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P38882

- UTP9_YEAST

UniProt

P38882 - UTP9_YEAST

Protein

U3 small nucleolar RNA-associated protein 9

Gene

UTP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. snoRNA binding Source: SGD

    GO - Biological processi

    1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. positive regulation of transcription from RNA polymerase I promoter Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing, Transcription

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31224-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 9
    Short name:
    U3 snoRNA-associated protein 9
    Alternative name(s):
    U three protein 9
    U3 protein 9 required for transcription
    t-UTP9
    Gene namesi
    Name:UTP9
    Ordered Locus Names:YHR196W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR196w.
    SGDiS000001239. UTP9.

    Subcellular locationi

    Nucleusnucleolus 2 Publications
    Note: Associated with ribosomal chromatin, even in the absence of transcription.

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. rDNA heterochromatin Source: SGD
    3. small-subunit processome Source: SGD
    4. t-UTP complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 575575U3 small nucleolar RNA-associated protein 9PRO_0000065744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei547 – 5471Phosphoserine1 Publication
    Modified residuei564 – 5641Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38882.
    PaxDbiP38882.
    PeptideAtlasiP38882.

    Expressioni

    Gene expression databases

    GenevestigatoriP38882.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UTP15Q043054EBI-24892,EBI-28183
    UTP8P532763EBI-24892,EBI-23301

    Protein-protein interaction databases

    BioGridi36630. 93 interactions.
    DIPiDIP-6634N.
    IntActiP38882. 52 interactions.
    MINTiMINT-628324.
    STRINGi4932.YHR196W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38882.
    SMRiP38882. Positions 60-86, 494-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG47655.
    HOGENOMiHOG000000891.
    KOiK14551.
    OMAiSHIDYET.
    OrthoDBiEOG7BZW27.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38882-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSLDLVAS FSHDSTRFAF QASVAQKNNV DIYPLNETKD YVVNSSLVSH    50
    IDYETNDMKV SDVIFFGWCS DLIDTQSSNI KRKLDEDEGT GESSEQRCEN 100
    FFVNGFPDGR IVVYSSNGKD IVNIIKNKKE ILGADTDESD IWILDSDKVV 150
    KKLQYNNSKP LKTFTLVDGK DDEIVHFQIL HQNGTLLVCI ITKQMVYIVD 200
    PSKRRPSTKY SFEISDAVAC EFSSDGKYLL IANNEELIAY DLKEDSKLIQ 250
    SWPVQVKTLK TLDDLIMALT TDGKINNYKI GEADKVCSIV VNEDLEIIDF 300
    TPINSKQQVL ISWLNVNEPN FESISLKEIE TQGYITINKN EKNNADEADQ 350
    KKLEEKEEEA QPEVQHEKKE TETKINKKVS KSDQVEIANI LSSHLEANST 400
    EILDDLMSGS WTEPEIKKFI LTKINTVDHL SKIFLTISKS ITQNPWNEEN 450
    LLPLWLKWLL TLKSGELNSI KDKHTKKNCK HLKSALRSSE EILPVLLGIQ 500
    GRLEMLRRQA KLREDLAQLS MQEGEDDEIE VIEHSNVISN PLQDQASPVE 550
    KLEPDSIVYA NGESDEFVDA SEYKD 575
    Length:575
    Mass (Da):65,271
    Last modified:February 1, 1995 - v1
    Checksum:i0C482C6A32855FF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00030 Genomic DNA. Translation: AAB68369.1.
    BK006934 Genomic DNA. Translation: DAA06888.1.
    PIRiS46692.
    RefSeqiNP_012066.1. NM_001179327.1.

    Genome annotation databases

    EnsemblFungiiYHR196W; YHR196W; YHR196W.
    GeneIDi856603.
    KEGGisce:YHR196W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00030 Genomic DNA. Translation: AAB68369.1 .
    BK006934 Genomic DNA. Translation: DAA06888.1 .
    PIRi S46692.
    RefSeqi NP_012066.1. NM_001179327.1.

    3D structure databases

    ProteinModelPortali P38882.
    SMRi P38882. Positions 60-86, 494-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36630. 93 interactions.
    DIPi DIP-6634N.
    IntActi P38882. 52 interactions.
    MINTi MINT-628324.
    STRINGi 4932.YHR196W.

    Proteomic databases

    MaxQBi P38882.
    PaxDbi P38882.
    PeptideAtlasi P38882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR196W ; YHR196W ; YHR196W .
    GeneIDi 856603.
    KEGGi sce:YHR196W.

    Organism-specific databases

    CYGDi YHR196w.
    SGDi S000001239. UTP9.

    Phylogenomic databases

    eggNOGi NOG47655.
    HOGENOMi HOG000000891.
    KOi K14551.
    OMAi SHIDYET.
    OrthoDBi EOG7BZW27.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31224-MONOMER.

    Miscellaneous databases

    NextBioi 982505.

    Gene expression databases

    Genevestigatori P38882.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
      Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
      Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547 AND SER-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUTP9_YEAST
    AccessioniPrimary (citable) accession number: P38882
    Secondary accession number(s): D3DLE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 20000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3