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P38890

- SET5_YEAST

UniProt

P38890 - SET5_YEAST

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Protein
Putative protein lysine methyltransferase SET5
Gene
SET5, YHR207C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV.1 Publication

GO - Molecular functioni

  1. S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  1. histone lysine methylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-31233-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein lysine methyltransferase SET5 (EC:2.1.1.-)
Alternative name(s):
SET domain-containing protein 5
Gene namesi
Name:SET5
Ordered Locus Names:YHR207C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR207c.
SGDiS000001250. SET5.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear chromatin Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Putative protein lysine methyltransferase SET5
PRO_0000202942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei517 – 5171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38890.
PaxDbiP38890.

Expressioni

Gene expression databases

GenevestigatoriP38890.

Interactioni

Protein-protein interaction databases

BioGridi36641. 47 interactions.
DIPiDIP-2725N.
IntActiP38890. 14 interactions.
MINTiMINT-402807.
STRINGi4932.YHR207C.

Structurei

3D structure databases

ProteinModelPortaliP38890.
SMRiP38890. Positions 339-432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 403292SET
Add
BLAST

Sequence similaritiesi

Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000074714.
KOiK07117.
OMAiRITERNQ.
OrthoDBiEOG7Q5HPF.

Family and domain databases

InterProiIPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38890-1 [UniParc]FASTAAdd to Basket

« Hide

MTLTIKIGTL NDSDQSAVHN GTENGSDFRK ITPTEEEICD DVVLLWKEEP    50
GTEDATIQHL YDRITERNQS WKLSASRFRK ILNEHHLYDT DLETVSLYKD 100
KIHFPKALDS DAKVEVKFID DEHGRGLFAK RDFSKGQIIL KENKPIVYIP 150
PLDKLFLISN GKACARCGKA LYDLTQHKIM VHYLDCEVCK AIWCSEKCKK 200
AHASLHELLY HSWRSNRIDI LHAGNWKRFV NYCEKYCFTA AFSVGLIYGS 250
MLLDTTGEVK EQWQKLASIS QRERIKLRDA SGIGSTFSLL NGTTVHTEEE 300
SDNGTKKGVE KNIDDETVWE KCYELFCGAF PKASEEIDFE KFLTMIGTFN 350
INQYNGQVYH WISFINHDCE PNAYIEQVEE HEELRLHARK PIKKGEQIRI 400
TYVNPLHGVR LRRRELRVNW GFLCQCDRCQ NELSTFERVP NLEKKNADAN 450
LGVEKIDSND SSEDGSKKST GNRKSSMREA QPDLKEILKN GKEFELDIPE 500
TVDTQGNVRK TSVRFDSNVS VAVDER 526
Length:526
Mass (Da):60,547
Last modified:February 1, 1995 - v1
Checksum:i1113CB9C5223DC7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00029 Genomic DNA. Translation: AAB69736.1.
BK006934 Genomic DNA. Translation: DAA06900.1.
PIRiS48988.
RefSeqiNP_012077.1. NM_001179338.1.

Genome annotation databases

EnsemblFungiiYHR207C; YHR207C; YHR207C.
GeneIDi856614.
KEGGisce:YHR207C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00029 Genomic DNA. Translation: AAB69736.1 .
BK006934 Genomic DNA. Translation: DAA06900.1 .
PIRi S48988.
RefSeqi NP_012077.1. NM_001179338.1.

3D structure databases

ProteinModelPortali P38890.
SMRi P38890. Positions 339-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36641. 47 interactions.
DIPi DIP-2725N.
IntActi P38890. 14 interactions.
MINTi MINT-402807.
STRINGi 4932.YHR207C.

Proteomic databases

MaxQBi P38890.
PaxDbi P38890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR207C ; YHR207C ; YHR207C .
GeneIDi 856614.
KEGGi sce:YHR207C.

Organism-specific databases

CYGDi YHR207c.
SGDi S000001250. SET5.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000074714.
KOi K07117.
OMAi RITERNQ.
OrthoDBi EOG7Q5HPF.

Enzyme and pathway databases

BioCyci YEAST:G3O-31233-MONOMER.

Miscellaneous databases

NextBioi 982538.

Gene expression databases

Genevestigatori P38890.

Family and domain databases

InterProi IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins."
    Boehm S., Frishman D., Mewes H.-W.
    Nucleic Acids Res. 25:2464-2469(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus."
    Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., Ahlquist P.
    Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSET5_YEAST
AccessioniPrimary (citable) accession number: P38890
Secondary accession number(s): D3DLF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5000 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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