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Protein

Peroxisomal membrane protein PEX18

Gene

PEX18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate.3 Publications

GO - Biological processi

  • protein import into peroxisome matrix Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31195-MONOMER

Protein family/group databases

TCDBi3.A.20.1.5 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX18
Alternative name(s):
Peroxin-18
Gene namesi
Name:PEX18
Ordered Locus Names:YHR160C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR160C
SGDiS000001203 PEX18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002029291 – 283Peroxisomal membrane protein PEX18Add BLAST283

Post-translational modificationi

Ubiquitinated in a UBC4/UBC5 dependent manner.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP38855
PRIDEiP38855

PTM databases

iPTMnetiP38855

Interactioni

Subunit structurei

Interacts with PEX7 and PEX13. The interaction with PEX7 stabilizes PEX18.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX7P391086EBI-24803,EBI-13183

Protein-protein interaction databases

BioGridi36594, 77 interactors
DIPiDIP-1502N
IntActiP38855, 5 interactors
MINTiP38855
STRINGi4932.YHR160C

Structurei

3D structure databases

ProteinModelPortaliP38855
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OrthoDBiEOG092C3RVX

Sequencei

Sequence statusi: Complete.

P38855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE
60 70 80 90 100
LKFLQHSEDL NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN
110 120 130 140 150
FPKNVEPPIE NQIANLNINN GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ
160 170 180 190 200
IFKTTGLEHP INSHIDSLIN AEFSELEASS LEEDVHTEEE NSGTSLEDEE
210 220 230 240 250
TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS DGSIVLKKDN
260 270 280
GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA
Length:283
Mass (Da):32,037
Last modified:February 1, 1995 - v1
Checksum:i574C644FD7ED7A71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA Translation: AAB68992.1
BK006934 Genomic DNA Translation: DAA06853.1
PIRiS46770
RefSeqiNP_012030.1, NM_001179291.1

Genome annotation databases

EnsemblFungiiYHR160C; YHR160C; YHR160C
GeneIDi856565
KEGGisce:YHR160C

Similar proteinsi

Entry informationi

Entry nameiPEX18_YEAST
AccessioniPrimary (citable) accession number: P38855
Secondary accession number(s): D3DLA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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