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Protein

Eukaryotic initiation factor 4A-III

Gene

EIF4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.7 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Enzyme regulationi

The ATPase activity is increased some 4-fold in the presence of RNA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601ATP; via carbonyl oxygen
Binding sitei65 – 651ATP
Binding sitei342 – 3421ATP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 906ATP
Nucleotide bindingi367 – 3715ATP

GO - Molecular functioni

  • ATP binding Source: HGNC
  • ATP-dependent RNA helicase activity Source: HGNC
  • mRNA binding Source: UniProtKB
  • poly(A) binding Source: HGNC
  • poly(A) RNA binding Source: UniProtKB
  • ribonucleoprotein complex binding Source: Ensembl
  • RNA stem-loop binding Source: Ensembl
  • selenocysteine insertion sequence binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, rRNA processing, Translation regulation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BRENDAi3.6.4.13. 2681.
ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-429947. Deadenylation of mRNA.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic initiation factor 4A-III (EC:3.6.4.13)
Short name:
eIF-4A-III
Short name:
eIF4A-III
Alternative name(s):
ATP-dependent RNA helicase DDX48
ATP-dependent RNA helicase eIF4A-3
DEAD box protein 48
Eukaryotic initiation factor 4A-like NUK-34
Eukaryotic translation initiation factor 4A isoform 3
Nuclear matrix protein 265
Short name:
NMP 265
Short name:
hNMP 265
Cleaved into the following chain:
Gene namesi
Name:EIF4A3
Synonyms:DDX48, KIAA0111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18683. EIF4A3.

Subcellular locationi

  • Nucleus
  • Nucleus speckle
  • Cytoplasm

  • Note: Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity).By similarity

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytoplasm Source: HGNC
  • cytosol Source: Reactome
  • dendrite Source: Ensembl
  • exon-exon junction complex Source: UniProtKB
  • membrane Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • nuclear speck Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Involvement in diseasei

Richieri-Costa-Pereira syndrome (RCPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. EIF4A3 mutations resulting in Richieri-Costa-Pereira syndrome include a repeat expansion of 18 or 20 nucleotides in the 5' untranslated region. Affected individuals have 14 to 16 repeats, while healthy individuals have 3 to 12 repeats (PubMed:24360810).1 Publication
Disease descriptionA syndrome characterized by a unique pattern of anomalies consisting of microstomia, micrognathia, abnormal fusion of mandible, cleft palate/Robin sequence, absence of central lower incisors, minor ears anomalies, hypoplastic first ray, abnormal tibiae, hypoplastic halluces, and clubfeet. Learning disability is also a common finding.
See also OMIM:268305
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701D → G in RCPS. 1 Publication
Corresponds to variant rs587777204 [ dbSNP | Ensembl ].
VAR_071090

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi88 – 881K → A: ATPase activity is not induced in presence of CASC3. Does not prevent EJC formation. Prevents the EJC disassembly. 1 Publication
Mutagenesisi270 – 2701D → K: Loss of CWC22-binding and loss of incorporation into EJCs; when associated with K-273. 1 Publication
Mutagenesisi273 – 2731D → K: Loss of CWC22-binding and loss of incorporation into EJCs; when associated with K-270. 1 Publication
Mutagenesisi276 – 2772TI → GD: Loss of CWC22-binding and loss of incorporation into EJCs. 1 Publication
Mutagenesisi301 – 3033NFT → LAG: Loss of CWC22-binding and loss of incorporation into EJCs. 1 Publication
Mutagenesisi334 – 3341T → V: Reduced incorporation into EJCs. 1 Publication
Mutagenesisi401 – 4011D → K: Loss of incorporation into EJCs; when associated with R-402. 1 Publication
Mutagenesisi402 – 4021E → R: Loss of incorporation into EJCs; when associated with K-401. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiEIF4A3.
MIMi268305. phenotype.
Orphaneti3102. Richieri Costa-Pereira syndrome.
PharmGKBiPA162384945.

Polymorphism and mutation databases

BioMutaiEIF4A3.
DMDMi20532400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Eukaryotic initiation factor 4A-IIIPRO_0000423267Add
BLAST
Initiator methionineiRemoved; alternateCombined sources1 Publication
Chaini2 – 411410Eukaryotic initiation factor 4A-III, N-terminally processedPRO_0000054942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei2 – 21N-acetylalanine; in Eukaryotic initiation factor 4A-III, N-terminally processedCombined sources1 Publication
Modified residuei12 – 121PhosphoserineCombined sources
Cross-linki19 – 19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei163 – 1631PhosphothreonineCombined sources
Modified residuei296 – 2961N6-acetyllysineCombined sources
Modified residuei321 – 3211N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP38919.
MaxQBiP38919.
PaxDbiP38919.
PeptideAtlasiP38919.
PRIDEiP38919.

2D gel databases

REPRODUCTION-2DPAGEIPI00009328.

PTM databases

iPTMnetiP38919.
PhosphoSiteiP38919.
SwissPalmiP38919.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000141543.
CleanExiHS_EIF4A3.
ExpressionAtlasiP38919. baseline and differential.
GenevisibleiP38919. HS.

Organism-specific databases

HPAiHPA021878.

Interactioni

Subunit structurei

Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. Identified in the spliceosome C complex. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Interacts with NCBP3 (PubMed:26382858).11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CASC3O152347EBI-299104,EBI-299118
CDCA7LQ96GN53EBI-299104,EBI-5278764
CWC22Q9HCG83EBI-299104,EBI-373289
MAGOHP6132620EBI-299104,EBI-299134
NOM1Q5C9Z43EBI-299104,EBI-2685618
PDCD4Q53EL63EBI-299104,EBI-935824
RBM8AQ9Y5S921EBI-299104,EBI-447231
THRAP3Q9Y2W12EBI-299104,EBI-352039
UPF3BQ9BZI77EBI-299104,EBI-372780

Protein-protein interaction databases

BioGridi115119. 262 interactions.
DIPiDIP-33218N.
IntActiP38919. 148 interactions.
MINTiMINT-1460615.
STRINGi9606.ENSP00000269349.

Structurei

Secondary structure

1
411
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 253Combined sources
Beta strandi28 – 325Combined sources
Helixi40 – 423Combined sources
Helixi47 – 5610Combined sources
Helixi65 – 739Combined sources
Beta strandi78 – 814Combined sources
Beta strandi84 – 863Combined sources
Helixi88 – 9811Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi109 – 1124Combined sources
Helixi116 – 12914Combined sources
Turni130 – 1345Combined sources
Beta strandi137 – 1393Combined sources
Helixi143 – 1453Combined sources
Helixi146 – 15510Combined sources
Beta strandi158 – 1625Combined sources
Helixi164 – 1729Combined sources
Beta strandi183 – 1864Combined sources
Helixi189 – 1957Combined sources
Helixi198 – 2069Combined sources
Beta strandi213 – 2197Combined sources
Helixi223 – 23210Combined sources
Beta strandi237 – 2415Combined sources
Helixi243 – 2453Combined sources
Beta strandi251 – 26010Combined sources
Helixi261 – 2633Combined sources
Helixi264 – 27411Combined sources
Beta strandi278 – 2836Combined sources
Helixi287 – 29913Combined sources
Beta strandi304 – 3074Combined sources
Beta strandi309 – 3113Combined sources
Helixi313 – 32412Combined sources
Beta strandi329 – 3335Combined sources
Helixi335 – 3373Combined sources
Beta strandi338 – 3403Combined sources
Beta strandi346 – 3538Combined sources
Beta strandi356 – 3583Combined sources
Helixi360 – 3656Combined sources
Beta strandi367 – 3693Combined sources
Helixi370 – 3723Combined sources
Beta strandi375 – 3828Combined sources
Helixi383 – 3853Combined sources
Helixi386 – 39611Combined sources
Beta strandi400 – 4023Combined sources
Helixi405 – 4106Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HXYX-ray3.30A/B/C/D23-411[»]
2HYIX-ray2.30C/I1-411[»]
2J0QX-ray3.20A/B2-411[»]
2J0SX-ray2.21A2-411[»]
2J0UX-ray3.00A/B38-411[»]
2XB2X-ray3.40A/X1-411[»]
3EX7X-ray2.30C/H1-411[»]
4C9BX-ray2.00A1-411[»]
ProteinModelPortaliP38919.
SMRiP38919. Positions 21-411.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38919.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 239171Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini250 – 411162Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 6629Q motifAdd
BLAST
Motifi187 – 1904DEAD box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0327. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00530000062880.
HOGENOMiHOG000268797.
HOVERGENiHBG107989.
InParanoidiP38919.
KOiK13025.
OMAiTATFCIS.
OrthoDBiEOG091G07OI.
PhylomeDBiP38919.
TreeFamiTF300466.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL
60 70 80 90 100
RGIYAYGFEK PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL
110 120 130 140 150
DIQVRETQAL ILAPTRELAV QIQKGLLALG DYMNVQCHAC IGGTNVGEDI
160 170 180 190 200
RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA IKMLVLDEAD EMLNKGFKEQ
210 220 230 240 250
IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL VKRDELTLEG
260 270 280 290 300
IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA
310 320 330 340 350
NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII
360 370 380 390 400
NYDLPNNREL YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI
410
DEMPMNVADL I
Length:411
Mass (Da):46,871
Last modified:January 23, 2007 - v4
Checksum:i3A21888CA96CA5EA
GO

Sequence cautioni

The sequence BAA04879 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101P → S in CAA56074 (Ref. 1) Curated
Sequence conflicti370 – 3701R → Q in CAA56074 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701D → G in RCPS. 1 Publication
Corresponds to variant rs587777204 [ dbSNP | Ensembl ].
VAR_071090

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79538 mRNA. Translation: CAA56074.1.
D21853 mRNA. Translation: BAA04879.2. Different initiation.
AK290608 mRNA. Translation: BAF83297.1.
CR456750 mRNA. Translation: CAG33031.1.
AC087741 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89584.1.
BC003662 mRNA. Translation: AAH03662.1.
BC004386 mRNA. Translation: AAH04386.1.
BC011151 mRNA. Translation: AAH11151.1.
CCDSiCCDS11767.1.
PIRiS45142.
RefSeqiNP_055555.1. NM_014740.3.
UniGeneiHs.389649.

Genome annotation databases

EnsembliENST00000269349; ENSP00000269349; ENSG00000141543.
GeneIDi9775.
KEGGihsa:9775.
UCSCiuc002jxs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79538 mRNA. Translation: CAA56074.1.
D21853 mRNA. Translation: BAA04879.2. Different initiation.
AK290608 mRNA. Translation: BAF83297.1.
CR456750 mRNA. Translation: CAG33031.1.
AC087741 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89584.1.
BC003662 mRNA. Translation: AAH03662.1.
BC004386 mRNA. Translation: AAH04386.1.
BC011151 mRNA. Translation: AAH11151.1.
CCDSiCCDS11767.1.
PIRiS45142.
RefSeqiNP_055555.1. NM_014740.3.
UniGeneiHs.389649.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HXYX-ray3.30A/B/C/D23-411[»]
2HYIX-ray2.30C/I1-411[»]
2J0QX-ray3.20A/B2-411[»]
2J0SX-ray2.21A2-411[»]
2J0UX-ray3.00A/B38-411[»]
2XB2X-ray3.40A/X1-411[»]
3EX7X-ray2.30C/H1-411[»]
4C9BX-ray2.00A1-411[»]
ProteinModelPortaliP38919.
SMRiP38919. Positions 21-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115119. 262 interactions.
DIPiDIP-33218N.
IntActiP38919. 148 interactions.
MINTiMINT-1460615.
STRINGi9606.ENSP00000269349.

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

PTM databases

iPTMnetiP38919.
PhosphoSiteiP38919.
SwissPalmiP38919.

Polymorphism and mutation databases

BioMutaiEIF4A3.
DMDMi20532400.

2D gel databases

REPRODUCTION-2DPAGEIPI00009328.

Proteomic databases

EPDiP38919.
MaxQBiP38919.
PaxDbiP38919.
PeptideAtlasiP38919.
PRIDEiP38919.

Protocols and materials databases

DNASUi9775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269349; ENSP00000269349; ENSG00000141543.
GeneIDi9775.
KEGGihsa:9775.
UCSCiuc002jxs.3. human.

Organism-specific databases

CTDi9775.
GeneCardsiEIF4A3.
HGNCiHGNC:18683. EIF4A3.
HPAiHPA021878.
MalaCardsiEIF4A3.
MIMi268305. phenotype.
608546. gene.
neXtProtiNX_P38919.
Orphaneti3102. Richieri Costa-Pereira syndrome.
PharmGKBiPA162384945.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0327. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00530000062880.
HOGENOMiHOG000268797.
HOVERGENiHBG107989.
InParanoidiP38919.
KOiK13025.
OMAiTATFCIS.
OrthoDBiEOG091G07OI.
PhylomeDBiP38919.
TreeFamiTF300466.

Enzyme and pathway databases

BRENDAi3.6.4.13. 2681.
ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-429947. Deadenylation of mRNA.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiEIF4A3. human.
EvolutionaryTraceiP38919.
GeneWikiiEIF4A3.
GenomeRNAii9775.
PROiP38919.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141543.
CleanExiHS_EIF4A3.
ExpressionAtlasiP38919. baseline and differential.
GenevisibleiP38919. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF4A3_HUMAN
AccessioniPrimary (citable) accession number: P38919
Secondary accession number(s): Q15033, Q6IBQ2, Q96A18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 192 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Translation initiation factors
    List of translation initiation factor entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.