Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38853

- KEL1_YEAST

UniProt

P38853 - KEL1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Kelch repeat-containing protein 1

Gene

KEL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. cytogamy Source: SGD
  2. negative regulation of exit from mitosis Source: SGD
  3. regulation of cell shape Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31193-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat-containing protein 1
Gene namesi
Name:KEL1
Ordered Locus Names:YHR158C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR158c.
SGDiS000001201. KEL1.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: SGD
  2. cellular bud neck Source: SGD
  3. cellular bud tip Source: SGD
  4. mating projection tip Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11641164Kelch repeat-containing protein 1PRO_0000119096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphoserine1 Publication
Modified residuei23 – 231Phosphoserine2 Publications
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei94 – 941Phosphoserine1 Publication
Modified residuei467 – 4671Phosphothreonine1 Publication
Modified residuei477 – 4771Phosphothreonine1 Publication
Modified residuei503 – 5031Phosphoserine2 Publications
Modified residuei604 – 6041Phosphothreonine1 Publication
Modified residuei613 – 6131Phosphoserine4 Publications
Modified residuei626 – 6261Phosphothreonine1 Publication
Modified residuei689 – 6891Phosphoserine1 Publication
Modified residuei691 – 6911Phosphoserine2 Publications
Modified residuei717 – 7171Phosphoserine1 Publication
Modified residuei748 – 7481Phosphoserine2 Publications
Modified residuei837 – 8371Phosphoserine1 Publication
Modified residuei848 – 8481Phosphoserine1 Publication
Modified residuei958 – 9581Phosphoserine1 Publication
Modified residuei997 – 9971Phosphoserine1 Publication
Modified residuei1003 – 10031Phosphoserine1 Publication
Modified residuei1022 – 10221Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38853.
PaxDbiP38853.
PeptideAtlasiP38853.

2D gel databases

COMPLUYEAST-2DPAGEP38853.

Expressioni

Gene expression databases

GenevestigatoriP38853.

Interactioni

Subunit structurei

Interacts with KEL2.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-9619,EBI-9619
BCK2P333062EBI-9619,EBI-3480
KEL2P500904EBI-9619,EBI-9630
LTE1P078664EBI-9619,EBI-10243
PAC1P399463EBI-9619,EBI-12838

Protein-protein interaction databases

BioGridi36592. 105 interactions.
DIPiDIP-1403N.
IntActiP38853. 31 interactions.
MINTiMINT-385237.
STRINGi4932.YHR158C.

Structurei

3D structure databases

ProteinModelPortaliP38853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati139 – 18648Kelch 1Add
BLAST
Repeati253 – 30755Kelch 2Add
BLAST
Repeati308 – 35750Kelch 3Add
BLAST
Repeati359 – 40951Kelch 4Add
BLAST
Repeati411 – 46050Kelch 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili777 – 931155Sequence AnalysisAdd
BLAST
Coiled coili974 – 1163190Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 5 Kelch repeats.Curated

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG145020.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000000942.
InParanoidiP38853.
OMAiPDNNFYL.
OrthoDBiEOG7008HF.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGFSFAKKF THKKHGKTPS DASISDQSRE ASLSTPPNEK FFTKQETPQK
60 70 80 90 100
GRQFSQGYHS NVNKTSSPPM FARKQVSESR IQPSAVPPQQ RNVSGPSTTL
110 120 130 140 150
HKQLSKQREY TVWNRIKLQN SPFPRYRHVA SAYVTDKNQI YVIGGLHDQS
160 170 180 190 200
VYGDTWILTA FDNATRFSTT TIDISEATPP PRVGHAAVLC GNAFVVFGGD
210 220 230 240 250
THKVNKEGLM DDDIYLLNIN SYKWTVPAPV GPRPLGRYGH KISIIATTQM
260 270 280 290 300
KTKLYVFGGQ FDDTYFNDLA VYDLSSFRRP DSHWEFLKPR TFTPPPITNF
310 320 330 340 350
TMISYDSKLW VFGGDTLQGL VNDVFMYDPA INDWFIIDTT GEKPPPVQEH
360 370 380 390 400
ATVVYNDLMC VVGGKDEHDA YLNSVYFLNL KSRKWFKLPV FTAGIPQGRS
410 420 430 440 450
GHSLTLLKND KILIMGGDKF DYARVEEYDL HTSDIDMQRG TIVYTLDLAR
460 470 480 490 500
IKDLCPGVMD VPTDTPTPRN GNLDLATPVT PTSHQTKNMN VPISAAPLAS
510 520 530 540 550
APSPAPKDFS DADRLNREVH NRNVSTEHQN QSHPVNSESH LIAEPNILTP
560 570 580 590 600
YVPSESSQTP VMKITSNKPF DTPTIQKEPD LSETMDPTVG NQRIPSSIYG
610 620 630 640 650
DNLTPANQIK NNSPILETLP SNEIKTPQNG NIEEIKHLPD ADEKIDSTTT
660 670 680 690 700
FDQEINGDKL GTSSMSKVEE DGNVADEDDE IGVAQMASSP SKDQFKIKHY
710 720 730 740 750
NESSELSQNN TEIDKLSEPV DITIKKSDTA GHDSANHVID ASDEKNVSPM
760 770 780 790 800
GDVPTDTKNE EASVPINRDA TTEVVDRALF EKLRSELQSL KELTHEKALE
810 820 830 840 850
AGAHIKELET ELWQLKSQKN SGTTKEIDEL DSVRLQSKCE ILEADNHSLE
860 870 880 890 900
DKVNELEELV NSKFLDIENL NEVIQFQNEK IKSLELEPNY KEKLEELQIE
910 920 930 940 950
HENLSRENER LKNESKQHNE DIINNVANYS SQLGSLISHW KENRANSSFL
960 970 980 990 1000
ESSSSLISVS DENGEKTVGE PYGDQSRHHR VVINKLTNRL DDLLERSQEL
1010 1020 1030 1040 1050
TISKEKLSSE YHALKMEHSS LSQDVLVKEN EIKKIQNDYK ESISSMDSAS
1060 1070 1080 1090 1100
KALMVSQREL EKYKSLNKKL IDELDELKFK NGVCSENFEN GLRSTEESSN
1110 1120 1130 1140 1150
NVKNSNSIRE NQFNIKINDL KAELFITNQE RDDLKSEVLE LKKRLLNLEN
1160
NTKQVNEDAD SDLL
Length:1,164
Mass (Da):131,094
Last modified:February 1, 1995 - v1
Checksum:i43D0FC570F1D5E4D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471D → A in AAT92822. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10397 Genomic DNA. Translation: AAB68991.1.
AY692803 Genomic DNA. Translation: AAT92822.1.
BK006934 Genomic DNA. Translation: DAA06851.1.
PIRiS46769.
RefSeqiNP_012028.1. NM_001179289.1.

Genome annotation databases

EnsemblFungiiYHR158C; YHR158C; YHR158C.
GeneIDi856563.
KEGGisce:YHR158C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10397 Genomic DNA. Translation: AAB68991.1 .
AY692803 Genomic DNA. Translation: AAT92822.1 .
BK006934 Genomic DNA. Translation: DAA06851.1 .
PIRi S46769.
RefSeqi NP_012028.1. NM_001179289.1.

3D structure databases

ProteinModelPortali P38853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36592. 105 interactions.
DIPi DIP-1403N.
IntActi P38853. 31 interactions.
MINTi MINT-385237.
STRINGi 4932.YHR158C.

2D gel databases

COMPLUYEAST-2DPAGE P38853.

Proteomic databases

MaxQBi P38853.
PaxDbi P38853.
PeptideAtlasi P38853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR158C ; YHR158C ; YHR158C .
GeneIDi 856563.
KEGGi sce:YHR158C.

Organism-specific databases

CYGDi YHR158c.
SGDi S000001201. KEL1.

Phylogenomic databases

eggNOGi NOG145020.
GeneTreei ENSGT00760000119086.
HOGENOMi HOG000000942.
InParanoidi P38853.
OMAi PDNNFYL.
OrthoDBi EOG7008HF.

Enzyme and pathway databases

BioCyci YEAST:G3O-31193-MONOMER.

Miscellaneous databases

NextBioi 982393.

Gene expression databases

Genevestigatori P38853.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
InterProi IPR015915. Kelch-typ_b-propeller.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae."
    Philips J., Herskowitz I.
    J. Cell Biol. 143:375-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-477; SER-613; SER-691 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-25; THR-467; SER-503; THR-604; SER-613; THR-626; SER-748; SER-837; SER-997 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-503; SER-613; SER-689; SER-691; SER-717; SER-748; SER-848; SER-958 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKEL1_YEAST
AccessioniPrimary (citable) accession number: P38853
Secondary accession number(s): D3DLA7, E9P8X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3