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Protein

Membrane-anchored lipid-binding protein LAM1

Gene

LAM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone (PubMed:15657396, PubMed:18800175). May be involved in sterol transfer between intracellular membranes (PubMed:26001273).3 Publications

GO - Molecular functioni

  • sterol transporter activity Source: SGD

GO - Biological processi

  • intracellular sterol transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31190-MONOMER.

Protein family/group databases

TCDBi9.B.198.1.1. the membrane-anchored lipid-binding protein (lam) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-anchored lipid-binding protein LAM11 Publication
Alternative name(s):
Lipid transfer protein anchored at membrane contact sites 11 Publication
Yeast suicide protein 11 Publication
Gene namesi
Name:LAM11 Publication
Synonyms:YSP11 Publication
Ordered Locus Names:YHR155WImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR155W.
SGDiS000001198. LAM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 10621062Cytoplasmic1 PublicationAdd
BLAST
Transmembranei1063 – 108321HelicalSequence analysisAdd
BLAST
Topological domaini1084 – 1228145LumenalBy similarityAdd
BLAST

GO - Cellular componenti

  • cortical endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12281228Membrane-anchored lipid-binding protein LAM1PRO_0000202927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi1205 – 12051N-linked (GlcNAc...)PROSITE-ProRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38851.
TopDownProteomicsiP38851.

Interactioni

Protein-protein interaction databases

BioGridi36589. 37 interactions.
IntActiP38851. 1 interaction.
MINTiMINT-2491961.

Structurei

3D structure databases

ProteinModelPortaliP38851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 421114PHPROSITE-ProRule annotationAdd
BLAST
Domaini773 – 978206VAStPROSITE-ProRule annotationAdd
BLAST

Domaini

The VASt domain bind sterols.By similarity

Sequence similaritiesi

Belongs to the SIP3 family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 VASt domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000016474.
HOGENOMiHOG000057112.
InParanoidiP38851.
OrthoDBiEOG092C0B9T.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR031968. DUF4782.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS51778. VAST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEHKAELRL ITVALNEAST DSPSFRASVN YFHTRMESLS SWMHSTVDYV
60 70 80 90 100
ENTYKPSFQD FQRIKETLFS QLLPSPILLS NGFVSNQPYT PLLVRDFTRD
110 120 130 140 150
VSDLSNTVMK IILGDENSQY TAALSALSSD AINPYFNKRK TFEYYQRKYD
160 170 180 190 200
SFLTDFLAAT NDGNTLIPQN LQNETFKLVD IKHKYIEASL DLTEAISLMK
210 220 230 240 250
VNLDKFLIET IDIVRKNNVI TTKDTKDVID ITPELTETLK DWTDWIESNL
260 270 280 290 300
QTLQALSSKL SEAKYAILKL SLARMKPSRL IQDYDLKSIQ NLKFNLPKSI
310 320 330 340 350
SNGNNSEEKG LSGWLYMKTT VGHDPKRVVW VRRWCFLQNN VFGVFSLSPS
360 370 380 390 400
KTYVEETDKF GILWITVEYL PKEPRNFCFK LRIQNPNCKT EEENTYIDII
410 420 430 440 450
LQAESIDELK SWINTLTSHK RIALSIKEEN DPRYQLARKK IEPQFFEFAS
460 470 480 490 500
SSSTSTDKLL TSFSSKTLTL VEELKKNYMS EDDIYSIIDN KAYHLRVIST
510 520 530 540 550
PIATQLTHLA LFSTFLSVSN YYPCATQANT WGTANWNDLS YLVNPLKGSS
560 570 580 590 600
VHKPATVSNS SRFSVSYPDY YPYSLKVDDI QFRSIFFSVN HDFLQVPKEL
610 620 630 640 650
VLLRYSSVWC PNNKQKFASM AFVTLNHIYV YLNISGFSYL RRIDLLDIDS
660 670 680 690 700
IEYDKSPKHV SSRMLHMQRG DGLRFNMSVF FTDRRAVASK LQFLIENKAM
710 720 730 740 750
HIPKGEKEVL EIFQELDEEI ENEKKIIKDN LSESEHYSKD YDYLLKSTYD
760 770 780 790 800
HHFENTNETP MELMSRKLRL EREAWCYFQD NFKVGSKTLF HVLFGDKSQV
810 820 830 840 850
FPSSLFLCKK GSNLNNNSYW ERIRRAKEDA SCQFELCRKL QFQLNRTSNF
860 870 880 890 900
IKDLLWLKDD NDNFKLVLQQ RVTKIKQGYY FEVEEGPIIV KFPLCHPLLL
910 920 930 940 950
RVRFIIAECI TSQGESLKKC DLAILYDFNY VESIDKLNTK VEKLWLFERI
960 970 980 990 1000
HLNWALRYCK LEHSEINRKT REYLKKFNDR EKMSDVIKLC GFLGVLPKER
1010 1020 1030 1040 1050
IENDEKAGDF MQPVYINYDF LSLSKIFTKL TVFYLSSVII KTMKVLLAMV
1060 1070 1080 1090 1100
MVIFKCFSKV NKTLYYCLLI SAVTNLFFVG KSIHSYFSVK SAETLFQNYA
1110 1120 1130 1140 1150
NGDQRGLQIM HRSLTVPDLN LLTRKMMDND QENPVFKRFD EDKNAYQYKG
1160 1170 1180 1190 1200
TRQEIAIKRN QVLTELKILQ NTEKELVQGS YRKFIITERD KCITTQNEIF
1210 1220
DLWINDTKLQ DYCMACFAEY NRLSAIPV
Length:1,228
Mass (Da):143,584
Last modified:February 1, 1995 - v1
Checksum:iC8872EAE8270A4B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68977.1.
BK006934 Genomic DNA. Translation: DAA06848.1.
PIRiS46754.
RefSeqiNP_012025.1. NM_001179286.1.

Genome annotation databases

EnsemblFungiiYHR155W; YHR155W; YHR155W.
GeneIDi856560.
KEGGisce:YHR155W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10397 Genomic DNA. Translation: AAB68977.1.
BK006934 Genomic DNA. Translation: DAA06848.1.
PIRiS46754.
RefSeqiNP_012025.1. NM_001179286.1.

3D structure databases

ProteinModelPortaliP38851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36589. 37 interactions.
IntActiP38851. 1 interaction.
MINTiMINT-2491961.

Protein family/group databases

TCDBi9.B.198.1.1. the membrane-anchored lipid-binding protein (lam) family.

Proteomic databases

MaxQBiP38851.
TopDownProteomicsiP38851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR155W; YHR155W; YHR155W.
GeneIDi856560.
KEGGisce:YHR155W.

Organism-specific databases

EuPathDBiFungiDB:YHR155W.
SGDiS000001198. LAM1.

Phylogenomic databases

GeneTreeiENSGT00390000016474.
HOGENOMiHOG000057112.
InParanoidiP38851.
OrthoDBiEOG092C0B9T.

Enzyme and pathway databases

BioCyciYEAST:G3O-31190-MONOMER.

Miscellaneous databases

PROiP38851.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR031968. DUF4782.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS51778. VAST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAM1_YEAST
AccessioniPrimary (citable) accession number: P38851
Secondary accession number(s): D3DLA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1170 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.