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P38929

- ATC2_YEAST

UniProt

P38929 - ATC2_YEAST

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Protein
Calcium-transporting ATPase 2
Gene
PMC1, YGL006W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei445 – 44514-aspartylphosphate intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: SGD
  3. metal ion binding Source: InterPro

GO - Biological processi

  1. calcium ion transport Source: SGD
  2. cellular calcium ion homeostasis Source: UniProtKB
  3. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30530-MONOMER.

Protein family/group databases

TCDBi3.A.3.2.2. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 2 (EC:3.6.3.8)
Alternative name(s):
Vacuolar Ca(2+)-ATPase
Gene namesi
Name:PMC1
Ordered Locus Names:YGL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL006w.
SGDiS000002974. PMC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 114114Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei115 – 13925Helical; Reviewed prediction
Add
BLAST
Topological domaini140 – 15213Extracellular Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Topological domaini174 – 349176Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei350 – 36819Helical; Reviewed prediction
Add
BLAST
Topological domaini369 – 38820Extracellular Reviewed prediction
Add
BLAST
Transmembranei389 – 40921Helical; Reviewed prediction
Add
BLAST
Topological domaini410 – 899490Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei900 – 92223Helical; Reviewed prediction
Add
BLAST
Topological domaini923 – 9297Extracellular Reviewed prediction
Transmembranei930 – 95021Helical; Reviewed prediction
Add
BLAST
Topological domaini951 – 97626Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei977 – 99822Helical; Reviewed prediction
Add
BLAST
Topological domaini999 – 101012Extracellular Reviewed prediction
Add
BLAST
Transmembranei1011 – 102919Helical; Reviewed prediction
Add
BLAST
Topological domaini1030 – 106536Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1066 – 108621Helical; Reviewed prediction
Add
BLAST
Topological domaini1087 – 109913Extracellular Reviewed prediction
Add
BLAST
Transmembranei1100 – 112021Helical; Reviewed prediction
Add
BLAST
Topological domaini1121 – 117353Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11731173Calcium-transporting ATPase 2
PRO_0000046232Add
BLAST

Proteomic databases

MaxQBiP38929.
PaxDbiP38929.
PeptideAtlasiP38929.

Expressioni

Gene expression databases

GenevestigatoriP38929.

Interactioni

Protein-protein interaction databases

BioGridi33239. 55 interactions.
DIPiDIP-5901N.
IntActiP38929. 29 interactions.
MINTiMINT-684286.
STRINGi4932.YGL006W.

Structurei

3D structure databases

ProteinModelPortaliP38929.
SMRiP38929. Positions 89-971.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00510000046331.
HOGENOMiHOG000265623.
KOiK01537.
OMAiISSEAYS.
OrthoDBiEOG7BS4JT.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38929-1 [UniParc]FASTAAdd to Basket

« Hide

MSRQDENSAL LANNENNKPS YTGNENGVYD NFKLSKSQLS DLHNPKSIRS     50
FVRLFGYESN SLFKYLKTDK NAGISLPEIS NYRKTNRYKN YGDNSLPERI 100
PKSFLQLVWA AFNDKTMQLL TVAAVVSFVL GLYELWMQPP QYDPEGNKIK 150
QVDWIEGVAI MIAVFVVVLV SAANDYQKEL QFAKLNKKKE NRKIIVIRND 200
QEILISIHHV LVGDVISLQT GDVVPADCVM ISGKCEADES SITGESNTIQ 250
KFPVDNSLRD FKKFNSIDSH NHSKPLDIGD VNEDGNKIAD CMLISGSRIL 300
SGLGRGVITS VGINSVYGQT MTSLNAEPES TPLQLHLSQL ADNISVYGCV 350
SAIILFLVLF TRYLFYIIPE DGRFHDLDPA QKGSKFMNIF ITSITVIVVA 400
VPEGLPLAVT LALAFATTRM TKDGNLVRVL RSCETMGSAT AVCSDKTGTL 450
TENVMTVVRG FPGNSKFDDS KSLPVSEQRK LNSKKVFEEN CSSSLRNDLL 500
ANIVLNSTAF ENRDYKKNDK NTNGSKNMSK NLSFLDKCKS RLSFFKKGNR 550
EDDEDQLFKN VNKGRQEPFI GSKTETALLS LARLSLGLQP GELQYLRDQP 600
MEKFNIEKVV QTIPFESSRK WAGLVVKYKE GKNKKPFYRF FIKGAAEIVS 650
KNCSYKRNSD DTLEEINEDN KKETDDEIKN LASDALRAIS VAHKDFCECD 700
SWPPEQLRDK DSPNIAALDL LFNSQKGLIL DGLLGIQDPL RAGVRESVQQ 750
CQRAGVTVRM VTGDNILTAK AIARNCAILS TDISSEAYSA MEGTEFRKLT 800
KNERIRILPN LRVLARSSPE DKRLLVETLK GMGDVVAVTG DGTNDAPALK 850
LADVGFSMGI SGTEVAREAS DIILMTDDFS AIVNAIKWGR CVSVSIKKFI 900
QFQLIVNITA VILTFVSSVA SSDETSVLTA VQLLWINLIM DTLAALALAT 950
DKPDPNIMDR KPRGRSTSLI SVSTWKMILS QATLQLIVTF ILHFYGPELF 1000
FKKHEDEITS HQQQQLNAMT FNTFVWLQFF TMLVSRKLDE GDGISNWRGR 1050
ISAANLNFFQ DLGRNYYFLT IMAIIGSCQV LIMFFGGAPF SIARQTKSMW 1100
ITAVLCGMLS LIMGVLVRIC PDEVAVKVFP AAFVQRFKYV FGLEFLRKNH 1150
TGKHDDEEAL LEESDSPEST AFY 1173
Length:1,173
Mass (Da):130,861
Last modified:February 1, 1995 - v1
Checksum:i5BD9ECFF8508F396
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03060 Unassigned DNA. Translation: AAC48919.1.
Z72528 Genomic DNA. Translation: CAA96706.1.
BK006941 Genomic DNA. Translation: DAA08093.1.
PIRiS48877.
RefSeqiNP_011509.1. NM_001180871.1.

Genome annotation databases

EnsemblFungiiYGL006W; YGL006W; YGL006W.
GeneIDi852878.
KEGGisce:YGL006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03060 Unassigned DNA. Translation: AAC48919.1 .
Z72528 Genomic DNA. Translation: CAA96706.1 .
BK006941 Genomic DNA. Translation: DAA08093.1 .
PIRi S48877.
RefSeqi NP_011509.1. NM_001180871.1.

3D structure databases

ProteinModelPortali P38929.
SMRi P38929. Positions 89-971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33239. 55 interactions.
DIPi DIP-5901N.
IntActi P38929. 29 interactions.
MINTi MINT-684286.
STRINGi 4932.YGL006W.

Protein family/group databases

TCDBi 3.A.3.2.2. the p-type atpase (p-atpase) superfamily.

Proteomic databases

MaxQBi P38929.
PaxDbi P38929.
PeptideAtlasi P38929.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL006W ; YGL006W ; YGL006W .
GeneIDi 852878.
KEGGi sce:YGL006W.

Organism-specific databases

CYGDi YGL006w.
SGDi S000002974. PMC1.

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00510000046331.
HOGENOMi HOG000265623.
KOi K01537.
OMAi ISSEAYS.
OrthoDBi EOG7BS4JT.

Enzyme and pathway databases

BioCyci YEAST:G3O-30530-MONOMER.

Miscellaneous databases

NextBioi 972517.

Gene expression databases

Genevestigatori P38929.

Family and domain databases

Gene3Di 1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProi IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases."
    Cunningham K.W., Fink G.R.
    J. Cell Biol. 124:351-363(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATC2_YEAST
AccessioniPrimary (citable) accession number: P38929
Secondary accession number(s): D6VUD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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