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P38945

- 4HDB_CLOK5

UniProt

P38945 - 4HDB_CLOK5

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Protein

NAD-dependent 4-hydroxybutyrate dehydrogenase

Gene

4hbD

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH.

Cofactori

Divalent cations.

GO - Molecular functioni

  1. 4-hydroxybutyrate dehydrogenase activity Source: UniProtKB-EC
  2. metal ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-3007-MONOMER.
MetaCyc:MONOMER-13466.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent 4-hydroxybutyrate dehydrogenase (EC:1.1.1.61)
Short name:
4HBD
Gene namesi
Name:4hbD
Ordered Locus Names:CKL_3014
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371NAD-dependent 4-hydroxybutyrate dehydrogenasePRO_0000087840Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_3014.

Structurei

3D structure databases

ProteinModelPortaliP38945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1454.
HOGENOMiHOG000233530.
KOiK18120.
OMAiGKYHVPH.
OrthoDBiEOG66F03S.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38945-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLKLAPDV YKFDTAEEFM KYFKVGKGDF ILTNEFLYKP FLEKFNDGAD
60 70 80 90 100
AVFQEKYGLG EPSDEMINNI IKDIGDKQYN RIIAVGGGSV IDIAKILSLK
110 120 130 140 150
YTDDSLDLFE GKVPLVKNKE LIIVPTTCGT GSEVTNVSVA ELKRRHTKKG
160 170 180 190 200
IASDELYATY AVLVPEFIKG LPYKFFVTSS VDALIHATEA YVSPNANPYT
210 220 230 240 250
DMFSVKAMEL ILNGYMQMVE KGNDYRVEII EDFVIGSNYA GIAFGNAGVG
260 270 280 290 300
AVHALSYPIG GNYHVPHGEA NYLFFTEIFK TYYEKNPNGK IKDVNKLLAG
310 320 330 340 350
ILKCDESEAY DSLSQLLDKL LSRKPLREYG MKEEEIETFA DSVIEGQQRL
360 370
LVNNYEPFSR EDIVNTYKKL Y
Length:371
Mass (Da):41,756
Last modified:February 1, 1995 - v1
Checksum:i8D4A8DCD94E252C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21902 Genomic DNA. Translation: AAA92348.1.
CP000673 Genomic DNA. Translation: EDK35022.1.
RefSeqiYP_001396393.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK35022; EDK35022; CKL_3014.
GeneIDi5394465.
KEGGickl:CKL_3014.
PATRICi19467576. VBICloKlu111549_3118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21902 Genomic DNA. Translation: AAA92348.1 .
CP000673 Genomic DNA. Translation: EDK35022.1 .
RefSeqi YP_001396393.1. NC_009706.1.

3D structure databases

ProteinModelPortali P38945.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_3014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK35022 ; EDK35022 ; CKL_3014 .
GeneIDi 5394465.
KEGGi ckl:CKL_3014.
PATRICi 19467576. VBICloKlu111549_3118.

Phylogenomic databases

eggNOGi COG1454.
HOGENOMi HOG000233530.
KOi K18120.
OMAi GKYHVPH.
OrthoDBi EOG66F03S.

Enzyme and pathway databases

BioCyci CKLU431943:GJF1-3007-MONOMER.
MetaCyc:MONOMER-13466.

Family and domain databases

InterProi IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view ]
Pfami PF00465. Fe-ADH. 1 hit.
[Graphical view ]
PROSITEi PS00060. ADH_IRON_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri."
    Soehling B., Gottschalk G.
    J. Bacteriol. 178:871-880(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry namei4HDB_CLOK5
AccessioniPrimary (citable) accession number: P38945
Secondary accession number(s): A5N1M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3