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P38956

- SNF11_YEAST

UniProt

P38956 - SNF11_YEAST

Protein

Transcription regulatory protein SNF11

Gene

SNF11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29679-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription regulatory protein SNF11
    Alternative name(s):
    SWI/SNF complex component SNF11
    Gene namesi
    Name:SNF11
    Ordered Locus Names:YDR073W
    ORF Names:D4411
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR073w.
    SGDiS000002480. SNF11.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: SGD
    3. SWI/SNF complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 169168Transcription regulatory protein SNF11PRO_0000072004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP38956.
    PaxDbiP38956.

    Expressioni

    Gene expression databases

    GenevestigatoriP38956.

    Interactioni

    Subunit structurei

    Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SNF2P220823EBI-17560,EBI-17526
    SNF6P188885EBI-17560,EBI-17550

    Protein-protein interaction databases

    BioGridi32128. 66 interactions.
    DIPiDIP-1530N.
    IntActiP38956. 19 interactions.
    MINTiMINT-403957.
    STRINGi4932.YDR073W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38956.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 3141-1
    Repeati32 – 3541-2
    Repeati36 – 3941-3
    Repeati40 – 4341-4
    Repeati44 – 4741-5
    Repeati48 – 5141-6
    Repeati76 – 8052-1
    Repeati160 – 16562-2

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 51246 X 4 AA tandem repeats of N-[AT]-[NT]-AAdd
    BLAST
    Regioni76 – 165902 X 5 AA repeats of L-L-A-R-VAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi93 – 10210Poly-Asn

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG39679.
    HOGENOMiHOG000141848.
    KOiK11774.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38956-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEIAYSNT NTNTENENRN TGAGVDVNTN ANANANATAN ATANATANAT    50
    AELNLPTVDE QRQYKVQLLL HINSILLARV IQMNNSLQNN LQNNINNSNN 100
    NNIIRIQQLI SQFLKRVHAN LQCISQINQG VPSAKPLILT PPQLANQQQP 150
    PQDILSKLYL LLARVFEIW 169
    Length:169
    Mass (Da):18,667
    Last modified:February 1, 1995 - v1
    Checksum:iFC626E373C32C2C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46796 Genomic DNA. Translation: CAA86795.1.
    Z74369 Genomic DNA. Translation: CAA98891.1.
    X82086 Genomic DNA. Translation: CAA57601.1.
    X82086 Genomic DNA. Translation: CAA57600.1.
    AY557668 Genomic DNA. Translation: AAS55994.1.
    BK006938 Genomic DNA. Translation: DAA11919.1.
    PIRiS48760.
    RefSeqiNP_010358.3. NM_001180381.3.

    Genome annotation databases

    EnsemblFungiiYDR073W; YDR073W; YDR073W.
    GeneIDi851645.
    KEGGisce:YDR073W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46796 Genomic DNA. Translation: CAA86795.1 .
    Z74369 Genomic DNA. Translation: CAA98891.1 .
    X82086 Genomic DNA. Translation: CAA57601.1 .
    X82086 Genomic DNA. Translation: CAA57600.1 .
    AY557668 Genomic DNA. Translation: AAS55994.1 .
    BK006938 Genomic DNA. Translation: DAA11919.1 .
    PIRi S48760.
    RefSeqi NP_010358.3. NM_001180381.3.

    3D structure databases

    ProteinModelPortali P38956.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32128. 66 interactions.
    DIPi DIP-1530N.
    IntActi P38956. 19 interactions.
    MINTi MINT-403957.
    STRINGi 4932.YDR073W.

    Proteomic databases

    MaxQBi P38956.
    PaxDbi P38956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR073W ; YDR073W ; YDR073W .
    GeneIDi 851645.
    KEGGi sce:YDR073W.

    Organism-specific databases

    CYGDi YDR073w.
    SGDi S000002480. SNF11.

    Phylogenomic databases

    eggNOGi NOG39679.
    HOGENOMi HOG000141848.
    KOi K11774.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29679-MONOMER.

    Miscellaneous databases

    NextBioi 969221.

    Gene expression databases

    Genevestigatori P38956.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2."
      Treich I., Cairns B.R., de Los Santos T., Brewster E., Carlson M.
      Mol. Cell. Biol. 15:4240-4248(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
      Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
      Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.

    Entry informationi

    Entry nameiSNF11_YEAST
    AccessioniPrimary (citable) accession number: P38956
    Secondary accession number(s): D6VS59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1030 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3