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P38890

- SET5_YEAST

UniProt

P38890 - SET5_YEAST

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Protein

Putative protein lysine methyltransferase SET5

Gene

SET5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Putative protein lysine methyltransferase that acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV.1 Publication

GO - Molecular functioni

  1. S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  1. histone lysine methylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-31233-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein lysine methyltransferase SET5 (EC:2.1.1.-)
Alternative name(s):
SET domain-containing protein 5
Gene namesi
Name:SET5
Ordered Locus Names:YHR207C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR207c.
SGDiS000001250. SET5.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nuclear chromatin Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Putative protein lysine methyltransferase SET5PRO_0000202942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei517 – 5171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38890.
PaxDbiP38890.

Expressioni

Gene expression databases

GenevestigatoriP38890.

Interactioni

Protein-protein interaction databases

BioGridi36641. 47 interactions.
DIPiDIP-2725N.
IntActiP38890. 14 interactions.
MINTiMINT-402807.
STRINGi4932.YHR207C.

Structurei

3D structure databases

ProteinModelPortaliP38890.
SMRiP38890. Positions 110-140, 339-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 403292SETPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000074714.
InParanoidiP38890.
KOiK07117.
OMAiRITERNQ.
OrthoDBiEOG7Q5HPF.

Family and domain databases

InterProiIPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38890-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLTIKIGTL NDSDQSAVHN GTENGSDFRK ITPTEEEICD DVVLLWKEEP
60 70 80 90 100
GTEDATIQHL YDRITERNQS WKLSASRFRK ILNEHHLYDT DLETVSLYKD
110 120 130 140 150
KIHFPKALDS DAKVEVKFID DEHGRGLFAK RDFSKGQIIL KENKPIVYIP
160 170 180 190 200
PLDKLFLISN GKACARCGKA LYDLTQHKIM VHYLDCEVCK AIWCSEKCKK
210 220 230 240 250
AHASLHELLY HSWRSNRIDI LHAGNWKRFV NYCEKYCFTA AFSVGLIYGS
260 270 280 290 300
MLLDTTGEVK EQWQKLASIS QRERIKLRDA SGIGSTFSLL NGTTVHTEEE
310 320 330 340 350
SDNGTKKGVE KNIDDETVWE KCYELFCGAF PKASEEIDFE KFLTMIGTFN
360 370 380 390 400
INQYNGQVYH WISFINHDCE PNAYIEQVEE HEELRLHARK PIKKGEQIRI
410 420 430 440 450
TYVNPLHGVR LRRRELRVNW GFLCQCDRCQ NELSTFERVP NLEKKNADAN
460 470 480 490 500
LGVEKIDSND SSEDGSKKST GNRKSSMREA QPDLKEILKN GKEFELDIPE
510 520
TVDTQGNVRK TSVRFDSNVS VAVDER
Length:526
Mass (Da):60,547
Last modified:February 1, 1995 - v1
Checksum:i1113CB9C5223DC7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00029 Genomic DNA. Translation: AAB69736.1.
BK006934 Genomic DNA. Translation: DAA06900.1.
PIRiS48988.
RefSeqiNP_012077.1. NM_001179338.1.

Genome annotation databases

EnsemblFungiiYHR207C; YHR207C; YHR207C.
GeneIDi856614.
KEGGisce:YHR207C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00029 Genomic DNA. Translation: AAB69736.1 .
BK006934 Genomic DNA. Translation: DAA06900.1 .
PIRi S48988.
RefSeqi NP_012077.1. NM_001179338.1.

3D structure databases

ProteinModelPortali P38890.
SMRi P38890. Positions 110-140, 339-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36641. 47 interactions.
DIPi DIP-2725N.
IntActi P38890. 14 interactions.
MINTi MINT-402807.
STRINGi 4932.YHR207C.

Proteomic databases

MaxQBi P38890.
PaxDbi P38890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR207C ; YHR207C ; YHR207C .
GeneIDi 856614.
KEGGi sce:YHR207C.

Organism-specific databases

CYGDi YHR207c.
SGDi S000001250. SET5.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000074714.
InParanoidi P38890.
KOi K07117.
OMAi RITERNQ.
OrthoDBi EOG7Q5HPF.

Enzyme and pathway databases

BioCyci YEAST:G3O-31233-MONOMER.

Miscellaneous databases

NextBioi 982538.

Gene expression databases

Genevestigatori P38890.

Family and domain databases

InterProi IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins."
    Boehm S., Frishman D., Mewes H.-W.
    Nucleic Acids Res. 25:2464-2469(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus."
    Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., Ahlquist P.
    Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSET5_YEAST
AccessioniPrimary (citable) accession number: P38890
Secondary accession number(s): D3DLF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3