170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi455 – 469Combined sources15
Helixi473 – 495Combined sources23
Helixi498 – 501Combined sources4
Beta strandi523 – 526Combined sources4
Helixi527 – 529Combined sources3
Helixi536 – 540Combined sources5
Helixi541 – 548Combined sources8
Helixi549 – 553Combined sources5
Beta strandi555 – 559Combined sources5
Helixi560 – 568Combined sources9
Beta strandi576 – 580Combined sources5
Turni581 – 583Combined sources3
Helixi591 – 600Combined sources10
Beta strandi604 – 607Combined sources4
Helixi608 – 611Combined sources4
Helixi616 – 618Combined sources3
Helixi619 – 626Combined sources8
Beta strandi629 – 634Combined sources6
Helixi635 – 642Combined sources8
Beta strandi650 – 653Combined sources4
Turni654 – 656Combined sources3
Beta strandi657 – 660Combined sources4
Turni661 – 663Combined sources3
Beta strandi664 – 668Combined sources5
Helixi676 – 705Combined sources30
Turni706 – 711Combined sources6
Helixi714 – 721Combined sources8
Turni722 – 726Combined sources5
Helixi727 – 734Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RSIX-ray2.90A396-792[»]
ProteinModelPortaliP38989
SMRiP38989
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni470 – 677Flexible hingeAdd BLAST208

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili172 – 469Sequence analysisAdd BLAST298
Coiled coili678 – 1027Sequence analysisAdd BLAST350

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1084 – 1119Ala/Asp-rich (DA-box)Add BLAST36

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC2 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00550000074857
HOGENOMiHOG000163792
InParanoidiP38989
KOiK06674
OMAiHNKIAME
OrthoDBiEOG092C0XGI

Family and domain databases

CDDicd03273 ABC_SMC2_euk, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR027120 Smc2_ABC
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 2 hits
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF75553 SSF75553, 1 hit

Sequencei

Sequence statusi: Complete.

P38989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEELIIDG FKSYATRTVI TDWDPQFNAI TGLNGSGKSN ILDAICFVLG
60 70 80 90 100
IASMSTVRAS SLQDLIYKRG QAGVTKASVT IVFDNTDKSN SPIGFTNSPQ
110 120 130 140 150
ISVTRQVVLG GTSKYLINGH RAPQQSVLQL FQSVQLNINN PNFLIMQGKI
160 170 180 190 200
TKVLNMKPSE ILSLIEEAAG TKMFEDRREK AERTMSKKET KLQENRTLLT
210 220 230 240 250
EEIEPKLEKL RNEKRMFLEF QSTQTDLEKT ERIVVSYEYY NIKHKHTSIR
260 270 280 290 300
ETLENGETRM KMLNEFVKKT SEEIDSLNED VEEIKLQKEK ELHKEGTISK
310 320 330 340 350
LENKENGLLN EISRLKTSLS IKVENLNDTT EKSKALESEI ASSSAKLIEK
360 370 380 390 400
KSAYANTEKD YKMVQEQLSK QRDLYKRKEE LVSTLTTGIS STGAADGGYN
410 420 430 440 450
AQLAKAKTEL NEVSLAIKKS SMKMELLKKE LLTIEPKLKE ATKDNELNVK
460 470 480 490 500
HVKQCQETCD KLRARLVEYG FDPSRIKDLK QREDKLKSHY YQTCKNSEYL
510 520 530 540 550
KRRVTNLEFN YTKPYPNFEA SFVHGVVGQL FQIDNDNIRY ATALQTCAGG
560 570 580 590 600
RLFNVVVQDS QTATQLLERG RLRKRVTIIP LDKIYTRPIS SQVLDLAKKI
610 620 630 640 650
APGKVELAIN LIRFDESITK AMEFIFGNSL ICEDPETAKK ITFHPKIRAR
660 670 680 690 700
SITLQGDVYD PEGTLSGGSR NTSESLLVDI QKYNQIQKQI ETIQADLNHV
710 720 730 740 750
TEELQTQYAT SQKTKTIQSD LNLSLHKLDL AKRNLDANPS SQIIARNEEI
760 770 780 790 800
LRDIGECENE IKTKQMSLKK CQEEVSTIEK DMKEYDSDKG SKLNELKKEL
810 820 830 840 850
KLLAKELEEQ ESESERKYDL FQNLELETEQ LSSELDSNKT LLHNHLKSIE
860 870 880 890 900
SLKLENSDLE GKIRGVEDDL VTVQTELNEE KKRLMDIDDE LNELETLIKK
910 920 930 940 950
KQDEKKSSEL ELQKLVHDLN KYKSNTNNME KIIEDLRQKH EFLEDFDLVR
960 970 980 990 1000
NIVKQNEGID LDTYRERSKQ LNEKFQELRK KVNPNIMNMI ENVEKKEAAL
1010 1020 1030 1040 1050
KTMIKTIEKD KMKIQETISK LNEYKRETLV KTWEKVTLDF GNIFADLLPN
1060 1070 1080 1090 1100
SFAKLVPCEG KDVTQGLEVK VKLGNIWKES LIELSGGQRS LIALSLIMAL
1110 1120 1130 1140 1150
LQFRPAPMYI LDEVDAALDL SHTQNIGHLI KTRFKGSQFI VVSLKEGMFA
1160 1170
NANRVFRTRF QDGTSVVSIM
Length:1,170
Mass (Da):133,928
Last modified:February 1, 1995 - v1
Checksum:i142B41AAE109621F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05820 Genomic DNA Translation: AAA17416.1
D50617 Genomic DNA Translation: BAA09270.1
BK006940 Genomic DNA Translation: DAA12471.1
PIRiA56157
RefSeqiNP_116687.1, NM_001179996.2

Genome annotation databases

EnsemblFungiiBAA09270; BAA09270; BAA09270
YFR031C; YFR031C; YFR031C
GeneIDi850589
KEGGisce:YFR031C

Similar proteinsi

Entry informationi

Entry nameiSMC2_YEAST
AccessioniPrimary (citable) accession number: P38989
Secondary accession number(s): D6VTR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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