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P38973

- CC2H1_TRYBB

UniProt

P38973 - CC2H1_TRYBB

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Protein
Cell division control protein 2 homolog 1
Gene
CRK1, KIN1
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Ser-15 or Tyr-16 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 6520.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog 1 (EC:2.7.11.22)
Gene namesi
Name:CRK1
Synonyms:KIN1
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Cell division control protein 2 homolog 1
PRO_0000085706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine By similarity
Modified residuei16 – 161Phosphotyrosine By similarity
Modified residuei160 – 1601Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP38973.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Structurei

3D structure databases

ProteinModelPortaliP38973.
SMRiP38973. Positions 4-298.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 297293Protein kinase
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38973-1 [UniParc]FASTAAdd to Basket

« Hide

MGSRYERLQK IGEGSYGVVF RARDVTTGTI VAVKRIRLEK EEEGVPCTAI    50
REISILKELR HENIVRLLDV CHSEKRLTLV FECMEMDLKK YMDHVGGDLD 100
AGTIQEFMRS LLSGVRFCHE RNVLHRDLKP PNLLISREKE LKLADFGLGR 150
AFGIPVKKFT QEVVTLWYRS PDVLLGSTQY GTPVDIWSVG CIFAEMAIGA 200
PLFTGKNDAD QLLRIFQFLG TPNRQVWPSM DTYPNSSNML SRPEFQQTLA 250
ATCEEQFQTN PAYAKLGPQG IDLLRWLLRY EPSERLTAAQ ALEHPYFSVE 300
F 301
Length:301
Mass (Da):34,351
Last modified:February 1, 1995 - v1
Checksum:i9D8B56DAAD9DEC6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64314 Genomic DNA. Translation: CAA45595.1.
PIRiS19209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64314 Genomic DNA. Translation: CAA45595.1 .
PIRi S19209.

3D structure databases

ProteinModelPortali P38973.
SMRi P38973. Positions 4-298.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P38973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.11.22. 6520.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of trypanosome cdc2-related protein kinases."
    Mottram J., Smith G.
    Gene 162:147-152(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ISTAT.

Entry informationi

Entry nameiCC2H1_TRYBB
AccessioniPrimary (citable) accession number: P38973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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