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P38945

- 4HDB_CLOK5

UniProt

P38945 - 4HDB_CLOK5

Protein

NAD-dependent 4-hydroxybutyrate dehydrogenase

Gene

4hbD

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH.

    Cofactori

    Divalent cations.

    GO - Molecular functioni

    1. 4-hydroxybutyrate dehydrogenase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCKLU431943:GJF1-3007-MONOMER.
    MetaCyc:MONOMER-13466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD-dependent 4-hydroxybutyrate dehydrogenase (EC:1.1.1.61)
    Short name:
    4HBD
    Gene namesi
    Name:4hbD
    Ordered Locus Names:CKL_3014
    OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
    Taxonomic identifieri431943 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371NAD-dependent 4-hydroxybutyrate dehydrogenasePRO_0000087840Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi431943.CKL_3014.

    Structurei

    3D structure databases

    ProteinModelPortaliP38945.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1454.
    HOGENOMiHOG000233530.
    KOiK18120.
    OMAiGKYHVPH.
    OrthoDBiEOG66F03S.

    Family and domain databases

    InterProiIPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    [Graphical view]
    PfamiPF00465. Fe-ADH. 1 hit.
    [Graphical view]
    PROSITEiPS00060. ADH_IRON_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLKLAPDV YKFDTAEEFM KYFKVGKGDF ILTNEFLYKP FLEKFNDGAD    50
    AVFQEKYGLG EPSDEMINNI IKDIGDKQYN RIIAVGGGSV IDIAKILSLK 100
    YTDDSLDLFE GKVPLVKNKE LIIVPTTCGT GSEVTNVSVA ELKRRHTKKG 150
    IASDELYATY AVLVPEFIKG LPYKFFVTSS VDALIHATEA YVSPNANPYT 200
    DMFSVKAMEL ILNGYMQMVE KGNDYRVEII EDFVIGSNYA GIAFGNAGVG 250
    AVHALSYPIG GNYHVPHGEA NYLFFTEIFK TYYEKNPNGK IKDVNKLLAG 300
    ILKCDESEAY DSLSQLLDKL LSRKPLREYG MKEEEIETFA DSVIEGQQRL 350
    LVNNYEPFSR EDIVNTYKKL Y 371
    Length:371
    Mass (Da):41,756
    Last modified:February 1, 1995 - v1
    Checksum:i8D4A8DCD94E252C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21902 Genomic DNA. Translation: AAA92348.1.
    CP000673 Genomic DNA. Translation: EDK35022.1.
    RefSeqiWP_012103357.1. NC_009706.1.
    YP_001396393.1. NC_009706.1.

    Genome annotation databases

    EnsemblBacteriaiEDK35022; EDK35022; CKL_3014.
    GeneIDi5394465.
    KEGGickl:CKL_3014.
    PATRICi19467576. VBICloKlu111549_3118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21902 Genomic DNA. Translation: AAA92348.1 .
    CP000673 Genomic DNA. Translation: EDK35022.1 .
    RefSeqi WP_012103357.1. NC_009706.1.
    YP_001396393.1. NC_009706.1.

    3D structure databases

    ProteinModelPortali P38945.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 431943.CKL_3014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EDK35022 ; EDK35022 ; CKL_3014 .
    GeneIDi 5394465.
    KEGGi ckl:CKL_3014.
    PATRICi 19467576. VBICloKlu111549_3118.

    Phylogenomic databases

    eggNOGi COG1454.
    HOGENOMi HOG000233530.
    KOi K18120.
    OMAi GKYHVPH.
    OrthoDBi EOG66F03S.

    Enzyme and pathway databases

    BioCyci CKLU431943:GJF1-3007-MONOMER.
    MetaCyc:MONOMER-13466.

    Family and domain databases

    InterProi IPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    [Graphical view ]
    Pfami PF00465. Fe-ADH. 1 hit.
    [Graphical view ]
    PROSITEi PS00060. ADH_IRON_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri."
      Soehling B., Gottschalk G.
      J. Bacteriol. 178:871-880(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

    Entry informationi

    Entry namei4HDB_CLOK5
    AccessioniPrimary (citable) accession number: P38945
    Secondary accession number(s): A5N1M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3