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P38865 (CTR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Copper transport protein CTR2

Short name=Copper transporter 2
Gene names
Name:CTR2
Ordered Locus Names:YHR175W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm. Ref.3 Ref.4

Subunit structure

Homomultimer. Ref.4

Subcellular location

Vacuole membrane; Multi-pass membrane protein Ref.4.

Sequence similarities

Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Copper transport protein CTR2
PRO_0000195046

Regions

Topological domain1 – 8181Cytoplasmic Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 14240Vacuolar Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 18926Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38865 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 15112FB67C9A47CD

FASTA18921,651
        10         20         30         40         50         60 
MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM GDGDDTCSMN 

        70         80         90        100        110        120 
MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE YLKYCVHKRQ LSQRVLLPNR 

       130        140        150        160        170        180 
SLTKINQADK VSNSILYGLQ VGFSFMLMLV FMTYNGWLML AVVCGAIWGN YSWCTSYSPE 


IDDSSLACH 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue."
Kampfenkel K.K.K., Kushnir S., Babiychuk E., Inze D., Vanmontagu M.
J. Biol. Chem. 270:28479-28486(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION.
[4]"Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter."
Rees E.M., Lee J., Thiele D.J.
J. Biol. Chem. 279:54221-54229(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00027 Genomic DNA. Translation: AAB68020.1.
BK006934 Genomic DNA. Translation: DAA06867.1.
PIRS48914.
RefSeqNP_012045.3. NM_001179306.3.

3D structure databases

ProteinModelPortalP38865.
SMRP38865. Positions 130-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36608. 19 interactions.
DIPDIP-4763N.
IntActP38865. 5 interactions.
MINTMINT-502203.
STRING4932.YHR175W.

Protein family/group databases

TCDB1.A.56.1.3. the copper transporter (ctr) family.

Proteomic databases

PaxDbP38865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR175W; YHR175W; YHR175W.
GeneID856580.
KEGGsce:YHR175W.

Organism-specific databases

CYGDYHR175w.
SGDS000001218. CTR2.

Phylogenomic databases

eggNOGNOG323808.
HOGENOMHOG000195393.
KOK14686.
OMAVFESWHI.
OrthoDBEOG74J9M5.

Enzyme and pathway databases

BioCycYEAST:G3O-31208-MONOMER.

Gene expression databases

GenevestigatorP38865.

Family and domain databases

InterProIPR007274. Cop_transporter.
[Graphical view]
PANTHERPTHR12483. PTHR12483. 1 hit.
PfamPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982441.
PROP38865.

Entry information

Entry nameCTR2_YEAST
AccessionPrimary (citable) accession number: P38865
Secondary accession number(s): D3DLC3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families