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P38853 (KEL1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch repeat-containing protein 1
Gene names
Name:KEL1
Ordered Locus Names:YHR158C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1164 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway.

Subunit structure

Interacts with KEL2.

Miscellaneous

Present with 1350 molecules/cell in log phase SD medium.

Sequence similarities

Contains 5 Kelch repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11641164Kelch repeat-containing protein 1
PRO_0000119096

Regions

Repeat139 – 18648Kelch 1
Repeat253 – 30755Kelch 2
Repeat308 – 35750Kelch 3
Repeat359 – 40951Kelch 4
Repeat411 – 46050Kelch 5
Coiled coil777 – 931155 Potential
Coiled coil974 – 1163190 Potential

Amino acid modifications

Modified residue201Phosphoserine Ref.10
Modified residue231Phosphoserine Ref.9 Ref.10
Modified residue251Phosphoserine Ref.9
Modified residue941Phosphoserine Ref.6
Modified residue4671Phosphothreonine Ref.9
Modified residue4771Phosphothreonine Ref.7
Modified residue5031Phosphoserine Ref.9 Ref.10
Modified residue6041Phosphothreonine Ref.9
Modified residue6131Phosphoserine Ref.6 Ref.7 Ref.9 Ref.10
Modified residue6261Phosphothreonine Ref.9
Modified residue6891Phosphoserine Ref.10
Modified residue6911Phosphoserine Ref.7 Ref.10
Modified residue7171Phosphoserine Ref.10
Modified residue7481Phosphoserine Ref.9 Ref.10
Modified residue8371Phosphoserine Ref.9
Modified residue8481Phosphoserine Ref.10
Modified residue9581Phosphoserine Ref.10
Modified residue9971Phosphoserine Ref.9
Modified residue10031Phosphoserine Ref.8
Modified residue10221Phosphoserine Ref.7 Ref.9 Ref.10

Experimental info

Sequence conflict4471D → A in AAT92822. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P38853 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 43D0FC570F1D5E4D

FASTA1,164131,094
        10         20         30         40         50         60 
MAGFSFAKKF THKKHGKTPS DASISDQSRE ASLSTPPNEK FFTKQETPQK GRQFSQGYHS 

        70         80         90        100        110        120 
NVNKTSSPPM FARKQVSESR IQPSAVPPQQ RNVSGPSTTL HKQLSKQREY TVWNRIKLQN 

       130        140        150        160        170        180 
SPFPRYRHVA SAYVTDKNQI YVIGGLHDQS VYGDTWILTA FDNATRFSTT TIDISEATPP 

       190        200        210        220        230        240 
PRVGHAAVLC GNAFVVFGGD THKVNKEGLM DDDIYLLNIN SYKWTVPAPV GPRPLGRYGH 

       250        260        270        280        290        300 
KISIIATTQM KTKLYVFGGQ FDDTYFNDLA VYDLSSFRRP DSHWEFLKPR TFTPPPITNF 

       310        320        330        340        350        360 
TMISYDSKLW VFGGDTLQGL VNDVFMYDPA INDWFIIDTT GEKPPPVQEH ATVVYNDLMC 

       370        380        390        400        410        420 
VVGGKDEHDA YLNSVYFLNL KSRKWFKLPV FTAGIPQGRS GHSLTLLKND KILIMGGDKF 

       430        440        450        460        470        480 
DYARVEEYDL HTSDIDMQRG TIVYTLDLAR IKDLCPGVMD VPTDTPTPRN GNLDLATPVT 

       490        500        510        520        530        540 
PTSHQTKNMN VPISAAPLAS APSPAPKDFS DADRLNREVH NRNVSTEHQN QSHPVNSESH 

       550        560        570        580        590        600 
LIAEPNILTP YVPSESSQTP VMKITSNKPF DTPTIQKEPD LSETMDPTVG NQRIPSSIYG 

       610        620        630        640        650        660 
DNLTPANQIK NNSPILETLP SNEIKTPQNG NIEEIKHLPD ADEKIDSTTT FDQEINGDKL 

       670        680        690        700        710        720 
GTSSMSKVEE DGNVADEDDE IGVAQMASSP SKDQFKIKHY NESSELSQNN TEIDKLSEPV 

       730        740        750        760        770        780 
DITIKKSDTA GHDSANHVID ASDEKNVSPM GDVPTDTKNE EASVPINRDA TTEVVDRALF 

       790        800        810        820        830        840 
EKLRSELQSL KELTHEKALE AGAHIKELET ELWQLKSQKN SGTTKEIDEL DSVRLQSKCE 

       850        860        870        880        890        900 
ILEADNHSLE DKVNELEELV NSKFLDIENL NEVIQFQNEK IKSLELEPNY KEKLEELQIE 

       910        920        930        940        950        960 
HENLSRENER LKNESKQHNE DIINNVANYS SQLGSLISHW KENRANSSFL ESSSSLISVS 

       970        980        990       1000       1010       1020 
DENGEKTVGE PYGDQSRHHR VVINKLTNRL DDLLERSQEL TISKEKLSSE YHALKMEHSS 

      1030       1040       1050       1060       1070       1080 
LSQDVLVKEN EIKKIQNDYK ESISSMDSAS KALMVSQREL EKYKSLNKKL IDELDELKFK 

      1090       1100       1110       1120       1130       1140 
NGVCSENFEN GLRSTEESSN NVKNSNSIRE NQFNIKINDL KAELFITNQE RDDLKSEVLE 

      1150       1160 
LKKRLLNLEN NTKQVNEDAD SDLL 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae."
Philips J., Herskowitz I.
J. Cell Biol. 143:375-389(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: YAL6B.
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-477; SER-613; SER-691 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-25; THR-467; SER-503; THR-604; SER-613; THR-626; SER-748; SER-837; SER-997 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-503; SER-613; SER-689; SER-691; SER-717; SER-748; SER-848; SER-958 AND SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10397 Genomic DNA. Translation: AAB68991.1.
AY692803 Genomic DNA. Translation: AAT92822.1.
BK006934 Genomic DNA. Translation: DAA06851.1.
PIRS46769.
RefSeqNP_012028.1. NM_001179289.1.

3D structure databases

ProteinModelPortalP38853.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36592. 102 interactions.
DIPDIP-1403N.
IntActP38853. 31 interactions.
MINTMINT-385237.
STRING4932.YHR158C.

2D gel databases

COMPLUYEAST-2DPAGEP38853.

Proteomic databases

PaxDbP38853.
PeptideAtlasP38853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR158C; YHR158C; YHR158C.
GeneID856563.
KEGGsce:YHR158C.

Organism-specific databases

CYGDYHR158c.
SGDS000001201. KEL1.

Phylogenomic databases

eggNOGNOG145020.
GeneTreeENSGT00720000108564.
HOGENOMHOG000000942.
OMAPDNNFYL.
OrthoDBEOG7008HF.

Enzyme and pathway databases

BioCycYEAST:G3O-31193-MONOMER.

Gene expression databases

GenevestigatorP38853.

Family and domain databases

Gene3D2.120.10.80. 1 hit.
InterProIPR015915. Kelch-typ_b-propeller.
[Graphical view]
ProtoNetSearch...

Other

NextBio982393.

Entry information

Entry nameKEL1_YEAST
AccessionPrimary (citable) accession number: P38853
Secondary accession number(s): D3DLA7, E9P8X4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families