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P38863

- SPC97_YEAST

UniProt

P38863 - SPC97_YEAST

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Protein

Spindle pole body component SPC97

Gene

SPC97

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: SGD

GO - Biological processi

  1. microtubule nucleation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31206-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle pole body component SPC97
Gene namesi
Name:SPC97
Ordered Locus Names:YHR172W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR172w.
SGDiS000001215. SPC97.

Subcellular locationi

GO - Cellular componenti

  1. gamma-tubulin small complex, spindle pole body Source: SGD
  2. inner plaque of spindle pole body Source: SGD
  3. microtubule Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
  5. outer plaque of spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 823823Spindle pole body component SPC97PRO_0000078117Add
BLAST

Proteomic databases

MaxQBiP38863.
PaxDbiP38863.

Expressioni

Gene expression databases

GenevestigatoriP38863.

Interactioni

Subunit structurei

Interacts with TUB4, SPC72 and SPC98.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPC98P535403EBI-17786,EBI-17794
TUB4P533784EBI-17786,EBI-19013

Protein-protein interaction databases

BioGridi36606. 17 interactions.
DIPiDIP-826N.
IntActiP38863. 14 interactions.
MINTiMINT-477633.
STRINGi4932.YHR172W.

Structurei

3D structure databases

ProteinModelPortaliP38863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2001.
HOGENOMiHOG000144398.
InParanoidiP38863.
KOiK16569.
OMAiRANKLLM.
OrthoDBiEOG77Q554.

Family and domain databases

InterProiIPR007259. TUBGCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIKEVDDRA ELLRYTNNIP LLGKLVNHQP LWSTNPKLKS FSLEKISAPD
60 70 80 90 100
QRRVQEALVV KDLLNVLIGL EGTYIRYFND YEPSDPETPI EFKIAKKMDP
110 120 130 140 150
SFKTFSRRIV RYGKQYMILT RAYEKWSDTS FGMVLQRFAY EIRRFLEDVY
160 170 180 190 200
LKTLVERLER DFNKVPNFSI RELEQIINET EVNKQMELLY NIYEEIFREI
210 220 230 240 250
EERRTNQSSQ EDFNNFMDSM KNESSLHLRL MVAFDTTVYP VPKGGAILKI
260 270 280 290 300
FQQKILENLG DRSSVMFLKK LLNNISQDYC TMLYEWLTQG ILNDPYQEFM
310 320 330 340 350
TYDDLEGKTD NIFDTRDRAW DTQYFIRKDV LLRDCDSEED KNLLFKMLRT
360 370 380 390 400
GILLKVVRAS LQIPTIPSNS SDITIQEIND FADLMEGSNL ELYVDKCYSR
410 420 430 440 450
ANEIFLKLFF QGYDLINVLK HLQQIFLGYQ SGHNVLKFLT KNMGELTKHY
460 470 480 490 500
RNDNNANYDK LLQNFELERQ SENPNNLMRQ LLMIQFDTET LPQVLSHYLQ
510 520 530 540 550
IYPEVPENNS ANDDSDPLMH ANNFKNMNAI LFDELSKERT GAYHGSNLEL
560 570 580 590 600
YTPKSAIYHL KFDINIPYPL NIIISRTCMI KYQIILRYQL VLQYHSRLLD
610 620 630 640 650
ETWMDLNKTP SWKYRGYSHT VKRRIVRATR VLHAKMNHFI KTIMEYFNQN
660 670 680 690 700
VIDKEVYSLE KCYRNPTLAV AIQNELEGGL TNIMTNRCLS DLIPLQLQIF
710 720 730 740 750
DIVYKFCKFI KSMRAKLCQL DPVLYEKHKS GMMKTLNEGY RTNNGGQEDV
760 770 780 790 800
GYQEDAALEL IQKLIEYISN ASSIFRKCLI NFTQELSTEK FDFYDSSSVD
810 820
AAGIERVLYS IVPPRSASAS SQR
Length:823
Mass (Da):96,825
Last modified:February 1, 1995 - v1
Checksum:iA3F7018957D96E8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00027 Genomic DNA. Translation: AAB68017.1.
BK006934 Genomic DNA. Translation: DAA06865.1.
PIRiS48911.
RefSeqiNP_012042.1. NM_001179303.1.

Genome annotation databases

EnsemblFungiiYHR172W; YHR172W; YHR172W.
GeneIDi856577.
KEGGisce:YHR172W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00027 Genomic DNA. Translation: AAB68017.1 .
BK006934 Genomic DNA. Translation: DAA06865.1 .
PIRi S48911.
RefSeqi NP_012042.1. NM_001179303.1.

3D structure databases

ProteinModelPortali P38863.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36606. 17 interactions.
DIPi DIP-826N.
IntActi P38863. 14 interactions.
MINTi MINT-477633.
STRINGi 4932.YHR172W.

Proteomic databases

MaxQBi P38863.
PaxDbi P38863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR172W ; YHR172W ; YHR172W .
GeneIDi 856577.
KEGGi sce:YHR172W.

Organism-specific databases

CYGDi YHR172w.
SGDi S000001215. SPC97.

Phylogenomic databases

eggNOGi KOG2001.
HOGENOMi HOG000144398.
InParanoidi P38863.
KOi K16569.
OMAi RANKLLM.
OrthoDBi EOG77Q554.

Enzyme and pathway databases

BioCyci YEAST:G3O-31206-MONOMER.

Miscellaneous databases

NextBioi 982435.
PROi P38863.

Gene expression databases

Genevestigatori P38863.

Family and domain databases

InterProi IPR007259. TUBGCP.
[Graphical view ]
PANTHERi PTHR19302. PTHR19302. 1 hit.
Pfami PF04130. Spc97_Spc98. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication."
    Knop M., Pereira G., Geissler S., Grein K., Schiebel E.
    EMBO J. 16:1550-1564(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation."
    Knop M., Schiebel E.
    EMBO J. 17:3952-3967(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPC72.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPC97_YEAST
AccessioniPrimary (citable) accession number: P38863
Secondary accession number(s): D3DLC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2230 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3