Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein SA

Gene

sta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development.UniRule annotation1 Publication

GO - Molecular functioni

  • ribosome binding Source: UniProtKB
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
Alternative name(s):
K14
Laminin receptor homolog
Protein stubaristaUniRule annotation
Gene namesi
Name:staUniRule annotation
ORF Names:CG14792
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003517. sta.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001343531 – 27040S ribosomal protein SAAdd BLAST270

Proteomic databases

PaxDbiP38979.
PRIDEiP38979.

Expressioni

Developmental stagei

Expressed both maternally and zygotically in embryos.1 Publication

Gene expression databases

BgeeiFBgn0003517.
GenevisibleiP38979. DM.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with oho23B/rpS21.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi57663. 21 interactors.
DIPiDIP-17178N.
IntActiP38979. 3 interactors.
MINTiMINT-1635735.
STRINGi7227.FBpp0070279.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AA1-270[»]
ProteinModelPortaliP38979.
SMRiP38979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0830. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000015036.
InParanoidiP38979.
KOiK02998.
OMAiYWILARE.
OrthoDBiEOG091G0J0Q.
PhylomeDBiP38979.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_03015. Ribosomal_S2_euk. 1 hit.
InterProiView protein in InterPro
IPR032281. 40S_SA_C.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom_sf.
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiView protein in Pfam
PF16122. 40S_SA_C. 1 hit.
PF00318. Ribosomal_S2. 2 hits.
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. uS2_euk_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P38979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGLDILSL KEDDITKMLV ATTHLGSENV NFQMEQYVYK RRADGVNILN
60 70 80 90 100
LGKTWEKLQL AARAIVAIDN PSDIFVISSR PIGQRAVLKF AKYTDTTPIA
110 120 130 140 150
GRFTPGAFTN QIQPAFREPR LLVVTDPNTD HQPIMEASYV NIPVIAFTNT
160 170 180 190 200
DSPLRYIDIA IPCNNKSAHS IGLMWWLLAR EVLRLRGTIS RSVEWPVVVD
210 220 230 240 250
LFFYRDPEEA EKEEAAAKEL LPPPKIEEAV DHPVEETTNW ADEVAAETVG
260 270
GVEDWNEDTV KTSWGSDGQF
Length:270
Mass (Da):30,228
Last modified:January 31, 2018 - v3
Checksum:iFEC452C3F1712C82
GO

Sequence cautioni

The sequence AAA28667 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90422 Genomic DNA. Translation: AAA28741.1.
AE014298 Genomic DNA. Translation: AAF45638.2.
AE014298 Genomic DNA. Translation: AAN09049.1.
AE014298 Genomic DNA. Translation: AAN09050.3.
AL031027 Genomic DNA. Translation: CAA19839.1.
AE014298 Genomic DNA. Translation: AHN59256.1.
AY118899 mRNA. Translation: AAM50759.1.
BT029094 mRNA. Translation: ABJ17027.1.
M77133 mRNA. Translation: AAA28667.1. Different initiation.
PIRiT13602.
RefSeqiNP_001284785.1. NM_001297856.1.
NP_476750.1. NM_057402.5.
NP_726744.1. NM_166889.2.
NP_726745.3. NM_166890.3.
UniGeneiDm.33985.
Dm.4723.

Genome annotation databases

EnsemblMetazoaiFBtr0070289; FBpp0070277; FBgn0003517.
FBtr0070290; FBpp0070278; FBgn0003517.
FBtr0339593; FBpp0308665; FBgn0003517.
FBtr0339594; FBpp0308666; FBgn0003517.
GeneIDi31106.
KEGGidme:Dmel_CG14792.

Similar proteinsi

Entry informationi

Entry nameiRSSA_DROME
AccessioniPrimary (citable) accession number: P38979
Secondary accession number(s): Q058X4
, Q7KW10, Q9W583, X2JC80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 31, 2018
Last modified: January 31, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Was originally thought to be a laminin receptor.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families