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Protein

Eukaryotic translation initiation factor 1A

Gene

TIF11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Miscellaneous

Present with 35100 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • double-stranded RNA binding Source: SGD
  • protein kinase binding Source: UniProtKB
  • ribosomal small subunit binding Source: SGD
  • translation initiation factor activity Source: SGD
  • translation initiation factor binding Source: SGD

GO - Biological processi

  • formation of cytoplasmic translation initiation complex Source: SGD
  • formation of translation preinitiation complex Source: SGD

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32935-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SCE-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A
Short name:
eIF-1A
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:TIF11
Ordered Locus Names:YMR260C
ORF Names:YM8156.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR260C
SGDiS000004873 TIF11

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001451131 – 153Eukaryotic translation initiation factor 1AAdd BLAST153

Proteomic databases

MaxQBiP38912
PaxDbiP38912
PRIDEiP38912

PTM databases

iPTMnetiP38912

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • translation initiation factor binding Source: SGD

Protein-protein interaction databases

BioGridi35438, 202 interactors
DIPiDIP-4401N
IntActiP38912, 3 interactors
MINTiP38912
STRINGi4932.YMR260C

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 43Combined sources11
Beta strandi46 – 51Combined sources6
Beta strandi56 – 61Combined sources6
Helixi63 – 65Combined sources3
Beta strandi76 – 81Combined sources6
Beta strandi86 – 94Combined sources9
Helixi98 – 106Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J80electron microscopy3.75i1-153[»]
3J81electron microscopy4.00i1-153[»]
3JAMelectron microscopy3.46i1-153[»]
3JAPelectron microscopy4.90i1-153[»]
3JAQelectron microscopy6.00i1-153[»]
3WBKX-ray3.30C27-153[»]
ProteinModelPortaliP38912
SMRiP38912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96S1-likeAdd BLAST75

Sequence similaritiesi

Belongs to the eIF-1A family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008256
HOGENOMiHOG000223675
InParanoidiP38912
KOiK03236
OMAiCTFEFGD
OrthoDBiEOG092C5KXX

Family and domain databases

CDDicd05793 S1_IF1A, 1 hit
HAMAPiMF_00216 aIF_1A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
IPR018104 TIF_eIF-1A_CS
PANTHERiPTHR21668 PTHR21668, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005579 TIF_eIF-1A, 1 hit
SMARTiView protein in SMART
SM00652 eIF1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00523 eIF-1A, 1 hit
PROSITEiView protein in PROSITE
PS01262 IF1A, 1 hit
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

P38912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKNTKGGK KGRRGKNDSD GPKRELIYKE EGQEYAQITK MLGNGRVEAS
60 70 80 90 100
CFDGNKRMAH IRGKLRKKVW MGQGDIILVS LRDFQDDQCD VVHKYNLDEA
110 120 130 140 150
RTLKNQGELP ENAKINETDN FGFESDEDVN FEFGNADEDD EEGEDEELDI

DDI
Length:153
Mass (Da):17,435
Last modified:February 1, 1995 - v1
Checksum:iAEF000104BBA3041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11585 Genomic DNA Translation: AAA82039.1
Z49260 Genomic DNA Translation: CAA89243.1
AY557964 Genomic DNA Translation: AAS56290.1
BK006946 Genomic DNA Translation: DAA10160.1
PIRiS47943
RefSeqiNP_013987.1, NM_001182767.1

Genome annotation databases

EnsemblFungiiYMR260C; YMR260C; YMR260C
GeneIDi855302
KEGGisce:YMR260C

Similar proteinsi

Entry informationi

Entry nameiIF1A_YEAST
AccessioniPrimary (citable) accession number: P38912
Secondary accession number(s): D6W086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health