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Protein

Thiol-specific monooxygenase

Gene

FMO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins.1 Publication

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciYEAST:G3O-31209-MONOMER.
ReactomeiR-SCE-217271. FMO oxidises nucleophiles.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol-specific monooxygenase (EC:1.14.13.-)
Alternative name(s):
Flavin-dependent monooxygenase
Gene namesi
Name:FMO1
Ordered Locus Names:YHR176W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR176W.
SGDiS000001219. FMO1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Thiol-specific monooxygenasePRO_0000147670Add
BLAST

Proteomic databases

MaxQBiP38866.
PRIDEiP38866.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028293EBI-24830,EBI-8659

Protein-protein interaction databases

BioGridi36609. 18 interactions.
IntActiP38866. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP38866.
SMRiP38866. Positions 7-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119232.
HOGENOMiHOG000160105.
InParanoidiP38866.
OMAiAFHSKDF.
OrthoDBiEOG7B31X1.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
[Graphical view]
PfamiPF00743. FMO-like. 2 hits.
[Graphical view]
PRINTSiPR00370. FMOXYGENASE.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

P38866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNDKKRLA IIGGGPGGLA AARVFSQSLP NFEIEIFVKD YDIGGVWHYP
60 70 80 90 100
EQKSDGRVMY DHLETNISKK LMQFSGFPFE ENVPLYPSRR NIWEYLKAYY
110 120 130 140 150
KTFIANKDAI SIHFSTEVTY LKKKNSQWEI TSKDELRTTK SDFDFVIVAS
160 170 180 190 200
GHYSVPKLPT NIAGLDLWFD NKGAFHSKDF KNCEFAREKV VIVVGNGSSG
210 220 230 240 250
QDIANQLTTV AKKVYNSIKE PASNQLKAKL IETVQTIDSA DWKNRSVTLS
260 270 280 290 300
DGRVLQNIDY IIFATGYYYS FPFIEPSVRL EVLGEGVTGD KHSSVNLHNL
310 320 330 340 350
WEHMIYVKDP TLSFILTPQL VIPFPLSELQ AAIMVEVFCK SLPITTTFDS
360 370 380 390 400
NACGTHNFPK GKDLEYYAEL QELLNSIPRR VGHFEPVVWD DRLIDLRNSS
410 420 430
YTDKEERNVL LAEHAQALKK KKAPYFLPAP HT
Length:432
Mass (Da):49,099
Last modified:July 19, 2004 - v2
Checksum:i813C1B2BC196FA60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY357258 Genomic DNA. Translation: AAQ62539.1.
U00027 Genomic DNA. Translation: AAB68021.2.
BK006934 Genomic DNA. Translation: DAA06869.1.
PIRiS48915.
RefSeqiNP_012046.4. NM_001179307.3.

Genome annotation databases

EnsemblFungiiYHR176W; YHR176W; YHR176W.
GeneIDi856581.
KEGGisce:YHR176W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY357258 Genomic DNA. Translation: AAQ62539.1.
U00027 Genomic DNA. Translation: AAB68021.2.
BK006934 Genomic DNA. Translation: DAA06869.1.
PIRiS48915.
RefSeqiNP_012046.4. NM_001179307.3.

3D structure databases

ProteinModelPortaliP38866.
SMRiP38866. Positions 7-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36609. 18 interactions.
IntActiP38866. 1 interaction.

Proteomic databases

MaxQBiP38866.
PRIDEiP38866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR176W; YHR176W; YHR176W.
GeneIDi856581.
KEGGisce:YHR176W.

Organism-specific databases

EuPathDBiFungiDB:YHR176W.
SGDiS000001219. FMO1.

Phylogenomic databases

GeneTreeiENSGT00760000119232.
HOGENOMiHOG000160105.
InParanoidiP38866.
OMAiAFHSKDF.
OrthoDBiEOG7B31X1.

Enzyme and pathway databases

BioCyciYEAST:G3O-31209-MONOMER.
ReactomeiR-SCE-217271. FMO oxidises nucleophiles.

Miscellaneous databases

NextBioi982444.
PROiP38866.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
[Graphical view]
PfamiPF00743. FMO-like. 2 hits.
[Graphical view]
PRINTSiPR00370. FMOXYGENASE.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a full-length flavin-dependent monooxygenase from yeast."
    Zhang M., Robertus J.D.
    Arch. Biochem. Biophys. 403:277-283(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
    Strain: ATCC 26109 / X2180.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Fisk D., Cherry J.M.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFMO1_YEAST
AccessioniPrimary (citable) accession number: P38866
Secondary accession number(s): D3DLC5, Q6UZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 19, 2004
Last modified: May 11, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.