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P38945 (4HDB_CLOK5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD-dependent 4-hydroxybutyrate dehydrogenase

Short name=4HBD
EC=1.1.1.61
Gene names
Name:4hbD
Ordered Locus Names:CKL_3014
OrganismClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]
Taxonomic identifier431943 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH.

Cofactor

Divalent cations.

Sequence similarities

Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function4-hydroxybutyrate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371NAD-dependent 4-hydroxybutyrate dehydrogenase
PRO_0000087840

Sequences

Sequence LengthMass (Da)Tools
P38945 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 8D4A8DCD94E252C4

FASTA37141,756
        10         20         30         40         50         60 
MKLLKLAPDV YKFDTAEEFM KYFKVGKGDF ILTNEFLYKP FLEKFNDGAD AVFQEKYGLG 

        70         80         90        100        110        120 
EPSDEMINNI IKDIGDKQYN RIIAVGGGSV IDIAKILSLK YTDDSLDLFE GKVPLVKNKE 

       130        140        150        160        170        180 
LIIVPTTCGT GSEVTNVSVA ELKRRHTKKG IASDELYATY AVLVPEFIKG LPYKFFVTSS 

       190        200        210        220        230        240 
VDALIHATEA YVSPNANPYT DMFSVKAMEL ILNGYMQMVE KGNDYRVEII EDFVIGSNYA 

       250        260        270        280        290        300 
GIAFGNAGVG AVHALSYPIG GNYHVPHGEA NYLFFTEIFK TYYEKNPNGK IKDVNKLLAG 

       310        320        330        340        350        360 
ILKCDESEAY DSLSQLLDKL LSRKPLREYG MKEEEIETFA DSVIEGQQRL LVNNYEPFSR 

       370 
EDIVNTYKKL Y 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri."
Soehling B., Gottschalk G.
J. Bacteriol. 178:871-880(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features."
Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L21902 Genomic DNA. Translation: AAA92348.1.
CP000673 Genomic DNA. Translation: EDK35022.1.
RefSeqYP_001396393.1. NC_009706.1.

3D structure databases

ProteinModelPortalP38945.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING431943.CKL_3014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEDK35022; EDK35022; CKL_3014.
GeneID5394465.
KEGGckl:CKL_3014.
PATRIC19467576. VBICloKlu111549_3118.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1454.
HOGENOMHOG000233530.
KOK18120.
OMAGKYHVPH.
OrthoDBEOG66F03S.

Enzyme and pathway databases

BioCycCKLU431943:GJF1-3007-MONOMER.
MetaCyc:MONOMER-13466.

Family and domain databases

InterProIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEPS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name4HDB_CLOK5
AccessionPrimary (citable) accession number: P38945
Secondary accession number(s): A5N1M6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families