Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38873

- KOG1_YEAST

UniProt

P38873 - KOG1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Target of rapamycin complex 1 subunit KOG1

Gene

KOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.1 Publication

GO - Molecular functioni

  1. ubiquitin binding Source: SGD

GO - Biological processi

  1. cellular response to starvation Source: SGD
  2. regulation of cell growth Source: SGD
  3. TOR signaling Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31216-MONOMER.
ReactomeiREACT_188481. S6K1-mediated signalling.
REACT_209479. Regulation of AMPK activity via LKB1.
REACT_219346. HSF1-dependent transactivation.
REACT_252465. mTOR signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Target of rapamycin complex 1 subunit KOG1
Short name:
TORC1 subunit KOG1
Alternative name(s):
Kontroller of growth protein 1
Local anesthetic-sensitive protein 24
Gene namesi
Name:KOG1
Synonyms:LAS24
Ordered Locus Names:YHR186C
ORF Names:H9998.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR186c.
SGDiS000001229. KOG1.

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
Note: Also localizes to membranous structures within the cell interior, probably endosomal or Golgi membranes.

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: SGD
  2. plasma membrane Source: SGD
  3. TORC1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15571557Target of rapamycin complex 1 subunit KOG1PRO_0000051476Add
BLAST

Proteomic databases

MaxQBiP38873.
PaxDbiP38873.

Expressioni

Gene expression databases

GenevestigatoriP38873.

Interactioni

Subunit structurei

The target of rapamycin complex 1 (TORC1) is composed of at least KOG1, LST8, TCO89 and either TOR1 (TORC1-A) or TOR2 (TORC1-B). TORC1 binds to and is inhibited by FKBP-rapamycin.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LST8P413183EBI-24864,EBI-28598
TOR1P351697EBI-24864,EBI-19374

Protein-protein interaction databases

BioGridi36620. 77 interactions.
DIPiDIP-2639N.
IntActiP38873. 32 interactions.
MINTiMINT-426011.
STRINGi4932.YHR186C.

Structurei

3D structure databases

ProteinModelPortaliP38873.
SMRiP38873. Positions 1219-1283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati548 – 58639HEAT 1Add
BLAST
Repeati588 – 62538HEAT 2Add
BLAST
Repeati777 – 81438HEAT 3Add
BLAST
Repeati888 – 92538HEAT 4Add
BLAST
Repeati1207 – 124842WD 1Add
BLAST
Repeati1252 – 129342WD 2Add
BLAST
Repeati1296 – 134651WD 3Add
BLAST
Repeati1350 – 139041WD 4Add
BLAST
Repeati1400 – 144041WD 5Add
BLAST
Repeati1452 – 149241WD 6Add
BLAST
Repeati1517 – 155741WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi513 – 52513Poly-GlnAdd
BLAST
Compositional biasi846 – 85510Poly-Gln

Sequence similaritiesi

Contains 4 HEAT repeats.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG269318.
GeneTreeiENSGT00640000091541.
HOGENOMiHOG000184479.
InParanoidiP38873.
KOiK07204.
OMAiFCDWSAK.
OrthoDBiEOG7D864S.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF02985. HEAT. 1 hit.
PF14538. Raptor_N. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38873-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN
60 70 80 90 100
GNPIPEEDKQ RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV
110 120 130 140 150
MKTHPCARVE AWVDPLNFQD SKKAIEQIGK NLQAQYETLS LRTRYKQSLD
160 170 180 190 200
PCVEDVKRFC NSLRRTSKED RILFHYNGHG VPKPTKSGEI WVFNRGYTQY
210 220 230 240 250
IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI KDDEEGNHDV
260 270 280 290 300
AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF
310 320 330 340 350
LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP
360 370 380 390 400
LGELNWIFTA ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP
410 420 430 440 450
WYNCHPVSDP ELPDSITTHP MWKSWDLAMD EVLTKIVIDL KNAPPATALE
460 470 480 490 500
SQMILQQQET LQNGGSSKSN AQDTKAGSIQ TQSRFAVANL STMSLVNNPA
510 520 530 540 550
LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW LKYASNVRHP
560 570 580 590 600
PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL
610 620 630 640 650
LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV
660 670 680 690 700
NGMSATNGSA MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL
710 720 730 740 750
PFYHSNDTTD EQKAMAVFVL ASFVRNFPLG QKNCFSLELV NKLCFYIDNS
760 770 780 790 800
EIPLLRQWCV ILLGLLFADN PLNRFVCMNT GAVEILLKSL KDPVPEVRTA
810 820 830 840 850
SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ NQSHLQQQQS
860 870 880 890 900
QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL
910 920 930 940 950
INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR
960 970 980 990 1000
NTSDKYSVSQ GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH
1010 1020 1030 1040 1050
KELGGPFAVM EKFLLKRSSK AHQTGKFGFN SSQVQFVKSS LRSFSPNERV
1060 1070 1080 1090 1100
DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS LGFSESNSDS DTQSSNTSMK
1110 1120 1130 1140 1150
SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL NSSFLDYSRE
1160 1170 1180 1190 1200
YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS
1210 1220 1230 1240 1250
KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG
1260 1270 1280 1290 1300
TPFGTKVTDL KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG
1310 1320 1330 1340 1350
LTDMLLTPRS TGLLTEWLQI RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK
1360 1370 1380 1390 1400
TSSLITSLTA DQLAGNIFVA GFADGSLRVY DRRLDPRDSM IRRWRAGNDK
1410 1420 1430 1440 1450
QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES FVDQNVTSQY
1460 1470 1480 1490 1500
GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT
1510 1520 1530 1540 1550
STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE

DERIDYF
Length:1,557
Mass (Da):177,609
Last modified:January 9, 2007 - v2
Checksum:iB927EE93700176D3
GO

Sequence cautioni

The sequence AAB68364.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. Translation: AAB68364.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06878.1.
PIRiS46686.
RefSeqiNP_012056.1. NM_001179317.1.

Genome annotation databases

EnsemblFungiiYHR186C; YHR186C; YHR186C.
GeneIDi856593.
KEGGisce:YHR186C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00030 Genomic DNA. Translation: AAB68364.1 . Different initiation.
BK006934 Genomic DNA. Translation: DAA06878.1 .
PIRi S46686.
RefSeqi NP_012056.1. NM_001179317.1.

3D structure databases

ProteinModelPortali P38873.
SMRi P38873. Positions 1219-1283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36620. 77 interactions.
DIPi DIP-2639N.
IntActi P38873. 32 interactions.
MINTi MINT-426011.
STRINGi 4932.YHR186C.

Proteomic databases

MaxQBi P38873.
PaxDbi P38873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR186C ; YHR186C ; YHR186C .
GeneIDi 856593.
KEGGi sce:YHR186C.

Organism-specific databases

CYGDi YHR186c.
SGDi S000001229. KOG1.

Phylogenomic databases

eggNOGi NOG269318.
GeneTreei ENSGT00640000091541.
HOGENOMi HOG000184479.
InParanoidi P38873.
KOi K07204.
OMAi FCDWSAK.
OrthoDBi EOG7D864S.

Enzyme and pathway databases

BioCyci YEAST:G3O-31216-MONOMER.
Reactomei REACT_188481. S6K1-mediated signalling.
REACT_209479. Regulation of AMPK activity via LKB1.
REACT_219346. HSF1-dependent transactivation.
REACT_252465. mTOR signalling.

Miscellaneous databases

NextBioi 982475.
PROi P38873.

Gene expression databases

Genevestigatori P38873.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
2.130.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR12848. PTHR12848. 1 hit.
Pfami PF02985. HEAT. 1 hit.
PF14538. Raptor_N. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."
    Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., Hall M.N.
    Mol. Cell 10:457-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TORC1, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae."
    Wedaman K.P., Reinke A., Anderson S., Yates J.R. III, McCaffery J.M., Powers T.
    Mol. Biol. Cell 14:1204-1220(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH TOR1.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast."
    Araki T., Uesono Y., Oguchi T., Toh-e A.
    Genes Genet. Syst. 80:325-343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKOG1_YEAST
AccessioniPrimary (citable) accession number: P38873
Secondary accession number(s): D3DLD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3