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Protein

Tryptophan permease

Gene

TAT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine.2 Publications

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • aromatic amino acid transmembrane transporter activity Source: SGD
  • catalytic activity Source: InterPro
  • high-affinity tryptophan transmembrane transporter activity Source: SGD

GO - Biological processi

  • aromatic amino acid transport Source: SGD
  • tryptophan transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33436-MONOMER

Protein family/group databases

TCDBi2.A.3.10.8 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan permease
Alternative name(s):
Tryptophan amino acid transporter
Gene namesi
Name:TAT2
Synonyms:LTG3, SAB2, SCM2, TAP2
Ordered Locus Names:YOL020W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL020W
SGDiS000005380 TAT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 113ExtracellularSequence analysis5
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 160CytoplasmicSequence analysisAdd BLAST26
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 192ExtracellularSequence analysisAdd BLAST11
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 226CytoplasmicSequence analysisAdd BLAST13
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 266ExtracellularSequence analysisAdd BLAST19
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 306CytoplasmicSequence analysisAdd BLAST19
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 358ExtracellularSequence analysisAdd BLAST31
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 404CytoplasmicSequence analysisAdd BLAST25
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 428ExtracellularSequence analysis3
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 472CytoplasmicSequence analysisAdd BLAST23
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 514ExtracellularSequence analysisAdd BLAST21
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 592CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541601 – 592Tryptophan permeaseAdd BLAST592

Proteomic databases

MaxQBiP38967
PaxDbiP38967
PRIDEiP38967
TopDownProteomicsiP38967

PTM databases

SwissPalmiP38967

Interactioni

Protein-protein interaction databases

BioGridi34382, 98 interactors
DIPiDIP-1782N
IntActiP38967, 4 interactors
MINTiP38967
STRINGi4932.YOL020W

Structurei

3D structure databases

ProteinModelPortaliP38967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
HOGENOMiHOG000261848
InParanoidiP38967
KOiK16261
OMAiFIGTEAV
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P38967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDFISSVK RSNEELKERK SNFGFVEYKS KQLTSSSSHN SNSSHHDDDN
60 70 80 90 100
QHGKRNIFQR CVDSFKSPLD GSFDTSNLKR TLKPRHLIMI AIGGSIGTGL
110 120 130 140 150
FVGSGKAIAE GGPLGVVIGW AIAGSQIIGT IHGLGEITVR FPVVGAFANY
160 170 180 190 200
GTRFLDPSIS FVVSTIYVLQ WFFVLPLEII AAAMTVQYWN SSIDPVIWVA
210 220 230 240 250
IFYAVIVSIN LFGVRGFGEA EFAFSTIKAI TVCGFIILCV VLICGGGPDH
260 270 280 290 300
EFIGAKYWHD PGCLANGFPG VLSVLVVASY SLGGIEMTCL ASGETDPKGL
310 320 330 340 350
PSAIKQVFWR ILFFFLISLT LVGFLVPYTN QNLLGGSSVD NSPFVIAIKL
360 370 380 390 400
HHIKALPSIV NAVILISVLS VGNSCIFASS RTLCSMAHQG LIPWWFGYID
410 420 430 440 450
RAGRPLVGIM ANSLFGLLAF LVKSGSMSEV FNWLMAIAGL ATCIVWLSIN
460 470 480 490 500
LSHIRFRLAM KAQGKSLDEL EFVSAVGIWG SAYSALINCL ILIAQFYCSL
510 520 530 540 550
WPIGGWTSGK ERAKIFFQNY LCALIMLFIF IVHKIYYKCQ TGKWWGVKAL
560 570 580 590
KDIDLETDRK DIDIEIVKQE IAEKKMYLDS RPWYVRQFHF WC
Length:592
Mass (Da):65,404
Last modified:February 1, 1995 - v1
Checksum:iA233BAD16264B319
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187Q → T in BAA03811 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79150 Genomic DNA Translation: CAA55777.1
L33461 Genomic DNA Translation: AAA60324.1
D16304 Genomic DNA Translation: BAA03811.1
U66834 Genomic DNA Translation: AAB07526.1
Z74761 Genomic DNA Translation: CAA99019.1
Z74762 Genomic DNA Translation: CAA99020.1
BK006948 Genomic DNA Translation: DAA10761.1
PIRiS46273
RefSeqiNP_014622.1, NM_001183274.1

Genome annotation databases

EnsemblFungiiYOL020W; YOL020W; YOL020W
GeneIDi854139
KEGGisce:YOL020W

Similar proteinsi

Entry informationi

Entry nameiTAT2_YEAST
AccessioniPrimary (citable) accession number: P38967
Secondary accession number(s): D6W245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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