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Protein

Cytochrome c mitochondrial import factor CYC2

Gene

CYC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Redox component that participates in c-type cytochrome biogenesis in the mitochondrial intermembrane space. May play a role in the reduction of heme prior to its ligation to apocytochrome c by cytochrome c heme lyase. Has oxidoreductase activity in vitro.1 Publication

Cofactori

FAD1 PublicationNote: Binds 1 FAD per monomer.1 Publication

Kineticsi

  1. KM=0.1 mM for NADPH1 Publication
  2. KM=30 mM for NADH1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • cytochrome c-heme linkage Source: SGD
    • mitochondrial membrane organization Source: SGD
    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33583-MONOMER.
    SABIO-RKP38909.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c mitochondrial import factor CYC2 (EC:1.-.-.-)
    Alternative name(s):
    Cytochrome c assembly flavoprotein CYC2
    Gene namesi
    Name:CYC2
    Ordered Locus Names:YOR037W
    ORF Names:OR26.30
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome XV

    Organism-specific databases

    EuPathDBiFungiDB:YOR037W.
    SGDiS000005563. CYC2.

    Subcellular locationi

    GO - Cellular componenti

    • extrinsic component of mitochondrial inner membrane Source: SGD
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transit peptidei1 – 50MitochondrionSequence analysisAdd BLAST50
    ChainiPRO_000007974951 – 366Cytochrome c mitochondrial import factor CYC2Add BLAST316

    Proteomic databases

    MaxQBiP38909.
    PRIDEiP38909.

    Interactioni

    Protein-protein interaction databases

    BioGridi34439. 73 interactors.
    DIPiDIP-3836N.
    IntActiP38909. 1 interactor.
    MINTiMINT-513576.

    Structurei

    3D structure databases

    ProteinModelPortaliP38909.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini63 – 184FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST122

    Sequence similaritiesi

    Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000112126.
    InParanoidiP38909.
    OMAiPEIMVVR.
    OrthoDBiEOG092C3MKD.

    Family and domain databases

    InterProiIPR017927. Fd_Rdtase_FAD-bd.
    IPR008333. OxRdtase_FAD-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00970. FAD_binding_6. 1 hit.
    [Graphical view]
    SUPFAMiSSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38909-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MLWKNYVLSS SRITRRLHKS PRKSSFSKNF FITGCLLTVG AVSSYLTYRY
    60 70 80 90 100
    TSERENKHEL SPSYFVKYKI SHKRDIDSSH FLLEVTPLFK QKVNIWSLMT
    110 120 130 140 150
    AENLWSVEIK QPEVMVVRNY TPLPLKFNPA SKEIEILKDG DNADGKLSFY
    160 170 180 190 200
    IKKYENGEVA RWLHHLPKGH IIEIRGPFID YEFPHLPNEL KRSRDCLYMD
    210 220 230 240 250
    NRNERGNNVR ENSQFIYQPY DIMMFTAGTG IVTALQLLLT ESPFRGTIKL
    260 270 280 290 300
    FHTDKNIKQL GPLYPILLRL QASNRVQLKI FETDRQTKQD VLKSIQKSIT
    310 320 330 340 350
    KPYPYKGLLP FSNVNNKNIM PVLALVCGPE SYISSISGRK YDLNQGPVGG
    360
    LLSKEGWNSD NVYKLS
    Length:366
    Mass (Da):42,368
    Last modified:September 5, 2006 - v3
    Checksum:iAE7ADA43C51824D7
    GO

    Sequence cautioni

    The sequence AAA72429 differs from that shown. Reason: Frameshift at position 144.Curated
    The sequence CAA60756 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAA99227 differs from that shown. Reason: Erroneous initiation.Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X87331 Genomic DNA. Translation: CAA60756.1. Different initiation.
    Z74945 Genomic DNA. Translation: CAA99227.1. Different initiation.
    L28428 Genomic DNA. Translation: AAA72429.1. Frameshift.
    BK006948 Genomic DNA. Translation: DAA10820.1.
    PIRiS62176.
    RefSeqiNP_014680.2. NM_001183456.1.

    Genome annotation databases

    EnsemblFungiiYOR037W; YOR037W; YOR037W.
    GeneIDi854202.
    KEGGisce:YOR037W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X87331 Genomic DNA. Translation: CAA60756.1. Different initiation.
    Z74945 Genomic DNA. Translation: CAA99227.1. Different initiation.
    L28428 Genomic DNA. Translation: AAA72429.1. Frameshift.
    BK006948 Genomic DNA. Translation: DAA10820.1.
    PIRiS62176.
    RefSeqiNP_014680.2. NM_001183456.1.

    3D structure databases

    ProteinModelPortaliP38909.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi34439. 73 interactors.
    DIPiDIP-3836N.
    IntActiP38909. 1 interactor.
    MINTiMINT-513576.

    Proteomic databases

    MaxQBiP38909.
    PRIDEiP38909.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblFungiiYOR037W; YOR037W; YOR037W.
    GeneIDi854202.
    KEGGisce:YOR037W.

    Organism-specific databases

    EuPathDBiFungiDB:YOR037W.
    SGDiS000005563. CYC2.

    Phylogenomic databases

    HOGENOMiHOG000112126.
    InParanoidiP38909.
    OMAiPEIMVVR.
    OrthoDBiEOG092C3MKD.

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33583-MONOMER.
    SABIO-RKP38909.

    Miscellaneous databases

    PROiP38909.

    Family and domain databases

    InterProiIPR017927. Fd_Rdtase_FAD-bd.
    IPR008333. OxRdtase_FAD-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00970. FAD_binding_6. 1 hit.
    [Graphical view]
    SUPFAMiSSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiCYC2_YEAST
    AccessioniPrimary (citable) accession number: P38909
    Secondary accession number(s): D6W2A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: September 5, 2006
    Last modified: November 2, 2016
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2730 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.