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P38863

- SPC97_YEAST

UniProt

P38863 - SPC97_YEAST

Protein

Spindle pole body component SPC97

Gene

SPC97

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural constituent of cytoskeleton Source: SGD

    GO - Biological processi

    1. microtubule nucleation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31206-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spindle pole body component SPC97
    Gene namesi
    Name:SPC97
    Ordered Locus Names:YHR172W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR172w.
    SGDiS000001215. SPC97.

    Subcellular locationi

    GO - Cellular componenti

    1. gamma-tubulin small complex, spindle pole body Source: SGD
    2. inner plaque of spindle pole body Source: SGD
    3. microtubule Source: UniProtKB-KW
    4. nucleus Source: UniProtKB-SubCell
    5. outer plaque of spindle pole body Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 823823Spindle pole body component SPC97PRO_0000078117Add
    BLAST

    Proteomic databases

    MaxQBiP38863.
    PaxDbiP38863.

    Expressioni

    Gene expression databases

    GenevestigatoriP38863.

    Interactioni

    Subunit structurei

    Interacts with TUB4, SPC72 and SPC98.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SPC98P535403EBI-17786,EBI-17794
    TUB4P533784EBI-17786,EBI-19013

    Protein-protein interaction databases

    BioGridi36606. 17 interactions.
    DIPiDIP-826N.
    IntActiP38863. 14 interactions.
    MINTiMINT-477633.
    STRINGi4932.YHR172W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38863.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TUBGCP family.Curated

    Phylogenomic databases

    eggNOGiKOG2001.
    HOGENOMiHOG000144398.
    KOiK16569.
    OMAiRANKLLM.
    OrthoDBiEOG77Q554.

    Family and domain databases

    InterProiIPR007259. TUBGCP.
    [Graphical view]
    PANTHERiPTHR19302. PTHR19302. 1 hit.
    PfamiPF04130. Spc97_Spc98. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38863-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIKEVDDRA ELLRYTNNIP LLGKLVNHQP LWSTNPKLKS FSLEKISAPD    50
    QRRVQEALVV KDLLNVLIGL EGTYIRYFND YEPSDPETPI EFKIAKKMDP 100
    SFKTFSRRIV RYGKQYMILT RAYEKWSDTS FGMVLQRFAY EIRRFLEDVY 150
    LKTLVERLER DFNKVPNFSI RELEQIINET EVNKQMELLY NIYEEIFREI 200
    EERRTNQSSQ EDFNNFMDSM KNESSLHLRL MVAFDTTVYP VPKGGAILKI 250
    FQQKILENLG DRSSVMFLKK LLNNISQDYC TMLYEWLTQG ILNDPYQEFM 300
    TYDDLEGKTD NIFDTRDRAW DTQYFIRKDV LLRDCDSEED KNLLFKMLRT 350
    GILLKVVRAS LQIPTIPSNS SDITIQEIND FADLMEGSNL ELYVDKCYSR 400
    ANEIFLKLFF QGYDLINVLK HLQQIFLGYQ SGHNVLKFLT KNMGELTKHY 450
    RNDNNANYDK LLQNFELERQ SENPNNLMRQ LLMIQFDTET LPQVLSHYLQ 500
    IYPEVPENNS ANDDSDPLMH ANNFKNMNAI LFDELSKERT GAYHGSNLEL 550
    YTPKSAIYHL KFDINIPYPL NIIISRTCMI KYQIILRYQL VLQYHSRLLD 600
    ETWMDLNKTP SWKYRGYSHT VKRRIVRATR VLHAKMNHFI KTIMEYFNQN 650
    VIDKEVYSLE KCYRNPTLAV AIQNELEGGL TNIMTNRCLS DLIPLQLQIF 700
    DIVYKFCKFI KSMRAKLCQL DPVLYEKHKS GMMKTLNEGY RTNNGGQEDV 750
    GYQEDAALEL IQKLIEYISN ASSIFRKCLI NFTQELSTEK FDFYDSSSVD 800
    AAGIERVLYS IVPPRSASAS SQR 823
    Length:823
    Mass (Da):96,825
    Last modified:February 1, 1995 - v1
    Checksum:iA3F7018957D96E8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00027 Genomic DNA. Translation: AAB68017.1.
    BK006934 Genomic DNA. Translation: DAA06865.1.
    PIRiS48911.
    RefSeqiNP_012042.1. NM_001179303.1.

    Genome annotation databases

    EnsemblFungiiYHR172W; YHR172W; YHR172W.
    GeneIDi856577.
    KEGGisce:YHR172W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00027 Genomic DNA. Translation: AAB68017.1 .
    BK006934 Genomic DNA. Translation: DAA06865.1 .
    PIRi S48911.
    RefSeqi NP_012042.1. NM_001179303.1.

    3D structure databases

    ProteinModelPortali P38863.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36606. 17 interactions.
    DIPi DIP-826N.
    IntActi P38863. 14 interactions.
    MINTi MINT-477633.
    STRINGi 4932.YHR172W.

    Proteomic databases

    MaxQBi P38863.
    PaxDbi P38863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR172W ; YHR172W ; YHR172W .
    GeneIDi 856577.
    KEGGi sce:YHR172W.

    Organism-specific databases

    CYGDi YHR172w.
    SGDi S000001215. SPC97.

    Phylogenomic databases

    eggNOGi KOG2001.
    HOGENOMi HOG000144398.
    KOi K16569.
    OMAi RANKLLM.
    OrthoDBi EOG77Q554.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31206-MONOMER.

    Miscellaneous databases

    NextBioi 982435.
    PROi P38863.

    Gene expression databases

    Genevestigatori P38863.

    Family and domain databases

    InterProi IPR007259. TUBGCP.
    [Graphical view ]
    PANTHERi PTHR19302. PTHR19302. 1 hit.
    Pfami PF04130. Spc97_Spc98. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication."
      Knop M., Pereira G., Geissler S., Grein K., Schiebel E.
      EMBO J. 16:1550-1564(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. "Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation."
      Knop M., Schiebel E.
      EMBO J. 17:3952-3967(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPC72.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPC97_YEAST
    AccessioniPrimary (citable) accession number: P38863
    Secondary accession number(s): D3DLC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2230 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3