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Protein

Pre-rRNA-processing protein RIX1

Gene

RIX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.3 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • ribosomal subunit export from nucleus Source: SGD
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31225-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein RIX1
Alternative name(s):
Involved in processing IST2 protein 2
Ribosomal export protein 1
Gene namesi
Name:RIX1
Synonyms:IPI2
Ordered Locus Names:YHR197W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR197W.
SGDiS000001240. RIX1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleoplasm Source: SGD
  • nucleus Source: SGD
  • Rix1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 763762Pre-rRNA-processing protein RIX1PRO_0000202938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP38883.

PTM databases

iPTMnetiP38883.

Interactioni

Subunit structurei

Component of the RIX1 complex, composed of at least IPI1, IPI3 and RIX1. The complex interacts with MDN1 and the pre-60S ribosome particles. Interacts with NUG1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IPI3P538777EBI-24899,EBI-29063

Protein-protein interaction databases

BioGridi36631. 92 interactions.
DIPiDIP-804N.
IntActiP38883. 46 interactions.
MINTiMINT-403308.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi690 – 76374Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the RIX1 family.Curated

Phylogenomic databases

HOGENOMiHOG000154134.
InParanoidiP38883.
KOiK14828.
OMAiWCGINLI.
OrthoDBiEOG092C0SY4.

Family and domain databases

InterProiIPR012583. RIX1_N.
[Graphical view]
PfamiPF08167. RIX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEFIAVST LARNLEIAKG NEFHTILATL RSPVYINEQL LKSELSFLVT
60 70 80 90 100
KILKLIRSGN DFDLWKGCHT SVVTCAYNPL VLSTHGGQLL AAIYSRLEQK
110 120 130 140 150
TGFYSSVISS SHGKQLFNTL ISSVAIIIDL MKNKPTLSRE ALVPKLKAII
160 170 180 190 200
PTLITLSQYE PELVLPVLQR ILKRNTTTFK PFTNKFRTVL INLIISDYAS
210 220 230 240 250
LGTKTQRLVC ENFAYLHLLK IQVSDTSDDE TQAHHKIYAD SNWRTGLMSI
260 270 280 290 300
LSQFKPIIQL CGEILDFEQD NELYKLIKSL PVIDESNNKE EFLPSLKLDF
310 320 330 340 350
NAPLTLWEIP QRLSLLADML VAFISLPTPF PIRVPLGGIN SLCEVLLGVS
360 370 380 390 400
NKYLPLKKEL RHDNELNGVI NTILPQIQFQ GIRLWEIMVS KYGKCGLSFF
410 420 430 440 450
EGILSSIELF IPLKKKSNNE IDFNVVGSLK FEFATVFRLV NMILSHLGHQ
460 470 480 490 500
LNIISVISQL IEVALFLSHD KTLIDSLFKN RKSIMKQQTK TKQSKRSKSA
510 520 530 540 550
EGAFSDIYTH PELFVCKNSM NWFNEINDFF ITALNNWILP STPHIQILKY
560 570 580 590 600
SITQSLRLKE RFGYIPESFV NLLRCEVLHP GSERVSILPI AISLLKNIND
610 620 630 640 650
DMFELLCHPK VPVGMVYQLH KPLDLGEDGE VRDDINKKEV ETNESSSNAN
660 670 680 690 700
TGLETLKALE NLENVTIPEP KHEVPKVVDD TAIFKKRSVE EVIERESTSS
710 720 730 740 750
HKKVKFVEET TVDNGEELIV KKAVSQTKEE EKPMEDSEDE EQEEFEIPAI
760
ELSDDEEEEE EEE
Length:763
Mass (Da):86,739
Last modified:July 27, 2011 - v2
Checksum:i14A0CE9A21F11711
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti762 – 7621E → G in AAB68356 (PubMed:8091229).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. Translation: AAB68356.1.
BK006934 Genomic DNA. Translation: DAA06889.2.
PIRiS46678.
RefSeqiNP_012067.4. NM_001179328.4.

Genome annotation databases

EnsemblFungiiYHR197W; YHR197W; YHR197W.
GeneIDi856604.
KEGGisce:YHR197W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. Translation: AAB68356.1.
BK006934 Genomic DNA. Translation: DAA06889.2.
PIRiS46678.
RefSeqiNP_012067.4. NM_001179328.4.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36631. 92 interactions.
DIPiDIP-804N.
IntActiP38883. 46 interactions.
MINTiMINT-403308.

PTM databases

iPTMnetiP38883.

Proteomic databases

MaxQBiP38883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR197W; YHR197W; YHR197W.
GeneIDi856604.
KEGGisce:YHR197W.

Organism-specific databases

EuPathDBiFungiDB:YHR197W.
SGDiS000001240. RIX1.

Phylogenomic databases

HOGENOMiHOG000154134.
InParanoidiP38883.
KOiK14828.
OMAiWCGINLI.
OrthoDBiEOG092C0SY4.

Enzyme and pathway databases

BioCyciYEAST:G3O-31225-MONOMER.

Miscellaneous databases

PROiP38883.

Family and domain databases

InterProiIPR012583. RIX1_N.
[Graphical view]
PfamiPF08167. RIX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIX1_YEAST
AccessioniPrimary (citable) accession number: P38883
Secondary accession number(s): D3DLE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7820 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.