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Protein

6-phosphogluconolactonase 3

Gene

SOL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: SGD

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. pentose-phosphate shunt, oxidative branch Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-4032.
ReactomeiREACT_318870. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase 3 (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:SOL3
Ordered Locus Names:YHR163W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR163W.
SGDiS000001206. SOL3.

Subcellular locationi

  1. Cytoplasm 1 Publication
  2. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2492496-phosphogluconolactonase 3PRO_0000090084Add
BLAST

Proteomic databases

MaxQBiP38858.
PaxDbiP38858.
PeptideAtlasiP38858.

Expressioni

Gene expression databases

GenevestigatoriP38858.

Interactioni

Protein-protein interaction databases

BioGridi36597. 42 interactions.
DIPiDIP-5625N.
IntActiP38858. 1 interaction.
MINTiMINT-508230.
STRINGi4932.YHR163W.

Structurei

3D structure databases

ProteinModelPortaliP38858.
SMRiP38858. Positions 19-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiP38858.
KOiK01057.
OMAiDHPERNS.
OrthoDBiEOG7MD51D.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P38858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVGVFSER ASLTHQLGEF IVKKQDEALQ KKSDFKVSVS GGSLIDALYE
60 70 80 90 100
SLVADESLSS RVQWSKWQIY FSDERIVPLT DADSNYGAFK RAVLDKLPST
110 120 130 140 150
SQPNVYPMDE SLIGSDAESN NKIAAEYERI VPQVLDLVLL GCGPDGHTCS
160 170 180 190 200
LFPGETHRYL LNETTKRVAW CHDSPKPPSD RITFTLPVLK DAKALCFVAE
210 220 230 240
GSSKQNIMHE IFDLKNDQLP TALVNKLFGE KTSWFVNEEA FGKVQTKTF
Length:249
Mass (Da):27,784
Last modified:June 16, 2009 - v2
Checksum:iF19B313390EA6B3D
GO

Sequence cautioni

The sequence AAB49323.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAB68008.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46560 Genomic DNA. Translation: AAB49323.1. Different initiation.
U00027 Genomic DNA. Translation: AAB68008.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06856.1.
PIRiS48903.
RefSeqiNP_012033.2. NM_001179294.1.

Genome annotation databases

EnsemblFungiiYHR163W; YHR163W; YHR163W.
GeneIDi856568.
KEGGisce:YHR163W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46560 Genomic DNA. Translation: AAB49323.1. Different initiation.
U00027 Genomic DNA. Translation: AAB68008.1. Different initiation.
BK006934 Genomic DNA. Translation: DAA06856.1.
PIRiS48903.
RefSeqiNP_012033.2. NM_001179294.1.

3D structure databases

ProteinModelPortaliP38858.
SMRiP38858. Positions 19-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36597. 42 interactions.
DIPiDIP-5625N.
IntActiP38858. 1 interaction.
MINTiMINT-508230.
STRINGi4932.YHR163W.

Proteomic databases

MaxQBiP38858.
PaxDbiP38858.
PeptideAtlasiP38858.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR163W; YHR163W; YHR163W.
GeneIDi856568.
KEGGisce:YHR163W.

Organism-specific databases

EuPathDBiFungiDB:YHR163W.
SGDiS000001206. SOL3.

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiP38858.
KOiK01057.
OMAiDHPERNS.
OrthoDBiEOG7MD51D.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciYEAST:MONOMER3O-4032.
ReactomeiREACT_318870. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi982408.
PROiP38858.

Gene expression databases

GenevestigatoriP38858.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family."
    Shen W.-C., Stanford D.R., Hopper A.K.
    Genetics 143:699-712(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism."
    Stanford D.R., Whitney M.L., Hurto R.L., Eisaman D.M., Shen W.-C., Hopper A.K.
    Genetics 168:117-127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
    Zhang Z., Dietrich F.S.
    Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSOL3_YEAST
AccessioniPrimary (citable) accession number: P38858
Secondary accession number(s): D3DLB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: April 29, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.