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P38873 (KOG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Target of rapamycin complex 1 subunit KOG1

Short name=TORC1 subunit KOG1
Alternative name(s):
Kontroller of growth protein 1
Local anesthetic-sensitive protein 24
Gene names
Name:KOG1
Synonyms:LAS24
Ordered Locus Names:YHR186C
ORF Names:H9998.14
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1557 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1. Ref.6

Subunit structure

The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin. Ref.3 Ref.4 Ref.6

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side. Note: Also localizes to membranous structures within the cell interior, probably endosomal or Golgi membranes. Ref.4 Ref.5 Ref.6

Sequence similarities

Contains 4 HEAT repeats.

Contains 7 WD repeats.

Sequence caution

The sequence AAB68364.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LST8P413183EBI-24864,EBI-28598
TOR1P351697EBI-24864,EBI-19374

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15571557Target of rapamycin complex 1 subunit KOG1
PRO_0000051476

Regions

Repeat548 – 58639HEAT 1
Repeat588 – 62538HEAT 2
Repeat777 – 81438HEAT 3
Repeat888 – 92538HEAT 4
Repeat1207 – 124842WD 1
Repeat1252 – 129342WD 2
Repeat1296 – 134651WD 3
Repeat1350 – 139041WD 4
Repeat1400 – 144041WD 5
Repeat1452 – 149241WD 6
Repeat1517 – 155741WD 7
Compositional bias513 – 52513Poly-Gln
Compositional bias846 – 85510Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
P38873 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: B927EE93700176D3

FASTA1,557177,609
        10         20         30         40         50         60 
MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN GNPIPEEDKQ 

        70         80         90        100        110        120 
RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV MKTHPCARVE AWVDPLNFQD 

       130        140        150        160        170        180 
SKKAIEQIGK NLQAQYETLS LRTRYKQSLD PCVEDVKRFC NSLRRTSKED RILFHYNGHG 

       190        200        210        220        230        240 
VPKPTKSGEI WVFNRGYTQY IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI 

       250        260        270        280        290        300 
KDDEEGNHDV AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF 

       310        320        330        340        350        360 
LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP LGELNWIFTA 

       370        380        390        400        410        420 
ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP WYNCHPVSDP ELPDSITTHP 

       430        440        450        460        470        480 
MWKSWDLAMD EVLTKIVIDL KNAPPATALE SQMILQQQET LQNGGSSKSN AQDTKAGSIQ 

       490        500        510        520        530        540 
TQSRFAVANL STMSLVNNPA LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW 

       550        560        570        580        590        600 
LKYASNVRHP PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL 

       610        620        630        640        650        660 
LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV NGMSATNGSA 

       670        680        690        700        710        720 
MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL PFYHSNDTTD EQKAMAVFVL 

       730        740        750        760        770        780 
ASFVRNFPLG QKNCFSLELV NKLCFYIDNS EIPLLRQWCV ILLGLLFADN PLNRFVCMNT 

       790        800        810        820        830        840 
GAVEILLKSL KDPVPEVRTA SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ 

       850        860        870        880        890        900 
NQSHLQQQQS QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL 

       910        920        930        940        950        960 
INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR NTSDKYSVSQ 

       970        980        990       1000       1010       1020 
GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH KELGGPFAVM EKFLLKRSSK 

      1030       1040       1050       1060       1070       1080 
AHQTGKFGFN SSQVQFVKSS LRSFSPNERV DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS 

      1090       1100       1110       1120       1130       1140 
LGFSESNSDS DTQSSNTSMK SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL 

      1150       1160       1170       1180       1190       1200 
NSSFLDYSRE YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS 

      1210       1220       1230       1240       1250       1260 
KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG TPFGTKVTDL 

      1270       1280       1290       1300       1310       1320 
KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG LTDMLLTPRS TGLLTEWLQI 

      1330       1340       1350       1360       1370       1380 
RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK TSSLITSLTA DQLAGNIFVA GFADGSLRVY 

      1390       1400       1410       1420       1430       1440 
DRRLDPRDSM IRRWRAGNDK QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES 

      1450       1460       1470       1480       1490       1500 
FVDQNVTSQY GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT 

      1510       1520       1530       1540       1550 
STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE DERIDYF 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."
Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N.
Mol. Cell 10:457-468(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TORC1, IDENTIFICATION BY MASS SPECTROMETRY.
[4]"Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae."
Wedaman K.P., Reinke A., Anderson S., Yates J.R. III, McCaffery J.M., Powers T.
Mol. Biol. Cell 14:1204-1220(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH TOR1.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast."
Araki T., Uesono Y., Oguchi T., Toh-e A.
Genes Genet. Syst. 80:325-343(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00030 Genomic DNA. Translation: AAB68364.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06878.1.
PIRS46686.
RefSeqNP_012056.1. NM_001179317.1.

3D structure databases

ProteinModelPortalP38873.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36620. 77 interactions.
DIPDIP-2639N.
IntActP38873. 32 interactions.
MINTMINT-426011.
STRING4932.YHR186C.

Proteomic databases

PaxDbP38873.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR186C; YHR186C; YHR186C.
GeneID856593.
KEGGsce:YHR186C.

Organism-specific databases

CYGDYHR186c.
SGDS000001229. KOG1.

Phylogenomic databases

eggNOGNOG269318.
GeneTreeENSGT00640000091541.
HOGENOMHOG000184479.
KOK07204.
OMATEVCTND.
OrthoDBEOG7D864S.

Enzyme and pathway databases

BioCycYEAST:G3O-31216-MONOMER.

Gene expression databases

GenevestigatorP38873.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
2.130.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR004083. Raptor.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR12848. PTHR12848. 1 hit.
PfamPF02985. HEAT. 1 hit.
[Graphical view]
PRINTSPR01547. YEAST176DUF.
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982475.
PROP38873.

Entry information

Entry nameKOG1_YEAST
AccessionPrimary (citable) accession number: P38873
Secondary accession number(s): D3DLD4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families