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Protein

Copper transport protein CTR2

Gene

CTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.1 Publication

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: SGD
  • copper ion import Source: SGD
  • intracellular copper ion transport Source: SGD

Keywordsi

Biological processCopper transport, Ion transport, Transport
LigandCopper

Enzyme and pathway databases

BioCyciYEAST:G3O-31208-MONOMER
ReactomeiR-SCE-425410 Metal ion SLC transporters

Protein family/group databases

TCDBi1.A.56.1.3 the copper transporter (ctr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein CTR2
Short name:
Copper transporter 2
Gene namesi
Name:CTR2
Ordered Locus Names:YHR175W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR175W
SGDiS000001218 CTR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 142VacuolarSequence analysisAdd BLAST40
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 189CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950461 – 189Copper transport protein CTR2Add BLAST189

Proteomic databases

PaxDbiP38865
PRIDEiP38865

Interactioni

Subunit structurei

Homomultimer.1 Publication

Protein-protein interaction databases

BioGridi36608, 37 interactors
DIPiDIP-4763N
IntActiP38865, 5 interactors
MINTiP38865
STRINGi4932.YHR175W

Structurei

3D structure databases

ProteinModelPortaliP38865
SMRiP38865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063415
HOGENOMiHOG000195393
InParanoidiP38865
KOiK14686
OMAiCIVFRQW
OrthoDBiEOG092C4OF0

Family and domain databases

InterProiView protein in InterPro
IPR007274 Cop_transporter
PANTHERiPTHR12483 PTHR12483, 2 hits
PfamiView protein in Pfam
PF04145 Ctr, 1 hit

Sequencei

Sequence statusi: Complete.

P38865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM
60 70 80 90 100
GDGDDTCSMN MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE
110 120 130 140 150
YLKYCVHKRQ LSQRVLLPNR SLTKINQADK VSNSILYGLQ VGFSFMLMLV
160 170 180
FMTYNGWLML AVVCGAIWGN YSWCTSYSPE IDDSSLACH
Length:189
Mass (Da):21,651
Last modified:February 1, 1995 - v1
Checksum:i15112FB67C9A47CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00027 Genomic DNA Translation: AAB68020.1
BK006934 Genomic DNA Translation: DAA06867.1
PIRiS48914
RefSeqiNP_012045.3, NM_001179306.3

Genome annotation databases

EnsemblFungiiYHR175W; YHR175W; YHR175W
GeneIDi856580
KEGGisce:YHR175W

Similar proteinsi

Entry informationi

Entry nameiCTR2_YEAST
AccessioniPrimary (citable) accession number: P38865
Secondary accession number(s): D3DLC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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