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P38890

- SET5_YEAST

UniProt

P38890 - SET5_YEAST

Protein

Putative protein lysine methyltransferase SET5

Gene

SET5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV.1 Publication

    GO - Molecular functioni

    1. S-adenosylmethionine-dependent methyltransferase activity Source: SGD

    GO - Biological processi

    1. histone lysine methylation Source: SGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31233-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative protein lysine methyltransferase SET5 (EC:2.1.1.-)
    Alternative name(s):
    SET domain-containing protein 5
    Gene namesi
    Name:SET5
    Ordered Locus Names:YHR207C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR207c.
    SGDiS000001250. SET5.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear chromatin Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Putative protein lysine methyltransferase SET5PRO_0000202942Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei517 – 5171Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38890.
    PaxDbiP38890.

    Expressioni

    Gene expression databases

    GenevestigatoriP38890.

    Interactioni

    Protein-protein interaction databases

    BioGridi36641. 47 interactions.
    DIPiDIP-2725N.
    IntActiP38890. 14 interactions.
    MINTiMINT-402807.
    STRINGi4932.YHR207C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38890.
    SMRiP38890. Positions 339-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 403292SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000074714.
    KOiK07117.
    OMAiRITERNQ.
    OrthoDBiEOG7Q5HPF.

    Family and domain databases

    InterProiIPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38890-1 [UniParc]FASTAAdd to Basket

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    MTLTIKIGTL NDSDQSAVHN GTENGSDFRK ITPTEEEICD DVVLLWKEEP    50
    GTEDATIQHL YDRITERNQS WKLSASRFRK ILNEHHLYDT DLETVSLYKD 100
    KIHFPKALDS DAKVEVKFID DEHGRGLFAK RDFSKGQIIL KENKPIVYIP 150
    PLDKLFLISN GKACARCGKA LYDLTQHKIM VHYLDCEVCK AIWCSEKCKK 200
    AHASLHELLY HSWRSNRIDI LHAGNWKRFV NYCEKYCFTA AFSVGLIYGS 250
    MLLDTTGEVK EQWQKLASIS QRERIKLRDA SGIGSTFSLL NGTTVHTEEE 300
    SDNGTKKGVE KNIDDETVWE KCYELFCGAF PKASEEIDFE KFLTMIGTFN 350
    INQYNGQVYH WISFINHDCE PNAYIEQVEE HEELRLHARK PIKKGEQIRI 400
    TYVNPLHGVR LRRRELRVNW GFLCQCDRCQ NELSTFERVP NLEKKNADAN 450
    LGVEKIDSND SSEDGSKKST GNRKSSMREA QPDLKEILKN GKEFELDIPE 500
    TVDTQGNVRK TSVRFDSNVS VAVDER 526
    Length:526
    Mass (Da):60,547
    Last modified:February 1, 1995 - v1
    Checksum:i1113CB9C5223DC7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00029 Genomic DNA. Translation: AAB69736.1.
    BK006934 Genomic DNA. Translation: DAA06900.1.
    PIRiS48988.
    RefSeqiNP_012077.1. NM_001179338.1.

    Genome annotation databases

    EnsemblFungiiYHR207C; YHR207C; YHR207C.
    GeneIDi856614.
    KEGGisce:YHR207C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00029 Genomic DNA. Translation: AAB69736.1 .
    BK006934 Genomic DNA. Translation: DAA06900.1 .
    PIRi S48988.
    RefSeqi NP_012077.1. NM_001179338.1.

    3D structure databases

    ProteinModelPortali P38890.
    SMRi P38890. Positions 339-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36641. 47 interactions.
    DIPi DIP-2725N.
    IntActi P38890. 14 interactions.
    MINTi MINT-402807.
    STRINGi 4932.YHR207C.

    Proteomic databases

    MaxQBi P38890.
    PaxDbi P38890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR207C ; YHR207C ; YHR207C .
    GeneIDi 856614.
    KEGGi sce:YHR207C.

    Organism-specific databases

    CYGDi YHR207c.
    SGDi S000001250. SET5.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000074714.
    KOi K07117.
    OMAi RITERNQ.
    OrthoDBi EOG7Q5HPF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31233-MONOMER.

    Miscellaneous databases

    NextBioi 982538.

    Gene expression databases

    Genevestigatori P38890.

    Family and domain databases

    InterProi IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins."
      Boehm S., Frishman D., Mewes H.-W.
      Nucleic Acids Res. 25:2464-2469(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus."
      Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., Ahlquist P.
      Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSET5_YEAST
    AccessioniPrimary (citable) accession number: P38890
    Secondary accession number(s): D3DLF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3