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Protein

Cytochrome c mitochondrial import factor CYC2

Gene

CYC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Redox component that participates in c-type cytochrome biogenesis in the mitochondrial intermembrane space. May play a role in the reduction of heme prior to its ligation to apocytochrome c by cytochrome c heme lyase. Has oxidoreductase activity in vitro.1 Publication

Miscellaneous

Present with 2730 molecules/cell in log phase SD medium.1 Publication

Cofactori

FAD1 PublicationNote: Binds 1 FAD per monomer.1 Publication

Kineticsi

  1. KM=0.1 mM for NADPH1 Publication
  2. KM=30 mM for NADH1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • cytochrome c-heme linkage Source: SGD
    • mitochondrial membrane organization Source: SGD

    Keywordsi

    Molecular functionOxidoreductase
    LigandFAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33583-MONOMER
    SABIO-RKiP38909

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c mitochondrial import factor CYC2 (EC:1.-.-.-)
    Alternative name(s):
    Cytochrome c assembly flavoprotein CYC2
    Gene namesi
    Name:CYC2
    Ordered Locus Names:YOR037W
    ORF Names:OR26.30
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome XV

    Organism-specific databases

    EuPathDBiFungiDB:YOR037W
    SGDiS000005563 CYC2

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transit peptidei1 – 50MitochondrionSequence analysisAdd BLAST50
    ChainiPRO_000007974951 – 366Cytochrome c mitochondrial import factor CYC2Add BLAST316

    Proteomic databases

    MaxQBiP38909
    PaxDbiP38909
    PRIDEiP38909

    Interactioni

    Protein-protein interaction databases

    BioGridi34439, 171 interactors
    DIPiDIP-3836N
    STRINGi4932.YOR037W

    Structurei

    3D structure databases

    ProteinModelPortaliP38909
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini63 – 184FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST122

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000112126
    InParanoidiP38909
    OMAiVKQPEIM
    OrthoDBiEOG092C3MKD

    Family and domain databases

    InterProiView protein in InterPro
    IPR017927 Fd_Rdtase_FAD-bd
    IPR008333 OxRdtase_FAD-bd_dom
    IPR017938 Riboflavin_synthase-like_b-brl
    PfamiView protein in Pfam
    PF00970 FAD_binding_6, 1 hit
    SUPFAMiSSF63380 SSF63380, 1 hit
    PROSITEiView protein in PROSITE
    PS51384 FAD_FR, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38909-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MLWKNYVLSS SRITRRLHKS PRKSSFSKNF FITGCLLTVG AVSSYLTYRY
    60 70 80 90 100
    TSERENKHEL SPSYFVKYKI SHKRDIDSSH FLLEVTPLFK QKVNIWSLMT
    110 120 130 140 150
    AENLWSVEIK QPEVMVVRNY TPLPLKFNPA SKEIEILKDG DNADGKLSFY
    160 170 180 190 200
    IKKYENGEVA RWLHHLPKGH IIEIRGPFID YEFPHLPNEL KRSRDCLYMD
    210 220 230 240 250
    NRNERGNNVR ENSQFIYQPY DIMMFTAGTG IVTALQLLLT ESPFRGTIKL
    260 270 280 290 300
    FHTDKNIKQL GPLYPILLRL QASNRVQLKI FETDRQTKQD VLKSIQKSIT
    310 320 330 340 350
    KPYPYKGLLP FSNVNNKNIM PVLALVCGPE SYISSISGRK YDLNQGPVGG
    360
    LLSKEGWNSD NVYKLS
    Length:366
    Mass (Da):42,368
    Last modified:September 5, 2006 - v3
    Checksum:iAE7ADA43C51824D7
    GO

    Sequence cautioni

    The sequence AAA72429 differs from that shown. Reason: Frameshift at position 144.Curated
    The sequence CAA60756 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAA99227 differs from that shown. Reason: Erroneous initiation.Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X87331 Genomic DNA Translation: CAA60756.1 Different initiation.
    Z74945 Genomic DNA Translation: CAA99227.1 Different initiation.
    L28428 Genomic DNA Translation: AAA72429.1 Frameshift.
    BK006948 Genomic DNA Translation: DAA10820.1
    PIRiS62176
    RefSeqiNP_014680.2, NM_001183456.1

    Genome annotation databases

    EnsemblFungiiYOR037W; YOR037W; YOR037W
    GeneIDi854202
    KEGGisce:YOR037W

    Similar proteinsi

    Entry informationi

    Entry nameiCYC2_YEAST
    AccessioniPrimary (citable) accession number: P38909
    Secondary accession number(s): D6W2A4
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: September 5, 2006
    Last modified: June 20, 2018
    This is version 143 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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