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Protein

60S ribosomal export protein NMD3

Gene

NMD3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Unlikely to play a significant role in nonsense-mediated mRNA decay (NMD).1 Publication

Miscellaneous

Present with 11900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ribosomal large subunit binding Source: SGD

GO - Biological processi

  • endoplasmic reticulum organization Source: EnsemblPlants
  • ribosomal large subunit export from nucleus Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal export protein NMD3
Alternative name(s):
Nonsense-mediated mRNA decay protein 3
Gene namesi
Name:NMD3
Ordered Locus Names:YHR170W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR170W.
SGDiS000001213. NMD3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968741 – 51860S ribosomal export protein NMD3Add BLAST518

Proteomic databases

MaxQBiP38861.
PRIDEiP38861.

PTM databases

iPTMnetiP38861.

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit.

Protein-protein interaction databases

BioGridi36604. 151 interactors.
DIPiDIP-1827N.
IntActiP38861. 33 interactors.
MINTiMINT-389613.
STRINGi4932.YHR170W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H4Pelectron microscopy3.07w155-402[»]
5T62electron microscopy3.30V1-518[»]
5T6Relectron microscopy4.50V2-518[»]
ProteinModelPortaliP38861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi399 – 415Nuclear localization signalAdd BLAST17
Motifi493 – 502Nuclear export signal10

Sequence similaritiesi

Belongs to the NMD3 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005104.
HOGENOMiHOG000168152.
InParanoidiP38861.
KOiK07562.
OMAiDIHSNTY.
OrthoDBiEOG092C2DPS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR007064. NMD3.
PfamiView protein in Pfam
PF04981. NMD3. 1 hit.

Sequencei

Sequence statusi: Complete.

P38861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFTPIDPHQ HQNAATLLCC NCGTPIDGST GLVMCYDCIK LTVDITQGIP
60 70 80 90 100
REANISFCRN CERFLQPPGQ WIRAELESRE LLAICLRRLK GLTKVRLVDA
110 120 130 140 150
SFIWTEPHSR RIRIKLTVQG EAMTNTIIQQ TFEVEYIVIA MQCPDCARSY
160 170 180 190 200
TTNTWRATVQ IRQKVPHKRT FLFLEQLILK HNAHVDTISI SEAKDGLDFF
210 220 230 240 250
YAQKNHAVKM IDFLNAVVPI KHKKSEELIS QDTHTGASTY KFSYSVEIVP
260 270 280 290 300
ICKDDLVVLP KKLAKSMGNI SQFVLCSKIS NTVQFMDPTT LQTADLSPSV
310 320 330 340 350
YWRAPFNALA DVTQLVEFIV LDVDSTGISR GNRVLADITV ARTSDLGVND
360 370 380 390 400
QVYYVRSHLG GICHAGDSVM GYFIANSNYN SDLFDGLNID YVPDVVLVKK
410 420 430 440 450
LYQRKSKKSR HWKLKRMAKE HKDIDASLDY NSRAQKQEME RAEKDYELFL
460 470 480 490 500
QELEEDAELR QSVNLYKNRE ANVPPEEHEM DEDEDEDAPQ INIDELLDEL
510
DEMTLEDGVE NTPVESQQ
Length:518
Mass (Da):59,095
Last modified:October 5, 2010 - v3
Checksum:i86405DDE49B3DCB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94K → F in AAA74491 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31376 Genomic DNA. Translation: AAA74491.1.
U00027 Genomic DNA. Translation: AAB68015.1.
BK006934 Genomic DNA. Translation: DAA06863.1.
PIRiS48909.
RefSeqiNP_012040.1. NM_001179301.1.

Genome annotation databases

EnsemblFungiiYHR170W; YHR170W; YHR170W.
GeneIDi856575.
KEGGisce:YHR170W.

Similar proteinsi

Entry informationi

Entry nameiNMD3_YEAST
AccessioniPrimary (citable) accession number: P38861
Secondary accession number(s): D3DLB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 5, 2010
Last modified: November 22, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names