Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P38855 (PEX18_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PEX18
Alternative name(s):
Peroxin-18
Gene names
Name:PEX18
Ordered Locus Names:YHR160C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Ref.3 Ref.5 Ref.6

Subunit structure

Interacts with PEX7 and PEX13. The interaction with PEX7 stabilizes PEX18. Ref.3 Ref.4 Ref.5

Subcellular location

Cytoplasm. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side Ref.3.

Post-translational modification

Ubiquitinated in a UBC4/UBC5 dependent manner. Ref.4

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PEX7P391085EBI-24803,EBI-13183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Peroxisomal membrane protein PEX18
PRO_0000202929

Sequences

Sequence LengthMass (Da)Tools
P38855 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 574C644FD7ED7A71

FASTA28332,037
        10         20         30         40         50         60 
MNSNRCQTNE VNKFISSTEK GPFTGRDNTL SFNKIGSRLN SPPILKDKIE LKFLQHSEDL 

        70         80         90        100        110        120 
NQSRSYVNIR PRTLEDQSYK FEAPNLNDNE TSWAKDFRYN FPKNVEPPIE NQIANLNINN 

       130        140        150        160        170        180 
GLRTSQTDFP LGFYSQKNFN IASFPVVDHQ IFKTTGLEHP INSHIDSLIN AEFSELEASS 

       190        200        210        220        230        240 
LEEDVHTEEE NSGTSLEDEE TAMKGLASDI IEFCDNNSAN KDVKERLNSS KFMGLMGSIS 

       250        260        270        280 
DGSIVLKKDN GTERNLQKHV GFCFQNSGNW AGLEFHDVED RIA 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway."
Purdue P.E., Yang X., Lazarow P.B.
J. Cell Biol. 143:1859-1869(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PEX7.
[4]"Pex18p is constitutively degraded during peroxisome biogenesis."
Purdue P.E., Lazarow P.B.
J. Biol. Chem. 276:47684-47689(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION, INTERACTION WITH PEX7, STABILITY.
[5]"Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import."
Stein K., Schell-Steven A., Erdmann R., Rottensteiner H.
Mol. Cell. Biol. 22:6056-6069(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PEX7 AND PEX13.
[6]"Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p."
Schaefer A., Kerssen D., Veenhuis M., Kunau W.-H., Schliebs W.
Mol. Cell. Biol. 24:8895-8906(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10397 Genomic DNA. Translation: AAB68992.1.
BK006934 Genomic DNA. Translation: DAA06853.1.
PIRS46770.
RefSeqNP_012030.1. NM_001179291.1.

3D structure databases

ProteinModelPortalP38855.
SMRP38855. Positions 201-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36594. 53 interactions.
DIPDIP-1502N.
IntActP38855. 5 interactions.
MINTMINT-409610.
STRING4932.YHR160C.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR160C; YHR160C; YHR160C.
GeneID856565.
KEGGsce:YHR160C.

Organism-specific databases

CYGDYHR160c.
SGDS000001203. PEX18.

Phylogenomic databases

OrthoDBEOG7TXKSZ.

Enzyme and pathway databases

BioCycYEAST:G3O-31195-MONOMER.

Gene expression databases

GenevestigatorP38855.

Family and domain databases

ProtoNetSearch...

Other

NextBio982399.

Entry information

Entry namePEX18_YEAST
AccessionPrimary (citable) accession number: P38855
Secondary accession number(s): D3DLA9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD