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P38855

- PEX18_YEAST

UniProt

P38855 - PEX18_YEAST

Protein

Peroxisomal membrane protein PEX18

Gene

PEX18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate.3 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. protein import into peroxisome matrix Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31195-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX18
    Alternative name(s):
    Peroxin-18
    Gene namesi
    Name:PEX18
    Ordered Locus Names:YHR160C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR160c.
    SGDiS000001203. PEX18.

    Subcellular locationi

    Cytoplasm 1 Publication. Peroxisome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. peroxisomal membrane Source: UniProtKB-SubCell
    3. peroxisome Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Peroxisomal membrane protein PEX18PRO_0000202929Add
    BLAST

    Post-translational modificationi

    Ubiquitinated in a UBC4/UBC5 dependent manner.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Expressioni

    Gene expression databases

    GenevestigatoriP38855.

    Interactioni

    Subunit structurei

    Interacts with PEX7 and PEX13. The interaction with PEX7 stabilizes PEX18.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX7P391085EBI-24803,EBI-13183

    Protein-protein interaction databases

    BioGridi36594. 53 interactions.
    DIPiDIP-1502N.
    IntActiP38855. 5 interactions.
    MINTiMINT-409610.
    STRINGi4932.YHR160C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38855.
    SMRiP38855. Positions 201-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    OMAiPINSHID.
    OrthoDBiEOG7TXKSZ.

    Sequencei

    Sequence statusi: Complete.

    P38855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE    50
    LKFLQHSEDL NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN 100
    FPKNVEPPIE NQIANLNINN GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ 150
    IFKTTGLEHP INSHIDSLIN AEFSELEASS LEEDVHTEEE NSGTSLEDEE 200
    TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS DGSIVLKKDN 250
    GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA 283
    Length:283
    Mass (Da):32,037
    Last modified:February 1, 1995 - v1
    Checksum:i574C644FD7ED7A71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10397 Genomic DNA. Translation: AAB68992.1.
    BK006934 Genomic DNA. Translation: DAA06853.1.
    PIRiS46770.
    RefSeqiNP_012030.1. NM_001179291.1.

    Genome annotation databases

    EnsemblFungiiYHR160C; YHR160C; YHR160C.
    GeneIDi856565.
    KEGGisce:YHR160C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10397 Genomic DNA. Translation: AAB68992.1 .
    BK006934 Genomic DNA. Translation: DAA06853.1 .
    PIRi S46770.
    RefSeqi NP_012030.1. NM_001179291.1.

    3D structure databases

    ProteinModelPortali P38855.
    SMRi P38855. Positions 201-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36594. 53 interactions.
    DIPi DIP-1502N.
    IntActi P38855. 5 interactions.
    MINTi MINT-409610.
    STRINGi 4932.YHR160C.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR160C ; YHR160C ; YHR160C .
    GeneIDi 856565.
    KEGGi sce:YHR160C.

    Organism-specific databases

    CYGDi YHR160c.
    SGDi S000001203. PEX18.

    Phylogenomic databases

    OMAi PINSHID.
    OrthoDBi EOG7TXKSZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31195-MONOMER.

    Miscellaneous databases

    NextBioi 982399.

    Gene expression databases

    Genevestigatori P38855.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway."
      Purdue P.E., Yang X., Lazarow P.B.
      J. Cell Biol. 143:1859-1869(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PEX7.
    4. "Pex18p is constitutively degraded during peroxisome biogenesis."
      Purdue P.E., Lazarow P.B.
      J. Biol. Chem. 276:47684-47689(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, INTERACTION WITH PEX7, STABILITY.
    5. "Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import."
      Stein K., Schell-Steven A., Erdmann R., Rottensteiner H.
      Mol. Cell. Biol. 22:6056-6069(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PEX7 AND PEX13.
    6. "Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p."
      Schaefer A., Kerssen D., Veenhuis M., Kunau W.-H., Schliebs W.
      Mol. Cell. Biol. 24:8895-8906(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPEX18_YEAST
    AccessioniPrimary (citable) accession number: P38855
    Secondary accession number(s): D3DLA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3