UniProtKB - P38902 (RPB11_YEAST)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
DNA-directed RNA polymerase II subunit RPB11
Gene
RPB11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination.1 Publication
Miscellaneous
Present with 4280 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA binding Source: InterPro
- protein dimerization activity Source: InterPro
- RNA polymerase II activity Source: InterPro
GO - Biological processi
- termination of RNA polymerase II transcription Source: SGD
- transcription, RNA-templated Source: GOC
- transcription by RNA polymerase II Source: SGD
Keywordsi
Biological process | Transcription |
Enzyme and pathway databases
BioCyci | YEAST:G3O-33422-MONOMER. |
Reactomei | R-SCE-113418. Formation of the Early Elongation Complex. R-SCE-674695. RNA Polymerase II Pre-transcription Events. R-SCE-6781823. Formation of TC-NER Pre-Incision Complex. R-SCE-6782135. Dual incision in TC-NER. R-SCE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-SCE-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-SCE-72086. mRNA Capping. R-SCE-72165. mRNA Splicing - Minor Pathway. R-SCE-73776. RNA Polymerase II Promoter Escape. R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-SCE-75953. RNA Polymerase II Transcription Initiation. R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. R-SCE-77075. RNA Pol II CTD phosphorylation and interaction with CE. |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase II subunit RPB11Short name: RNA polymerase II subunit B11 Alternative name(s): B13.6 DNA-directed RNA polymerase II 13.6 kDa polypeptide |
Gene namesi | Name:RPB11 Ordered Locus Names:YOL005C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOL005C. |
SGDi | S000005365. RPB11. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 108 | E → G or V: Transcript termination readthrough. 1 Publication | 1 | |
Mutagenesisi | 108 | E → K: Transcript termination readthrough. Lethal. 1 Publication | 1 | |
Mutagenesisi | 111 | L → P: Transcript termination readthrough. 1 Publication | 1 | |
Mutagenesisi | 114 | L → P: Transcript termination readthrough. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149315 | 1 – 120 | DNA-directed RNA polymerase II subunit RPB11Add BLAST | 120 |
Proteomic databases
MaxQBi | P38902. |
PaxDbi | P38902. |
PRIDEi | P38902. |
Interactioni
Subunit structurei
Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.3 Publications
Binary interactionsi
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGridi | 34399. 387 interactors. |
DIPi | DIP-937N. |
IntActi | P38902. 34 interactors. |
MINTi | P38902. |
STRINGi | 4932.YOL005C. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 7 – 9 | Combined sources | 3 | |
Beta strandi | 18 – 20 | Combined sources | 3 | |
Beta strandi | 21 – 23 | Combined sources | 3 | |
Beta strandi | 25 – 27 | Combined sources | 3 | |
Beta strandi | 30 – 37 | Combined sources | 8 | |
Helixi | 40 – 50 | Combined sources | 11 | |
Beta strandi | 56 – 62 | Combined sources | 7 | |
Beta strandi | 66 – 68 | Combined sources | 3 | |
Beta strandi | 70 – 77 | Combined sources | 8 | |
Helixi | 83 – 108 | Combined sources | 26 | |
Turni | 109 – 111 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I3Q | X-ray | 3.10 | K | 1-120 | [»] | |
1I50 | X-ray | 2.80 | K | 1-120 | [»] | |
1I6H | X-ray | 3.30 | K | 1-120 | [»] | |
1K83 | X-ray | 2.80 | K | 1-120 | [»] | |
1NIK | X-ray | 4.10 | K | 1-120 | [»] | |
1NT9 | X-ray | 4.20 | K | 1-120 | [»] | |
1PQV | X-ray | 3.80 | K | 1-120 | [»] | |
1R5U | X-ray | 4.50 | K | 1-120 | [»] | |
1R9S | X-ray | 4.25 | K | 1-120 | [»] | |
1R9T | X-ray | 3.50 | K | 1-120 | [»] | |
1SFO | X-ray | 3.61 | K | 1-120 | [»] | |
1TWA | X-ray | 3.20 | K | 1-120 | [»] | |
1TWC | X-ray | 3.00 | K | 1-120 | [»] | |
1TWF | X-ray | 2.30 | K | 1-120 | [»] | |
1TWG | X-ray | 3.30 | K | 1-120 | [»] | |
1TWH | X-ray | 3.40 | K | 1-120 | [»] | |
1WCM | X-ray | 3.80 | K | 1-120 | [»] | |
1Y1V | X-ray | 3.80 | K | 1-120 | [»] | |
1Y1W | X-ray | 4.00 | K | 1-120 | [»] | |
1Y1Y | X-ray | 4.00 | K | 1-120 | [»] | |
1Y77 | X-ray | 4.50 | K | 1-120 | [»] | |
2B63 | X-ray | 3.80 | K | 1-120 | [»] | |
2B8K | X-ray | 4.15 | K | 1-120 | [»] | |
2E2H | X-ray | 3.95 | K | 1-120 | [»] | |
2E2I | X-ray | 3.41 | K | 1-120 | [»] | |
2E2J | X-ray | 3.50 | K | 1-120 | [»] | |
2JA5 | X-ray | 3.80 | K | 1-120 | [»] | |
2JA6 | X-ray | 4.00 | K | 1-120 | [»] | |
2JA7 | X-ray | 3.80 | K/W | 1-120 | [»] | |
2JA8 | X-ray | 3.80 | K | 1-120 | [»] | |
2NVQ | X-ray | 2.90 | K | 1-120 | [»] | |
2NVT | X-ray | 3.36 | K | 1-120 | [»] | |
2NVX | X-ray | 3.60 | K | 1-120 | [»] | |
2NVY | X-ray | 3.40 | K | 1-120 | [»] | |
2NVZ | X-ray | 4.30 | K | 1-120 | [»] | |
2R7Z | X-ray | 3.80 | K | 1-120 | [»] | |
2R92 | X-ray | 3.80 | K | 1-120 | [»] | |
2R93 | X-ray | 4.00 | K | 1-120 | [»] | |
2VUM | X-ray | 3.40 | K | 1-120 | [»] | |
2YU9 | X-ray | 3.40 | K | 1-120 | [»] | |
3CQZ | X-ray | 2.80 | K | 1-120 | [»] | |
3FKI | X-ray | 3.88 | K | 1-120 | [»] | |
3GTG | X-ray | 3.78 | K | 1-120 | [»] | |
3GTJ | X-ray | 3.42 | K | 1-120 | [»] | |
3GTK | X-ray | 3.80 | K | 1-120 | [»] | |
3GTL | X-ray | 3.38 | K | 1-120 | [»] | |
3GTM | X-ray | 3.80 | K | 1-120 | [»] | |
3GTO | X-ray | 4.00 | K | 1-120 | [»] | |
3GTP | X-ray | 3.90 | K | 1-120 | [»] | |
3GTQ | X-ray | 3.80 | K | 1-120 | [»] | |
3H3V | X-ray | 4.00 | L | 1-120 | [»] | |
3HOU | X-ray | 3.20 | K/W | 1-120 | [»] | |
3HOV | X-ray | 3.50 | K | 1-120 | [»] | |
3HOW | X-ray | 3.60 | K | 1-120 | [»] | |
3HOX | X-ray | 3.65 | K | 1-120 | [»] | |
3HOY | X-ray | 3.40 | K | 1-120 | [»] | |
3HOZ | X-ray | 3.65 | K | 1-120 | [»] | |
3I4M | X-ray | 3.70 | K | 1-120 | [»] | |
3I4N | X-ray | 3.90 | K | 1-120 | [»] | |
3J0K | electron microscopy | 36.00 | K | 1-120 | [»] | |
3J1N | electron microscopy | 16.00 | K | 1-120 | [»] | |
3K1F | X-ray | 4.30 | K | 1-120 | [»] | |
3K7A | X-ray | 3.80 | K | 1-120 | [»] | |
3M3Y | X-ray | 3.18 | K | 1-120 | [»] | |
3M4O | X-ray | 3.57 | K | 1-120 | [»] | |
3PO2 | X-ray | 3.30 | K | 1-120 | [»] | |
3PO3 | X-ray | 3.30 | K | 1-120 | [»] | |
3QT1 | X-ray | 4.30 | K | 1-120 | [»] | |
3RZD | X-ray | 3.30 | K | 1-120 | [»] | |
3RZO | X-ray | 3.00 | K | 1-120 | [»] | |
3S14 | X-ray | 2.85 | K | 1-120 | [»] | |
3S15 | X-ray | 3.30 | K | 1-120 | [»] | |
3S16 | X-ray | 3.24 | K | 1-120 | [»] | |
3S17 | X-ray | 3.20 | K | 1-120 | [»] | |
3S1M | X-ray | 3.13 | K | 1-120 | [»] | |
3S1N | X-ray | 3.10 | K | 1-120 | [»] | |
3S1Q | X-ray | 3.30 | K | 1-120 | [»] | |
3S1R | X-ray | 3.20 | K | 1-120 | [»] | |
3S2D | X-ray | 3.20 | K | 1-120 | [»] | |
3S2H | X-ray | 3.30 | K | 1-120 | [»] | |
4A3B | X-ray | 3.50 | K | 1-120 | [»] | |
4A3C | X-ray | 3.50 | K | 1-120 | [»] | |
4A3D | X-ray | 3.40 | K | 1-120 | [»] | |
4A3E | X-ray | 3.40 | K | 1-120 | [»] | |
4A3F | X-ray | 3.50 | K | 1-120 | [»] | |
4A3G | X-ray | 3.50 | K | 1-120 | [»] | |
4A3I | X-ray | 3.80 | K | 1-120 | [»] | |
4A3J | X-ray | 3.70 | K | 1-120 | [»] | |
4A3K | X-ray | 3.50 | K | 1-120 | [»] | |
4A3L | X-ray | 3.50 | K | 1-120 | [»] | |
4A3M | X-ray | 3.90 | K | 1-120 | [»] | |
4A93 | X-ray | 3.40 | K | 1-120 | [»] | |
4BBR | X-ray | 3.40 | K | 1-120 | [»] | |
4BBS | X-ray | 3.60 | K | 1-120 | [»] | |
4BXX | X-ray | 3.28 | K | 1-120 | [»] | |
4BXZ | X-ray | 4.80 | K | 1-120 | [»] | |
4BY1 | X-ray | 3.60 | K | 1-120 | [»] | |
4BY7 | X-ray | 3.15 | K | 1-120 | [»] | |
4V1M | electron microscopy | 6.60 | K | 1-120 | [»] | |
4V1N | electron microscopy | 7.80 | K | 1-120 | [»] | |
4V1O | electron microscopy | 9.70 | K | 1-120 | [»] | |
4X67 | X-ray | 4.10 | K | 1-120 | [»] | |
4X6A | X-ray | 3.96 | K | 1-120 | [»] | |
4Y52 | X-ray | 3.50 | K | 1-120 | [»] | |
4Y7N | X-ray | 3.30 | K | 1-120 | [»] | |
5C3E | X-ray | 3.70 | K | 1-120 | [»] | |
5C44 | X-ray | 3.95 | K | 1-120 | [»] | |
5C4A | X-ray | 4.20 | K | 1-120 | [»] | |
5C4J | X-ray | 4.00 | K | 1-120 | [»] | |
5C4X | X-ray | 4.00 | K | 1-120 | [»] | |
5FMF | electron microscopy | 6.00 | K | 1-115 | [»] | |
5FYW | electron microscopy | 4.35 | K | 1-120 | [»] | |
5FZ5 | electron microscopy | 8.80 | K | 1-120 | [»] | |
5IP7 | X-ray | 3.52 | K | 1-115 | [»] | |
5IP9 | X-ray | 3.90 | K | 1-115 | [»] | |
5OT2 | X-ray | 3.20 | K | 1-120 | [»] | |
5SVA | electron microscopy | 15.30 | K | 1-120 | [»] | |
5U5Q | X-ray | 3.80 | K | 1-120 | [»] | |
5VVR | electron microscopy | 5.80 | K | 1-120 | [»] | |
5VVS | electron microscopy | 6.40 | K | 1-120 | [»] | |
ProteinModelPortali | P38902. | |||||
SMRi | P38902. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P38902. |
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.Curated
Phylogenomic databases
GeneTreei | ENSGT00550000074975. |
HOGENOMi | HOG000179862. |
InParanoidi | P38902. |
KOi | K03008. |
OMAi | MAGYKIA. |
OrthoDBi | EOG092C5QHE. |
Family and domain databases
CDDi | cd06926. RNAP_II_RPB11. 1 hit. |
Gene3Di | 3.30.1360.10. 1 hit. |
InterProi | View protein in InterPro IPR037685. RBP11. IPR036603. RBP11-like. IPR009025. RBP11-like_dimer. IPR008193. RNA_pol_Rpb11_13-16kDa_CS. |
Pfami | View protein in Pfam PF13656. RNA_pol_L_2. 1 hit. |
SUPFAMi | SSF55257. SSF55257. 1 hit. |
PROSITEi | View protein in PROSITE PS01154. RNA_POL_L_13KD. 1 hit. |
i Sequence
Sequence statusi: Complete.
P38902-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAPDRFELF LLGEGESKLK IDPDTKAPNA VVITFEKEDH TLGNLIRAEL
60 70 80 90 100
LNDRKVLFAA YKVEHPFFAR FKLRIQTTEG YDPKDALKNA CNSIINKLGA
110 120
LKTNFETEWN LQTLAADDAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62624 Genomic DNA. Translation: AAB27135.1. Z74747 Genomic DNA. Translation: CAA99004.1. AY557998 Genomic DNA. Translation: AAS56324.1. BK006948 Genomic DNA. Translation: DAA10778.1. |
PIRi | S58933. |
RefSeqi | NP_014638.1. NM_001183259.1. |
Genome annotation databases
EnsemblFungii | YOL005C; YOL005C; YOL005C. |
GeneIDi | 854157. |
KEGGi | sce:YOL005C. |
Similar proteinsi
Entry informationi
Entry namei | RPB11_YEAST | |
Accessioni | P38902Primary (citable) accession number: P38902 Secondary accession number(s): D6W262 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |