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P38869

- SVP26_YEAST

UniProt

P38869 - SVP26_YEAST

Protein

Protein SVP26

Gene

SVP26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5.2 Publications

    GO - Molecular functioni

    1. COPII adaptor activity Source: SGD

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. fungal-type cell wall organization Source: SGD
    3. protein glycosylation Source: SGD
    4. protein retention in Golgi apparatus Source: SGD
    5. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31212-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SVP26
    Alternative name(s):
    Sed5 compartment vesicle protein of 26 kDa
    Gene namesi
    Name:SVP26
    Ordered Locus Names:YHR181W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR181w.
    SGDiS000001224. SVP26.

    Subcellular locationi

    Golgi apparatuscis-Golgi network membrane 3 Publications; Multi-pass membrane protein 3 Publications
    Note: Early Golgi.

    GO - Cellular componenti

    1. ER to Golgi transport vesicle Source: SGD
    2. integral component of endoplasmic reticulum membrane Source: SGD
    3. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Protein SVP26PRO_0000202934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP38869.
    PaxDbiP38869.

    Expressioni

    Gene expression databases

    GenevestigatoriP38869.

    Interactioni

    Subunit structurei

    Interacts with itself. Interacts with KTR3, MNN2 and MNN5.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERP1Q053591EBI-24844,EBI-6581
    ERP4Q124501EBI-24844,EBI-6598
    ERV25P548371EBI-24844,EBI-6642

    Protein-protein interaction databases

    BioGridi36614. 59 interactions.
    IntActiP38869. 3 interactions.
    MINTiMINT-4489297.
    STRINGi4932.YHR181W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38869.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11CytoplasmicSequence Analysis
    Topological domaini23 – 4220LumenalSequence AnalysisAdd
    BLAST
    Topological domaini60 – 8829CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 14237LumenalSequence AnalysisAdd
    BLAST
    Topological domaini167 – 22862CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 5917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16624HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SVP26 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG114708.
    GeneTreeiENSGT00390000010888.
    HOGENOMiHOG000116065.
    OMAiTMGTEPV.
    OrthoDBiEOG7VX96G.

    Family and domain databases

    InterProiIPR007277. Transmembrane_adaptor_Erv26.
    [Graphical view]
    PANTHERiPTHR13144. PTHR13144. 1 hit.
    PfamiPF04148. Erv26. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38869-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLELISYAG TVSGFLFLTL SIASGLYYIS ELVEEHTEPT RRFLTRAIYG    50
    IILILILLLL LDGFPFKLTL FSIACYIVYY QNLKSFPFIS LTSPTFLLSC 100
    VCVVLNHYFW FKYFNDTEVP PQFKFDPNYI PRRRASFAEV ASFFGICVWF 150
    IPFALFVSLS AGDYVLPTTS EQHMAKKNDD ITTNNQPKFR KRAVGLARVV 200
    INSVRKYIYS LARVFGYEIE PDFDRLAV 228
    Length:228
    Mass (Da):26,284
    Last modified:February 1, 1995 - v1
    Checksum:iC86FD804BC4EEAFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00028 Genomic DNA. Translation: AAB68454.1.
    BK006934 Genomic DNA. Translation: DAA06873.1.
    PIRiS46673.
    RefSeqiNP_012051.3. NM_001179312.3.

    Genome annotation databases

    EnsemblFungiiYHR181W; YHR181W; YHR181W.
    GeneIDi856587.
    KEGGisce:YHR181W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00028 Genomic DNA. Translation: AAB68454.1 .
    BK006934 Genomic DNA. Translation: DAA06873.1 .
    PIRi S46673.
    RefSeqi NP_012051.3. NM_001179312.3.

    3D structure databases

    ProteinModelPortali P38869.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36614. 59 interactions.
    IntActi P38869. 3 interactions.
    MINTi MINT-4489297.
    STRINGi 4932.YHR181W.

    Proteomic databases

    MaxQBi P38869.
    PaxDbi P38869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR181W ; YHR181W ; YHR181W .
    GeneIDi 856587.
    KEGGi sce:YHR181W.

    Organism-specific databases

    CYGDi YHR181w.
    SGDi S000001224. SVP26.

    Phylogenomic databases

    eggNOGi NOG114708.
    GeneTreei ENSGT00390000010888.
    HOGENOMi HOG000116065.
    OMAi TMGTEPV.
    OrthoDBi EOG7VX96G.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31212-MONOMER.

    Miscellaneous databases

    NextBioi 982458.
    PROi P38869.

    Gene expression databases

    Genevestigatori P38869.

    Family and domain databases

    InterProi IPR007277. Transmembrane_adaptor_Erv26.
    [Graphical view ]
    PANTHERi PTHR13144. PTHR13144. 1 hit.
    Pfami PF04148. Erv26. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH KTR3.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Svp26 facilitates endoplasmic reticulum to Golgi transport of a set of mannosyltransferases in Saccharomyces cerevisiae."
      Noda Y., Yoda K.
      J. Biol. Chem. 285:15420-15429(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MNN2 AND MNN5.

    Entry informationi

    Entry nameiSVP26_YEAST
    AccessioniPrimary (citable) accession number: P38869
    Secondary accession number(s): D3DLC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1810 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3