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P38873

- KOG1_YEAST

UniProt

P38873 - KOG1_YEAST

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Protein
Target of rapamycin complex 1 subunit KOG1
Gene
KOG1, LAS24, YHR186C, H9998.14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. ubiquitin binding Source: SGD

GO - Biological processi

  1. TOR signaling Source: SGD
  2. cellular response to starvation Source: SGD
  3. regulation of cell growth Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31216-MONOMER.
ReactomeiREACT_188481. S6K1-mediated signalling.
REACT_209479. Regulation of AMPK activity via LKB1.
REACT_219346. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Target of rapamycin complex 1 subunit KOG1
Short name:
TORC1 subunit KOG1
Alternative name(s):
Kontroller of growth protein 1
Local anesthetic-sensitive protein 24
Gene namesi
Name:KOG1
Synonyms:LAS24
Ordered Locus Names:YHR186C
ORF Names:H9998.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR186c.
SGDiS000001229. KOG1.

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
Note: Also localizes to membranous structures within the cell interior, probably endosomal or Golgi membranes.3 Publications

GO - Cellular componenti

  1. TORC1 complex Source: SGD
  2. fungal-type vacuole membrane Source: SGD
  3. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15571557Target of rapamycin complex 1 subunit KOG1
PRO_0000051476Add
BLAST

Proteomic databases

MaxQBiP38873.
PaxDbiP38873.

Expressioni

Gene expression databases

GenevestigatoriP38873.

Interactioni

Subunit structurei

The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LST8P413183EBI-24864,EBI-28598
TOR1P351697EBI-24864,EBI-19374

Protein-protein interaction databases

BioGridi36620. 77 interactions.
DIPiDIP-2639N.
IntActiP38873. 32 interactions.
MINTiMINT-426011.
STRINGi4932.YHR186C.

Structurei

3D structure databases

ProteinModelPortaliP38873.
SMRiP38873. Positions 1353-1433, 1521-1549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati548 – 58639HEAT 1
Add
BLAST
Repeati588 – 62538HEAT 2
Add
BLAST
Repeati777 – 81438HEAT 3
Add
BLAST
Repeati888 – 92538HEAT 4
Add
BLAST
Repeati1207 – 124842WD 1
Add
BLAST
Repeati1252 – 129342WD 2
Add
BLAST
Repeati1296 – 134651WD 3
Add
BLAST
Repeati1350 – 139041WD 4
Add
BLAST
Repeati1400 – 144041WD 5
Add
BLAST
Repeati1452 – 149241WD 6
Add
BLAST
Repeati1517 – 155741WD 7
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi513 – 52513Poly-Gln
Add
BLAST
Compositional biasi846 – 85510Poly-Gln

Sequence similaritiesi

Contains 4 HEAT repeats.
Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG269318.
GeneTreeiENSGT00640000091541.
HOGENOMiHOG000184479.
KOiK07204.
OMAiFCDWSAK.
OrthoDBiEOG7D864S.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF02985. HEAT. 1 hit.
PF14538. Raptor_N. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38873-1 [UniParc]FASTAAdd to Basket

« Hide

MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN     50
GNPIPEEDKQ RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV 100
MKTHPCARVE AWVDPLNFQD SKKAIEQIGK NLQAQYETLS LRTRYKQSLD 150
PCVEDVKRFC NSLRRTSKED RILFHYNGHG VPKPTKSGEI WVFNRGYTQY 200
IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI KDDEEGNHDV 250
AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF 300
LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP 350
LGELNWIFTA ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP 400
WYNCHPVSDP ELPDSITTHP MWKSWDLAMD EVLTKIVIDL KNAPPATALE 450
SQMILQQQET LQNGGSSKSN AQDTKAGSIQ TQSRFAVANL STMSLVNNPA 500
LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW LKYASNVRHP 550
PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL 600
LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV 650
NGMSATNGSA MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL 700
PFYHSNDTTD EQKAMAVFVL ASFVRNFPLG QKNCFSLELV NKLCFYIDNS 750
EIPLLRQWCV ILLGLLFADN PLNRFVCMNT GAVEILLKSL KDPVPEVRTA 800
SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ NQSHLQQQQS 850
QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL 900
INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR 950
NTSDKYSVSQ GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH 1000
KELGGPFAVM EKFLLKRSSK AHQTGKFGFN SSQVQFVKSS LRSFSPNERV 1050
DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS LGFSESNSDS DTQSSNTSMK 1100
SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL NSSFLDYSRE 1150
YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS 1200
KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG 1250
TPFGTKVTDL KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG 1300
LTDMLLTPRS TGLLTEWLQI RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK 1350
TSSLITSLTA DQLAGNIFVA GFADGSLRVY DRRLDPRDSM IRRWRAGNDK 1400
QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES FVDQNVTSQY 1450
GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT 1500
STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE 1550
DERIDYF 1557
Length:1,557
Mass (Da):177,609
Last modified:January 9, 2007 - v2
Checksum:iB927EE93700176D3
GO

Sequence cautioni

The sequence AAB68364.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00030 Genomic DNA. Translation: AAB68364.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06878.1.
PIRiS46686.
RefSeqiNP_012056.1. NM_001179317.1.

Genome annotation databases

EnsemblFungiiYHR186C; YHR186C; YHR186C.
GeneIDi856593.
KEGGisce:YHR186C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00030 Genomic DNA. Translation: AAB68364.1 . Different initiation.
BK006934 Genomic DNA. Translation: DAA06878.1 .
PIRi S46686.
RefSeqi NP_012056.1. NM_001179317.1.

3D structure databases

ProteinModelPortali P38873.
SMRi P38873. Positions 1353-1433, 1521-1549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36620. 77 interactions.
DIPi DIP-2639N.
IntActi P38873. 32 interactions.
MINTi MINT-426011.
STRINGi 4932.YHR186C.

Proteomic databases

MaxQBi P38873.
PaxDbi P38873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR186C ; YHR186C ; YHR186C .
GeneIDi 856593.
KEGGi sce:YHR186C.

Organism-specific databases

CYGDi YHR186c.
SGDi S000001229. KOG1.

Phylogenomic databases

eggNOGi NOG269318.
GeneTreei ENSGT00640000091541.
HOGENOMi HOG000184479.
KOi K07204.
OMAi FCDWSAK.
OrthoDBi EOG7D864S.

Enzyme and pathway databases

BioCyci YEAST:G3O-31216-MONOMER.
Reactomei REACT_188481. S6K1-mediated signalling.
REACT_209479. Regulation of AMPK activity via LKB1.
REACT_219346. HSF1-dependent transactivation.

Miscellaneous databases

NextBioi 982475.
PROi P38873.

Gene expression databases

Genevestigatori P38873.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
2.130.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR12848. PTHR12848. 1 hit.
Pfami PF02985. HEAT. 1 hit.
PF14538. Raptor_N. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."
    Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N.
    Mol. Cell 10:457-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TORC1, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae."
    Wedaman K.P., Reinke A., Anderson S., Yates J.R. III, McCaffery J.M., Powers T.
    Mol. Biol. Cell 14:1204-1220(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH TOR1.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast."
    Araki T., Uesono Y., Oguchi T., Toh-e A.
    Genes Genet. Syst. 80:325-343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKOG1_YEAST
AccessioniPrimary (citable) accession number: P38873
Secondary accession number(s): D3DLD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi