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Protein

Cyclin-dependent kinase inhibitor 1

Gene

CDKN1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 41C4-typeSequence analysisAdd BLAST29

GO - Molecular functioni

  • cyclin-dependent protein kinase activating kinase activity Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • animal organ regeneration Source: Ensembl
  • cell cycle arrest Source: UniProtKB
  • cellular response to amino acid starvation Source: UniProtKB
  • cellular response to DNA damage stimulus Source: BHF-UCL
  • cellular response to extracellular stimulus Source: BHF-UCL
  • cellular response to gamma radiation Source: Ensembl
  • cellular response to heat Source: Ensembl
  • cellular response to ionizing radiation Source: BHF-UCL
  • cellular response to UV-B Source: UniProtKB
  • cellular senescence Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  • G1/S transition of mitotic cell cycle Source: BHF-UCL
  • G2/M transition of mitotic cell cycle Source: BHF-UCL
  • intestinal epithelial cell maturation Source: Ensembl
  • intrinsic apoptotic signaling pathway Source: ProtInc
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  • mitotic cell cycle arrest Source: Ensembl
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of cell growth Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  • negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  • negative regulation of gene expression Source: Ensembl
  • negative regulation of phosphorylation Source: BHF-UCL
  • positive regulation of B cell proliferation Source: Ensembl
  • positive regulation of fibroblast proliferation Source: BHF-UCL
  • positive regulation of programmed cell death Source: Ensembl
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  • protein stabilization Source: Reactome
  • Ras protein signal transduction Source: BHF-UCL
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  • regulation of DNA biosynthetic process Source: Ensembl
  • regulation of protein import into nucleus, translocation Source: Ensembl
  • response to arsenic-containing substance Source: Ensembl
  • response to corticosterone Source: Ensembl
  • response to drug Source: Ensembl
  • response to hyperoxia Source: Ensembl
  • response to organonitrogen compound Source: Ensembl
  • response to toxic substance Source: Ensembl
  • response to X-ray Source: Ensembl
  • stress-induced premature senescence Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-198323. AKT phosphorylates targets in the cytosol.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-HSA-5674400. Constitutive Signaling by AKT1 E17K in Cancer.
R-HSA-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-69202. Cyclin E associated events during G1/S transition.
R-HSA-69231. Cyclin D associated events in G1.
R-HSA-69563. p53-Dependent G1 DNA Damage Response.
R-HSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-HSA-69895. Transcriptional activation of cell cycle inhibitor p21.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-HSA-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.
SIGNORiP38936.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 1
Alternative name(s):
CDK-interacting protein 1
Melanoma differentiation-associated protein 6
Short name:
MDA-6
p21
Gene namesi
Name:CDKN1A
Synonyms:CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1784. CDKN1A.

Subcellular locationi

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: BHF-UCL
  • cytosol Source: Reactome
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: BHF-UCL
  • PCNA-p21 complex Source: UniProtKB
  • perinuclear region of cytoplasm Source: Ensembl
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi80T → A: Abolishes UV radiation-induced phosphorylation and subsequent degradation. 1 Publication1
Mutagenesisi114S → E: Phosphomimetic mutant, increases ubiquitination by the DCX(DTL) complex. 1 Publication1
Mutagenesisi144 – 150QTSMTDF → ATSATDA: Abolishes interaction with PCNA and subsequent degradation by the proteasome. 1 Publication7
Mutagenesisi145T → A: Reduces phosphorylation by Akt; no change in interaction with PCNA, CDK2 or CDK4; no change in subcellular location. 1 Publication1
Mutagenesisi145T → D: No interaction with PCNA; 59% inhibition of CDK2 binding; modest inhibition of CDK4 binding; no change in subcellular location. 1 Publication1
Mutagenesisi146S → A: No change in interaction with PCNA. Abolishes UV radiation-induced phosphorylation and subsequent degradation. 2 Publications1
Mutagenesisi146S → D: Reduces interaction with PCNA. 1 Publication1
Mutagenesisi147 – 151MTDFY → ATDAAA: Abolishes interaction with PCNA and subsequent degradation by the proteasome. 1 Publication5
Mutagenesisi154 – 156KRR → AAA: Abolishes degradation by the proteasome without affecting the interaction with PCNA. 1 Publication3

Organism-specific databases

DisGeNETi1026.
MalaCardsiCDKN1A.
OpenTargetsiENSG00000124762.
Orphaneti652. Multiple endocrine neoplasia type 1.
PharmGKBiPA104.

Chemistry databases

ChEMBLiCHEMBL5021.

Polymorphism and mutation databases

BioMutaiCDKN1A.
DMDMi729143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001900792 – 164Cyclin-dependent kinase inhibitor 1Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Cross-linki2Glycyl serine ester (Ser-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei80Phosphothreonine; by LKB11 Publication1
Modified residuei114Phosphoserine; by GSK3-beta1 Publication1
Modified residuei130PhosphoserineCombined sources1
Modified residuei145Phosphothreonine; by PKA; PKB/AKT1, PIM1 and PIM25 Publications1
Modified residuei146Phosphoserine; by PKC and NUAK12 Publications1
Modified residuei160Phosphoserine; by PKC; in vitro1 Publication1

Post-translational modificationi

Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.7 Publications
Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation by the proteasome pathway. Ubiquitinated by RNF114; leading to proteasomal degradation.1 Publication
Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP38936.
PaxDbiP38936.
PeptideAtlasiP38936.
PRIDEiP38936.

2D gel databases

SWISS-2DPAGEP38936.

PTM databases

iPTMnetiP38936.
PhosphoSitePlusiP38936.

Expressioni

Tissue specificityi

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Inductioni

Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1.2 Publications

Gene expression databases

BgeeiENSG00000124762.
CleanExiHS_CDKN1A.
ExpressionAtlasiP38936. baseline and differential.
GenevisibleiP38936. HS.

Organism-specific databases

HPAiCAB000064.
CAB069401.

Interactioni

Subunit structurei

Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1 (PubMed:19536131). Interacts with PSMA3 (PubMed:11350925). Interacts with PCNA (PubMed:11595739, PubMed:18794347, PubMed:18703516, PubMed:8861913). Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4 (PubMed:9106657). Binding to CDK2 leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair (PubMed:19445729). Interacts with PIM1 (PubMed:12431783). Interacts with STK11 and NUAK1 (PubMed:25329316).By similarity10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P279583EBI-375077,EBI-6377335From a different organism.
CCNA1P783963EBI-375077,EBI-375065
CCNA2P202483EBI-375077,EBI-457097
CCND1P2438515EBI-375077,EBI-375001
CCND2P3027914EBI-375077,EBI-748789
CCND3P3028117EBI-375077,EBI-375013
CCNE1P248649EBI-375077,EBI-519526
CCNE2O960202EBI-375077,EBI-375033
CDC45O754192EBI-375077,EBI-374969
CDC6Q997412EBI-375077,EBI-374862
CDK1P064933EBI-375077,EBI-444308
CDK14O949218EBI-375077,EBI-1043945
CDK2P2494119EBI-375077,EBI-375096
CDK4P118025EBI-375077,EBI-295644
CDK5Q005354EBI-375077,EBI-1041567
IKZF3Q9UKT93EBI-375077,EBI-747204
KRT31Q153235EBI-375077,EBI-948001
MKRN1Q9UHC75EBI-375077,EBI-373524
NABP2Q9BQ157EBI-375077,EBI-2120336
PCNAP1200428EBI-375077,EBI-358311
PCNAQ6FI352EBI-375077,EBI-8469539
SIPA1Q96FS42EBI-375077,EBI-1054981
SKP1P632083EBI-375077,EBI-307486
SKP2Q133092EBI-375077,EBI-456291
TCF4P158843EBI-375077,EBI-533224
TEX11Q8IYF34EBI-375077,EBI-742397
TP53P046373EBI-375077,EBI-366083
TRAF1Q130773EBI-375077,EBI-359224
TRIM54Q9BYV25EBI-375077,EBI-2130429

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107460. 268 interactors.
DIPiDIP-246N.
IntActiP38936. 173 interactors.
MINTiMINT-104203.
STRINGi9606.ENSP00000244741.

Chemistry databases

BindingDBiP38936.

Structurei

Secondary structure

1164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi147 – 149Combined sources3
Beta strandi153 – 158Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXCX-ray2.60B/D/F139-160[»]
2ZVVX-ray2.00X/Y139-160[»]
2ZVWX-ray2.50I/J/K/L/M/N/O/P139-160[»]
4RJFX-ray2.01B/D/F139-160[»]
5E0UX-ray1.93D/E/F139-160[»]
DisProtiDP00016.
ProteinModelPortaliP38936.
SMRiP38936.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38936.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 24Required for binding cyclins8
Regioni53 – 58Required for binding CDKs6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 164PIP-box K+4 motifAdd BLAST25
Motifi141 – 156Nuclear localization signalSequence analysisAdd BLAST16

Domaini

The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex.

Sequence similaritiesi

Belongs to the CDI family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 41C4-typeSequence analysisAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4743. Eukaryota.
ENOG410XXN5. LUCA.
GeneTreeiENSGT00530000063588.
HOGENOMiHOG000285999.
HOVERGENiHBG050868.
InParanoidiP38936.
KOiK06625.
OMAiFAWERVW.
OrthoDBiEOG091G19PZ.
PhylomeDBiP38936.
TreeFamiTF101038.

Family and domain databases

InterProiIPR003175. CDI.
IPR029841. CDKN1A_vertebrate.
[Graphical view]
PANTHERiPTHR10265. PTHR10265. 1 hit.
PTHR10265:SF16. PTHR10265:SF16. 1 hit.
PfamiPF02234. CDI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN
60 70 80 90 100
FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA
110 120 130 140 150
LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF
160
YHSKRRLIFS KRKP
Length:164
Mass (Da):18,119
Last modified:January 23, 2007 - v3
Checksum:i98D1E7C519ADFCA9
GO

Sequence cautioni

The sequence AAB59559 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAB59560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0486864P → L.Corresponds to variant rs4986866dbSNPEnsembl.1
Natural variantiVAR_01187031S → R.3 PublicationsCorresponds to variant rs1801270dbSNPEnsembl.1
Natural variantiVAR_04868763F → L.Corresponds to variant rs4986867dbSNPEnsembl.1
Natural variantiVAR_014875149D → G.Corresponds to variant rs1801724dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25610 mRNA. Translation: AAA16109.1.
S67388 mRNA. Translation: AAB29246.1.
U09579 mRNA. Translation: AAA85641.1.
U03106 mRNA. Translation: AAC04313.1.
L26165 mRNA. Translation: AAA19811.1.
L47232 mRNA. Translation: AAB59559.1. Different initiation.
L47233 mRNA. Translation: AAB59560.1. Different initiation.
AF497972 Genomic DNA. Translation: AAM11787.1.
BT006719 mRNA. Translation: AAP35365.1.
AB451290 mRNA. Translation: BAG70104.1.
AB451422 mRNA. Translation: BAG70236.1.
CR536533 mRNA. Translation: CAG38770.1.
Z85996 Genomic DNA. Translation: CAB06656.1.
CH471081 Genomic DNA. Translation: EAX03904.1.
BC000275 mRNA. Translation: AAH00275.1.
BC000312 mRNA. Translation: AAH00312.1.
BC001935 mRNA. Translation: AAH01935.1.
BC013967 mRNA. Translation: AAH13967.1.
CCDSiCCDS4824.1.
PIRiI54380.
I68674.
RefSeqiNP_000380.1. NM_000389.4.
NP_001207706.1. NM_001220777.1.
NP_001207707.1. NM_001220778.1.
NP_001278478.1. NM_001291549.1.
NP_510867.1. NM_078467.2.
UniGeneiHs.370771.
Hs.732576.

Genome annotation databases

EnsembliENST00000244741; ENSP00000244741; ENSG00000124762.
ENST00000373711; ENSP00000362815; ENSG00000124762.
ENST00000405375; ENSP00000384849; ENSG00000124762.
ENST00000448526; ENSP00000409259; ENSG00000124762.
ENST00000615513; ENSP00000482768; ENSG00000124762.
GeneIDi1026.
KEGGihsa:1026.
UCSCiuc003omm.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25610 mRNA. Translation: AAA16109.1.
S67388 mRNA. Translation: AAB29246.1.
U09579 mRNA. Translation: AAA85641.1.
U03106 mRNA. Translation: AAC04313.1.
L26165 mRNA. Translation: AAA19811.1.
L47232 mRNA. Translation: AAB59559.1. Different initiation.
L47233 mRNA. Translation: AAB59560.1. Different initiation.
AF497972 Genomic DNA. Translation: AAM11787.1.
BT006719 mRNA. Translation: AAP35365.1.
AB451290 mRNA. Translation: BAG70104.1.
AB451422 mRNA. Translation: BAG70236.1.
CR536533 mRNA. Translation: CAG38770.1.
Z85996 Genomic DNA. Translation: CAB06656.1.
CH471081 Genomic DNA. Translation: EAX03904.1.
BC000275 mRNA. Translation: AAH00275.1.
BC000312 mRNA. Translation: AAH00312.1.
BC001935 mRNA. Translation: AAH01935.1.
BC013967 mRNA. Translation: AAH13967.1.
CCDSiCCDS4824.1.
PIRiI54380.
I68674.
RefSeqiNP_000380.1. NM_000389.4.
NP_001207706.1. NM_001220777.1.
NP_001207707.1. NM_001220778.1.
NP_001278478.1. NM_001291549.1.
NP_510867.1. NM_078467.2.
UniGeneiHs.370771.
Hs.732576.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXCX-ray2.60B/D/F139-160[»]
2ZVVX-ray2.00X/Y139-160[»]
2ZVWX-ray2.50I/J/K/L/M/N/O/P139-160[»]
4RJFX-ray2.01B/D/F139-160[»]
5E0UX-ray1.93D/E/F139-160[»]
DisProtiDP00016.
ProteinModelPortaliP38936.
SMRiP38936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107460. 268 interactors.
DIPiDIP-246N.
IntActiP38936. 173 interactors.
MINTiMINT-104203.
STRINGi9606.ENSP00000244741.

Chemistry databases

BindingDBiP38936.
ChEMBLiCHEMBL5021.

PTM databases

iPTMnetiP38936.
PhosphoSitePlusiP38936.

Polymorphism and mutation databases

BioMutaiCDKN1A.
DMDMi729143.

2D gel databases

SWISS-2DPAGEP38936.

Proteomic databases

EPDiP38936.
PaxDbiP38936.
PeptideAtlasiP38936.
PRIDEiP38936.

Protocols and materials databases

DNASUi1026.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244741; ENSP00000244741; ENSG00000124762.
ENST00000373711; ENSP00000362815; ENSG00000124762.
ENST00000405375; ENSP00000384849; ENSG00000124762.
ENST00000448526; ENSP00000409259; ENSG00000124762.
ENST00000615513; ENSP00000482768; ENSG00000124762.
GeneIDi1026.
KEGGihsa:1026.
UCSCiuc003omm.5. human.

Organism-specific databases

CTDi1026.
DisGeNETi1026.
GeneCardsiCDKN1A.
HGNCiHGNC:1784. CDKN1A.
HPAiCAB000064.
CAB069401.
MalaCardsiCDKN1A.
MIMi116899. gene.
neXtProtiNX_P38936.
OpenTargetsiENSG00000124762.
Orphaneti652. Multiple endocrine neoplasia type 1.
PharmGKBiPA104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4743. Eukaryota.
ENOG410XXN5. LUCA.
GeneTreeiENSGT00530000063588.
HOGENOMiHOG000285999.
HOVERGENiHBG050868.
InParanoidiP38936.
KOiK06625.
OMAiFAWERVW.
OrthoDBiEOG091G19PZ.
PhylomeDBiP38936.
TreeFamiTF101038.

Enzyme and pathway databases

ReactomeiR-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-198323. AKT phosphorylates targets in the cytosol.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-HSA-5674400. Constitutive Signaling by AKT1 E17K in Cancer.
R-HSA-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-69202. Cyclin E associated events during G1/S transition.
R-HSA-69231. Cyclin D associated events in G1.
R-HSA-69563. p53-Dependent G1 DNA Damage Response.
R-HSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-HSA-69895. Transcriptional activation of cell cycle inhibitor p21.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-HSA-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.
SIGNORiP38936.

Miscellaneous databases

ChiTaRSiCDKN1A. human.
EvolutionaryTraceiP38936.
GeneWikiiP21.
GenomeRNAii1026.
PROiP38936.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124762.
CleanExiHS_CDKN1A.
ExpressionAtlasiP38936. baseline and differential.
GenevisibleiP38936. HS.

Family and domain databases

InterProiIPR003175. CDI.
IPR029841. CDKN1A_vertebrate.
[Graphical view]
PANTHERiPTHR10265. PTHR10265. 1 hit.
PTHR10265:SF16. PTHR10265:SF16. 1 hit.
PfamiPF02234. CDI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDN1A_HUMAN
AccessioniPrimary (citable) accession number: P38936
Secondary accession number(s): Q14010, Q6FI05, Q9BUT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 193 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.