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Protein

Casein kinase II subunit beta'

Gene

CKB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity

GO - Molecular functioni

  • protein kinase regulator activity Source: SGD
  • protein serine/threonine kinase inhibitor activity Source: SGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • peptidyl-serine phosphorylation Source: SGD
  • peptidyl-threonine phosphorylation Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of transcription from RNA polymerase III promoter Source: SGD
  • regulation of transcription from RNA polymerase I promoter Source: SGD
  • rRNA methylation Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33585-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.
R-SCE-6790901. rRNA modification in the nucleus.
R-SCE-6804756. Regulation of TP53 Activity through Phosphorylation.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta'
Short name:
CK II beta'
Gene namesi
Name:CKB2
Ordered Locus Names:YOR039W
ORF Names:OR26.32
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR039W.
SGDiS000005565. CKB2.

Subcellular locationi

GO - Cellular componenti

  • CURI complex Source: SGD
  • nucleoplasm Source: Reactome
  • protein kinase CK2 complex Source: SGD
  • UTP-C complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Casein kinase II subunit beta'PRO_0000068258Add
BLAST

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity
The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38930.

PTM databases

iPTMnetiP38930.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit. Interacts with FACT subunits POB3 and SPT16.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CKA1P157907EBI-9578,EBI-9533
CKA2P1945410EBI-9578,EBI-9548
CKB1P436397EBI-9578,EBI-9563

Protein-protein interaction databases

BioGridi34441. 265 interactions.
DIPiDIP-262N.
IntActiP38930. 40 interactions.
MINTiMINT-412350.

Structurei

3D structure databases

ProteinModelPortaliP38930.
SMRiP38930. Positions 38-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
KOiK03115.
OMAiCEGHALL.
OrthoDBiEOG092C4DSU.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRSENVGT VTREGSRVEQ DDVLMDDDSD SSEYVDMWID LFLGRKGHEY
60 70 80 90 100
FCDVDPEYIT DRFNLMNLQK TVSKFSYVVQ YIVDDLDDSI LENMTHARLE
110 120 130 140 150
QLESDSRKLY GLIHARYIIT IKGLQKMYAK YKEADFGRCP RVYCNLQQLL
160 170 180 190 200
PVGLHDIPGI DCVKLYCPSC EDLYIPKSSR HSSIDGAYFG TSFPGMFLQA
210 220 230 240 250
FPDMVPKHPT KRYVPKIFGF ELHKQAQLTR WQELQRLKLV EKLESKDVDL

TKSGGFKT
Length:258
Mass (Da):29,842
Last modified:February 1, 1995 - v1
Checksum:iD6060CB3D70B19A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08849 Genomic DNA. Translation: AAA21656.1.
X87331 Genomic DNA. Translation: CAA60758.1.
Z74947 Genomic DNA. Translation: CAA99229.1.
AY692981 Genomic DNA. Translation: AAT93000.1.
X82893 Genomic DNA. Translation: CAA58064.1.
BK006948 Genomic DNA. Translation: DAA10822.1.
PIRiA54907.
RefSeqiNP_014682.1. NM_001183458.1.

Genome annotation databases

EnsemblFungiiYOR039W; YOR039W; YOR039W.
GeneIDi854204.
KEGGisce:YOR039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08849 Genomic DNA. Translation: AAA21656.1.
X87331 Genomic DNA. Translation: CAA60758.1.
Z74947 Genomic DNA. Translation: CAA99229.1.
AY692981 Genomic DNA. Translation: AAT93000.1.
X82893 Genomic DNA. Translation: CAA58064.1.
BK006948 Genomic DNA. Translation: DAA10822.1.
PIRiA54907.
RefSeqiNP_014682.1. NM_001183458.1.

3D structure databases

ProteinModelPortaliP38930.
SMRiP38930. Positions 38-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34441. 265 interactions.
DIPiDIP-262N.
IntActiP38930. 40 interactions.
MINTiMINT-412350.

PTM databases

iPTMnetiP38930.

Proteomic databases

MaxQBiP38930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR039W; YOR039W; YOR039W.
GeneIDi854204.
KEGGisce:YOR039W.

Organism-specific databases

EuPathDBiFungiDB:YOR039W.
SGDiS000005565. CKB2.

Phylogenomic databases

GeneTreeiENSGT00390000003781.
HOGENOMiHOG000039270.
KOiK03115.
OMAiCEGHALL.
OrthoDBiEOG092C4DSU.

Enzyme and pathway databases

BioCyciYEAST:G3O-33585-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.
R-SCE-6790901. rRNA modification in the nucleus.
R-SCE-6804756. Regulation of TP53 Activity through Phosphorylation.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP38930.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 1 hit.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2C_YEAST
AccessioniPrimary (citable) accession number: P38930
Secondary accession number(s): D6W2A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7160 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.