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Protein

Manganese transporter SMF1

Gene

SMF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity manganese transporter involved in manganese uptake from the extracellular environment. Contributes also to cellular accumulation of other divalent metal ions such as cadmium, cobalt, copper, iron and nickel.2 Publications

GO - Molecular functioni

  • inorganic cation transmembrane transporter activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • metal ion transmembrane transporter activity Source: InterPro
  • solute:proton symporter activity Source: SGD

GO - Biological processi

  • cadmium ion transport Source: SGD
  • cellular cadmium ion homeostasis Source: SGD
  • cellular copper ion homeostasis Source: SGD
  • cellular manganese ion homeostasis Source: SGD
  • copper ion transport Source: SGD
  • iron ion transport Source: SGD
  • manganese ion transport Source: SGD

Keywordsi

Biological processTransport
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33518-MONOMER
ReactomeiR-SCE-1222556 ROS, RNS production in phagocytes
R-SCE-425410 Metal ion SLC transporters
R-SCE-6798695 Neutrophil degranulation
R-SCE-6803544 Ion influx/efflux at host-pathogen interface
R-SCE-917937 Iron uptake and transport

Protein family/group databases

TCDBi2.A.55.1.1 the metal ion (mn(2+)-iron) transporter (nramp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese transporter SMF1
Gene namesi
Name:SMF1
Synonyms:ESP1
Ordered Locus Names:YOL122C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL122C
SGDiS000005482 SMF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70ExtracellularSequence analysisAdd BLAST70
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 108CytoplasmicSequence analysisAdd BLAST17
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 156ExtracellularSequence analysisAdd BLAST27
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 179CytoplasmicSequence analysis2
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 218ExtracellularSequence analysisAdd BLAST18
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 266CytoplasmicSequence analysisAdd BLAST27
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 344ExtracellularSequence analysisAdd BLAST57
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 396CytoplasmicSequence analysisAdd BLAST31
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Topological domaini418 – 463ExtracellularSequence analysisAdd BLAST46
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 543CytoplasmicSequence analysisAdd BLAST59
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 575ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126051 – 575Manganese transporter SMF1Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38925
PaxDbiP38925
PRIDEiP38925
TopDownProteomicsiP38925

PTM databases

iPTMnetiP38925

Interactioni

Protein-protein interaction databases

BioGridi34279, 65 interactors
IntActiP38925, 3 interactors
MINTiP38925
STRINGi4932.YOL122C

Structurei

3D structure databases

ProteinModelPortaliP38925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006526
HOGENOMiHOG000152204
InParanoidiP38925
KOiK12346
OMAiSLRPVMN
OrthoDBiEOG092C1BTT

Family and domain databases

HAMAPiMF_00221 NRAMP, 1 hit
InterProiView protein in InterPro
IPR001046 NRAMP_fam
PANTHERiPTHR11706 PTHR11706, 1 hit
PfamiView protein in Pfam
PF01566 Nramp, 1 hit
PRINTSiPR00447 NATRESASSCMP
TIGRFAMsiTIGR01197 nramp, 1 hit

Sequencei

Sequence statusi: Complete.

P38925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNVGPSHAA VAVDASEARK RNISEEVFEL RDKKDSTVVI EGEAPVRTFT
60 70 80 90 100
SSSSNHERED TYVSKRQVMR DIFAKYLKFI GPGLMVSVAY IDPGNYSTAV
110 120 130 140 150
DAGASNQFSL LCIILLSNFI AIFLQCLCIK LGSVTGLDLS RACREYLPRW
160 170 180 190 200
LNWTLYFFAE CAVIATDIAE VIGTAIALNI LIKVPLPAGV AITVVDVFLI
210 220 230 240 250
MFTYKPGASS IRFIRIFECF VAVLVVGVCI CFAIELAYIP KSTSVKQVFR
260 270 280 290 300
GFVPSAQMFD HNGIYTAISI LGATVMPHSL FLGSALVQPR LLDYDVKHGN
310 320 330 340 350
YTVSEEQDKV KKSKSTEEIM EEKYFNYRPT NAAIKYCMKY SMVELSITLF
360 370 380 390 400
TLALFVNCAI LVVAGSTLYN SPEADGADLF TIHELLSRNL APAAGTIFML
410 420 430 440 450
ALLLSGQSAG VVCTMSGQIV SEGHINWKLQ PWQRRLATRC ISIIPCLVIS
460 470 480 490 500
ICIGREALSK ALNASQVVLS IVLPFLVAPL IFFTCKKSIM KTEITVDHTE
510 520 530 540 550
EDSHNHQNNN DRSAGSVIEQ DGSSGMEIEN GKDVKIVYMA NNWIITVIAI
560 570
IVWLFLSLLN VYAIVQLGMS HGDIS
Length:575
Mass (Da):63,264
Last modified:November 1, 1997 - v2
Checksum:iAC0EEEF1BBF34ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti305E → D (PubMed:1447206).Curated1
Sequence conflicti416S → A (PubMed:1447206).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15929 Genomic DNA Translation: AAB48984.1
X95258 Genomic DNA Translation: CAA64547.1
Z74864 Genomic DNA Translation: CAA99141.1
BK006948 Genomic DNA Translation: DAA10662.1
PIRiS58647
RefSeqiNP_014519.1, NM_001183376.1

Genome annotation databases

EnsemblFungiiYOL122C; YOL122C; YOL122C
GeneIDi854027
KEGGisce:YOL122C

Similar proteinsi

Entry informationi

Entry nameiSMF1_YEAST
AccessioniPrimary (citable) accession number: P38925
Secondary accession number(s): D6W1U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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