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Protein

Protein SVP26

Gene

SVP26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5.2 Publications

GO - Molecular functioni

  1. COPII adaptor activity Source: SGD

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. fungal-type cell wall organization Source: SGD
  3. protein glycosylation Source: SGD
  4. protein retention in Golgi apparatus Source: SGD
  5. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SVP26
Alternative name(s):
Sed5 compartment vesicle protein of 26 kDa
Gene namesi
Name:SVP26
Ordered Locus Names:YHR181W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR181w.
EuPathDBiFungiDB:YHR181W.
SGDiS000001224. SVP26.

Subcellular locationi

  1. Golgi apparatuscis-Golgi network membrane 3 Publications; Multi-pass membrane protein 3 Publications

  2. Note: Early Golgi.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11CytoplasmicSequence Analysis
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Topological domaini23 – 4220LumenalSequence AnalysisAdd
BLAST
Transmembranei43 – 5917HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 8829CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei89 – 10517HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 14237LumenalSequence AnalysisAdd
BLAST
Transmembranei143 – 16624HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 22862CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. ER to Golgi transport vesicle Source: SGD
  2. integral component of endoplasmic reticulum membrane Source: SGD
  3. integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Protein SVP26PRO_0000202934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38869.
PaxDbiP38869.

Expressioni

Gene expression databases

GenevestigatoriP38869.

Interactioni

Subunit structurei

Interacts with itself. Interacts with KTR3, MNN2 and MNN5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERP1Q053591EBI-24844,EBI-6581
ERP4Q124501EBI-24844,EBI-6598
ERV25P548371EBI-24844,EBI-6642

Protein-protein interaction databases

BioGridi36614. 59 interactions.
IntActiP38869. 3 interactions.
MINTiMINT-4489297.
STRINGi4932.YHR181W.

Structurei

3D structure databases

ProteinModelPortaliP38869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SVP26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG114708.
GeneTreeiENSGT00390000010888.
HOGENOMiHOG000116065.
InParanoidiP38869.
OMAiPYIPPLE.
OrthoDBiEOG7VX96G.

Family and domain databases

InterProiIPR007277. Transmembrane_adaptor_Erv26.
[Graphical view]
PANTHERiPTHR13144. PTHR13144. 1 hit.
PfamiPF04148. Erv26. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLELISYAG TVSGFLFLTL SIASGLYYIS ELVEEHTEPT RRFLTRAIYG
60 70 80 90 100
IILILILLLL LDGFPFKLTL FSIACYIVYY QNLKSFPFIS LTSPTFLLSC
110 120 130 140 150
VCVVLNHYFW FKYFNDTEVP PQFKFDPNYI PRRRASFAEV ASFFGICVWF
160 170 180 190 200
IPFALFVSLS AGDYVLPTTS EQHMAKKNDD ITTNNQPKFR KRAVGLARVV
210 220
INSVRKYIYS LARVFGYEIE PDFDRLAV
Length:228
Mass (Da):26,284
Last modified:February 1, 1995 - v1
Checksum:iC86FD804BC4EEAFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00028 Genomic DNA. Translation: AAB68454.1.
BK006934 Genomic DNA. Translation: DAA06873.1.
PIRiS46673.
RefSeqiNP_012051.3. NM_001179312.3.

Genome annotation databases

EnsemblFungiiYHR181W; YHR181W; YHR181W.
GeneIDi856587.
KEGGisce:YHR181W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00028 Genomic DNA. Translation: AAB68454.1.
BK006934 Genomic DNA. Translation: DAA06873.1.
PIRiS46673.
RefSeqiNP_012051.3. NM_001179312.3.

3D structure databases

ProteinModelPortaliP38869.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36614. 59 interactions.
IntActiP38869. 3 interactions.
MINTiMINT-4489297.
STRINGi4932.YHR181W.

Proteomic databases

MaxQBiP38869.
PaxDbiP38869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR181W; YHR181W; YHR181W.
GeneIDi856587.
KEGGisce:YHR181W.

Organism-specific databases

CYGDiYHR181w.
EuPathDBiFungiDB:YHR181W.
SGDiS000001224. SVP26.

Phylogenomic databases

eggNOGiNOG114708.
GeneTreeiENSGT00390000010888.
HOGENOMiHOG000116065.
InParanoidiP38869.
OMAiPYIPPLE.
OrthoDBiEOG7VX96G.

Enzyme and pathway databases

BioCyciYEAST:G3O-31212-MONOMER.

Miscellaneous databases

NextBioi982458.
PROiP38869.

Gene expression databases

GenevestigatoriP38869.

Family and domain databases

InterProiIPR007277. Transmembrane_adaptor_Erv26.
[Graphical view]
PANTHERiPTHR13144. PTHR13144. 1 hit.
PfamiPF04148. Erv26. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH KTR3.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Svp26 facilitates endoplasmic reticulum to Golgi transport of a set of mannosyltransferases in Saccharomyces cerevisiae."
    Noda Y., Yoda K.
    J. Biol. Chem. 285:15420-15429(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MNN2 AND MNN5.

Entry informationi

Entry nameiSVP26_YEAST
AccessioniPrimary (citable) accession number: P38869
Secondary accession number(s): D3DLC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1810 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.