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P38865

- CTR2_YEAST

UniProt

P38865 - CTR2_YEAST

Protein

Copper transport protein CTR2

Gene

CTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.1 Publication

    GO - Molecular functioni

    1. copper ion transmembrane transporter activity Source: SGD
    2. copper uptake transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. cellular copper ion homeostasis Source: SGD
    2. copper ion import Source: SGD
    3. intracellular copper ion transport Source: SGD

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    Copper

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31208-MONOMER.

    Protein family/group databases

    TCDBi1.A.56.1.3. the copper transporter (ctr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Copper transport protein CTR2
    Short name:
    Copper transporter 2
    Gene namesi
    Name:CTR2
    Ordered Locus Names:YHR175W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR175w.
    SGDiS000001218. CTR2.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Copper transport protein CTR2PRO_0000195046Add
    BLAST

    Proteomic databases

    PaxDbiP38865.

    Expressioni

    Gene expression databases

    GenevestigatoriP38865.

    Interactioni

    Subunit structurei

    Homomultimer.1 Publication

    Protein-protein interaction databases

    BioGridi36608. 19 interactions.
    DIPiDIP-4763N.
    IntActiP38865. 5 interactions.
    MINTiMINT-502203.
    STRINGi4932.YHR175W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38865.
    SMRiP38865. Positions 130-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8181CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 14240VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini164 – 18926CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323808.
    HOGENOMiHOG000195393.
    KOiK14686.
    OMAiVFESWHI.
    OrthoDBiEOG74J9M5.

    Family and domain databases

    InterProiIPR007274. Cop_transporter.
    [Graphical view]
    PANTHERiPTHR12483. PTHR12483. 1 hit.
    PfamiPF04145. Ctr. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38865-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM    50
    GDGDDTCSMN MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE 100
    YLKYCVHKRQ LSQRVLLPNR SLTKINQADK VSNSILYGLQ VGFSFMLMLV 150
    FMTYNGWLML AVVCGAIWGN YSWCTSYSPE IDDSSLACH 189
    Length:189
    Mass (Da):21,651
    Last modified:February 1, 1995 - v1
    Checksum:i15112FB67C9A47CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00027 Genomic DNA. Translation: AAB68020.1.
    BK006934 Genomic DNA. Translation: DAA06867.1.
    PIRiS48914.
    RefSeqiNP_012045.3. NM_001179306.3.

    Genome annotation databases

    EnsemblFungiiYHR175W; YHR175W; YHR175W.
    GeneIDi856580.
    KEGGisce:YHR175W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00027 Genomic DNA. Translation: AAB68020.1 .
    BK006934 Genomic DNA. Translation: DAA06867.1 .
    PIRi S48914.
    RefSeqi NP_012045.3. NM_001179306.3.

    3D structure databases

    ProteinModelPortali P38865.
    SMRi P38865. Positions 130-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36608. 19 interactions.
    DIPi DIP-4763N.
    IntActi P38865. 5 interactions.
    MINTi MINT-502203.
    STRINGi 4932.YHR175W.

    Protein family/group databases

    TCDBi 1.A.56.1.3. the copper transporter (ctr) family.

    Proteomic databases

    PaxDbi P38865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR175W ; YHR175W ; YHR175W .
    GeneIDi 856580.
    KEGGi sce:YHR175W.

    Organism-specific databases

    CYGDi YHR175w.
    SGDi S000001218. CTR2.

    Phylogenomic databases

    eggNOGi NOG323808.
    HOGENOMi HOG000195393.
    KOi K14686.
    OMAi VFESWHI.
    OrthoDBi EOG74J9M5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31208-MONOMER.

    Miscellaneous databases

    NextBioi 982441.
    PROi P38865.

    Gene expression databases

    Genevestigatori P38865.

    Family and domain databases

    InterProi IPR007274. Cop_transporter.
    [Graphical view ]
    PANTHERi PTHR12483. PTHR12483. 1 hit.
    Pfami PF04145. Ctr. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue."
      Kampfenkel K.K.K., Kushnir S., Babiychuk E., Inze D., Vanmontagu M.
      J. Biol. Chem. 270:28479-28486(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION.
    4. "Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter."
      Rees E.M., Lee J., Thiele D.J.
      J. Biol. Chem. 279:54221-54229(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiCTR2_YEAST
    AccessioniPrimary (citable) accession number: P38865
    Secondary accession number(s): D3DLC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3