Protein SVP26 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Contribute

Send feedback

Read comments (?) or add your own

P38869 (SVP26_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein SVP26

Alternative name(s):
Sed5 compartment vesicle protein of 26 kDa

Gene names

Name:	SVP26
Ordered Locus Names:	YHR181W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5. Ref.5 Ref.7
Subunit structure	Interacts with itself. Interacts with KTR3, MNN2 and MNN5. Ref.5 Ref.7
Subcellular location	Golgi apparatus › cis-Golgi network membrane; Multi-pass membrane protein. Note: Early Golgi. Ref.4 Ref.5 Ref.7
Post-translational modification	N-glycosylated.
Miscellaneous	Present with 1810 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the SVP26 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from direct assay PubMed 16957051. Source: SGD fungal-type cell wall organization Inferred from mutant phenotype Ref.5. Source: SGD protein glycosylation Inferred from mutant phenotype Ref.5. Source: SGD protein retention in Golgi apparatus Inferred from mutant phenotype Ref.5. Source: SGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle Inferred from direct assay PubMed 16957051. Source: SGD integral to Golgi membrane Inferred from direct assay Ref.5. Source: SGD integral to endoplasmic reticulum membrane Inferred from direct assay PubMed 16957051. Source: SGD
Molecular_function	COPII adaptor activity Inferred from mutant phenotype Ref.7. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
ERP1	Q05359	1	EBI-24844,EBI-6581
ERP4	Q12450	1	EBI-24844,EBI-6598
ERV25	P54837	1	EBI-24844,EBI-6642

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 228

228

Protein SVP26

PRO_0000202934

Regions

Topological domain

Cytoplasmic Potential

Transmembrane

2 – 22

Helical; Potential

Topological domain

23 – 42

Lumenal Potential

Transmembrane

43 – 59

Helical; Potential

Topological domain

60 – 88

Cytoplasmic Potential

Transmembrane

89 – 105

Helical; Potential

Topological domain

106 – 142

Lumenal Potential

Transmembrane

143 – 166

Helical; Potential

Topological domain

167 – 228

Cytoplasmic Potential

Amino acid modifications

Glycosylation

115

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P38869 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C86FD804BC4EEAFD
Show »

FASTA

228

26,284

        10         20         30         40         50         60 
MLLELISYAG TVSGFLFLTL SIASGLYYIS ELVEEHTEPT RRFLTRAIYG IILILILLLL 

        70         80         90        100        110        120 
LDGFPFKLTL FSIACYIVYY QNLKSFPFIS LTSPTFLLSC VCVVLNHYFW FKYFNDTEVP 

       130        140        150        160        170        180 
PQFKFDPNYI PRRRASFAEV ASFFGICVWF IPFALFVSLS AGDYVLPTTS EQHMAKKNDD 

       190        200        210        220 
ITTNNQPKFR KRAVGLARVV INSVRKYIYS LARVFGYEIE PDFDRLAV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments." Inadome H., Noda Y., Adachi H., Yoda K. Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH KTR3.
[6]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
[7]	"Svp26 facilitates endoplasmic reticulum to Golgi transport of a set of mannosyltransferases in Saccharomyces cerevisiae." Noda Y., Yoda K. J. Biol. Chem. 285:15420-15429(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MNN2 AND MNN5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00028 Genomic DNA. Translation: AAB68454.1. BK006934 Genomic DNA. Translation: DAA06873.1.
PIR	S46673.
RefSeq	NP_012051.3. NM_001179312.3.
3D structure databases
ProteinModelPortal	P38869.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38869. 3 interactions.
STRING	4932.YHR181W.
Proteomic databases
PaxDb	P38869.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR181W; YHR181W; YHR181W.
GeneID	856587.
KEGG	sce:YHR181W. sce:YHR183W.
Organism-specific databases
CYGD	YHR181w.
SGD	S000001224. SVP26.
Phylogenomic databases
eggNOG	NOG114708.
GeneTree	ENSGT00390000010888.
HOGENOM	HOG000116065.
KO	K00033.
OMA	ICVWFIP.
OrthoDB	EOG40S3QV.
Gene expression databases
Genevestigator	P38869.
GermOnline	YHR181W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007277. Transmembrane_adaptor_Erv26. [Graphical view]
PANTHER	PTHR13144. PTHR13144. 1 hit.
Pfam	PF04148. Erv26. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982458.

Entry information

Entry name

SVP26_YEAST

Accession

Primary (citable) accession number: P38869
Secondary accession number(s): D3DLC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents