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P38853

- KEL1_YEAST

UniProt

P38853 - KEL1_YEAST

Protein

Kelch repeat-containing protein 1

Gene

KEL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cytogamy Source: SGD
    2. negative regulation of exit from mitosis Source: SGD
    3. regulation of cell shape Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31193-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch repeat-containing protein 1
    Gene namesi
    Name:KEL1
    Ordered Locus Names:YHR158C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR158c.
    SGDiS000001201. KEL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: SGD
    2. cellular bud neck Source: SGD
    3. cellular bud tip Source: SGD
    4. mating projection tip Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11641164Kelch repeat-containing protein 1PRO_0000119096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Phosphoserine1 Publication
    Modified residuei23 – 231Phosphoserine2 Publications
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei94 – 941Phosphoserine1 Publication
    Modified residuei467 – 4671Phosphothreonine1 Publication
    Modified residuei477 – 4771Phosphothreonine1 Publication
    Modified residuei503 – 5031Phosphoserine2 Publications
    Modified residuei604 – 6041Phosphothreonine1 Publication
    Modified residuei613 – 6131Phosphoserine4 Publications
    Modified residuei626 – 6261Phosphothreonine1 Publication
    Modified residuei689 – 6891Phosphoserine1 Publication
    Modified residuei691 – 6911Phosphoserine2 Publications
    Modified residuei717 – 7171Phosphoserine1 Publication
    Modified residuei748 – 7481Phosphoserine2 Publications
    Modified residuei837 – 8371Phosphoserine1 Publication
    Modified residuei848 – 8481Phosphoserine1 Publication
    Modified residuei958 – 9581Phosphoserine1 Publication
    Modified residuei997 – 9971Phosphoserine1 Publication
    Modified residuei1003 – 10031Phosphoserine1 Publication
    Modified residuei1022 – 10221Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38853.
    PaxDbiP38853.
    PeptideAtlasiP38853.

    2D gel databases

    COMPLUYEAST-2DPAGEP38853.

    Expressioni

    Gene expression databases

    GenevestigatoriP38853.

    Interactioni

    Subunit structurei

    Interacts with KEL2.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself5EBI-9619,EBI-9619
    BCK2P333062EBI-9619,EBI-3480
    KEL2P500904EBI-9619,EBI-9630
    LTE1P078664EBI-9619,EBI-10243
    PAC1P399463EBI-9619,EBI-12838

    Protein-protein interaction databases

    BioGridi36592. 104 interactions.
    DIPiDIP-1403N.
    IntActiP38853. 31 interactions.
    MINTiMINT-385237.
    STRINGi4932.YHR158C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38853.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati139 – 18648Kelch 1Add
    BLAST
    Repeati253 – 30755Kelch 2Add
    BLAST
    Repeati308 – 35750Kelch 3Add
    BLAST
    Repeati359 – 40951Kelch 4Add
    BLAST
    Repeati411 – 46050Kelch 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili777 – 931155Sequence AnalysisAdd
    BLAST
    Coiled coili974 – 1163190Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 Kelch repeats.Curated

    Keywords - Domaini

    Coiled coil, Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG145020.
    GeneTreeiENSGT00720000108564.
    HOGENOMiHOG000000942.
    OMAiPDNNFYL.
    OrthoDBiEOG7008HF.

    Family and domain databases

    Gene3Di2.120.10.80. 1 hit.
    InterProiIPR015915. Kelch-typ_b-propeller.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGFSFAKKF THKKHGKTPS DASISDQSRE ASLSTPPNEK FFTKQETPQK     50
    GRQFSQGYHS NVNKTSSPPM FARKQVSESR IQPSAVPPQQ RNVSGPSTTL 100
    HKQLSKQREY TVWNRIKLQN SPFPRYRHVA SAYVTDKNQI YVIGGLHDQS 150
    VYGDTWILTA FDNATRFSTT TIDISEATPP PRVGHAAVLC GNAFVVFGGD 200
    THKVNKEGLM DDDIYLLNIN SYKWTVPAPV GPRPLGRYGH KISIIATTQM 250
    KTKLYVFGGQ FDDTYFNDLA VYDLSSFRRP DSHWEFLKPR TFTPPPITNF 300
    TMISYDSKLW VFGGDTLQGL VNDVFMYDPA INDWFIIDTT GEKPPPVQEH 350
    ATVVYNDLMC VVGGKDEHDA YLNSVYFLNL KSRKWFKLPV FTAGIPQGRS 400
    GHSLTLLKND KILIMGGDKF DYARVEEYDL HTSDIDMQRG TIVYTLDLAR 450
    IKDLCPGVMD VPTDTPTPRN GNLDLATPVT PTSHQTKNMN VPISAAPLAS 500
    APSPAPKDFS DADRLNREVH NRNVSTEHQN QSHPVNSESH LIAEPNILTP 550
    YVPSESSQTP VMKITSNKPF DTPTIQKEPD LSETMDPTVG NQRIPSSIYG 600
    DNLTPANQIK NNSPILETLP SNEIKTPQNG NIEEIKHLPD ADEKIDSTTT 650
    FDQEINGDKL GTSSMSKVEE DGNVADEDDE IGVAQMASSP SKDQFKIKHY 700
    NESSELSQNN TEIDKLSEPV DITIKKSDTA GHDSANHVID ASDEKNVSPM 750
    GDVPTDTKNE EASVPINRDA TTEVVDRALF EKLRSELQSL KELTHEKALE 800
    AGAHIKELET ELWQLKSQKN SGTTKEIDEL DSVRLQSKCE ILEADNHSLE 850
    DKVNELEELV NSKFLDIENL NEVIQFQNEK IKSLELEPNY KEKLEELQIE 900
    HENLSRENER LKNESKQHNE DIINNVANYS SQLGSLISHW KENRANSSFL 950
    ESSSSLISVS DENGEKTVGE PYGDQSRHHR VVINKLTNRL DDLLERSQEL 1000
    TISKEKLSSE YHALKMEHSS LSQDVLVKEN EIKKIQNDYK ESISSMDSAS 1050
    KALMVSQREL EKYKSLNKKL IDELDELKFK NGVCSENFEN GLRSTEESSN 1100
    NVKNSNSIRE NQFNIKINDL KAELFITNQE RDDLKSEVLE LKKRLLNLEN 1150
    NTKQVNEDAD SDLL 1164
    Length:1,164
    Mass (Da):131,094
    Last modified:February 1, 1995 - v1
    Checksum:i43D0FC570F1D5E4D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti447 – 4471D → A in AAT92822. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10397 Genomic DNA. Translation: AAB68991.1.
    AY692803 Genomic DNA. Translation: AAT92822.1.
    BK006934 Genomic DNA. Translation: DAA06851.1.
    PIRiS46769.
    RefSeqiNP_012028.1. NM_001179289.1.

    Genome annotation databases

    EnsemblFungiiYHR158C; YHR158C; YHR158C.
    GeneIDi856563.
    KEGGisce:YHR158C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10397 Genomic DNA. Translation: AAB68991.1 .
    AY692803 Genomic DNA. Translation: AAT92822.1 .
    BK006934 Genomic DNA. Translation: DAA06851.1 .
    PIRi S46769.
    RefSeqi NP_012028.1. NM_001179289.1.

    3D structure databases

    ProteinModelPortali P38853.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36592. 104 interactions.
    DIPi DIP-1403N.
    IntActi P38853. 31 interactions.
    MINTi MINT-385237.
    STRINGi 4932.YHR158C.

    2D gel databases

    COMPLUYEAST-2DPAGE P38853.

    Proteomic databases

    MaxQBi P38853.
    PaxDbi P38853.
    PeptideAtlasi P38853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR158C ; YHR158C ; YHR158C .
    GeneIDi 856563.
    KEGGi sce:YHR158C.

    Organism-specific databases

    CYGDi YHR158c.
    SGDi S000001201. KEL1.

    Phylogenomic databases

    eggNOGi NOG145020.
    GeneTreei ENSGT00720000108564.
    HOGENOMi HOG000000942.
    OMAi PDNNFYL.
    OrthoDBi EOG7008HF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31193-MONOMER.

    Miscellaneous databases

    NextBioi 982393.

    Gene expression databases

    Genevestigatori P38853.

    Family and domain databases

    Gene3Di 2.120.10.80. 1 hit.
    InterProi IPR015915. Kelch-typ_b-propeller.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae."
      Philips J., Herskowitz I.
      J. Cell Biol. 143:375-389(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-477; SER-613; SER-691 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-25; THR-467; SER-503; THR-604; SER-613; THR-626; SER-748; SER-837; SER-997 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-503; SER-613; SER-689; SER-691; SER-717; SER-748; SER-848; SER-958 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKEL1_YEAST
    AccessioniPrimary (citable) accession number: P38853
    Secondary accession number(s): D3DLA7, E9P8X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1350 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3