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P38855

- PEX18_YEAST

UniProt

P38855 - PEX18_YEAST

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Protein

Peroxisomal membrane protein PEX18

Gene

PEX18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate.3 Publications

GO - Biological processi

  1. protein import into peroxisome matrix Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31195-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX18
Alternative name(s):
Peroxin-18
Gene namesi
Name:PEX18
Ordered Locus Names:YHR160C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR160c.
SGDiS000001203. PEX18.

Subcellular locationi

Cytoplasm 1 Publication. Peroxisome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. membrane Source: UniProtKB-KW
  3. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Peroxisomal membrane protein PEX18PRO_0000202929Add
BLAST

Post-translational modificationi

Ubiquitinated in a UBC4/UBC5 dependent manner.1 Publication

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

GenevestigatoriP38855.

Interactioni

Subunit structurei

Interacts with PEX7 and PEX13. The interaction with PEX7 stabilizes PEX18.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX7P391085EBI-24803,EBI-13183

Protein-protein interaction databases

BioGridi36594. 53 interactions.
DIPiDIP-1502N.
IntActiP38855. 5 interactions.
MINTiMINT-409610.
STRINGi4932.YHR160C.

Structurei

3D structure databases

ProteinModelPortaliP38855.
SMRiP38855. Positions 201-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OMAiPINSHID.
OrthoDBiEOG7TXKSZ.

Sequencei

Sequence statusi: Complete.

P38855-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE
60 70 80 90 100
LKFLQHSEDL NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN
110 120 130 140 150
FPKNVEPPIE NQIANLNINN GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ
160 170 180 190 200
IFKTTGLEHP INSHIDSLIN AEFSELEASS LEEDVHTEEE NSGTSLEDEE
210 220 230 240 250
TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS DGSIVLKKDN
260 270 280
GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA
Length:283
Mass (Da):32,037
Last modified:February 1, 1995 - v1
Checksum:i574C644FD7ED7A71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68992.1.
BK006934 Genomic DNA. Translation: DAA06853.1.
PIRiS46770.
RefSeqiNP_012030.1. NM_001179291.1.

Genome annotation databases

EnsemblFungiiYHR160C; YHR160C; YHR160C.
GeneIDi856565.
KEGGisce:YHR160C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68992.1 .
BK006934 Genomic DNA. Translation: DAA06853.1 .
PIRi S46770.
RefSeqi NP_012030.1. NM_001179291.1.

3D structure databases

ProteinModelPortali P38855.
SMRi P38855. Positions 201-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36594. 53 interactions.
DIPi DIP-1502N.
IntActi P38855. 5 interactions.
MINTi MINT-409610.
STRINGi 4932.YHR160C.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR160C ; YHR160C ; YHR160C .
GeneIDi 856565.
KEGGi sce:YHR160C.

Organism-specific databases

CYGDi YHR160c.
SGDi S000001203. PEX18.

Phylogenomic databases

OMAi PINSHID.
OrthoDBi EOG7TXKSZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-31195-MONOMER.

Miscellaneous databases

NextBioi 982399.

Gene expression databases

Genevestigatori P38855.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway."
    Purdue P.E., Yang X., Lazarow P.B.
    J. Cell Biol. 143:1859-1869(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PEX7.
  4. "Pex18p is constitutively degraded during peroxisome biogenesis."
    Purdue P.E., Lazarow P.B.
    J. Biol. Chem. 276:47684-47689(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH PEX7, STABILITY.
  5. "Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import."
    Stein K., Schell-Steven A., Erdmann R., Rottensteiner H.
    Mol. Cell. Biol. 22:6056-6069(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PEX7 AND PEX13.
  6. "Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p."
    Schaefer A., Kerssen D., Veenhuis M., Kunau W.-H., Schliebs W.
    Mol. Cell. Biol. 24:8895-8906(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPEX18_YEAST
AccessioniPrimary (citable) accession number: P38855
Secondary accession number(s): D3DLA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3