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Protein

FK506-binding nuclear protein

Gene

FPR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. FK506- and rapamycin-binding protein. Specifically binds nuclear localization sequences. May be involved in the assembly or folding of ribosomal proteins.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  • FK506 binding Source: GO_Central
  • macrolide binding Source: SGD
  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • histone peptidyl-prolyl isomerization Source: InterPro
  • meiotic recombination checkpoint Source: SGD
  • nucleosome assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YML074C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding nuclear protein (EC:5.2.1.8)
Alternative name(s):
FKBP-70
Nucleolar proline isomerase
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Proline rotamase
Gene namesi
Name:FPR3
Synonyms:NPI46
Ordered Locus Names:YML074C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML074C.
SGDiS000004539. FPR3.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: GO_Central
  • nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 411410FK506-binding nuclear proteinPRO_0000075313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei81 – 811PhosphoserineCombined sources
Modified residuei89 – 891PhosphothreonineCombined sources
Modified residuei184 – 1841Phosphotyrosine; by CK21 Publication
Modified residuei186 – 1861Phosphoserine; by CK21 Publication

Post-translational modificationi

Phosphorylated at tyrosine and dephosphorylated by the phosphotyrosine-specific phosphoprotein phosphatase PTP1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP38911.

PTM databases

iPTMnetiP38911.

Interactioni

Subunit structurei

Interacts with NOP53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LOC1P435863EBI-6951,EBI-22906
NOP53Q120803EBI-6951,EBI-29395

Protein-protein interaction databases

BioGridi35067. 82 interactions.
DIPiDIP-6578N.
IntActiP38911. 65 interactions.
MINTiMINT-673400.

Structurei

3D structure databases

ProteinModelPortaliP38911.
SMRiP38911. Positions 255-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini324 – 41188PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi256 – 27116Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 8728Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi88 – 9912Lys-rich (highly basic)Add
BLAST
Compositional biasi101 – 11919Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi173 – 24876Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi250 – 29849Lys-rich (highly basic)Add
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000064286.
HOGENOMiHOG000216214.
InParanoidiP38911.
KOiK14826.
OMAiKGECIKG.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR026257. FK506_BP.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001473. FK506-bp_FPR3. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLLPLATY SLNVEPYTPV PAIDVTMPIT VRITMAALNP EAIDEENKPS
60 70 80 90 100
TLRIIKRNPD FEDDDFLGGD FDEDEIDEES SEEEEEEKTQ KKKKSKGKKA
110 120 130 140 150
ESESEDDEED DDEDDEFQES VLLTLSPEAQ YQQSLDLTIT PEEEVQFIVT
160 170 180 190 200
GSYAISLSGN YVKHPFDTPM GVEGEDEDED ADIYDSEDYD LTPDEDEIIG
210 220 230 240 250
DDMDDLDDEE EEEVRIEEVQ EEDEEDNDGE EEQEEEEEEE QKEEVKPEPK
260 270 280 290 300
KSKKEKKRKH EEKEEEKKAK KVKKVEFKKD LEEGPTKPKS KKEQDKHKPK
310 320 330 340 350
SKVLEGGIVI EDRTIGDGPQ AKRGARVGMR YIGKLKNGKV FDKNTSGKPF
360 370 380 390 400
AFKLGRGEVI KGWDIGVAGM SVGGERRIII PAPYAYGKQA LPGIPANSEL
410
TFDVKLVSMK N
Length:411
Mass (Da):46,553
Last modified:November 1, 1995 - v2
Checksum:iA01D24DE0078FE11
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221L → P in AAB04165 (PubMed:7925954).Curated
Sequence conflicti240 – 2401E → EEE (PubMed:7925954).Curated
Sequence conflicti335 – 3351L → F in AAB04165 (PubMed:7925954).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34569 Genomic DNA. Translation: AAB04165.1.
X79379 Genomic DNA. Translation: CAA55924.1.
S73876 Genomic DNA. Translation: AAB31995.1.
Z46373 Genomic DNA. Translation: CAA86504.1.
AY693136 Genomic DNA. Translation: AAT93155.1.
BK006946 Genomic DNA. Translation: DAA09823.1.
PIRiS48647.
RefSeqiNP_013637.1. NM_001182433.1.

Genome annotation databases

EnsemblFungiiYML074C; YML074C; YML074C.
GeneIDi854901.
KEGGisce:YML074C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34569 Genomic DNA. Translation: AAB04165.1.
X79379 Genomic DNA. Translation: CAA55924.1.
S73876 Genomic DNA. Translation: AAB31995.1.
Z46373 Genomic DNA. Translation: CAA86504.1.
AY693136 Genomic DNA. Translation: AAT93155.1.
BK006946 Genomic DNA. Translation: DAA09823.1.
PIRiS48647.
RefSeqiNP_013637.1. NM_001182433.1.

3D structure databases

ProteinModelPortaliP38911.
SMRiP38911. Positions 255-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35067. 82 interactions.
DIPiDIP-6578N.
IntActiP38911. 65 interactions.
MINTiMINT-673400.

PTM databases

iPTMnetiP38911.

Proteomic databases

MaxQBiP38911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML074C; YML074C; YML074C.
GeneIDi854901.
KEGGisce:YML074C.

Organism-specific databases

EuPathDBiFungiDB:YML074C.
SGDiS000004539. FPR3.

Phylogenomic databases

GeneTreeiENSGT00530000064286.
HOGENOMiHOG000216214.
InParanoidiP38911.
KOiK14826.
OMAiKGECIKG.
OrthoDBiEOG092C52SD.

Enzyme and pathway databases

BioCyciYEAST:YML074C-MONOMER.

Miscellaneous databases

PROiP38911.

Family and domain databases

InterProiIPR026257. FK506_BP.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001473. FK506-bp_FPR3. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP3_YEAST
AccessioniPrimary (citable) accession number: P38911
Secondary accession number(s): D6W0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9490 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.