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P38882 (UTP9_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar RNA-associated protein 9

Short name=U3 snoRNA-associated protein 9
Alternative name(s):
U three protein 9
U3 protein 9 required for transcription
t-UTP9
Gene names
Name:UTP9
Ordered Locus Names:YHR196W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Ref.3 Ref.5

Subunit structure

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs. Ref.3 Ref.5

Subcellular location

Nucleusnucleolus. Note: Associated with ribosomal chromatin, even in the absence of transcription. Ref.3 Ref.5

Miscellaneous

Present with 20000 molecules/cell in log phase SD medium.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UTP15Q043054EBI-24892,EBI-28183
UTP8P532763EBI-24892,EBI-23301

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 575575U3 small nucleolar RNA-associated protein 9
PRO_0000065744

Amino acid modifications

Modified residue5471Phosphoserine Ref.6
Modified residue5641Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P38882 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 0C482C6A32855FF1

FASTA57565,271
        10         20         30         40         50         60 
MGSSLDLVAS FSHDSTRFAF QASVAQKNNV DIYPLNETKD YVVNSSLVSH IDYETNDMKV 

        70         80         90        100        110        120 
SDVIFFGWCS DLIDTQSSNI KRKLDEDEGT GESSEQRCEN FFVNGFPDGR IVVYSSNGKD 

       130        140        150        160        170        180 
IVNIIKNKKE ILGADTDESD IWILDSDKVV KKLQYNNSKP LKTFTLVDGK DDEIVHFQIL 

       190        200        210        220        230        240 
HQNGTLLVCI ITKQMVYIVD PSKRRPSTKY SFEISDAVAC EFSSDGKYLL IANNEELIAY 

       250        260        270        280        290        300 
DLKEDSKLIQ SWPVQVKTLK TLDDLIMALT TDGKINNYKI GEADKVCSIV VNEDLEIIDF 

       310        320        330        340        350        360 
TPINSKQQVL ISWLNVNEPN FESISLKEIE TQGYITINKN EKNNADEADQ KKLEEKEEEA 

       370        380        390        400        410        420 
QPEVQHEKKE TETKINKKVS KSDQVEIANI LSSHLEANST EILDDLMSGS WTEPEIKKFI 

       430        440        450        460        470        480 
LTKINTVDHL SKIFLTISKS ITQNPWNEEN LLPLWLKWLL TLKSGELNSI KDKHTKKNCK 

       490        500        510        520        530        540 
HLKSALRSSE EILPVLLGIQ GRLEMLRRQA KLREDLAQLS MQEGEDDEIE VIEHSNVISN 

       550        560        570 
PLQDQASPVE KLEPDSIVYA NGESDEFVDA SEYKD 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.
Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547 AND SER-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00030 Genomic DNA. Translation: AAB68369.1.
BK006934 Genomic DNA. Translation: DAA06888.1.
PIRS46692.
RefSeqNP_012066.1. NM_001179327.1.

3D structure databases

ProteinModelPortalP38882.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36630. 93 interactions.
DIPDIP-6634N.
IntActP38882. 52 interactions.
MINTMINT-628324.
STRING4932.YHR196W.

Proteomic databases

PaxDbP38882.
PeptideAtlasP38882.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR196W; YHR196W; YHR196W.
GeneID856603.
KEGGsce:YHR196W.

Organism-specific databases

CYGDYHR196w.
SGDS000001239. UTP9.

Phylogenomic databases

eggNOGNOG47655.
HOGENOMHOG000000891.
KOK14551.
OMANVNEPNF.
OrthoDBEOG7BZW27.

Enzyme and pathway databases

BioCycYEAST:G3O-31224-MONOMER.

Gene expression databases

GenevestigatorP38882.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
ProtoNetSearch...

Other

NextBio982505.

Entry information

Entry nameUTP9_YEAST
AccessionPrimary (citable) accession number: P38882
Secondary accession number(s): D3DLE4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD