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Protein

6-phosphogluconolactonase 3

Gene

SOL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

Miscellaneous

Present with 3420 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (ZWF1)
  2. 6-phosphogluconolactonase 3 (SOL3), 6-phosphogluconolactonase 4 (SOL4)
  3. 6-phosphogluconate dehydrogenase, decarboxylating 2 (GND2), 6-phosphogluconate dehydrogenase, decarboxylating 1 (GND1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: SGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • pentose-phosphate shunt, oxidative branch Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-4032.
ReactomeiR-SCE-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase 3 (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:SOL3
Ordered Locus Names:YHR163W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR163W.
SGDiS000001206. SOL3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900841 – 2496-phosphogluconolactonase 3Add BLAST249

Proteomic databases

MaxQBiP38858.
PRIDEiP38858.

Interactioni

Protein-protein interaction databases

BioGridi36597. 88 interactors.
DIPiDIP-5625N.
IntActiP38858. 5 interactors.
MINTiMINT-508230.
STRINGi4932.YHR163W.

Structurei

3D structure databases

ProteinModelPortaliP38858.
SMRiP38858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiP38858.
KOiK01057.
OMAiSVDWSKW.
OrthoDBiEOG092C54SY.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiView protein in InterPro
IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
PfamiView protein in Pfam
PF01182. Glucosamine_iso. 1 hit.
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P38858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVGVFSER ASLTHQLGEF IVKKQDEALQ KKSDFKVSVS GGSLIDALYE
60 70 80 90 100
SLVADESLSS RVQWSKWQIY FSDERIVPLT DADSNYGAFK RAVLDKLPST
110 120 130 140 150
SQPNVYPMDE SLIGSDAESN NKIAAEYERI VPQVLDLVLL GCGPDGHTCS
160 170 180 190 200
LFPGETHRYL LNETTKRVAW CHDSPKPPSD RITFTLPVLK DAKALCFVAE
210 220 230 240
GSSKQNIMHE IFDLKNDQLP TALVNKLFGE KTSWFVNEEA FGKVQTKTF
Length:249
Mass (Da):27,784
Last modified:June 16, 2009 - v2
Checksum:iF19B313390EA6B3D
GO

Sequence cautioni

The sequence AAB49323 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB68008 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46560 Genomic DNA. Translation: AAB49323.1. Different initiation.
U00027 Genomic DNA. Translation: AAB68008.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06856.1.
PIRiS48903.
RefSeqiNP_012033.2. NM_001179294.1.

Genome annotation databases

EnsemblFungiiYHR163W; YHR163W; YHR163W.
GeneIDi856568.
KEGGisce:YHR163W.

Similar proteinsi

Entry informationi

Entry nameiSOL3_YEAST
AccessioniPrimary (citable) accession number: P38858
Secondary accession number(s): D3DLB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names