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P38873

- KOG1_YEAST

UniProt

P38873 - KOG1_YEAST

Protein

Target of rapamycin complex 1 subunit KOG1

Gene

KOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitin binding Source: SGD

    GO - Biological processi

    1. cellular response to starvation Source: SGD
    2. regulation of cell growth Source: SGD
    3. TOR signaling Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31216-MONOMER.
    ReactomeiREACT_188481. S6K1-mediated signalling.
    REACT_209479. Regulation of AMPK activity via LKB1.
    REACT_219346. HSF1-dependent transactivation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Target of rapamycin complex 1 subunit KOG1
    Short name:
    TORC1 subunit KOG1
    Alternative name(s):
    Kontroller of growth protein 1
    Local anesthetic-sensitive protein 24
    Gene namesi
    Name:KOG1
    Synonyms:LAS24
    Ordered Locus Names:YHR186C
    ORF Names:H9998.14
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR186c.
    SGDiS000001229. KOG1.

    Subcellular locationi

    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
    Note: Also localizes to membranous structures within the cell interior, probably endosomal or Golgi membranes.

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: SGD
    2. plasma membrane Source: SGD
    3. TORC1 complex Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15571557Target of rapamycin complex 1 subunit KOG1PRO_0000051476Add
    BLAST

    Proteomic databases

    MaxQBiP38873.
    PaxDbiP38873.

    Expressioni

    Gene expression databases

    GenevestigatoriP38873.

    Interactioni

    Subunit structurei

    The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LST8P413183EBI-24864,EBI-28598
    TOR1P351697EBI-24864,EBI-19374

    Protein-protein interaction databases

    BioGridi36620. 77 interactions.
    DIPiDIP-2639N.
    IntActiP38873. 32 interactions.
    MINTiMINT-426011.
    STRINGi4932.YHR186C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38873.
    SMRiP38873. Positions 1353-1433, 1521-1549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati548 – 58639HEAT 1Add
    BLAST
    Repeati588 – 62538HEAT 2Add
    BLAST
    Repeati777 – 81438HEAT 3Add
    BLAST
    Repeati888 – 92538HEAT 4Add
    BLAST
    Repeati1207 – 124842WD 1Add
    BLAST
    Repeati1252 – 129342WD 2Add
    BLAST
    Repeati1296 – 134651WD 3Add
    BLAST
    Repeati1350 – 139041WD 4Add
    BLAST
    Repeati1400 – 144041WD 5Add
    BLAST
    Repeati1452 – 149241WD 6Add
    BLAST
    Repeati1517 – 155741WD 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi513 – 52513Poly-GlnAdd
    BLAST
    Compositional biasi846 – 85510Poly-Gln

    Sequence similaritiesi

    Contains 4 HEAT repeats.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG269318.
    GeneTreeiENSGT00640000091541.
    HOGENOMiHOG000184479.
    KOiK07204.
    OMAiFCDWSAK.
    OrthoDBiEOG7D864S.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    2.130.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    IPR004083. Raptor.
    IPR029347. Raptor_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR12848. PTHR12848. 1 hit.
    PfamiPF02985. HEAT. 1 hit.
    PF14538. Raptor_N. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38873-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN     50
    GNPIPEEDKQ RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV 100
    MKTHPCARVE AWVDPLNFQD SKKAIEQIGK NLQAQYETLS LRTRYKQSLD 150
    PCVEDVKRFC NSLRRTSKED RILFHYNGHG VPKPTKSGEI WVFNRGYTQY 200
    IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI KDDEEGNHDV 250
    AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF 300
    LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP 350
    LGELNWIFTA ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP 400
    WYNCHPVSDP ELPDSITTHP MWKSWDLAMD EVLTKIVIDL KNAPPATALE 450
    SQMILQQQET LQNGGSSKSN AQDTKAGSIQ TQSRFAVANL STMSLVNNPA 500
    LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW LKYASNVRHP 550
    PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL 600
    LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV 650
    NGMSATNGSA MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL 700
    PFYHSNDTTD EQKAMAVFVL ASFVRNFPLG QKNCFSLELV NKLCFYIDNS 750
    EIPLLRQWCV ILLGLLFADN PLNRFVCMNT GAVEILLKSL KDPVPEVRTA 800
    SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ NQSHLQQQQS 850
    QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL 900
    INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR 950
    NTSDKYSVSQ GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH 1000
    KELGGPFAVM EKFLLKRSSK AHQTGKFGFN SSQVQFVKSS LRSFSPNERV 1050
    DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS LGFSESNSDS DTQSSNTSMK 1100
    SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL NSSFLDYSRE 1150
    YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS 1200
    KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG 1250
    TPFGTKVTDL KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG 1300
    LTDMLLTPRS TGLLTEWLQI RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK 1350
    TSSLITSLTA DQLAGNIFVA GFADGSLRVY DRRLDPRDSM IRRWRAGNDK 1400
    QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES FVDQNVTSQY 1450
    GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT 1500
    STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE 1550
    DERIDYF 1557
    Length:1,557
    Mass (Da):177,609
    Last modified:January 9, 2007 - v2
    Checksum:iB927EE93700176D3
    GO

    Sequence cautioni

    The sequence AAB68364.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00030 Genomic DNA. Translation: AAB68364.1. Different initiation.
    BK006934 Genomic DNA. Translation: DAA06878.1.
    PIRiS46686.
    RefSeqiNP_012056.1. NM_001179317.1.

    Genome annotation databases

    EnsemblFungiiYHR186C; YHR186C; YHR186C.
    GeneIDi856593.
    KEGGisce:YHR186C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00030 Genomic DNA. Translation: AAB68364.1 . Different initiation.
    BK006934 Genomic DNA. Translation: DAA06878.1 .
    PIRi S46686.
    RefSeqi NP_012056.1. NM_001179317.1.

    3D structure databases

    ProteinModelPortali P38873.
    SMRi P38873. Positions 1353-1433, 1521-1549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36620. 77 interactions.
    DIPi DIP-2639N.
    IntActi P38873. 32 interactions.
    MINTi MINT-426011.
    STRINGi 4932.YHR186C.

    Proteomic databases

    MaxQBi P38873.
    PaxDbi P38873.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR186C ; YHR186C ; YHR186C .
    GeneIDi 856593.
    KEGGi sce:YHR186C.

    Organism-specific databases

    CYGDi YHR186c.
    SGDi S000001229. KOG1.

    Phylogenomic databases

    eggNOGi NOG269318.
    GeneTreei ENSGT00640000091541.
    HOGENOMi HOG000184479.
    KOi K07204.
    OMAi FCDWSAK.
    OrthoDBi EOG7D864S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31216-MONOMER.
    Reactomei REACT_188481. S6K1-mediated signalling.
    REACT_209479. Regulation of AMPK activity via LKB1.
    REACT_219346. HSF1-dependent transactivation.

    Miscellaneous databases

    NextBioi 982475.
    PROi P38873.

    Gene expression databases

    Genevestigatori P38873.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    2.130.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    IPR004083. Raptor.
    IPR029347. Raptor_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR12848. PTHR12848. 1 hit.
    Pfami PF02985. HEAT. 1 hit.
    PF14538. Raptor_N. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."
      Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N.
      Mol. Cell 10:457-468(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TORC1, IDENTIFICATION BY MASS SPECTROMETRY.
    4. "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae."
      Wedaman K.P., Reinke A., Anderson S., Yates J.R. III, McCaffery J.M., Powers T.
      Mol. Biol. Cell 14:1204-1220(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH TOR1.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. "LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast."
      Araki T., Uesono Y., Oguchi T., Toh-e A.
      Genes Genet. Syst. 80:325-343(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKOG1_YEAST
    AccessioniPrimary (citable) accession number: P38873
    Secondary accession number(s): D3DLD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3