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P38869 (SVP26_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SVP26
Alternative name(s):
Sed5 compartment vesicle protein of 26 kDa
Gene names
Name:SVP26
Ordered Locus Names:YHR181W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5. Ref.5 Ref.7

Subunit structure

Interacts with itself. Interacts with KTR3, MNN2 and MNN5. Ref.5 Ref.7

Subcellular location

Golgi apparatuscis-Golgi network membrane; Multi-pass membrane protein. Note: Early Golgi. Ref.4 Ref.5 Ref.7

Post-translational modification

N-glycosylated.

Miscellaneous

Present with 1810 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SVP26 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Protein SVP26
PRO_0000202934

Regions

Topological domain11Cytoplasmic Potential
Transmembrane2 – 2221Helical; Potential
Topological domain23 – 4220Lumenal Potential
Transmembrane43 – 5917Helical; Potential
Topological domain60 – 8829Cytoplasmic Potential
Transmembrane89 – 10517Helical; Potential
Topological domain106 – 14237Lumenal Potential
Transmembrane143 – 16624Helical; Potential
Topological domain167 – 22862Cytoplasmic Potential

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P38869 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C86FD804BC4EEAFD

FASTA22826,284
        10         20         30         40         50         60 
MLLELISYAG TVSGFLFLTL SIASGLYYIS ELVEEHTEPT RRFLTRAIYG IILILILLLL 

        70         80         90        100        110        120 
LDGFPFKLTL FSIACYIVYY QNLKSFPFIS LTSPTFLLSC VCVVLNHYFW FKYFNDTEVP 

       130        140        150        160        170        180 
PQFKFDPNYI PRRRASFAEV ASFFGICVWF IPFALFVSLS AGDYVLPTTS EQHMAKKNDD 

       190        200        210        220 
ITTNNQPKFR KRAVGLARVV INSVRKYIYS LARVFGYEIE PDFDRLAV 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH KTR3.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[7]"Svp26 facilitates endoplasmic reticulum to Golgi transport of a set of mannosyltransferases in Saccharomyces cerevisiae."
Noda Y., Yoda K.
J. Biol. Chem. 285:15420-15429(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MNN2 AND MNN5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00028 Genomic DNA. Translation: AAB68454.1.
BK006934 Genomic DNA. Translation: DAA06873.1.
PIRS46673.
RefSeqNP_012051.3. NM_001179312.3.

3D structure databases

ProteinModelPortalP38869.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36614. 59 interactions.
IntActP38869. 3 interactions.
MINTMINT-4489297.
STRING4932.YHR181W.

Proteomic databases

MaxQBP38869.
PaxDbP38869.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR181W; YHR181W; YHR181W.
GeneID856587.
KEGGsce:YHR181W.

Organism-specific databases

CYGDYHR181w.
SGDS000001224. SVP26.

Phylogenomic databases

eggNOGNOG114708.
GeneTreeENSGT00390000010888.
HOGENOMHOG000116065.
OMATMGTEPV.
OrthoDBEOG7VX96G.

Enzyme and pathway databases

BioCycYEAST:G3O-31212-MONOMER.

Gene expression databases

GenevestigatorP38869.

Family and domain databases

InterProIPR007277. Transmembrane_adaptor_Erv26.
[Graphical view]
PANTHERPTHR13144. PTHR13144. 1 hit.
PfamPF04148. Erv26. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982458.
PROP38869.

Entry information

Entry nameSVP26_YEAST
AccessionPrimary (citable) accession number: P38869
Secondary accession number(s): D3DLC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families