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P38973 (CC2H1_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog 1

EC=2.7.11.22
Gene names
Name:CRK1
Synonyms:KIN1
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Ser-15 or Tyr-16 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Cell division control protein 2 homolog 1
PRO_0000085706

Regions

Domain5 – 297293Protein kinase
Nucleotide binding11 – 199ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site341ATP By similarity

Amino acid modifications

Modified residue151Phosphoserine By similarity
Modified residue161Phosphotyrosine By similarity
Modified residue1601Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
P38973 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9D8B56DAAD9DEC6A

FASTA30134,351
        10         20         30         40         50         60 
MGSRYERLQK IGEGSYGVVF RARDVTTGTI VAVKRIRLEK EEEGVPCTAI REISILKELR 

        70         80         90        100        110        120 
HENIVRLLDV CHSEKRLTLV FECMEMDLKK YMDHVGGDLD AGTIQEFMRS LLSGVRFCHE 

       130        140        150        160        170        180 
RNVLHRDLKP PNLLISREKE LKLADFGLGR AFGIPVKKFT QEVVTLWYRS PDVLLGSTQY 

       190        200        210        220        230        240 
GTPVDIWSVG CIFAEMAIGA PLFTGKNDAD QLLRIFQFLG TPNRQVWPSM DTYPNSSNML 

       250        260        270        280        290        300 
SRPEFQQTLA ATCEEQFQTN PAYAKLGPQG IDLLRWLLRY EPSERLTAAQ ALEHPYFSVE 


F 

« Hide

References

[1]"A family of trypanosome cdc2-related protein kinases."
Mottram J., Smith G.
Gene 162:147-152(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ISTAT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64314 Genomic DNA. Translation: CAA45595.1.
PIRS19209.

3D structure databases

ProteinModelPortalP38973.
SMRP38973. Positions 4-298.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP38973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.22. 6520.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCC2H1_TRYBB
AccessionPrimary (citable) accession number: P38973
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families