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Protein

Basic amino-acid permease

Gene

ALP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity permease for basic amino acids.1 Publication

GO - Molecular functioni

GO - Biological processi

  • basic amino acid transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33264-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.11. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Basic amino-acid permease
Gene namesi
Name:ALP1
Ordered Locus Names:YNL270C
ORF Names:N0660
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL270C.
SGDiS000005214. ALP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 73CytoplasmicSequence analysisAdd BLAST73
Transmembranei74 – 93HelicalSequence analysisAdd BLAST20
Topological domaini94 – 95ExtracellularSequence analysis2
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 153CytoplasmicSequence analysisAdd BLAST37
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 179ExtracellularSequence analysis5
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 209CytoplasmicSequence analysis9
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 265ExtracellularSequence analysisAdd BLAST35
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 306CytoplasmicSequence analysisAdd BLAST20
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 359ExtracellularSequence analysisAdd BLAST32
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 403CytoplasmicSequence analysisAdd BLAST23
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 431ExtracellularSequence analysis7
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 477CytoplasmicSequence analysisAdd BLAST25
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 510ExtracellularSequence analysisAdd BLAST12
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Topological domaini532 – 573CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541451 – 573Basic amino-acid permeaseAdd BLAST573

Proteomic databases

PRIDEiP38971.
TopDownProteomicsiP38971.

Interactioni

Protein-protein interaction databases

BioGridi35570. 38 interactors.
IntActiP38971. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP38971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
InParanoidiP38971.
KOiK16261.
OMAiCASHYVF.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDETVNIQMS KEGQYEINSS SIIKEEEFVD EQYSGENVTK AITTERKVED
60 70 80 90 100
DAAKETESSP QERREVKRKL KQRHIGMIAL GGTIGTGLII GIGPPLAHAG
110 120 130 140 150
PVGALISYLF MGTVIYSVTQ SLGEMVTFIP VTSSFSVFAQ RFLSPALGAT
160 170 180 190 200
NGYMYWLSWC FTFALELSVL GKVIQYWTEA VPLAAWIVIF WCLLTSMNMF
210 220 230 240 250
PVKYYGEFEF CIASIKVIAL LGFIIFSFCV VCGAGQSDGP IGFRYWRNPG
260 270 280 290 300
AWGPGIISSD KNEGRFLGWV SSLINAAFTY QGTELVGITA GEAANPRKAL
310 320 330 340 350
PRAIKKVVVR ILVFYILSLF FIGLLVPYND PKLDSDGIFV SSSPFMISIE
360 370 380 390 400
NSGTKVLPDI FNAVVLITIL SAGNSNVYIG SRVLYSLSKN SLAPRFLSNV
410 420 430 440 450
TRGGVPYFSV LSTSVFGFLA FLEVSAGSGK AFNWLLNITG VAGFFAWLLI
460 470 480 490 500
SFSHIRFMQA IRKRGISRDD LPYKAQMMPF LAYYASFFIA LIVLIQGFTA
510 520 530 540 550
FAPTFQPIDF VAAYISIFLF LAIWLSFQVW FKCRLLWKLQ DIDIDSDRRQ
560 570
IEELVWIEPE CKTRWQRVWD VLS
Length:573
Mass (Da):64,014
Last modified:October 1, 1996 - v2
Checksum:i359DFE1466C348A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51D → DD in CAA52199 (PubMed:7941748).Curated1
Sequence conflicti126V → A in CAA52199 (PubMed:7941748).Curated1
Sequence conflicti260D → N in CAA52199 (PubMed:7941748).Curated1
Sequence conflicti517I → V in CAA52199 (PubMed:7941748).Curated1
Sequence conflicti548R → H in CAA52199 (PubMed:7941748).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74069 Genomic DNA. Translation: CAA52199.1.
X92494 Genomic DNA. Translation: CAA63228.1.
Z71546 Genomic DNA. Translation: CAA96177.1.
BK006947 Genomic DNA. Translation: DAA10290.1.
PIRiS60912.
RefSeqiNP_014129.1. NM_001183108.1.

Genome annotation databases

EnsemblFungiiYNL270C; YNL270C; YNL270C.
GeneIDi855451.
KEGGisce:YNL270C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74069 Genomic DNA. Translation: CAA52199.1.
X92494 Genomic DNA. Translation: CAA63228.1.
Z71546 Genomic DNA. Translation: CAA96177.1.
BK006947 Genomic DNA. Translation: DAA10290.1.
PIRiS60912.
RefSeqiNP_014129.1. NM_001183108.1.

3D structure databases

ProteinModelPortaliP38971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35570. 38 interactors.
IntActiP38971. 1 interactor.

Protein family/group databases

TCDBi2.A.3.10.11. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEiP38971.
TopDownProteomicsiP38971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL270C; YNL270C; YNL270C.
GeneIDi855451.
KEGGisce:YNL270C.

Organism-specific databases

EuPathDBiFungiDB:YNL270C.
SGDiS000005214. ALP1.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
InParanoidiP38971.
KOiK16261.
OMAiCASHYVF.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-33264-MONOMER.

Miscellaneous databases

PROiP38971.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALP1_YEAST
AccessioniPrimary (citable) accession number: P38971
Secondary accession number(s): D6W0S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.