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Protein

Thiol-specific monooxygenase

Gene

FMO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins.1 Publication

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 17FADBy similarity5
Nucleotide bindingi46 – 47FADBy similarity2
Nucleotide bindingi65 – 66NADPBy similarity2
Nucleotide bindingi117 – 118FADBy similarity2
Nucleotide bindingi199 – 202NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: SGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciYEAST:G3O-31209-MONOMER
ReactomeiR-SCE-217271 FMO oxidises nucleophiles

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol-specific monooxygenase (EC:1.14.13.-)
Alternative name(s):
Flavin-dependent monooxygenase
Gene namesi
Name:FMO1
Ordered Locus Names:YHR176W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YHR176W
SGDiS000001219 FMO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476701 – 432Thiol-specific monooxygenaseAdd BLAST432

Proteomic databases

MaxQBiP38866
PaxDbiP38866
PRIDEiP38866

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi36609, 48 interactors
IntActiP38866, 1 interactor
STRINGi4932.YHR176W

Structurei

3D structure databases

ProteinModelPortaliP38866
SMRiP38866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119232
HOGENOMiHOG000160105
InParanoidiP38866
OMAiFDAQAWY
OrthoDBiEOG092C28KK

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
PfamiView protein in Pfam
PF00743 FMO-like, 2 hits
PRINTSiPR00370 FMOXYGENASE
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P38866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNDKKRLA IIGGGPGGLA AARVFSQSLP NFEIEIFVKD YDIGGVWHYP
60 70 80 90 100
EQKSDGRVMY DHLETNISKK LMQFSGFPFE ENVPLYPSRR NIWEYLKAYY
110 120 130 140 150
KTFIANKDAI SIHFSTEVTY LKKKNSQWEI TSKDELRTTK SDFDFVIVAS
160 170 180 190 200
GHYSVPKLPT NIAGLDLWFD NKGAFHSKDF KNCEFAREKV VIVVGNGSSG
210 220 230 240 250
QDIANQLTTV AKKVYNSIKE PASNQLKAKL IETVQTIDSA DWKNRSVTLS
260 270 280 290 300
DGRVLQNIDY IIFATGYYYS FPFIEPSVRL EVLGEGVTGD KHSSVNLHNL
310 320 330 340 350
WEHMIYVKDP TLSFILTPQL VIPFPLSELQ AAIMVEVFCK SLPITTTFDS
360 370 380 390 400
NACGTHNFPK GKDLEYYAEL QELLNSIPRR VGHFEPVVWD DRLIDLRNSS
410 420 430
YTDKEERNVL LAEHAQALKK KKAPYFLPAP HT
Length:432
Mass (Da):49,099
Last modified:July 19, 2004 - v2
Checksum:i813C1B2BC196FA60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY357258 Genomic DNA Translation: AAQ62539.1
U00027 Genomic DNA Translation: AAB68021.2
BK006934 Genomic DNA Translation: DAA06869.1
PIRiS48915
RefSeqiNP_012046.4, NM_001179307.3

Genome annotation databases

EnsemblFungiiYHR176W; YHR176W; YHR176W
GeneIDi856581
KEGGisce:YHR176W

Entry informationi

Entry nameiFMO1_YEAST
AccessioniPrimary (citable) accession number: P38866
Secondary accession number(s): D3DLC5, Q6UZ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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