P38852 (LIN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein LIN1

Gene names

Name:	LIN1
Ordered Locus Names:	YHR156C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with the cohesin subunit IRR1. Interacts with PRP8, HEX3, NFI1, WSS1, RFC1 and YJL149W. Ref.4
Subcellular location	Nucleus. Note: Probably associated with chromatin. Ref.4
Miscellaneous	Present with 799 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the LIN1 family. Contains 1 GYF domain.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	U5 snRNP Inferred from direct assay. Source: SGD chromatin Inferred from direct assay Ref.4. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRP8	P33334	3	EBI-570,EBI-465

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Protein LIN1		PRO_0000195038
Regions
	Domain	282 – 340	59	GYF

Sequences

	Sequence		Length	Mass (Da)
	P38852 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 59A10D63E0C8715C	FASTA	340	40,369
	10 20 30 40 50 60 MKYTQYPNSS KLKRNSDRRE HDEKLSDELH NQSTIYEDEE LSRAEYDSDS DSSVEDSTDN 70 80 90 100 110 120 ENSGKEMDEK SYEKNEDHVE DHRKRKKSKI QLLDIAEFKK ENLADLDYQI GNSESKVEKG 130 140 150 160 170 180 VNIEPFNIDD EIKHGVFDKD GNYIKTENAT ENDQQDNEEW MNDVINTEEV NRLEKEQSVK 190 200 210 220 230 240 TQNSRHYMVH EALNLLKFFL VDENETVLES LGRLNKLRKI AISKKNKSLK YVIHGIELLS 250 260 270 280 290 300 DLINILEKKG FSEVYEYNRL KVQDAIEEEI FDDSSRIVNH KTKLWGFKWL NKLDEYHGLY 310 320 330 340 TNYEMSYWQK SYFKNSVIVK FHSEPDRDEN WIHVSCLSFM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Proteins interacting with Lin 1p, a putative link between chromosome segregation, mRNA splicing and DNA replication in Saccharomyces cerevisiae." Bialkowska A., Kurlandzka A. Yeast 19:1323-1333(2002) [PubMed: 12402242] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH IRR1; PRP8; HEX3; NFI1; WSS1; RFC1 AND YJL149W.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10397 Genomic DNA. Translation: AAB68990.1. AY557881 Genomic DNA. Translation: AAS56207.1. BK006934 Genomic DNA. Translation: DAA06849.1.
PIR	S46768.
RefSeq	NP_012026.1. NM_001179287.1.
3D structure databases
ProteinModelPortal	P38852.
SMR	P38852. Positions 282-339.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4407N.
IntAct	P38852. 12 interactions.
MINT	MINT-552042.
STRING	P38852.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR156C; YHR156C; YHR156C.
GeneID	856561.
KEGG	sce:YHR156C.
NMPDR	fig|4932.3.peg.3190.
Organism-specific databases
CYGD	YHR156c.
SGD	S000001199. LIN1.
Phylogenomic databases
eggNOG	fuNOG11633.
OMA	MQYWKEN.
OrthoDB	EOG4KSSVF.
Gene expression databases
ArrayExpress	P38852.
Genevestigator	P38852.
GermOnline	YHR156C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003169. GYF. [Graphical view]
Pfam	PF02213. GYF. 1 hit. [Graphical view]
SMART	SM00444. GYF. 1 hit. [Graphical view]
PROSITE	PS50829. GYF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982387.

Entry information

Entry name

LIN1_YEAST

Accession

Primary (citable) accession number: P38852
Secondary accession number(s): D3DLA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program