P38872 (ADY1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prospore formation at selected spindle poles protein 1

Alternative name(s):
Accumulates dyads protein 1

Gene names

Name:	PFS1
Synonyms:	ADY1
Ordered Locus Names:	YHR185C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Required to localize MPC54 to all four spindle pole bodies, and localize DON1 and SPO14 to four prospore membranes. Ref.3
Subcellular location	Nucleus. Cytoplasm › cytoskeleton › spindle pole body. Note: Nuclear in mononucleate meiotic cells. May not be localized to the spindle pole body or prospore membrane. Ref.3

Ontologies

Keywords
Biological process	Sporulation
Cellular component	Cytoplasm Cytoskeleton Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ascospore wall assembly Inferred from mutant phenotype Ref.3. Source: SGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell spindle pole body Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HRR25	P29295	3	EBI-24859,EBI-8536
NAS2	P40555	3	EBI-24859,EBI-14024

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Prospore formation at selected spindle poles protein 1		PRO_0000064460

Sequences

	Sequence		Length	Mass (Da)
	P38872 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 027F01058C0CFE6E	FASTA	237	27,884
	10 20 30 40 50 60 MNQGYTQLSA PELKETKTSK LNKMNNFRSS PIAEIINKIP PDCGKIQNTT FPEFNPALRR 70 80 90 100 110 120 RQHEQWPAYE KPIRVTDSMS PQLSSINCLP NLYPHGTLPL PNPYLSYLNH IEKVNCQDVK 130 140 150 160 170 180 FSNWSVLHNS NNGFEIPTYF SPRTTQNMPC SEKVESWLER LPIFVGFDGY LFTNCFDYEY 190 200 210 220 230 MLDWEETEFT FEKTSCMETD YSKALTDTDI IYIQEKKIEA LIRNQYLKEY EFSQKDF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"ADY1, a novel gene required for prospore membrane formation at selected spindle poles in Saccharomyces cerevisiae." Deng C., Saunders W.S. Mol. Biol. Cell 12:2646-2659(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00030 Genomic DNA. Translation: AAB68363.1. BK006934 Genomic DNA. Translation: DAA06877.1.
PIR	S46685.
RefSeq	NP_012055.3. NM_001179316.3.
3D structure databases
ProteinModelPortal	P38872.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1372N.
IntAct	P38872. 6 interactions.
MINT	MINT-394703.
STRING	4932.YHR185C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR185C; YHR185C; YHR185C.
GeneID	856591.
KEGG	sce:YHR185C.
Organism-specific databases
CYGD	YHR185c.
SGD	S000001228. PFS1.
Phylogenomic databases
eggNOG	NOG69411.
OrthoDB	EOG4NGKXG.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31215-MONOMER.
Gene expression databases
Genevestigator	P38872.
GermOnline	YHR185C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	982470.

Entry information

Entry name

ADY1_YEAST

Accession

Primary (citable) accession number: P38872
Secondary accession number(s): D3DLD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 29, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program