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P38865

- CTR2_YEAST

UniProt

P38865 - CTR2_YEAST

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Protein
Copper transport protein CTR2
Gene
CTR2, YHR175W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.2 Publications

GO - Molecular functioni

  1. copper ion transmembrane transporter activity Source: SGD
  2. copper uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  1. cellular copper ion homeostasis Source: SGD
  2. copper ion import Source: SGD
  3. intracellular copper ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Enzyme and pathway databases

BioCyciYEAST:G3O-31208-MONOMER.

Protein family/group databases

TCDBi1.A.56.1.3. the copper transporter (ctr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein CTR2
Short name:
Copper transporter 2
Gene namesi
Name:CTR2
Ordered Locus Names:YHR175W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR175w.
SGDiS000001218. CTR2.

Subcellular locationi

Vacuole membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8181Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 14240Vacuolar Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 18926Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Copper transport protein CTR2
PRO_0000195046Add
BLAST

Proteomic databases

PaxDbiP38865.

Expressioni

Gene expression databases

GenevestigatoriP38865.

Interactioni

Subunit structurei

Homomultimer.1 Publication

Protein-protein interaction databases

BioGridi36608. 19 interactions.
DIPiDIP-4763N.
IntActiP38865. 5 interactions.
MINTiMINT-502203.
STRINGi4932.YHR175W.

Structurei

3D structure databases

ProteinModelPortaliP38865.
SMRiP38865. Positions 130-156.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323808.
HOGENOMiHOG000195393.
KOiK14686.
OMAiVFESWHI.
OrthoDBiEOG74J9M5.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38865-1 [UniParc]FASTAAdd to Basket

« Hide

MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM    50
GDGDDTCSMN MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE 100
YLKYCVHKRQ LSQRVLLPNR SLTKINQADK VSNSILYGLQ VGFSFMLMLV 150
FMTYNGWLML AVVCGAIWGN YSWCTSYSPE IDDSSLACH 189
Length:189
Mass (Da):21,651
Last modified:February 1, 1995 - v1
Checksum:i15112FB67C9A47CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00027 Genomic DNA. Translation: AAB68020.1.
BK006934 Genomic DNA. Translation: DAA06867.1.
PIRiS48914.
RefSeqiNP_012045.3. NM_001179306.3.

Genome annotation databases

EnsemblFungiiYHR175W; YHR175W; YHR175W.
GeneIDi856580.
KEGGisce:YHR175W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00027 Genomic DNA. Translation: AAB68020.1 .
BK006934 Genomic DNA. Translation: DAA06867.1 .
PIRi S48914.
RefSeqi NP_012045.3. NM_001179306.3.

3D structure databases

ProteinModelPortali P38865.
SMRi P38865. Positions 130-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36608. 19 interactions.
DIPi DIP-4763N.
IntActi P38865. 5 interactions.
MINTi MINT-502203.
STRINGi 4932.YHR175W.

Protein family/group databases

TCDBi 1.A.56.1.3. the copper transporter (ctr) family.

Proteomic databases

PaxDbi P38865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR175W ; YHR175W ; YHR175W .
GeneIDi 856580.
KEGGi sce:YHR175W.

Organism-specific databases

CYGDi YHR175w.
SGDi S000001218. CTR2.

Phylogenomic databases

eggNOGi NOG323808.
HOGENOMi HOG000195393.
KOi K14686.
OMAi VFESWHI.
OrthoDBi EOG74J9M5.

Enzyme and pathway databases

BioCyci YEAST:G3O-31208-MONOMER.

Miscellaneous databases

NextBioi 982441.
PROi P38865.

Gene expression databases

Genevestigatori P38865.

Family and domain databases

InterProi IPR007274. Cop_transporter.
[Graphical view ]
PANTHERi PTHR12483. PTHR12483. 1 hit.
Pfami PF04145. Ctr. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue."
    Kampfenkel K.K.K., Kushnir S., Babiychuk E., Inze D., Vanmontagu M.
    J. Biol. Chem. 270:28479-28486(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  4. "Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter."
    Rees E.M., Lee J., Thiele D.J.
    J. Biol. Chem. 279:54221-54229(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiCTR2_YEAST
AccessioniPrimary (citable) accession number: P38865
Secondary accession number(s): D3DLC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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