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P38883

- RIX1_YEAST

UniProt

P38883 - RIX1_YEAST

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Protein

Pre-rRNA-processing protein RIX1

Gene

RIX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: SGD

GO - Biological processi

  1. pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  2. regulation of DNA-dependent DNA replication initiation Source: SGD
  3. ribosomal large subunit assembly Source: SGD
  4. ribosomal subunit export from nucleus Source: SGD
  5. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31225-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein RIX1
Alternative name(s):
Involved in processing IST2 protein 2
Ribosomal export protein 1
Gene namesi
Name:RIX1
Synonyms:IPI2
Ordered Locus Names:YHR197W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR197w.
SGDiS000001240. RIX1.

Subcellular locationi

Nucleus 3 Publications

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleoplasm Source: SGD
  3. nucleus Source: SGD
  4. Rix1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 763762Pre-rRNA-processing protein RIX1PRO_0000202938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP38883.
PaxDbiP38883.
PeptideAtlasiP38883.

Expressioni

Gene expression databases

GenevestigatoriP38883.

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles. Interacts with NUG1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IPI3P538777EBI-24899,EBI-29063

Protein-protein interaction databases

BioGridi36631. 97 interactions.
DIPiDIP-804N.
IntActiP38883. 45 interactions.
MINTiMINT-403308.
STRINGi4932.YHR197W.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi690 – 76374Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the RIX1 family.Curated

Phylogenomic databases

eggNOGiNOG45551.
HOGENOMiHOG000154134.
InParanoidiP38883.
KOiK14828.
OMAiWCGINLI.
OrthoDBiEOG7MKWG4.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38883-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEEFIAVST LARNLEIAKG NEFHTILATL RSPVYINEQL LKSELSFLVT
60 70 80 90 100
KILKLIRSGN DFDLWKGCHT SVVTCAYNPL VLSTHGGQLL AAIYSRLEQK
110 120 130 140 150
TGFYSSVISS SHGKQLFNTL ISSVAIIIDL MKNKPTLSRE ALVPKLKAII
160 170 180 190 200
PTLITLSQYE PELVLPVLQR ILKRNTTTFK PFTNKFRTVL INLIISDYAS
210 220 230 240 250
LGTKTQRLVC ENFAYLHLLK IQVSDTSDDE TQAHHKIYAD SNWRTGLMSI
260 270 280 290 300
LSQFKPIIQL CGEILDFEQD NELYKLIKSL PVIDESNNKE EFLPSLKLDF
310 320 330 340 350
NAPLTLWEIP QRLSLLADML VAFISLPTPF PIRVPLGGIN SLCEVLLGVS
360 370 380 390 400
NKYLPLKKEL RHDNELNGVI NTILPQIQFQ GIRLWEIMVS KYGKCGLSFF
410 420 430 440 450
EGILSSIELF IPLKKKSNNE IDFNVVGSLK FEFATVFRLV NMILSHLGHQ
460 470 480 490 500
LNIISVISQL IEVALFLSHD KTLIDSLFKN RKSIMKQQTK TKQSKRSKSA
510 520 530 540 550
EGAFSDIYTH PELFVCKNSM NWFNEINDFF ITALNNWILP STPHIQILKY
560 570 580 590 600
SITQSLRLKE RFGYIPESFV NLLRCEVLHP GSERVSILPI AISLLKNIND
610 620 630 640 650
DMFELLCHPK VPVGMVYQLH KPLDLGEDGE VRDDINKKEV ETNESSSNAN
660 670 680 690 700
TGLETLKALE NLENVTIPEP KHEVPKVVDD TAIFKKRSVE EVIERESTSS
710 720 730 740 750
HKKVKFVEET TVDNGEELIV KKAVSQTKEE EKPMEDSEDE EQEEFEIPAI
760
ELSDDEEEEE EEE
Length:763
Mass (Da):86,739
Last modified:July 27, 2011 - v2
Checksum:i14A0CE9A21F11711
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti762 – 7621E → G in AAB68356. (PubMed:8091229)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. Translation: AAB68356.1.
BK006934 Genomic DNA. Translation: DAA06889.2.
PIRiS46678.
RefSeqiNP_012067.4. NM_001179328.4.

Genome annotation databases

EnsemblFungiiYHR197W; YHR197W; YHR197W.
GeneIDi856604.
KEGGisce:YHR197W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. Translation: AAB68356.1 .
BK006934 Genomic DNA. Translation: DAA06889.2 .
PIRi S46678.
RefSeqi NP_012067.4. NM_001179328.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36631. 97 interactions.
DIPi DIP-804N.
IntActi P38883. 45 interactions.
MINTi MINT-403308.
STRINGi 4932.YHR197W.

Proteomic databases

MaxQBi P38883.
PaxDbi P38883.
PeptideAtlasi P38883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR197W ; YHR197W ; YHR197W .
GeneIDi 856604.
KEGGi sce:YHR197W.

Organism-specific databases

CYGDi YHR197w.
SGDi S000001240. RIX1.

Phylogenomic databases

eggNOGi NOG45551.
HOGENOMi HOG000154134.
InParanoidi P38883.
KOi K14828.
OMAi WCGINLI.
OrthoDBi EOG7MKWG4.

Enzyme and pathway databases

BioCyci YEAST:G3O-31225-MONOMER.

Miscellaneous databases

NextBioi 982508.

Gene expression databases

Genevestigatori P38883.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 762.
    Strain: ATCC 204508 / S288c.
  3. "Identification of a 60S preribosomal particle that is closely linked to nuclear export."
    Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E.
    Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NUG1.
  4. "Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p."
    Gadal O., Strauss D., Kessl J., Trumpower B., Tollervey D., Hurt E.
    Mol. Cell. Biol. 21:3405-3415(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
    Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
    J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE RIX1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
    Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
    Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, INTERACTION WITH MDN1 AND PRE-60S RIBOSOMAL PARTICLES, IDENTIFICATION BY MASS SPECTROMETRY.
  10. Cited for: IDENTIFICATION IN THE RIX1 COMPLEX, FUNCTION OF THE RIX1 COMPLEX.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRIX1_YEAST
AccessioniPrimary (citable) accession number: P38883
Secondary accession number(s): D3DLE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7820 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3