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Protein

Mitochondrial GTP/GDP carrier protein 1

Gene

GGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial GTP/GDP transporter required for GTP uptake and GDP exit from mitochondria. Involved in mitochondrial iron transport and essential for mitochondrial genome maintenance.2 Publications

Kineticsi

  1. KM=1.2 µM for GTP1 Publication
  2. KM=4.7 µM for GDP1 Publication
  3. KM=15.9 µM for dGTP1 Publication
  1. Vmax=2.0 mmol/min/g enzyme1 Publication

GO - Molecular functioni

  • guanine nucleotide transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • guanine nucleotide transport Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29582-MONOMER.

Protein family/group databases

TCDBi2.A.29.21.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial GTP/GDP carrier protein 1
Gene namesi
Name:GGC1
Synonyms:SHM1, YHM1
Ordered Locus Names:YDL198C
ORF Names:D1214
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL198C.
SGDiS000002357. GGC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei85 – 101Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei173 – 189Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei214 – 234Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei268 – 285Helical; Name=6Sequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906871 – 300Mitochondrial GTP/GDP carrier protein 1Add BLAST300

Proteomic databases

MaxQBiP38988.
PRIDEiP38988.

Interactioni

Protein-protein interaction databases

BioGridi31848. 23 interactors.
DIPiDIP-7756N.
IntActiP38988. 21 interactors.
MINTiMINT-1359691.

Structurei

3D structure databases

ProteinModelPortaliP38988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 108Solcar 1Add BLAST101
Repeati117 – 198Solcar 2Add BLAST82
Repeati208 – 293Solcar 3Add BLAST86

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP38988.
OMAiWGWTMAR.
OrthoDBiEOG092C3ME7.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHTDKKQSG LARLLGSASA GIMEIAVFHP VDTISKRLMS NHTKITSGQE
60 70 80 90 100
LNRVIFRDHF SEPLGKRLFT LFPGLGYAAS YKVLQRVYKY GGQPFANEFL
110 120 130 140 150
NKHYKKDFDN LFGEKTGKAM RSAAAGSLIG IGEIVLLPLD VLKIKRQTNP
160 170 180 190 200
ESFKGRGFIK ILRDEGLFNL YRGWGWTAAR NAPGSFALFG GNAFAKEYIL
210 220 230 240 250
GLKDYSQATW SQNFISSIVG ACSSLIVSAP LDVIKTRIQN RNFDNPESGL
260 270 280 290 300
RIVKNTLKNE GVTAFFKGLT PKLLTTGPKL VFSFALAQSL IPRFDNLLSK
Length:300
Mass (Da):33,215
Last modified:February 1, 1995 - v1
Checksum:i3B0AB95EF563E85C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08352 Genomic DNA. Translation: AAC49493.1.
X83276 Genomic DNA. Translation: CAA58249.1.
X99000 Genomic DNA. Translation: CAA67471.1.
Z74246 Genomic DNA. Translation: CAA98775.1.
AY693086 Genomic DNA. Translation: AAT93105.1.
BK006938 Genomic DNA. Translation: DAA11666.1.
PIRiS58779.
RefSeqiNP_010083.1. NM_001180258.1.

Genome annotation databases

EnsemblFungiiYDL198C; YDL198C; YDL198C.
GeneIDi851329.
KEGGisce:YDL198C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08352 Genomic DNA. Translation: AAC49493.1.
X83276 Genomic DNA. Translation: CAA58249.1.
X99000 Genomic DNA. Translation: CAA67471.1.
Z74246 Genomic DNA. Translation: CAA98775.1.
AY693086 Genomic DNA. Translation: AAT93105.1.
BK006938 Genomic DNA. Translation: DAA11666.1.
PIRiS58779.
RefSeqiNP_010083.1. NM_001180258.1.

3D structure databases

ProteinModelPortaliP38988.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31848. 23 interactors.
DIPiDIP-7756N.
IntActiP38988. 21 interactors.
MINTiMINT-1359691.

Protein family/group databases

TCDBi2.A.29.21.1. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiP38988.
PRIDEiP38988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL198C; YDL198C; YDL198C.
GeneIDi851329.
KEGGisce:YDL198C.

Organism-specific databases

EuPathDBiFungiDB:YDL198C.
SGDiS000002357. GGC1.

Phylogenomic databases

InParanoidiP38988.
OMAiWGWTMAR.
OrthoDBiEOG092C3ME7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29582-MONOMER.

Miscellaneous databases

PROiP38988.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGC1_YEAST
AccessioniPrimary (citable) accession number: P38988
Secondary accession number(s): D6VRF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.