Reviewed,
UniProtKB/Swiss-Prot P38945 (4HDB_CLOK5)
Last modified
June 16, 2009.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: NAD-dependent 4-hydroxybutyrate dehydrogenase Short name=4HBD EC=1.1.1.61 | ||||
| Gene names |
| ||||
| Organism | Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 431943 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium |
Protein attributes
| Sequence length | 371 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH. |
| Cofactor | Divalent cations. |
| Sequence similarities | Belongs to the iron-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4-hydroxybutyrate dehydrogenase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 371 | 371 | NAD-dependent 4-hydroxybutyrate dehydrogenase | PRO_0000087840 | |||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri." Soehling B., Gottschalk G. J. Bacteriol. 178:871-880(1996) [PubMed: 8550525] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| L21902 Genomic DNA. Translation: AAA92348.1. CP000673 Genomic DNA. Translation: EDK35022.1. | |
| RefSeq | YP_001396393.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5394465. |
| GenomeReviews | Gene locus CKL_3014 in contig CP000673_GR. |
| KEGG | ckl:CKL_3014. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | P38945. EEYRNTI. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MON-13466. |
Family and domain databases | |
| InterPro | IPR001670. ADH_Fe. IPR018211. ADH_Fe_CS. [Graphical view] |
| Pfam | PF00465. Fe-ADH. 1 hit. [Graphical view] |
| PROSITE | PS00913. ADH_IRON_1. False negative. PS00060. ADH_IRON_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | 4HDB_CLOK5 | ||||||||
| Accession | Primary (citable) accession number: P38945 Secondary accession number(s): A5N1M6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


