P38890 (SET5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative protein lysine methyltransferase SET5
EC=2.1.1.-

Alternative name(s):
SET domain-containing protein 5

Gene names

Name:	SET5
Ordered Locus Names:	YHR207C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV. Ref.6
Subcellular location	Cytoplasm. Nucleus Ref.4.
Miscellaneous	Present with 5000 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the SET5 family. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Methyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from mutant phenotype PubMed 22343720. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay Ref.4. Source: SGD nuclear chromatin Inferred from direct assay PubMed 22343720. Source: SGD
Molecular_function	S-adenosylmethionine-dependent methyltransferase activity Inferred from direct assay PubMed 22343720. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Putative protein lysine methyltransferase SET5		PRO_0000202942
Regions
	Domain	111 – 407	297	SET
Amino acid modifications
	Modified residue	458	1	Phosphoserine Ref.8
	Modified residue	475	1	Phosphoserine Ref.7
	Modified residue	476	1	Phosphoserine Ref.7
	Modified residue	517	1	Phosphoserine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P38890 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 1113CB9C5223DC7D	FASTA	526	60,547
	10 20 30 40 50 60 MTLTIKIGTL NDSDQSAVHN GTENGSDFRK ITPTEEEICD DVVLLWKEEP GTEDATIQHL 70 80 90 100 110 120 YDRITERNQS WKLSASRFRK ILNEHHLYDT DLETVSLYKD KIHFPKALDS DAKVEVKFID 130 140 150 160 170 180 DEHGRGLFAK RDFSKGQIIL KENKPIVYIP PLDKLFLISN GKACARCGKA LYDLTQHKIM 190 200 210 220 230 240 VHYLDCEVCK AIWCSEKCKK AHASLHELLY HSWRSNRIDI LHAGNWKRFV NYCEKYCFTA 250 260 270 280 290 300 AFSVGLIYGS MLLDTTGEVK EQWQKLASIS QRERIKLRDA SGIGSTFSLL NGTTVHTEEE 310 320 330 340 350 360 SDNGTKKGVE KNIDDETVWE KCYELFCGAF PKASEEIDFE KFLTMIGTFN INQYNGQVYH 370 380 390 400 410 420 WISFINHDCE PNAYIEQVEE HEELRLHARK PIKKGEQIRI TYVNPLHGVR LRRRELRVNW 430 440 450 460 470 480 GFLCQCDRCQ NELSTFERVP NLEKKNADAN LGVEKIDSND SSEDGSKKST GNRKSSMREA 490 500 510 520 QPDLKEILKN GKEFELDIPE TVDTQGNVRK TSVRFDSNVS VAVDER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins." Boehm S., Frishman D., Mewes H.-W. Nucleic Acids Res. 25:2464-2469(1997) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus." Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., Ahlquist P. Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475 AND SER-476, MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458 AND SER-517, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00029 Genomic DNA. Translation: AAB69736.1. BK006934 Genomic DNA. Translation: DAA06900.1.
PIR	S48988.
RefSeq	NP_012077.1. NM_001179338.1.
3D structure databases
ProteinModelPortal	P38890.
SMR	P38890. Positions 339-432.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2725N.
IntAct	P38890. 14 interactions.
MINT	MINT-402807.
STRING	4932.YHR207C.
Proteomic databases
PaxDb	P38890.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR207C; YHR207C; YHR207C.
GeneID	856614.
KEGG	sce:YHR207C.
Organism-specific databases
CYGD	YHR207c.
SGD	S000001250. SET5.
Phylogenomic databases
eggNOG	COG2940.
HOGENOM	HOG000074714.
KO	K07117.
OMA	LRVNWGF.
OrthoDB	EOG422DTP.
Gene expression databases
Genevestigator	P38890.
GermOnline	YHR207C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982538.

Entry information

Entry name

SET5_YEAST

Accession

Primary (citable) accession number: P38890
Secondary accession number(s): D3DLF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program