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Protein

Protein STN1

Gene

STN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi62 – 15998OBAdd
BLAST

GO - Molecular functioni

  • single-stranded telomeric DNA binding Source: SGD

GO - Biological processi

  • negative regulation of telomere maintenance via telomerase Source: SGD
  • telomere capping Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STN1
Gene namesi
Name:STN1
Ordered Locus Names:YDR082W
ORF Names:D4456, YD8554.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR082W.
SGDiS000002489. STN1.

Subcellular locationi

GO - Cellular componenti

  • CST complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Telomere

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi397 – 3971D → A: Modest telomere elongation phenotype. 1 Publication
Mutagenesisi466 – 4661W → E: Elongated telomeres. 1 Publication
Mutagenesisi466 – 4661W → R: Elongated telomeres and severe growth defects. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Protein STN1PRO_0000072279Add
BLAST

Proteomic databases

MaxQBiP38960.

PTM databases

iPTMnetiP38960.

Interactioni

Subunit structurei

Interacts with CDC13 and TEN1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC13P327975EBI-18427,EBI-4187
POL12P381212EBI-18427,EBI-6111
TEN1Q079217EBI-18427,EBI-35131

Protein-protein interaction databases

BioGridi32138. 30 interactions.
DIPiDIP-1230N.
IntActiP38960. 6 interactions.
MINTiMINT-402087.

Structurei

Secondary structure

1
494
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi315 – 32511Combined sources
Beta strandi326 – 3327Combined sources
Helixi333 – 3375Combined sources
Helixi340 – 35617Combined sources
Helixi365 – 38218Combined sources
Beta strandi385 – 3906Combined sources
Turni391 – 3944Combined sources
Beta strandi395 – 3973Combined sources
Helixi399 – 41719Combined sources
Beta strandi421 – 4266Combined sources
Helixi427 – 4348Combined sources
Helixi441 – 45818Combined sources
Turni460 – 4623Combined sources
Beta strandi463 – 4708Combined sources
Beta strandi482 – 4898Combined sources
Turni491 – 4933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K10X-ray2.50A313-491[»]
3KEYX-ray2.10A311-494[»]
ProteinModelPortaliP38960.
SMRiP38960. Positions 312-494.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38960.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni311 – 39787Winged helix-turn-helix (wHTH) 1Add
BLAST
Regioni396 – 49499Winged helix-turn-helix (wHTH) 2Add
BLAST

Domaini

The C-terminal wHLH region seems to mediate telomere-specific function.

Sequence similaritiesi

Contains 1 OB DNA-binding domain.Curated

Phylogenomic databases

InParanoidiP38960.
KOiK11117.
OMAiVICNITE.
OrthoDBiEOG092C1MNX.

Family and domain databases

InterProiIPR024263. Stn1_C_fungi.
IPR018856. Stn1_N.
[Graphical view]
PfamiPF10451. Stn1. 1 hit.
PF12659. Stn1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKYGHIAHQ EGDVCYYIPR LFKYNSYYSG TEDVRIFVGD LKYRMRVSLQ
60 70 80 90 100
ICEKYYDRRL SMLFWKNHPL QQIHLIGCII GLQFKWIGKQ EYIFFQLDDC
110 120 130 140 150
TSDSSLVGYT SDMRFLTCKV KKDSILSWGL NITDLIGLTL HVYGQASLNY
160 170 180 190 200
QELQVEYLRL CYSLTEEIDH WKITMNMREQ LDTPWSLSDF VIGELFTQEQ
210 220 230 240 250
EWTPETSQIE VVNPDFVGIG YKTPESKRNE TTFIEQLQEE RLKDELEIIS
260 270 280 290 300
PYNSTDTSNS VHSLSFRFVS SLKDFPETHF LNSGDQIDNG NDEQLKKLEY
310 320 330 340 350
QSANLPVMIP NRTSAKSNLM LILLGLQMKE ISNSDLYKLK EVRSVVTSLA
360 370 380 390 400
SFLFQQQNVG VMKSFDSLEK EAFRDLVNRL VSQGLIGLKD KTSETFDLLP
410 420 430 440 450
LKNLFEYAEK RISVLMKLQC YTGTVQLSHV QEKLHLPYIT TNGIVDVFKE
460 470 480 490
CLKRTKKQYP EVLKNWWIDL DPKNGMEDQN SGILLHLEYA AAYS
Length:494
Mass (Da):57,511
Last modified:February 1, 1995 - v1
Checksum:i61B691C8D4A2E650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002132 Genomic DNA. Translation: AAB60885.1.
X82086 Genomic DNA. Translation: CAA57609.1.
Z46796 Genomic DNA. Translation: CAA86804.1.
Z74378 Genomic DNA. Translation: CAA98902.1.
AY723774 Genomic DNA. Translation: AAU09691.1.
BK006938 Genomic DNA. Translation: DAA11929.1.
PIRiS48769.
RefSeqiNP_010367.1. NM_001180390.1.

Genome annotation databases

EnsemblFungiiYDR082W; YDR082W; YDR082W.
GeneIDi851655.
KEGGisce:YDR082W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002132 Genomic DNA. Translation: AAB60885.1.
X82086 Genomic DNA. Translation: CAA57609.1.
Z46796 Genomic DNA. Translation: CAA86804.1.
Z74378 Genomic DNA. Translation: CAA98902.1.
AY723774 Genomic DNA. Translation: AAU09691.1.
BK006938 Genomic DNA. Translation: DAA11929.1.
PIRiS48769.
RefSeqiNP_010367.1. NM_001180390.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K10X-ray2.50A313-491[»]
3KEYX-ray2.10A311-494[»]
ProteinModelPortaliP38960.
SMRiP38960. Positions 312-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32138. 30 interactions.
DIPiDIP-1230N.
IntActiP38960. 6 interactions.
MINTiMINT-402087.

PTM databases

iPTMnetiP38960.

Proteomic databases

MaxQBiP38960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR082W; YDR082W; YDR082W.
GeneIDi851655.
KEGGisce:YDR082W.

Organism-specific databases

EuPathDBiFungiDB:YDR082W.
SGDiS000002489. STN1.

Phylogenomic databases

InParanoidiP38960.
KOiK11117.
OMAiVICNITE.
OrthoDBiEOG092C1MNX.

Enzyme and pathway databases

BioCyciYEAST:G3O-29687-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38960.
PROiP38960.

Family and domain databases

InterProiIPR024263. Stn1_C_fungi.
IPR018856. Stn1_N.
[Graphical view]
PfamiPF10451. Stn1. 1 hit.
PF12659. Stn1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTN1_YEAST
AccessioniPrimary (citable) accession number: P38960
Secondary accession number(s): D6VS69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.