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Protein

Copper transport protein CTR2

Gene

CTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.1 Publication

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: SGD
  • copper uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: SGD
  • copper ion import Source: SGD
  • intracellular copper ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Enzyme and pathway databases

BioCyciYEAST:G3O-31208-MONOMER.

Protein family/group databases

TCDBi1.A.56.1.3. the copper transporter (ctr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein CTR2
Short name:
Copper transporter 2
Gene namesi
Name:CTR2
Ordered Locus Names:YHR175W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR175w.
EuPathDBiFungiDB:YHR175W.
SGDiS000001218. CTR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8181CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 14240VacuolarSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 18926CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Copper transport protein CTR2PRO_0000195046Add
BLAST

Proteomic databases

PaxDbiP38865.

Expressioni

Gene expression databases

GenevestigatoriP38865.

Interactioni

Subunit structurei

Homomultimer.1 Publication

Protein-protein interaction databases

BioGridi36608. 19 interactions.
DIPiDIP-4763N.
IntActiP38865. 5 interactions.
MINTiMINT-502203.
STRINGi4932.YHR175W.

Structurei

3D structure databases

ProteinModelPortaliP38865.
SMRiP38865. Positions 130-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323808.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
InParanoidiP38865.
KOiK14686.
OMAiVFESWHI.
OrthoDBiEOG74J9M5.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM
60 70 80 90 100
GDGDDTCSMN MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE
110 120 130 140 150
YLKYCVHKRQ LSQRVLLPNR SLTKINQADK VSNSILYGLQ VGFSFMLMLV
160 170 180
FMTYNGWLML AVVCGAIWGN YSWCTSYSPE IDDSSLACH
Length:189
Mass (Da):21,651
Last modified:February 1, 1995 - v1
Checksum:i15112FB67C9A47CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00027 Genomic DNA. Translation: AAB68020.1.
BK006934 Genomic DNA. Translation: DAA06867.1.
PIRiS48914.
RefSeqiNP_012045.3. NM_001179306.3.

Genome annotation databases

EnsemblFungiiYHR175W; YHR175W; YHR175W.
GeneIDi856580.
KEGGisce:YHR175W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00027 Genomic DNA. Translation: AAB68020.1.
BK006934 Genomic DNA. Translation: DAA06867.1.
PIRiS48914.
RefSeqiNP_012045.3. NM_001179306.3.

3D structure databases

ProteinModelPortaliP38865.
SMRiP38865. Positions 130-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36608. 19 interactions.
DIPiDIP-4763N.
IntActiP38865. 5 interactions.
MINTiMINT-502203.
STRINGi4932.YHR175W.

Protein family/group databases

TCDBi1.A.56.1.3. the copper transporter (ctr) family.

Proteomic databases

PaxDbiP38865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR175W; YHR175W; YHR175W.
GeneIDi856580.
KEGGisce:YHR175W.

Organism-specific databases

CYGDiYHR175w.
EuPathDBiFungiDB:YHR175W.
SGDiS000001218. CTR2.

Phylogenomic databases

eggNOGiNOG323808.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
InParanoidiP38865.
KOiK14686.
OMAiVFESWHI.
OrthoDBiEOG74J9M5.

Enzyme and pathway databases

BioCyciYEAST:G3O-31208-MONOMER.

Miscellaneous databases

NextBioi982441.
PROiP38865.

Gene expression databases

GenevestigatoriP38865.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue."
    Kampfenkel K.K.K., Kushnir S., Babiychuk E., Inze D., Vanmontagu M.
    J. Biol. Chem. 270:28479-28486(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  4. "Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter."
    Rees E.M., Lee J., Thiele D.J.
    J. Biol. Chem. 279:54221-54229(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiCTR2_YEAST
AccessioniPrimary (citable) accession number: P38865
Secondary accession number(s): D3DLC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.