Reviewed, UniProtKB/Swiss-Prot P38973 (CC2H1_TRYBB)

Names and origin

Protein names

Recommended name:
    Cell division control protein 2 homolog 1
    EC=2.7.11.22

Gene names

Name:	CRK1
Synonyms:	KIN1

Organism

Trypanosoma brucei brucei

Taxonomic identifier

5702 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Probably involved in the control of the cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Ser-15 or Tyr-16 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity.
Subunit structure	Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Cell division control protein 2 homolog 1		PRO_0000085706
Regions
	Domain	5 – 297	293	Protein kinase
	Nucleotide binding	11 – 19	9	ATP By similarity
Sites
	Active site	127	1	Proton acceptor By similarity
	Binding site	34	1	ATP By similarity
Amino acid modifications
	Modified residue	15	1	Phosphoserine By similarity
	Modified residue	16	1	Phosphotyrosine By similarity
	Modified residue	160	1	Phosphothreonine; by CAK By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38973-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 9D8B56DAAD9DEC6A	FASTA	301	34,351
	10 20 30 40 50 60 MGSRYERLQK IGEGSYGVVF RARDVTTGTI VAVKRIRLEK EEEGVPCTAI REISILKELR 70 80 90 100 110 120 HENIVRLLDV CHSEKRLTLV FECMEMDLKK YMDHVGGDLD AGTIQEFMRS LLSGVRFCHE 130 140 150 160 170 180 RNVLHRDLKP PNLLISREKE LKLADFGLGR AFGIPVKKFT QEVVTLWYRS PDVLLGSTQY 190 200 210 220 230 240 GTPVDIWSVG CIFAEMAIGA PLFTGKNDAD QLLRIFQFLG TPNRQVWPSM DTYPNSSNML 250 260 270 280 290 300 SRPEFQQTLA ATCEEQFQTN PAYAKLGPQG IDLLRWLLRY EPSERLTAAQ ALEHPYFSVE F

References

[1]	"A family of trypanosome cdc2-related protein kinases." Mottram J., Smith G. Gene 162:147-152(1995) [PubMed: 7557404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ISTAT.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X64314 Genomic DNA. Translation: CAA45595.1.
PIR	S19209.
3D structure databases
HSSP	HSSP built from PDB template 1H0W based on UniProtKB P24941.
ModBase	Search...
Phylogenomic databases
OMA	TIKSFMH.
Enzyme and pathway databases
BRENDA	2.7.11.22. 74165.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CC2H1_TRYBB

Accession

Primary (citable) accession number: P38973

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)