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Protein

Major pollen allergen Car b 1 isoforms 1A and 1B

Gene
N/A
Organism
Carpinus betulus (European hornbeam) (Carpinus caucasica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Car b 1 isoforms 1A and 1B
Alternative name(s):
Allergen Car b I
Allergen: Car b 1
OrganismiCarpinus betulus (European hornbeam) (Carpinus caucasica)
Taxonomic identifieri12990 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeCarpinus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei180. Car b 1.
181. Car b 1.0101.
182. Car b 1.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 160159Major pollen allergen Car b 1 isoforms 1A and 1BPRO_0000154185Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP38949.
SMRiP38949. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYEAET PSVIPAARLF KSYVLDGDKL IPKVAPQVIS SVENVGGNGG
60 70 80 90 100
PGTIKNITFA EGIPFKFVKE RVDEVDNANF KYNYTVIEGD VLGDKLEKVS
110 120 130 140 150
HELKIVAAPG GGSIVKISSK FHAKGYHEVN AEKMKGAKEM AEKLLRAVES
160
YLLAHTAEYN
Length:160
Mass (Da):17,402
Last modified:January 23, 2007 - v2
Checksum:iDE891173C8E587AE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381V → A in isoform 1B.
Natural varianti63 – 631I → S in isoform 1B.
Natural varianti133 – 1331K → E in isoform 1B.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66932 mRNA. Translation: CAA47366.1.
X66918 mRNA. Translation: CAA47357.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66932 mRNA. Translation: CAA47366.1.
X66918 mRNA. Translation: CAA47357.1.

3D structure databases

ProteinModelPortaliP38949.
SMRiP38949. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei180. Car b 1.
181. Car b 1.0101.
182. Car b 1.0102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "PCR based cloning and sequencing of isogenes encoding the tree pollen major allergen Car b I from Carpinus betulus, hornbeam."
    Nedergaard Larsen J., Stroeman P., Ipsen H.
    Mol. Immunol. 29:703-711(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.

Entry informationi

Entry nameiMPAC1_CARBE
AccessioniPrimary (citable) accession number: P38949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence shown is that of isoform 1A.

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.