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Protein

DNA polymerase zeta processivity subunit

Gene

REV7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites.4 Publications

GO - Biological processi

  • error-free translesion synthesis Source: SGD
  • error-prone translesion synthesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-31390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase zeta processivity subunit
Alternative name(s):
Revertibility protein 7
Gene namesi
Name:REV7
Ordered Locus Names:YIL139C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL139C.
SGDiS000001401. REV7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
  • zeta DNA polymerase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245DNA polymerase zeta processivity subunitPRO_0000126116Add
BLAST

PTM databases

iPTMnetiP38927.

Interactioni

Subunit structurei

Forms DNA polymerase zeta with REV3.

Binary interactionsi

WithEntry#Exp.IntActNotes
DDC1Q089493EBI-14960,EBI-30769
MEC3Q025743EBI-14960,EBI-10658
REV1P126893EBI-14960,EBI-14951

Protein-protein interaction databases

BioGridi34852. 46 interactions.
DIPiDIP-819N.
IntActiP38927. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliP38927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 203201HORMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAD2 family.Curated
Contains 1 HORMA domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000141973.
InParanoidiP38927.
KOiK03508.
OMAiYRNVYPP.
OrthoDBiEOG7KWSW3.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRWVEKWLR VYLKCYINLI LFYRNVYPPQ SFDYTTYQSF NLPQFVPINR
60 70 80 90 100
HPALIDYIEE LILDVLSKLT HVYRFSICII NKKNDLCIEK YVLDFSELQH
110 120 130 140 150
VDKDDQIITE TEVFDEFRSS LNSLIMHLEK LPKVNDDTIT FEAVINAIEL
160 170 180 190 200
ELGHKLDRNR RVDSLEEKAE IERDSNWVKC QEDENLPDNN GFQPPKIKLT
210 220 230 240
SLVGSDVGPL IIHQFSEKLI SGDDKILNGV YSQYEEGESI FGSLF
Length:245
Mass (Da):28,760
Last modified:February 1, 1995 - v1
Checksum:i325668130CD13259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86139.1.
U07228 Genomic DNA. Translation: AAA67918.1.
U49845 Genomic DNA. Translation: AAA98667.1.
BK006942 Genomic DNA. Translation: DAA08413.1.
PIRiS48395.
RefSeqiNP_012127.1. NM_001179487.1.

Genome annotation databases

EnsemblFungiiYIL139C; YIL139C; YIL139C.
GeneIDi854667.
KEGGisce:YIL139C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86139.1.
U07228 Genomic DNA. Translation: AAA67918.1.
U49845 Genomic DNA. Translation: AAA98667.1.
BK006942 Genomic DNA. Translation: DAA08413.1.
PIRiS48395.
RefSeqiNP_012127.1. NM_001179487.1.

3D structure databases

ProteinModelPortaliP38927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34852. 46 interactions.
DIPiDIP-819N.
IntActiP38927. 6 interactions.

PTM databases

iPTMnetiP38927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIL139C; YIL139C; YIL139C.
GeneIDi854667.
KEGGisce:YIL139C.

Organism-specific databases

EuPathDBiFungiDB:YIL139C.
SGDiS000001401. REV7.

Phylogenomic databases

HOGENOMiHOG000141973.
InParanoidiP38927.
KOiK03508.
OMAiYRNVYPP.
OrthoDBiEOG7KWSW3.

Enzyme and pathway databases

BioCyciYEAST:G3O-31390-MONOMER.

Miscellaneous databases

PROiP38927.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiae."
    Torpey L.E., Gibbs P.E.M., Nelson J., Lawrence C.W.
    Yeast 10:1503-1509(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Thymine-thymine dimer bypass by yeast DNA polymerase zeta."
    Nelson J.R., Lawrence C.W., Hinkle D.C.
    Science 272:1646-1649(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH REV3.
  5. "Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites."
    Haracska L., Unk I., Johnson R.E., Johansson E., Burgers P.M.J., Prakash S., Prakash L.
    Genes Dev. 15:945-954(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Saccharomyces cerevisiae polymerase zeta functions in mitochondria."
    Zhang H., Chatterjee A., Singh K.K.
    Genetics 172:2683-2688(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiREV7_YEAST
AccessioniPrimary (citable) accession number: P38927
Secondary accession number(s): D6VVE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.