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Protein

Serine/threonine-protein kinase HAL5

Gene

HAL5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase involved in salt tolerance and pH sensitivity, probably by regulating plasma membrane potential and cation influx. Positively controls the TRK1-TRK2 potassium transport system in response to potassium starvation. Stabilizes TRK1 in the plasma membrane by preventing its vacuolar sorting and degradation. Also stabilizes other plasma membrane nutrient transporters like CAN1, FUR4 and HXT1. May itself be subject to regulation by ARL1.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei546ATPPROSITE-ProRule annotation1
Active sitei688Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi509 – 517ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cellular cation homeostasis Source: SGD
  • cellular protein localization Source: SGD
  • intracellular signal transduction Source: GO_Central
  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31605-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase HAL5 (EC:2.7.11.1)
Alternative name(s):
Halotolerance protein 5
Gene namesi
Name:HAL5
Ordered Locus Names:YJL165C
ORF Names:J0531
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL165C
SGDiS000003701 HAL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859881 – 855Serine/threonine-protein kinase HAL5Add BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38970
PaxDbiP38970
PRIDEiP38970

PTM databases

iPTMnetiP38970

Interactioni

Protein-protein interaction databases

BioGridi33594, 209 interactors
DIPiDIP-6399N
IntActiP38970, 5 interactors
MINTiP38970
STRINGi4932.YJL165C

Structurei

3D structure databases

ProteinModelPortaliP38970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini503 – 837Protein kinasePROSITE-ProRule annotationAdd BLAST335

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 377Poly-Gln9

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075309
HOGENOMiHOG000112846
InParanoidiP38970
KOiK08286
OMAiRLVDCWS
OrthoDBiEOG092C2CDU

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P38970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEKLSRHT SLKRARSLSE SIKGLFKPSG ISGSNNAAAP SSRPGQDQAH
60 70 80 90 100
SHQTARIITS NVSSPSISPV HSPVLQAAPK HHKLGVPNIA KLSLSPSREP
110 120 130 140 150
SLNSENEMFS QESFISEKDE DEANLLERED LQNKKEEKAR AKHVRSKEAY
160 170 180 190 200
VPHHRYTVGS DEVERQPRER LKNFPQNAGS SNPANSNANH VLDQENNFSI
210 220 230 240 250
DAMLDYDEES KLRRRNSLGV RNHSNRTRSR KNSLSTPRSP PMKNGNGGMN
260 270 280 290 300
SNATNNVGNG TGNRIYMRGR NHSDSISASS LPKFQEIECK CILDLGHFKV
310 320 330 340 350
FENGYHEHSL RVLPIITNNK NVDSGDEKDA DASVNSGDDG DNDSEANMHK
360 370 380 390 400
QKSVFSLSGL FKSHKDGNQQ QQQQQQQEEN GEQINLEKAF SIIPSQRFIK
410 420 430 440 450
SQTLKKSRTS NLKNGNNDEL MKNDGKNIPQ IVNPNAAVGV EELKLINALS
460 470 480 490 500
EKIRKGLKSE NTKGNNGEGR SNSNKQEDSD DTEGKAGTTN DDTSHKPCSQ
510 520 530 540 550
KYGKSIGVVG AGAYGVVKIC ARCKTAKDVL PYSTYSNGKK LFFAVKELKP
560 570 580 590 600
KPGDQIDKFC TRLTSEFIIG HSLSHPHFEA NAMIAGNVSR TTPPKHVFNA
610 620 630 640 650
PNILKILDLM EYSNSFVEVM EFCASGDLYS LLTRNNISNE SNNGSSRLIQ
660 670 680 690 700
TVKEGSGSPL HPLEADCFMK QLLNGVQYMH DHGIAHCDLK PENILFQPNG
710 720 730 740 750
LLKICDFGTS SVFQTAWEKH VHFQSGAMGS EPYVAPEEFI RDAEYDPRLV
760 770 780 790 800
DCWSCGIVYC TMVMGQYLWK IAIPEKDSLF KSFLSEIKDD GQFYLFEELR
810 820 830 840 850
HVSSELNRLR KIALYRTFQV DPTKRITIEQ LLQSSWMRKT KCCVVYRHLH

TKVSK
Length:855
Mass (Da):95,455
Last modified:November 1, 1995 - v2
Checksum:i4F23A97996489F39
GO

Sequence cautioni

The sequence AAA50395 differs from that shown. Reason: Frameshift at positions 587 and 606.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15300 mRNA Translation: AAA50395.1 Frameshift.
Z49440 Genomic DNA Translation: CAA89460.1
BK006943 Genomic DNA Translation: DAA08638.1
PIRiS56948
RefSeqiNP_012370.1, NM_001181598.1

Genome annotation databases

EnsemblFungiiYJL165C; YJL165C; YJL165C
GeneIDi853274
KEGGisce:YJL165C

Similar proteinsi

Entry informationi

Entry nameiHAL5_YEAST
AccessioniPrimary (citable) accession number: P38970
Secondary accession number(s): D6VW22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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