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Protein

Casein kinase II subunit beta'

Gene

CKB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity

Miscellaneous

Present with 7160 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein kinase regulator activity Source: SGD
  • protein serine/threonine kinase inhibitor activity Source: SGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • peptidyl-serine phosphorylation Source: SGD
  • peptidyl-threonine phosphorylation Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of transcription from RNA polymerase III promoter Source: SGD
  • regulation of transcription from RNA polymerase I promoter Source: SGD
  • rRNA methylation Source: Reactome

Enzyme and pathway databases

BioCyciYEAST:G3O-33585-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.
R-SCE-6790901. rRNA modification in the nucleus and cytosol.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-6804756. Regulation of TP53 Activity through Phosphorylation.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta'
Short name:
CK II beta'
Gene namesi
Name:CKB2
Ordered Locus Names:YOR039W
ORF Names:OR26.32
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR039W.
SGDiS000005565. CKB2.

Subcellular locationi

GO - Cellular componenti

  • CURI complex Source: SGD
  • nucleoplasm Source: Reactome
  • protein kinase CK2 complex Source: SGD
  • UTP-C complex Source: SGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000682581 – 258Casein kinase II subunit beta'Add BLAST258

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity
The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38930.
PRIDEiP38930.

PTM databases

iPTMnetiP38930.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit. Interacts with FACT subunits POB3 and SPT16.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34441. 482 interactors.
DIPiDIP-262N.
IntActiP38930. 42 interactors.
MINTiMINT-412350.
STRINGi4932.YOR039W.

Structurei

3D structure databases

ProteinModelPortaliP38930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
KOiK03115.
OMAiCPRVLCQ.
OrthoDBiEOG092C4DSU.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
InterProiView protein in InterPro
IPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR000704. Casein_kinase_II_reg-sub.
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiView protein in Pfam
PF01214. CK_II_beta. 1 hit.
PRINTSiPR00472. CASNKINASEII.
SMARTiView protein in SMART
SM01085. CK_II_beta. 1 hit.
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiView protein in PROSITE
PS01101. CK2_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

P38930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRSENVGT VTREGSRVEQ DDVLMDDDSD SSEYVDMWID LFLGRKGHEY
60 70 80 90 100
FCDVDPEYIT DRFNLMNLQK TVSKFSYVVQ YIVDDLDDSI LENMTHARLE
110 120 130 140 150
QLESDSRKLY GLIHARYIIT IKGLQKMYAK YKEADFGRCP RVYCNLQQLL
160 170 180 190 200
PVGLHDIPGI DCVKLYCPSC EDLYIPKSSR HSSIDGAYFG TSFPGMFLQA
210 220 230 240 250
FPDMVPKHPT KRYVPKIFGF ELHKQAQLTR WQELQRLKLV EKLESKDVDL

TKSGGFKT
Length:258
Mass (Da):29,842
Last modified:February 1, 1995 - v1
Checksum:iD6060CB3D70B19A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08849 Genomic DNA. Translation: AAA21656.1.
X87331 Genomic DNA. Translation: CAA60758.1.
Z74947 Genomic DNA. Translation: CAA99229.1.
AY692981 Genomic DNA. Translation: AAT93000.1.
X82893 Genomic DNA. Translation: CAA58064.1.
BK006948 Genomic DNA. Translation: DAA10822.1.
PIRiA54907.
RefSeqiNP_014682.1. NM_001183458.1.

Genome annotation databases

EnsemblFungiiYOR039W; YOR039W; YOR039W.
GeneIDi854204.
KEGGisce:YOR039W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCSK2C_YEAST
AccessioniPrimary (citable) accession number: P38930
Secondary accession number(s): D6W2A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names