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P38929

- ATC2_YEAST

UniProt

P38929 - ATC2_YEAST

Protein

Calcium-transporting ATPase 2

Gene

PMC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei445 – 44514-aspartylphosphate intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-transporting ATPase activity Source: SGD
    3. metal ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: SGD
    2. cellular calcium ion homeostasis Source: UniProtKB
    3. transmembrane transport Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30530-MONOMER.

    Protein family/group databases

    TCDBi3.A.3.2.2. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-transporting ATPase 2 (EC:3.6.3.8)
    Alternative name(s):
    Vacuolar Ca(2+)-ATPase
    Gene namesi
    Name:PMC1
    Ordered Locus Names:YGL006W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL006w.
    SGDiS000002974. PMC1.

    Subcellular locationi

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11731173Calcium-transporting ATPase 2PRO_0000046232Add
    BLAST

    Proteomic databases

    MaxQBiP38929.
    PaxDbiP38929.
    PeptideAtlasiP38929.

    Expressioni

    Gene expression databases

    GenevestigatoriP38929.

    Interactioni

    Protein-protein interaction databases

    BioGridi33239. 55 interactions.
    DIPiDIP-5901N.
    IntActiP38929. 29 interactions.
    MINTiMINT-684286.
    STRINGi4932.YGL006W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38929.
    SMRiP38929. Positions 89-971.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 114114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini140 – 15213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 349176CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini369 – 38820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini410 – 899490CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini923 – 9297ExtracellularSequence Analysis
    Topological domaini951 – 97626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini999 – 101012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1030 – 106536CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1087 – 109913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1121 – 117353CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei115 – 13925HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 36819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei900 – 92223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei930 – 95021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei977 – 99822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1011 – 102919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1066 – 108621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1100 – 112021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    GeneTreeiENSGT00510000046331.
    HOGENOMiHOG000265623.
    KOiK01537.
    OMAiISSEAYS.
    OrthoDBiEOG7BS4JT.

    Family and domain databases

    Gene3Di1.20.1110.10. 1 hit.
    2.70.150.10. 2 hits.
    3.40.1110.10. 2 hits.
    InterProiIPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 2 hits.
    TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38929-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRQDENSAL LANNENNKPS YTGNENGVYD NFKLSKSQLS DLHNPKSIRS     50
    FVRLFGYESN SLFKYLKTDK NAGISLPEIS NYRKTNRYKN YGDNSLPERI 100
    PKSFLQLVWA AFNDKTMQLL TVAAVVSFVL GLYELWMQPP QYDPEGNKIK 150
    QVDWIEGVAI MIAVFVVVLV SAANDYQKEL QFAKLNKKKE NRKIIVIRND 200
    QEILISIHHV LVGDVISLQT GDVVPADCVM ISGKCEADES SITGESNTIQ 250
    KFPVDNSLRD FKKFNSIDSH NHSKPLDIGD VNEDGNKIAD CMLISGSRIL 300
    SGLGRGVITS VGINSVYGQT MTSLNAEPES TPLQLHLSQL ADNISVYGCV 350
    SAIILFLVLF TRYLFYIIPE DGRFHDLDPA QKGSKFMNIF ITSITVIVVA 400
    VPEGLPLAVT LALAFATTRM TKDGNLVRVL RSCETMGSAT AVCSDKTGTL 450
    TENVMTVVRG FPGNSKFDDS KSLPVSEQRK LNSKKVFEEN CSSSLRNDLL 500
    ANIVLNSTAF ENRDYKKNDK NTNGSKNMSK NLSFLDKCKS RLSFFKKGNR 550
    EDDEDQLFKN VNKGRQEPFI GSKTETALLS LARLSLGLQP GELQYLRDQP 600
    MEKFNIEKVV QTIPFESSRK WAGLVVKYKE GKNKKPFYRF FIKGAAEIVS 650
    KNCSYKRNSD DTLEEINEDN KKETDDEIKN LASDALRAIS VAHKDFCECD 700
    SWPPEQLRDK DSPNIAALDL LFNSQKGLIL DGLLGIQDPL RAGVRESVQQ 750
    CQRAGVTVRM VTGDNILTAK AIARNCAILS TDISSEAYSA MEGTEFRKLT 800
    KNERIRILPN LRVLARSSPE DKRLLVETLK GMGDVVAVTG DGTNDAPALK 850
    LADVGFSMGI SGTEVAREAS DIILMTDDFS AIVNAIKWGR CVSVSIKKFI 900
    QFQLIVNITA VILTFVSSVA SSDETSVLTA VQLLWINLIM DTLAALALAT 950
    DKPDPNIMDR KPRGRSTSLI SVSTWKMILS QATLQLIVTF ILHFYGPELF 1000
    FKKHEDEITS HQQQQLNAMT FNTFVWLQFF TMLVSRKLDE GDGISNWRGR 1050
    ISAANLNFFQ DLGRNYYFLT IMAIIGSCQV LIMFFGGAPF SIARQTKSMW 1100
    ITAVLCGMLS LIMGVLVRIC PDEVAVKVFP AAFVQRFKYV FGLEFLRKNH 1150
    TGKHDDEEAL LEESDSPEST AFY 1173
    Length:1,173
    Mass (Da):130,861
    Last modified:February 1, 1995 - v1
    Checksum:i5BD9ECFF8508F396
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03060 Unassigned DNA. Translation: AAC48919.1.
    Z72528 Genomic DNA. Translation: CAA96706.1.
    BK006941 Genomic DNA. Translation: DAA08093.1.
    PIRiS48877.
    RefSeqiNP_011509.1. NM_001180871.1.

    Genome annotation databases

    EnsemblFungiiYGL006W; YGL006W; YGL006W.
    GeneIDi852878.
    KEGGisce:YGL006W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03060 Unassigned DNA. Translation: AAC48919.1 .
    Z72528 Genomic DNA. Translation: CAA96706.1 .
    BK006941 Genomic DNA. Translation: DAA08093.1 .
    PIRi S48877.
    RefSeqi NP_011509.1. NM_001180871.1.

    3D structure databases

    ProteinModelPortali P38929.
    SMRi P38929. Positions 89-971.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33239. 55 interactions.
    DIPi DIP-5901N.
    IntActi P38929. 29 interactions.
    MINTi MINT-684286.
    STRINGi 4932.YGL006W.

    Protein family/group databases

    TCDBi 3.A.3.2.2. the p-type atpase (p-atpase) superfamily.

    Proteomic databases

    MaxQBi P38929.
    PaxDbi P38929.
    PeptideAtlasi P38929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL006W ; YGL006W ; YGL006W .
    GeneIDi 852878.
    KEGGi sce:YGL006W.

    Organism-specific databases

    CYGDi YGL006w.
    SGDi S000002974. PMC1.

    Phylogenomic databases

    eggNOGi COG0474.
    GeneTreei ENSGT00510000046331.
    HOGENOMi HOG000265623.
    KOi K01537.
    OMAi ISSEAYS.
    OrthoDBi EOG7BS4JT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30530-MONOMER.

    Miscellaneous databases

    NextBioi 972517.

    Gene expression databases

    Genevestigatori P38929.

    Family and domain databases

    Gene3Di 1.20.1110.10. 1 hit.
    2.70.150.10. 2 hits.
    3.40.1110.10. 2 hits.
    InterProi IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 2 hits.
    TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases."
      Cunningham K.W., Fink G.R.
      J. Cell Biol. 124:351-363(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATC2_YEAST
    AccessioniPrimary (citable) accession number: P38929
    Secondary accession number(s): D6VUD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 98 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3