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Protein

Peroxisomal membrane protein PEX18

Gene

PEX18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate.3 Publications

GO - Biological processi

  1. protein import into peroxisome matrix Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31195-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX18
Alternative name(s):
Peroxin-18
Gene namesi
Name:PEX18
Ordered Locus Names:YHR160C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR160c.
SGDiS000001203. PEX18.

Subcellular locationi

Cytoplasm 1 Publication. Peroxisome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. peroxisomal membrane Source: UniProtKB-SubCell
  3. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Peroxisomal membrane protein PEX18PRO_0000202929Add
BLAST

Post-translational modificationi

Ubiquitinated in a UBC4/UBC5 dependent manner.1 Publication

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

GenevestigatoriP38855.

Interactioni

Subunit structurei

Interacts with PEX7 and PEX13. The interaction with PEX7 stabilizes PEX18.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX7P391085EBI-24803,EBI-13183

Protein-protein interaction databases

BioGridi36594. 56 interactions.
DIPiDIP-1502N.
IntActiP38855. 5 interactions.
MINTiMINT-409610.
STRINGi4932.YHR160C.

Structurei

3D structure databases

ProteinModelPortaliP38855.
SMRiP38855. Positions 201-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OrthoDBiEOG7TXKSZ.

Sequencei

Sequence statusi: Complete.

P38855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE
60 70 80 90 100
LKFLQHSEDL NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN
110 120 130 140 150
FPKNVEPPIE NQIANLNINN GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ
160 170 180 190 200
IFKTTGLEHP INSHIDSLIN AEFSELEASS LEEDVHTEEE NSGTSLEDEE
210 220 230 240 250
TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS DGSIVLKKDN
260 270 280
GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA
Length:283
Mass (Da):32,037
Last modified:February 1, 1995 - v1
Checksum:i574C644FD7ED7A71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68992.1.
BK006934 Genomic DNA. Translation: DAA06853.1.
PIRiS46770.
RefSeqiNP_012030.1. NM_001179291.1.

Genome annotation databases

EnsemblFungiiYHR160C; YHR160C; YHR160C.
GeneIDi856565.
KEGGisce:YHR160C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68992.1.
BK006934 Genomic DNA. Translation: DAA06853.1.
PIRiS46770.
RefSeqiNP_012030.1. NM_001179291.1.

3D structure databases

ProteinModelPortaliP38855.
SMRiP38855. Positions 201-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36594. 56 interactions.
DIPiDIP-1502N.
IntActiP38855. 5 interactions.
MINTiMINT-409610.
STRINGi4932.YHR160C.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR160C; YHR160C; YHR160C.
GeneIDi856565.
KEGGisce:YHR160C.

Organism-specific databases

CYGDiYHR160c.
SGDiS000001203. PEX18.

Phylogenomic databases

OrthoDBiEOG7TXKSZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31195-MONOMER.

Miscellaneous databases

NextBioi982399.

Gene expression databases

GenevestigatoriP38855.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway."
    Purdue P.E., Yang X., Lazarow P.B.
    J. Cell Biol. 143:1859-1869(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PEX7.
  4. "Pex18p is constitutively degraded during peroxisome biogenesis."
    Purdue P.E., Lazarow P.B.
    J. Biol. Chem. 276:47684-47689(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH PEX7, STABILITY.
  5. "Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import."
    Stein K., Schell-Steven A., Erdmann R., Rottensteiner H.
    Mol. Cell. Biol. 22:6056-6069(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PEX7 AND PEX13.
  6. "Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p."
    Schaefer A., Kerssen D., Veenhuis M., Kunau W.-H., Schliebs W.
    Mol. Cell. Biol. 24:8895-8906(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPEX18_YEAST
AccessioniPrimary (citable) accession number: P38855
Secondary accession number(s): D3DLA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.