true1995-02-012024-01-24134PEX18_YEASTComplete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.Johnston M.Andrews S.Brinkman R.Cooper J.Ding H.Dover J.Du Z.Favello A.Fulton L.Gattung S.Geisel C.Kirsten J.Kucaba T.Hillier L.W.Jier M.Johnston L.Langston Y.Latreille P.Louis E.J.Macri C.Mardis E.Menezes S.Mouser L.Nhan M.Rifkin L.Riles L.St Peter H.Trevaskis E.Vaughan K.Vignati D.Wilcox L.Wohldman P.Waterston R.Wilson R.Vaudin M.doi:10.1126/science.80912291994Science2652077-2082NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]ATCC 204508 / S288cThe reference genome sequence of Saccharomyces cerevisiae: Then and now.Engel S.R.Dietrich F.S.Fisk D.G.Binkley G.Balakrishnan R.Costanzo M.C.Dwight S.S.Hitz B.C.Karra K.Nash R.S.Weng S.Wong E.D.Lloyd P.Skrzypek M.S.Miyasato S.R.Simison M.Cherry J.M.doi:10.1534/g3.113.0089952014G3 (Bethesda)4389-398GENOME REANNOTATIONPex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway.Purdue P.E.Yang X.Lazarow P.B.doi:10.1083/jcb.143.7.18591998J. Cell Biol.1431859-1869FUNCTIONSUBCELLULAR LOCATIONINTERACTION WITH PEX7Pex18p is constitutively degraded during peroxisome biogenesis.Purdue P.E.Lazarow P.B.doi:10.1074/jbc.m1068232002001J. Biol. Chem.27647684-47689UBIQUITINATIONINTERACTION WITH PEX7STABILITYInteractions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import.Stein K.Schell-Steven A.Erdmann R.Rottensteiner H.doi:10.1128/mcb.22.17.6056-6069.20022002Mol. Cell. Biol.226056-6069FUNCTIONINTERACTION WITH PEX7 AND PEX13Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p.Schaefer A.Kerssen D.Veenhuis M.Kunau W.-H.Schliebs W.doi:10.1128/mcb.24.20.8895-8906.20042004Mol. Cell. Biol.248895-8906FUNCTIONYarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway.Einwaechter H.Sowinski S.Kunau W.H.Schliebs W.doi:10.1093/embo-reports/kve2282001EMBO Rep.21035-1039INTERACTION WITH PEX7MUTAGENESIS OF SER-23079Peroxisomal PEX7-PEX18 receptor complex5the peroxisomal protein importer (ppi) familyPEX180 hits in 10 CRISPR screensProteinPeroxisomal membrane protein PEX18Peroxin-18PEX18YHR160CInvolved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2 (PubMed:12167700, PubMed:15456864, PubMed:9864360). Required for peroxisomal targeting of PEX7 and growth on oleate (PubMed:12167700, PubMed:15456864, PubMed:9864360).Interacts with PEX7; The interaction with PEX7 stabilizes PEX18 (PubMed:12167700, PubMed:11590152, PubMed:9864360, PubMed:11606420). Interacts with PEX13 (PubMed:12167700).Ubiquitinated in a UBC4/UBC5 dependent manner.Peroxisomal membrane protein PEX18320371283Disordered179201Abolished interaction with PEX7.F230false6PEX71995-02-011320375c32def5ca870f473071565e462e09f5MNSNRCQTNEVNKFISSTEKGPFTGRDNTLSFNKIGSRLNSPPILKDKIELKFLQHSEDLNQSRSYVNIRPRTLEDQSYKFEAPNLNDNETSWAKDFRYNFPKNVEPPIENQIANLNINNGLRTSQTDFPLGFYSQKNFNIASFPVVDHQIFKTTGLEHPINSHIDSLINAEFSELEASSLEEDVHTEEENSGTSLEDEETAMKGLASDIIEFCDNNSANKDVKERLNSSKFMGLMGSISDGSIVLKKDNGTERNLQKHVGFCFQNSGNWAGLEFHDVEDRIAtruetruetruetruetruetruetruetruetrue