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Protein

Protein HRB1

Gene

HRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: SGD

GO - Biological processi

  • nuclear mRNA surveillance Source: SGD
  • poly(A)+ mRNA export from nucleus Source: SGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33046-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HRB1
Alternative name(s):
Protein TOM34
Gene namesi
Name:HRB1
Synonyms:TOM34
Ordered Locus Names:YNL004W
ORF Names:N2009
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL004W.
SGDiS000004949. HRB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816121 – 454Protein HRB1Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei343PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38922.
PRIDEiP38922.

PTM databases

iPTMnetiP38922.

Interactioni

Protein-protein interaction databases

BioGridi35821. 67 interactors.
DIPiDIP-4959N.
IntActiP38922. 23 interactors.
MINTiMINT-475842.

Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi161 – 168Combined sources8
Helixi174 – 181Combined sources8
Helixi182 – 184Combined sources3
Beta strandi187 – 191Combined sources5
Beta strandi203 – 208Combined sources6
Helixi212 – 217Combined sources6
Turni218 – 222Combined sources5
Beta strandi232 – 234Combined sources3
Beta strandi263 – 265Combined sources3
Helixi274 – 282Combined sources9
Beta strandi289 – 291Combined sources3
Beta strandi304 – 307Combined sources4
Helixi311 – 321Combined sources11
Beta strandi325 – 330Combined sources6
Beta strandi333 – 335Combined sources3
Helixi359 – 363Combined sources5
Turni364 – 367Combined sources4
Beta strandi368 – 371Combined sources4
Beta strandi376 – 382Combined sources7
Helixi389 – 396Combined sources8
Turni397 – 399Combined sources3
Beta strandi402 – 413Combined sources12
Beta strandi415 – 425Combined sources11
Helixi426 – 435Combined sources10
Turni436 – 438Combined sources3
Beta strandi447 – 453Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MZRNMR-A144-236[»]
2MZSNMR-A262-358[»]
2MZTNMR-A357-454[»]
ProteinModelPortaliP38922.
SMRiP38922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 237RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini261 – 338RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini376 – 453RRM 3PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 127Arg-richAdd BLAST115

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00410000025635.
HOGENOMiHOG000111155.
InParanoidiP38922.
OMAiQDYPPPE.
OrthoDBiEOG092C5H62.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQERGSEN NNRSRSRSRS PVRRRMSDDH GYERDNHLSR RSGNYNGRRK
60 70 80 90 100
FADTYRGSRD RGEYRGGRER SDYRERERFN NRDNPRSRDR YDDRRRGRDV
110 120 130 140 150
TGRYGNRRDD YPRSFRSRHN TRDDSRRGGF GSSGARGDYG PLLARELDST
160 170 180 190 200
YEEKVNRNYS NSIFVGNLTY DSTPEDLTEF FSQIGKVVRA DIITSRGHHR
210 220 230 240 250
GMGTVEFTNS DDVDRAIRQY DGAFFMDRKI FVRQDNPPPS NNIKERKALD
260 270 280 290 300
RGELRHNRKT HEVIVKNLPA SVNWQALKDI FKECGNVAHA DVELDGDGVS
310 320 330 340 350
TGSGTVSFYD IKDLHRAIEK YNGYSIEGNV LDVKSKESVH NHSDGDDVDI
360 370 380 390 400
PMDDSPVNEE ARKFTENVVG GGERNRLIYC SNLPFSTAKS DLYDLFETIG
410 420 430 440 450
KVNNAELRYD SKGAPTGIAV VEYDNVDDAD VCIERLNNYN YGGCDLDISY

AKRL
Length:454
Mass (Da):52,142
Last modified:July 10, 2007 - v2
Checksum:iC54D858C77076583
GO

Sequence cautioni

The sequence AAA64803 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA54378 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA95863 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02536 Genomic DNA. Translation: AAA64803.1. Sequence problems.
X77114 Genomic DNA. Translation: CAA54378.1. Sequence problems.
Z71280 Genomic DNA. Translation: CAA95863.1. Sequence problems.
DQ881449 mRNA. Translation: ABI95876.1.
EF123128 mRNA. Translation: ABM97472.1.
BK006947 Genomic DNA. Translation: DAA10539.1.
PIRiS45459.
RefSeqiNP_014394.2. NM_001182843.1.

Genome annotation databases

EnsemblFungiiYNL004W; YNL004W; YNL004W.
GeneIDi855728.
KEGGisce:YNL004W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02536 Genomic DNA. Translation: AAA64803.1. Sequence problems.
X77114 Genomic DNA. Translation: CAA54378.1. Sequence problems.
Z71280 Genomic DNA. Translation: CAA95863.1. Sequence problems.
DQ881449 mRNA. Translation: ABI95876.1.
EF123128 mRNA. Translation: ABM97472.1.
BK006947 Genomic DNA. Translation: DAA10539.1.
PIRiS45459.
RefSeqiNP_014394.2. NM_001182843.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MZRNMR-A144-236[»]
2MZSNMR-A262-358[»]
2MZTNMR-A357-454[»]
ProteinModelPortaliP38922.
SMRiP38922.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35821. 67 interactors.
DIPiDIP-4959N.
IntActiP38922. 23 interactors.
MINTiMINT-475842.

PTM databases

iPTMnetiP38922.

Proteomic databases

MaxQBiP38922.
PRIDEiP38922.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL004W; YNL004W; YNL004W.
GeneIDi855728.
KEGGisce:YNL004W.

Organism-specific databases

EuPathDBiFungiDB:YNL004W.
SGDiS000004949. HRB1.

Phylogenomic databases

GeneTreeiENSGT00410000025635.
HOGENOMiHOG000111155.
InParanoidiP38922.
OMAiQDYPPPE.
OrthoDBiEOG092C5H62.

Enzyme and pathway databases

BioCyciYEAST:G3O-33046-MONOMER.

Miscellaneous databases

PROiP38922.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRB1_YEAST
AccessioniPrimary (citable) accession number: P38922
Secondary accession number(s): A2TBM5, D6W1H3, Q06HN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1990 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.